{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T03:52:18Z","timestamp":1784605938102,"version":"3.55.0"},"reference-count":52,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T00:00:00Z","timestamp":1665705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and Higher Education of the Russian Federation","award":["N 075-15-2020-777"],"award-info":[{"award-number":["N 075-15-2020-777"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>In this work a new donor of nitric oxide (NO) with antibacterial properties, namely nitrosyl iron complex of [Fe(C6H5C-SNH2)2(NO)2][Fe(C6H5C-SNH2)(S2O3)(NO)2] composition (complex I), has been synthesized and studied. Complex I was produced by the reduction of the aqueous solution of [Fe2(S2O3)2(NO)2]2\u2212 dianion by the thiosulfate, with the further treatment of the mixture by the acidified alcohol solution of thiobenzamide. Based on the structural study of I (X-ray analysis, quantum chemical calculations by NBO and QTAIM methods in the frame of DFT), the data were obtained on the presence of the NO\u2026NO interactions, which stabilize the DNIC dimer in the solid phase. The conformation properties, electronic structure and free energies of complex I hydration were studied using B3LYP functional and the set of 6\u201331 + G(d,p) basis functions. The effect of an aquatic surrounding was taken into account in the frame of a polarized continuous model (PCM). The NO-donating activity of complex I was studied by the amperometry method using an \u201camiNO-700\u201d sensor electrode of the \u201cinNO Nitric Oxide Measuring System\u201d. The antibacterial activity of I was studied on gram-negative (Escherichia coli) and gram-positive (Micrococcus luteus) bacteria. Cytotoxicity was studied using Vero cells. Complex I was found to exhibit antibacterial activity comparable to that of antibiotics, and moderate toxicity to Vero cells.<\/jats:p>","DOI":"10.3390\/molecules27206886","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T03:43:58Z","timestamp":1665978238000},"page":"6886","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Novel Type of Tetranitrosyl Iron Salt: Synthesis, Structure and Antibacterial Activity of Complex [FeL\u20192(NO)2][FeL\u2019L\u201d(NO)2] with L\u2019-thiobenzamide and L\u201d-thiosulfate"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5344-6220","authenticated-orcid":false,"given":"Nataliya A.","family":"Sanina","sequence":"first","affiliation":[{"name":"Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, RAS, 1, Acad. Semenov Av., 142432 Chernogolovka, Russia"},{"name":"Faculty of Fundamental Physical-Chemical Engineering, M.V. Lomonosov Moscow State University, 1\/51 Leninskie Gory, 119991 Moscow, Russia"},{"name":"Scientific and Educational Center in Chernogolovka, Medical-Biological Institute, Moscow Regional State University, 24, Vera Voloshina Street, 141014 Mytischi, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arina A.","family":"Starostina","sequence":"additional","affiliation":[{"name":"Faculty of Fundamental Physical-Chemical Engineering, M.V. Lomonosov Moscow State University, 1\/51 Leninskie Gory, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey N.","family":"Utenyshev","sequence":"additional","affiliation":[{"name":"Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, RAS, 1, Acad. Semenov Av., 142432 Chernogolovka, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel V.","family":"Dorovatovskii","sequence":"additional","affiliation":[{"name":"National Research Centre \u201cKurchatov Institute\u201d, 1 Acad. Kurchatov Square, 123182 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0381-7695","authenticated-orcid":false,"given":"Nina S.","family":"Emel\u2019yanova","sequence":"additional","affiliation":[{"name":"Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, RAS, 1, Acad. Semenov Av., 142432 Chernogolovka, Russia"},{"name":"Faculty of Fundamental Physical-Chemical Engineering, M.V. Lomonosov Moscow State University, 1\/51 Leninskie Gory, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir B.","family":"Krapivin","sequence":"additional","affiliation":[{"name":"Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, RAS, 1, Acad. Semenov Av., 142432 Chernogolovka, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2528-4567","authenticated-orcid":false,"given":"Victor B.","family":"Luzhkov","sequence":"additional","affiliation":[{"name":"Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, RAS, 1, Acad. Semenov Av., 142432 Chernogolovka, Russia"},{"name":"Faculty of Fundamental Physical-Chemical Engineering, M.V. Lomonosov Moscow State University, 1\/51 Leninskie Gory, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoriya A.","family":"Mumyatova","sequence":"additional","affiliation":[{"name":"Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, RAS, 1, Acad. Semenov Av., 142432 Chernogolovka, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasiya A.","family":"Balakina","sequence":"additional","affiliation":[{"name":"Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, RAS, 1, Acad. Semenov Av., 142432 Chernogolovka, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2259-8184","authenticated-orcid":false,"given":"Alexei A.","family":"Terentiev","sequence":"additional","affiliation":[{"name":"Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, RAS, 1, Acad. Semenov Av., 142432 Chernogolovka, Russia"},{"name":"Faculty of Fundamental Physical-Chemical Engineering, M.V. Lomonosov Moscow State University, 1\/51 Leninskie Gory, 119991 Moscow, Russia"},{"name":"Scientific and Educational Center in Chernogolovka, Medical-Biological Institute, Moscow Regional State University, 24, Vera Voloshina Street, 141014 Mytischi, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3555-7442","authenticated-orcid":false,"given":"Sergey M.","family":"Aldoshin","sequence":"additional","affiliation":[{"name":"Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, RAS, 1, Acad. Semenov Av., 142432 Chernogolovka, Russia"},{"name":"Faculty of Fundamental Physical-Chemical Engineering, M.V. Lomonosov Moscow State University, 1\/51 Leninskie Gory, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1002\/med.21636","article-title":"Inducible nitric oxide synthase inhibitors: A comprehensive update","volume":"40","author":"Minhas","year":"2020","journal-title":"Med. Res. Rev."},{"key":"ref_2","unstructured":"Ignarro, L.J., and Freeman, B.A. (2017). Nitric Oxide Biology and Pathobiology, Elsevier Inc.. [3rd ed.]."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Vanin, A.F. (2021). Physico-Chemistry of Dinitrosyl Iron Complexes as a Determinant of Their Biological Activity. Int. J. Mol. 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