{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T12:22:04Z","timestamp":1775132524727,"version":"3.50.1"},"reference-count":203,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2022,10,16]],"date-time":"2022-10-16T00:00:00Z","timestamp":1665878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The Omicron variant (B.529) of COVID-19 caused disease outbreaks worldwide because of its contagious and diverse mutations. To reduce these outbreaks, therapeutic drugs and adjuvant vaccines have been applied for the treatment of the disease. However, these drugs have not shown high efficacy in reducing COVID-19 severity, and even antiviral drugs have not shown to be effective. Researchers thus continue to search for an effective adjuvant therapy with a combination of drugs or vaccines to treat COVID-19 disease. We were motivated to consider melatonin as a defensive agent against SARS-CoV-2 because of its various unique properties. Over 200 scientific publications have shown the significant effects of melatonin in treating diseases, with strong antioxidant, anti-inflammatory, and immunomodulatory effects. Melatonin has a high safety profile, but it needs further clinical trials and experiments for use as a therapeutic agent against the Omicron variant of COVID-19. It might immediately be able to prevent the development of severe symptoms caused by the coronavirus and can reduce the severity of the infection by improving immunity.<\/jats:p>","DOI":"10.3390\/molecules27206934","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T03:43:58Z","timestamp":1665978238000},"page":"6934","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Potential Therapeutic Approach of Melatonin against Omicron and Some Other Variants of SARS-CoV-2"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1510-5748","authenticated-orcid":false,"given":"Rahima","family":"Begum","sequence":"first","affiliation":[{"name":"Department of Microbiology, Gono Bishwabidyalay, Dhaka 1344, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0155-4676","authenticated-orcid":false,"given":"A. N. M.","family":"Mamun-Or-Rashid","sequence":"additional","affiliation":[{"name":"Anti-Aging Medical Research Center, Graduate School of Life and Medical Sciences, Doshisha University 1-3 TataraMiyakodani, Kyoto 610-0394, Japan"},{"name":"Glycative Stress Research Center, Graduate School of Life and Medical Sciences, Doshisha University 1-3 Tatara Miyakodani, Kyoto 610-0394, Japan"},{"name":"Department of Environmental & Occupational Health, School of Public Health, University of Pittsburgh, 130 De Soto Str., Pittsburgh, PA 15231, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanzima Tarannum","family":"Lucy","sequence":"additional","affiliation":[{"name":"Anti-Aging Medical Research Center, Graduate School of Life and Medical Sciences, Doshisha University 1-3 TataraMiyakodani, Kyoto 610-0394, Japan"},{"name":"Glycative Stress Research Center, Graduate School of Life and Medical Sciences, Doshisha University 1-3 Tatara Miyakodani, Kyoto 610-0394, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md. Kamruzzaman","family":"Pramanik","sequence":"additional","affiliation":[{"name":"Microbiology and Industrial Irradiation Division, Institute of Food and Radiation Biology, Atomic Energy Research Establishment, Savar 1349, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bijon Kumar","family":"Sil","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Gono Bishwabidyalay, Dhaka 1344, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobendu","family":"Mukerjee","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Ramakrishna Mission Vivekananda Centenary College, Kolkata 700118, India"},{"name":"Department of Health Sciences, Novel Global Community Educational Foundation, Sydney 37729, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0375-9165","authenticated-orcid":false,"given":"Priti","family":"Tagde","sequence":"additional","affiliation":[{"name":"Patel College of Pharmacy, Madhyanchal Professional University, Bhopal 462044, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6005-8632","authenticated-orcid":false,"given":"Masayuki","family":"Yagi","sequence":"additional","affiliation":[{"name":"Anti-Aging Medical Research Center, Graduate School of Life and Medical Sciences, Doshisha University 1-3 TataraMiyakodani, Kyoto 610-0394, Japan"},{"name":"Glycative Stress Research Center, Graduate School of Life and Medical Sciences, Doshisha University 1-3 Tatara Miyakodani, Kyoto 610-0394, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2682-752X","authenticated-orcid":false,"given":"Yoshikazu","family":"Yonei","sequence":"additional","affiliation":[{"name":"Anti-Aging Medical Research Center, Graduate School of Life and Medical Sciences, Doshisha University 1-3 TataraMiyakodani, Kyoto 610-0394, Japan"},{"name":"Glycative Stress Research Center, Graduate School of Life and Medical Sciences, Doshisha University 1-3 Tatara Miyakodani, Kyoto 610-0394, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1007\/s40520-020-01631-y","article-title":"COVID-19 and the elderly: Insights into pathogenesis and clinical decision-making","volume":"32","author":"Perrotta","year":"2020","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1002\/jmv.27516","article-title":"Sequence analysis of the emerging SARS-CoV-2 variant Omicron in South Africa","volume":"94","author":"Wang","year":"2022","journal-title":"J. Med. Virol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3633","DOI":"10.1111\/febs.15375","article-title":"A Guide to COVID-19: A global pandemic caused by the novel coronavirus SARS-CoV-2","volume":"287","author":"Atzrodt","year":"2020","journal-title":"FEBS J."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Artigas, L., Coma, M., Matos-Filipe, P., Aguirre-Plans, J., Farr\u00e9s, J., Valls, R., and Mas, J.M. (2020). In-silico drug repurposing study predicts the combination of pirfenidone and melatonin as a promising candidate therapy to reduce SARS-CoV-2 infection progressionand respiretory distress caused by cytokine storm. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0240149"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"115","DOI":"10.37201\/req\/158.2021","article-title":"Pharmacological treatment of COVID-19: An opinion paper","volume":"35","year":"2022","journal-title":"Rev. Esp. Quim."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Heustess, A., Allard, M., Thompson, D., and Fasinu, P. (2021). Clinical Management of COVID-19: A Review of Pharmacological Treatment Options. Pharmaceuticals, 14.","DOI":"10.3390\/ph14060520"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nri1732","article-title":"Immunopathogenesis of coronavirus infections: Implications for SARS","volume":"5","author":"Dandekar","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.3389\/fphar.2020.01169","article-title":"Cellular and Molecular Pathways of COVID-19 and Potential Points of Therapeutic Intervention","volume":"11","author":"Hussman","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"30","DOI":"10.32794\/mr11250081","article-title":"Melatonin: A potential therapeutic agent against COVID-19","volume":"4","author":"Gurunathan","year":"2021","journal-title":"Melatonin Res."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Mannino, G., Pernici, C., Serio, G., Gentile, C., and Bertea, C.M. (2021). Melatonin and Phytomelatonin: Chemistry, Biosynthesis, Metabolism, Distribution and Bioactivity in Plants and Animals\u2014An Overview. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22189996"},{"key":"ref_11","first-page":"59","article-title":"An overview of melatonin as an antioxidant molecule: A biochemical approach","volume":"5","author":"Baba","year":"2018","journal-title":"Melatonin Mol. Biol. Clin. Pharm. Approaches"},{"key":"ref_12","first-page":"55","article-title":"Extra-pineal melatonin in the retina: Its regulation and physiological function","volume":"4","author":"Pang","year":"1986","journal-title":"Pineal Res. Rev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1159\/000179137","article-title":"Localization of Melatonin in the Digestive Tract of the Rat","volume":"12","author":"Bubenik","year":"1980","journal-title":"Horm. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/S0304-4165(99)00125-7","article-title":"Identification of highly elevated levels of melatonin in bone marrow: Its origin and significance","volume":"1472","author":"Tan","year":"1999","journal-title":"Biochim. Biophys. Acta (BBA) Gen. Subj."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1034\/j.1600-079X.2000.280401.x","article-title":"Evidence for melatonin synthesis in mouse and human bone marrow cells","volume":"28","author":"Conti","year":"2000","journal-title":"J. Pineal Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/0024-3205(83)90192-3","article-title":"Rhythms in immunoreactive melatonin in the retina and harderian gland of rats: Persistence after pinealectomy","volume":"32","author":"Reiter","year":"1983","journal-title":"Life Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1096\/fj.01-0952fje","article-title":"Serotoninergic and melatoninergic systems are fully expressed in human skin","volume":"16","author":"Slominski","year":"2002","journal-title":"FASEB J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1096\/fj.03-0694fje","article-title":"Evidence of melatonin synthesis by human lymphocytes and its physiological significance: Possible role as intracrine, autocrine, and\/or paracrine substance","volume":"18","author":"Calvo","year":"2004","journal-title":"FASEB J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1600-079X.2006.00389.x","article-title":"Expression and cellular localization of melatonin-synthesizing enzymes in the rat lens","volume":"42","author":"Itoh","year":"2007","journal-title":"J. Pineal Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1503\/jpn.130009","article-title":"CCNP Award Paper: Unveiling the role of melatonin MT2 receptors in sleep, anxiety and other neuropsychiatric diseases: A novel target in psychopharmacology","volume":"39","author":"Comai","year":"2014","journal-title":"J. Psychiatry Neurosci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e936292-1","DOI":"10.12659\/MSM.936292","article-title":"A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Management of Mild-to-Moderate Symptomatic COVID-19","volume":"28","author":"Fazio","year":"2022","journal-title":"Med. Sci. Monit."},{"key":"ref_22","first-page":"732","article-title":"Computational and spectroscopy study of melatonin","volume":"60","author":"Omer","year":"2021","journal-title":"Indian J. Chem. Section B"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"181","DOI":"10.2174\/1568026023394443","article-title":"Chemical and Physical Properties and Potential Mechanisms: Melatonin as a Broad Spectrum Antioxidant and Free Radical Scavenger","volume":"2","author":"Tan","year":"2002","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_24","first-page":"11","article-title":"Medical implications of melatonin: Receptor-mediated and receptor-independent actions","volume":"52","author":"Reiter","year":"2007","journal-title":"Adv. Med. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s11154-020-09570-9","article-title":"Melatonin, an ubiquitous metabolic regulator: Functions, mechanisms and effects on circadian disruption and degenerative diseases","volume":"21","author":"Socaciu","year":"2020","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/jpi.12026","article-title":"Mitochondria and chloroplasts as the original sites of melatonin synthesis: A hypothesis related to melatonin\u2019s primary function and evolution in eukaryotes","volume":"54","author":"Tan","year":"2013","journal-title":"J. Pineal Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/1750-3841.14952","article-title":"Influence of Dietary Sources of Melatonin on Sleep Quality: A Review","volume":"85","author":"Pereira","year":"2019","journal-title":"J. Food Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3390\/cimb44010003","article-title":"Protective effect of melatonin administration against SARS-CoV-2 infection: A systematic review","volume":"44","author":"Agil","year":"2021","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_29","first-page":"838","article-title":"Melatonin rhythm in human milk","volume":"77","author":"Presl","year":"1993","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_30","first-page":"58","article-title":"Serum melatonin levels and antioxidant capacities after consumption of pineapple, orange, or banana by healthy male volunteers","volume":"55","author":"Johns","year":"2012","journal-title":"J. Pineal Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1600-079X.2006.00369.x","article-title":"Therapeutic treatments potentially mediated by melatonin receptors: Potential clinical uses in the prevention of osteoporosis, cancer and as an adjuvant therapy","volume":"41","author":"Radio","year":"2006","journal-title":"J. Pineal Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e2109","DOI":"10.1002\/rmv.2109","article-title":"Melatonin: Roles in influenza, Covid-19, and other viral infections","volume":"30","author":"Anderson","year":"2020","journal-title":"Rev. Med. Virol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1046\/j.1600-079X.2003.00105.x","article-title":"Melatonin and viral infections","volume":"36","author":"Bonilla","year":"2004","journal-title":"J. Pineal Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"117583","DOI":"10.1016\/j.lfs.2020.117583","article-title":"COVID-19: Melatonin as a potential adjuvant treatment","volume":"250","author":"Zhang","year":"2020","journal-title":"Life Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.3389\/fimmu.2018.01914","article-title":"The Combined Use of Melatonin and an Indoleamine 2,3-Dioxygenase-1 Inhibitor Enhances Vaccine-Induced Protective Cellular Immunity to HPV16-Associated Tumors","volume":"9","author":"Moreno","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.brainres.2015.06.034","article-title":"Melatonin, minocycline and ascorbic acid reduce oxidative stress and viral titers and increase survival rate in experimental Venezuelan equine encephalitis","volume":"1622","author":"Valero","year":"2015","journal-title":"Brain Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"173329","DOI":"10.1016\/j.ejphar.2020.173329","article-title":"Melatonin is a potential adjuvant to improve clinical outcomes in individuals with obesity and diabetes with coexistence of COVID-19","volume":"882","author":"Othman","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Capote-Moreno, A., Ramos, E., Egea, J., L\u00f3pez-Mu\u00f1oz, F., Gil-Mart\u00edn, E., and Romero, A. (2019). Potential of Melatonin as Adjuvant Therapy of Oral Cancer in the Era of Epigenomics. Cancers, 11.","DOI":"10.3390\/cancers11111712"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"198108","DOI":"10.1016\/j.virusres.2020.198108","article-title":"Melatonin potentials against viral infections including COVID-19: Current evidence and new findings","volume":"287","author":"Juybari","year":"2020","journal-title":"Virus Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41586-020-2521-4","article-title":"Factors associated with COVID-19-related death using OpenSAFELY","volume":"584","author":"Williamson","year":"2020","journal-title":"Nature"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.bbabio.2008.10.006","article-title":"Pathophysiology of mitochondrial volume homeostasis: Potassium transport and permeability transition","volume":"1787","author":"Nowikovsky","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.arcmed.2020.04.019","article-title":"Oxidative stress as key player in severe acute respiratory syndrome coronavirus (SARS-CoV) infection","volume":"51","author":"Mesta","year":"2020","journal-title":"Arch. Med. Res."},{"key":"ref_43","first-page":"12","article-title":"COVID-19 infection and oxidative stress: An under-explored approach for prevention and treatment?","volume":"35","year":"2020","journal-title":"Pan Afr. Med. J."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e104","DOI":"10.1055\/s-0040-1716713","article-title":"Possible Protective Role of Melatonin in Pediatric Infectious Diseases and Neurodevelopmental Pathologies","volume":"10","year":"2020","journal-title":"J. Child Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.arcmed.2021.06.006","article-title":"Efficacy of a Low Dose of Melatonin as an Adjunctive Therapy in Hospitalized Patients with COVID-19: A Randomized, Double-blind Clinical Trial","volume":"53","author":"Farnoosh","year":"2021","journal-title":"Arch. Med. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"695","DOI":"10.3122\/jabfm.2022.04.210529","article-title":"A Pilot of a Randomized Control Trial of Melatonin and Vitamin C for Mild-to-Moderate COVID-19","volume":"35","author":"Fogleman","year":"2022","journal-title":"J. Am. Board Fam. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.3906\/sag-2012-361","article-title":"Impact of COVID-19 on serum melatonin levels and sleep parameters in children","volume":"51","author":"Bayhan","year":"2021","journal-title":"Turk. J. Med. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ijid.2021.10.012","article-title":"The Effect of Melatonin on Thrombosis, Sepsis and Mortality Rate in COVID-19 Patients","volume":"114","author":"Hasan","year":"2021","journal-title":"Int. J. Infect. Dis."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"4061","DOI":"10.1007\/s11033-022-07419-9","article-title":"Melatonin and REGN-CoV2 combination as a vaccine adjuvant for Omicron variant of SARS-CoV-2","volume":"49","author":"Haskologlu","year":"2022","journal-title":"Mol. Biol. Rep."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1056\/NEJMsa1012065","article-title":"The ClinicalTrials. gov results database\u2014Update and key issues","volume":"364","author":"Zarin","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"297","DOI":"10.32794\/mr11250063","article-title":"Melatonin as adjuvant treatment for coronavirus disease 2019 pneumonia patients requiring hospitalization (MAC-19 PRO): A case series","volume":"3","author":"Castillo","year":"2020","journal-title":"Melatonin Res."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Ramlall, V., Zucker, J., and Tatonetti, N. (2020). Melatonin is significantly associated with survival of intubated COVID-19 patients. MedRxiv.","DOI":"10.1101\/2020.10.15.20213546"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-079X.2011.00916.x","article-title":"Melatonin as a natural ally against oxidative stress: A physicochemical examination","volume":"51","author":"Galano","year":"2011","journal-title":"J. Pineal Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/jpi.12162","article-title":"Melatonin: A well-documented antioxidant with conditional pro-oxidant actions","volume":"57","author":"Zhang","year":"2014","journal-title":"J. Pineal Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"3603","DOI":"10.1096\/fj.10-154450","article-title":"Melatonin signaling and cell protection function","volume":"24","author":"Luchetti","year":"2010","journal-title":"FASEB J."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1096\/fasebj.9.7.7737461","article-title":"Oxidative processes and antioxidative defense mechanisms in the aging brain 1","volume":"9","author":"Reiter","year":"1995","journal-title":"FASEB J."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0303-7207(91)90154-K","article-title":"5-Aminolevulinate synthase mRNA levels in the Harderian gland of Syrian hamsters: Correlation with porphyrin concentrations and regulation by androgens and melatonin","volume":"80","author":"Rodriguez","year":"1991","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1096\/fasebj.10.8.8666165","article-title":"Neurohormone melatonin prevents cell damage: Effect on gene expression for antioxidant enzymes","volume":"10","author":"Mayo","year":"1996","journal-title":"FASEB J."},{"key":"ref_59","first-page":"159","article-title":"Pharmacological utility of melatonin in reducing oxidative cellular and molecular damage","volume":"56","author":"Kilic","year":"2004","journal-title":"Pol. J. Pharmacol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1093\/humupd\/dmt054","article-title":"Melatonin and stable circadian rhythms optimize maternal, placental and fetal physiology","volume":"20","author":"Reiter","year":"2013","journal-title":"Hum. Reprod. Updat."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Galano, A., Tan, D.-X., and Reiter, R.J. (2018). Melatonin: A Versatile Protector against Oxidative DNA Damage. Molecules, 23.","DOI":"10.3390\/molecules23030530"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/jpi.12010","article-title":"On the free radical scavenging activities of melatonin\u2019s metabolites, AFMK and AMK","volume":"54","author":"Galano","year":"2013","journal-title":"J. Pineal Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"43","DOI":"10.32794\/mr11250047","article-title":"Treatment of Ebola and other infectious diseases: Melatonin \u201cgoes viral\u201d","volume":"3","author":"Reiter","year":"2020","journal-title":"Melatonin Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.brainres.2006.01.022","article-title":"Affective-motivational influences on feedback-related ERPs in a gambling task","volume":"1105","author":"Masaki","year":"2006","journal-title":"Brain Res."},{"key":"ref_65","first-page":"439","article-title":"Melatonin augments apoptotic adipose-derived mesenchymal stem cell treatment against sepsis-induced acute lung injury","volume":"6","author":"Chen","year":"2014","journal-title":"Am. J. Transl. Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1097\/00024382-200204000-00005","article-title":"Acute Hypoxemia in Humans Enhances the Neutrophil Inflammatory Response","volume":"17","author":"Tamura","year":"2002","journal-title":"Shock"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1600-079X.2005.00251.x","article-title":"Correlation among cytokines, bronchopulmonary dysplasia and modality of ventilation in preterm newborns: Improvement with melatonin treatment","volume":"39","author":"Gitto","year":"2005","journal-title":"J. Pineal Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"e12676","DOI":"10.1111\/jpi.12676","article-title":"Melatonin restores neutrophil functions and prevents apoptosis amid dysfunctional glutathione redox system","volume":"69","author":"Naveenkumar","year":"2020","journal-title":"J. Pineal Res."},{"key":"ref_69","first-page":"75","article-title":"SARS-CoV-2 Virus; Immune Responses and The Immunopathogenesis","volume":"19","author":"Kazemibabaahmadi","year":"2022","journal-title":"Sci. J. Iran Blood Transfus Organ"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"391","DOI":"10.3389\/fendo.2019.00391","article-title":"Melatonin: Countering Chaotic Time Cues","volume":"10","author":"Arendt","year":"2019","journal-title":"Front. Endocrinol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.actatropica.2017.01.004","article-title":"Melatonin inhibits snake venom and antivenom induced oxidative stress and augments treatment efficacy","volume":"169","author":"Sharma","year":"2017","journal-title":"Acta Trop."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.cytogfr.2020.06.001","article-title":"SARS-CoV-2 infection: The role of cytokines in COVID-19 disease","volume":"54","author":"Ruiz","year":"2020","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.lfs.2018.08.037","article-title":"MicroRNA-494 inhibition alleviates acute lung injury through Nrf2 signaling pathway via NQO1 in sepsis-associated acute respiratory distress syndrome","volume":"210","author":"Ling","year":"2018","journal-title":"Life Sci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-079X.2012.01014.x","article-title":"A review of the molecular aspects of melatonin\u2019s anti-inflammatory actions: Recent insights and new perspectives","volume":"54","author":"Mauriz","year":"2013","journal-title":"J. Pineal Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1096\/fj.02-0501fje","article-title":"Melatonin counteracts the inhibitory effect of PGE 2 on IL-2 production in human lymphocytes via its mt1 membrane receptor","volume":"17","author":"Calvo","year":"2003","journal-title":"FASEB J."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1007\/s11357-012-9419-5","article-title":"Tryptophan-enriched cereal intake improves nocturnal sleep, melatonin, serotonin, and total antioxidant capacity levels and mood in elderly humans","volume":"35","author":"Bravo","year":"2013","journal-title":"Age"},{"key":"ref_77","first-page":"454","article-title":"High dose melatonin as an adjuvant therapy in intubated patients with COVID-19: A randomized clinical trial","volume":"17","author":"Alizadeh","year":"2022","journal-title":"J. Taibah Univ. Med. Sci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"174193","DOI":"10.1016\/j.ejphar.2021.174193","article-title":"Evaluation of Th1 and Th2 mediated cellular and humoral immunity in patients with COVID-19 following the use of melatonin as an adjunctive treatment","volume":"904","author":"Hosseini","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/ibd.20527","article-title":"Melatonin and ulcerative colitis: Evidence, biological mechanisms, and future research","volume":"15","author":"Terry","year":"2009","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1080\/17474124.2019.1595588","article-title":"Circadian rhythms: A regulator of gastrointestinal health and dysfunction","volume":"13","author":"Voigt","year":"2019","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1016\/j.cgh.2022.05.044","article-title":"The COVID-19 Pandemic and Post-Infection Irritable Bowel Syndrome: What Lies Ahead for Gastroenterologists","volume":"20","author":"Chan","year":"2022","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"e01689-21","DOI":"10.1128\/spectrum.01689-21","article-title":"Correlation Analysis between Gut Microbiota Alterations and the Cytokine Response in Patients with Coronavirus Disease during Hospitalization","volume":"10","author":"Mizutani","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1136\/gutjnl-2020-320926","article-title":"Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms","volume":"69","author":"Jin","year":"2020","journal-title":"Gut"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"608259","DOI":"10.3389\/fmed.2020.608259","article-title":"Gastrointestinal Symptoms Associated With Unfavorable Prognosis of COVID-19 Patients: A Retrospective Study","volume":"7","author":"Chen","year":"2020","journal-title":"Front. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"4372","DOI":"10.2174\/138161211798999357","article-title":"Melatonin, a promising supplement in inflammatory bowel disease: A comprehensive review of evidences","volume":"17","author":"Mozaffari","year":"2011","journal-title":"Curr. Pharm. Des."},{"key":"ref_86","first-page":"139","article-title":"Gut clock: Implication of circadian rhythms in the gastrointestinal tract","volume":"62","author":"Konturek","year":"2011","journal-title":"J. Physiol. Pharmacol. Off. J. Pol. Physiol. Soc."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"4150","DOI":"10.2174\/092986710793348536","article-title":"Melatonin, a Potential Therapeutic Agent for Smooth Muscle-Related Pathological Conditions and Aging","volume":"17","author":"Pozo","year":"2010","journal-title":"Curr. Med. Chem."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1600-079X.2011.00904.x","article-title":"Melatonin, and to a lesser extent growth hormone, restores colonic smooth muscle physiology in old rats","volume":"51","author":"Pascua","year":"2011","journal-title":"J. Pineal Res."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/j.1600-079X.2007.00544.x","article-title":"Melatonin restores impaired contractility in aged guinea pig urinary bladder","volume":"44","author":"Gomez","year":"2008","journal-title":"J. Pineal Res."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1600-079X.2008.00580.x","article-title":"Potential role of tryptophan derivatives in stress responses characterized by the generation of reactive oxygen and nitrogen species","volume":"45","author":"Peyrot","year":"2008","journal-title":"J. Pineal Res."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1600-079X.2009.00701.x","article-title":"Kynuramines, metabolites of melatonin and other indoles: The resurrection of an almost forgotten class of biogenic amines","volume":"47","author":"Hardeland","year":"2009","journal-title":"J. Pineal Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s13105-011-0138-7","article-title":"Aging-induced alterations in female rat colon smooth muscle: The protective effects of hormonal therapy","volume":"68","author":"Pascua","year":"2011","journal-title":"J. Physiol. Biochem."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1124\/jpet.106.109256","article-title":"Melatonin treatment reverts age-related changes in Guinea pig gall bladder neuromuscular transmission and contractility","volume":"319","author":"Moreno","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1600-079X.2008.00576.x","article-title":"Age-related alterations in Ca2+signals and mitochondrial membrane potential in exocrine cells are prevented by melatonin","volume":"45","author":"Pozo","year":"2008","journal-title":"J. Pineal Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1600-079X.2007.00526.x","article-title":"Melatonin reverses lipopolysaccharide-induced gastro-intestinal motility disturbances through the inhibition of oxidative stress","volume":"44","author":"Iuvone","year":"2008","journal-title":"J. Pineal Res."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jneuroim.2005.05.002","article-title":"Anti-inflammatory actions of melatonin and its metabolites, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) and N1-acetyl-5-methoxykynuramine (AMK), in macrophages","volume":"165","author":"Mayo","year":"2005","journal-title":"J. Neuroimmunol."},{"key":"ref_97","first-page":"386","article-title":"Immune-Modulating Effects of Melatonin, N-Acetylserotonin, and N-Acetyldopamine","volume":"1053","author":"Perianayagam","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1385\/ENDO:27:2:189","article-title":"A review of the multiple actions of melatonin on the immune system","volume":"27","author":"Guerrero","year":"2005","journal-title":"Endocrine"},{"key":"ref_99","first-page":"423","article-title":"The modulatory role of melatonin on immune responsiveness","volume":"7","author":"Reiter","year":"2006","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"ref_100","first-page":"2336","article-title":"REVIEW: Gastrointestinal Melatonin: Localization, Function, and Clinical Relevance","volume":"47","author":"Bubenik","year":"2002","journal-title":"Am. J. Dig. Dis."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Rogers, M.C., and William, J.V. (2019). Reining in the CD8+ T cell: Respiratory virus infection and PD-1-mediated T-cell impairment. PLoS Pathog., 15.","DOI":"10.1371\/journal.ppat.1007387"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1385\/ENDO:27:2:101","article-title":"Functional MT1 and MT2 Melatonin Receptors in Mammals","volume":"27","author":"Dubocovich","year":"2005","journal-title":"Endocrine"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0165-5728(86)90047-0","article-title":"Role of the pineal gland in immunity: Circadian synthesis and release of melatonin modulates the antibody response and antagonizes the immunosuppressive effect of corticosterone","volume":"13","author":"Maestroni","year":"1986","journal-title":"J. Neuroimmunol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0140-6736(20)30211-7","article-title":"Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study","volume":"395","author":"Chen","year":"2020","journal-title":"Lancet"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.0959-9673.2006.00474.x","article-title":"The role of melatonin in immuno-enhancement: Potential application in cancer","volume":"87","author":"Miller","year":"2006","journal-title":"Int. J. Exp. Pathol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep27912","article-title":"Reassessing the role of the NLRP3 inflammasome during pathogenic influenza A virus inftion via temporal inhibition","volume":"6","author":"Tate","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/3832648","article-title":"Melatonin Alleviates Radiation-Induced Lung Injury via Regulation of miR-30e\/NLRP3 Axis","volume":"2019","author":"Wu","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Wang, K., Chen, W., Zhou, Y.S., Lian, J.Q., Zhang, Z., Du, P., Gong, L., Zhang, Y., Cui, H.Y., and Geng, J.J. (2020). SARS-CoV-2 invades host cells via a novel route: CD147-spike protein. bioRxiv.","DOI":"10.1101\/2020.03.14.988345"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s11010-016-2808-9","article-title":"Melatonin attenuates angiotensin II-induced cardiomyocyte hypertrophy through the CPA\/CD147 signaling pathway","volume":"422","author":"Su","year":"2016","journal-title":"Mol. Cell. Biochem."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1128\/MMBR.65.1.131-150.2001","article-title":"Molecular Pathways in Virus-Induced Cytokine Production","volume":"65","author":"Mogensen","year":"2001","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Goodall, K.J., Poon, I.K., Phipps, S., and Hulett, M.D. (2014). Soluble heparan sulfate fragments generated by heparanase trigger the release of pro-inflammatory cytokines through TLR-4. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0109596"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1600-079X.2011.00858.x","article-title":"Melatonin protects liver against ischemia and reperfusion injury through inhibition of toll-like receptor signaling pathway","volume":"50","author":"Kang","year":"2011","journal-title":"J. Pineal Res."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.cmet.2020.07.007","article-title":"Elevated glucose levels favor SARS-CoV-2 infection and monocyte response through a HIF-1\u03b1\/glycolysis-dependent axis","volume":"32","author":"Codo","year":"2020","journal-title":"Cell Metab."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"362","DOI":"10.32794\/mr11250068","article-title":"Plasticity of glucose metabolism in activated immune cells: Advantages for melatonin inhibition of COVID-19 disease","volume":"3","author":"Reiter","year":"2020","journal-title":"Melatonin Res."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1146\/annurev.immunol.021908.132710","article-title":"IL-17 and Th17 Cells","volume":"27","author":"Korn","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/jpi.12184","article-title":"Melatonin attenuates hypoxic pulmonary hypertension by inhibiting the inflammation and the proliferation of pulmonary arterial smooth muscle cells","volume":"57","author":"Jin","year":"2014","journal-title":"J. Pineal Res."},{"key":"ref_117","first-page":"e001568","article-title":"Melatonin may decrease risk for and aid treatment of COVID-19 and other RNA viral infections","volume":"8","author":"DiNicolantonio","year":"2021","journal-title":"Open Hearch. Dis. Child."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s12272-021-01331-9","article-title":"COVID-19 and pulmonary fibrosis: Therapeutics in clinical trials, repurposing, and potential development","volume":"44","author":"Yim","year":"2021","journal-title":"Arch. Pharmacal Res."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1177\/1753465810379801","article-title":"The pathogenesis of idiopathic pulmonary fibrosis","volume":"4","author":"Coward","year":"2010","journal-title":"Ther. Adv. Respir. Dis."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/S2213-2600(20)30225-3","article-title":"Pulmonary fibrosis and COVID-19: The potential role for antifibrotic therapy","volume":"8","author":"George","year":"2020","journal-title":"Lancet Respir. Med."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1046\/j.1440-1827.2003.01446.x","article-title":"Pulmonary fibrosis: Cellular and molecular events","volume":"53","author":"Razzaque","year":"2003","journal-title":"Pathol. Int."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"637","DOI":"10.14348\/molcells.2014.0150","article-title":"Regulation of Wound Healing and Fibrosis by Hypoxia and Hypoxia-Inducible Factor-1","volume":"37","author":"Ruthenborg","year":"2014","journal-title":"Mol. Cells"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"e12404","DOI":"10.1111\/jpi.12404","article-title":"Melatonin protects against lipid-induced mitochondrial dysfunction in hepatocytes and inhibits stellate cell activation during hepatic fibrosis in mice","volume":"62","author":"Das","year":"2017","journal-title":"J. Pineal Res."},{"key":"ref_124","first-page":"121","article-title":"Oxidative stress associated with SARS-CoV-2 (COVID-19) increases the severity of the lung disease-a systematic review","volume":"6","author":"Derouiche","year":"2020","journal-title":"J. Infect. Dis. Epidemiol."},{"key":"ref_125","first-page":"567","article-title":"Protective effects of melatonin against thioacetamide-induced liver fibrosis in rats","volume":"66","author":"Czechowska","year":"2015","journal-title":"J. Physiol. Pharmacol. Off. J. Pol. Physiol. Soc."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"117808","DOI":"10.1016\/j.lfs.2020.117808","article-title":"Lungs as target of COVID-19 infection: Protective common molecular mechanisms of vitamin D and melatonin as a new potential synergistic treatment","volume":"254","author":"Inserra","year":"2020","journal-title":"Life Sci."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Zhao, X., Sun, J., Su, W., Shan, H., Zhang, B., Wang, Y., Shabanova, A., Shan, H., and Liang, H. (2018). Melatonin Protects against Lung Fibrosis by Regulating the Hippo\/YAP Pathway. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19041118"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1002\/jcb.26388","article-title":"Oroxylin A prevents angiogenesis of LSECs in liver fibrosis via inhibition of YAP\/HIF-1\u03b1 signaling","volume":"119","author":"Zhang","year":"2017","journal-title":"J. Cell. Biochem."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Lo Sardo, F., Muti, P., Blandino, G., and Strano, S. (2017). Melatonin and Hippo pathway: Is there existing cross-talk?. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18091913"},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Liu, Y., Garron, T.M., Chang, Q., Su, Z., Zhou, C., Qiu, Y., Gong, E.C., Zheng, J., Yin, Y.W., and Ksiazek, T. (2021). Cell-type apoptosis in lung during SARS-CoV-2 infection. Pathogens, 10.","DOI":"10.3390\/pathogens10050509"},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Paolini, A., Borella, R., De Biasi, S., Neroni, A., Mattioli, M., Tartaro, D.L., Simonini, C., Franceschini, L., Cicco, G., and Piparo, A. (2021). Cell Death in Coronavirus Infections: Uncovering Its Role during COVID-19. Cells, 10.","DOI":"10.3390\/cells10071585"},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Singh, S., Amar, S., Gehlot, P., Patra, S., Kanwar, N., and Kanwal, A. (2021). Mitochondrial Modulations, Autophagy Pathways Shifts in Viral Infections: Consequences of COVID-19. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22158180"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"e00266","DOI":"10.1128\/mSystems.00266-20","article-title":"SARS-CoV-2 and ORF3a: Nonsynonymous mutations, functional domains, and viral pathogenesis","volume":"5","author":"Issa","year":"2020","journal-title":"Msystems"},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Casta\u00f1o-Rodriguez, C., Honrubia, J.M., Guti\u00e9rrez-\u00c1lvarez, J., DeDiego, M.L., Nieto-Torres, J.L., Jimenez-Guarde\u00f1o, J.M., Regla-Nava, J.A., Fernandez-Delgado, R., Verdia-B\u00e1guena, C., and Queralt-Mart\u00edn, M. (2018). Role of Severe Acute Respiratory Syndrome Coronavirus Viroporins E, 3a, and 8a in Replication and Pathogenesis. mBio, 9.","DOI":"10.1128\/mBio.02325-17"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/s41423-020-0485-9","article-title":"The ORF3a protein of SARS-CoV-2 induces apoptosis in cells","volume":"17","author":"Ren","year":"2020","journal-title":"Cell. Mol. Immunol."},{"key":"ref_136","first-page":"38","article-title":"Melatonin attenuates apoptotic liver damage in fulminant hepatic failure induced by the rabbit hemorrhagic disease virus","volume":"50","author":"Miguel","year":"2010","journal-title":"J. Pineal Res."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.3389\/fphar.2018.01384","article-title":"Melatonin Ameliorates Coxsackievirus B3-Induced Myocarditis by Regulating Apoptosis and Autophagy","volume":"9","author":"Sang","year":"2018","journal-title":"Front. Pharmacol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s10735-019-09836-w","article-title":"Inhibitory effect of melatonin on Mst1 ameliorates myocarditis through attenuating ER stress and mitochondrial dysfunction","volume":"50","author":"Ouyang","year":"2019","journal-title":"J. Mol. Histol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1177\/2040206616660851","article-title":"Melatonin decreases brain apoptosis, oxidative stress, and CD200 expression and increased survival rate in mice infected by Venezuelan equine encephalitis virus","volume":"24","author":"Montiel","year":"2015","journal-title":"Antivir. Chem. Chemother."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1080\/17512433.2020.1814141","article-title":"Melatonin as a putative protection against myocardial injury in COVID-19 infection","volume":"13","author":"Simko","year":"2020","journal-title":"Expert Rev. Clin. Pharmacol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41419-019-1556-7","article-title":"Melatonin as a master regulator of cell death and inflammation: Molecular mechanisms and clinical implications for newborn care","volume":"10","author":"Tarocco","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1177\/074873049701200606","article-title":"Melatonin Receptors: Molecular Biology of a New Family of G Protein-Coupled Receptors","volume":"12","author":"Reppert","year":"1997","journal-title":"J. Biol. Rhythm."},{"key":"ref_143","first-page":"1","article-title":"Melatonin prevents lung injury by regulating apelin 13 to improve mitochondrial dysfunction","volume":"51","author":"Zhang","year":"2019","journal-title":"Exp. Mol. Med."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0006-8993(91)90146-M","article-title":"Melatonin modifies calmodulin cell levels in MDCK and N1E-115 cell lines and inhibits phosphodiesterase activity in vitro","volume":"557","year":"1991","journal-title":"Brain Res."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.biopha.2006.01.002","article-title":"Melatonin receptors in humans: Biological role and clinical relevance","volume":"60","author":"Ekmekcioglu","year":"2006","journal-title":"Biomed. Pharmacother."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/s41579-018-0003-6","article-title":"Autophagy during viral infection\u2014A double-edged sword","volume":"16","author":"Choi","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Siri, M., Dastghaib, S., Zamani, M., Rahmani-Kukia, N., Geraylow, K.R., Fakher, S., Keshvarzi, F., Mehrbod, P., Ahmadi, M., and Mokarram, P. (2021). Autophagy, unfolded protein response, and neuropilin-1 cross-talk in SARS-CoV-2 infection: What can be learned from other coronaviruses. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22115992"},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Wongchitrat, P., Shukla, M., Sharma, R., Govitrapong, P., and Reiter, R.J. (2021). Role of melatonin on virus-induced neuropathogenesis\u2014A concomitant therapeutic strategy to understand SARS-CoV-2 infection. Antioxidants, 10.","DOI":"10.3390\/antiox10010047"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1080\/21505594.2020.1780088","article-title":"Autophagy and SARS-CoV-2 infection: A possible smart targeting of the autophagy pathway","volume":"11","author":"Shojaei","year":"2020","journal-title":"Virulence"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1007\/s13238-014-0104-6","article-title":"Coronavirus membrane-associated papain-like proteases induce autophagy through interacting with Beclin1 to negatively regulate antiviral innate immunity","volume":"5","author":"Chen","year":"2014","journal-title":"Protein Cell"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"e24","DOI":"10.1016\/j.jinf.2020.03.058","article-title":"Evolutionary analysis of SARS-CoV-2: How mutation of Non-Structural Protein 6 (NSP6) could affect viral autophagy","volume":"81","author":"Benvenuto","year":"2020","journal-title":"J. Infect."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/jpi.12124","article-title":"Melatonin modulates the autophagic response in acute liver failure induced by the rabbit hemorrhagic disease virus","volume":"56","author":"Crespo","year":"2014","journal-title":"J. Pineal Res."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1080\/15548627.2015.1082020","article-title":"Melatonin attenuates MPTP-induced neurotoxicity via preventing CDK5-mediated autophagy and SNCA\/\u03b1-synuclein aggregation","volume":"11","author":"Su","year":"2015","journal-title":"Autophagy"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/j.1600-079X.2011.00945.x","article-title":"Melatonin attenuates kainic acid-induced neurotoxicity in mouse hippocampus via inhibition of autophagy and \u03b1-synuclein aggregation","volume":"52","author":"Chang","year":"2011","journal-title":"J. Pineal Res."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"389","DOI":"10.4062\/biomolther.2017.071","article-title":"Melatonin rescues mesenchymal stem cells from senescence induced by the uremic toxin p-cresol via inhibiting mTOR-dependent autophagy","volume":"26","author":"Yun","year":"2018","journal-title":"Biomol. Ther."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1080\/07420528.2017.1354871","article-title":"Diurnal opposite variation between angiotensinase activities in photo\u2013neuro\u2013endocrine tissues of rats","volume":"34","author":"Prieto","year":"2017","journal-title":"Chronobiol. Int."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.tem.2019.07.008","article-title":"Impact of Circadian Disruption on Cardiovascular Function and Disease","volume":"30","author":"Chellappa","year":"2019","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_158","first-page":"1","article-title":"The Impact of Sleep and Circadian Disturbance on Hormones and Metabolism","volume":"2015","author":"Kim","year":"2015","journal-title":"Int. J. Endocrinol."},{"key":"ref_159","first-page":"219","article-title":"Predictive factors of insomnia during the COVID-19 pandemic in Bangladesh: A GIS-based nationwide distribution","volume":"91","author":"Gozal","year":"2021","journal-title":"Sleep Med."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"e13119","DOI":"10.1111\/jsr.13119","article-title":"The Coconel Group Covid-19 health crisis and lockdown associated with high level of sleep complaints and hypnotic uptake at the population level","volume":"30","author":"Beck","year":"2020","journal-title":"J. Sleep Res."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1093\/rpd\/ncs255","article-title":"Pineal melatonin level disruption in humans due to electromagnetic fields and ICNIRP limits","volume":"154","author":"Halgamuge","year":"2012","journal-title":"Radiat. Prot. Dosim."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1210\/er.2018-00084","article-title":"Melatonin as a hormone: New physiological and clinical insights","volume":"39","author":"Amaral","year":"2018","journal-title":"Endocr. Rev."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cell.2020.05.032","article-title":"Proteomic and Metabolomic Characterization of COVID-19 Patient Sera","volume":"182","author":"Shen","year":"2020","journal-title":"Cell"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"3576","DOI":"10.1093\/brain\/awab302","article-title":"Acute and chronic neurological disorders in COVID-19: Potential mechanisms of disease","volume":"144","author":"Balcom","year":"2021","journal-title":"Brain"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"566680","DOI":"10.3389\/fneur.2020.566680","article-title":"Revisiting the Immune Balance Theory: A Neurological Insight Into the Epidemic of COVID-19 and Its Alike","volume":"11","author":"Wu","year":"2020","journal-title":"Front. Neurol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S1474-4422(20)30109-5","article-title":"Guillain-Barr\u00e9 syndrome associated with SARS-CoV-2 infection: Causality or coincidence?","volume":"19","author":"Zhao","year":"2020","journal-title":"Lancet Neurol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"E119","DOI":"10.1148\/radiol.2020201187","article-title":"COVID-19\u2013associated Acute Hemorrhagic Necrotizing Encephalopathy: Imaging Features","volume":"296","author":"Poyiadji","year":"2020","journal-title":"Radiology"},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Hsu, J.T.A., Tien, C.F., Yu, G.Y., Shen, S., Lee, Y.H., Hsu, P.C., Wang, Y., Chao, P.K., Tsay, H.J., and Shie, F.S. (2021). The Effects of A\u03b21-42 Binding to the SARS-CoV-2 Spike Protein S1 Subunit and Angiotensin-Converting Enzyme 2. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22158226"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s10571-020-00938-8","article-title":"Coronavirus Disease 2019 (COVID-19) and its neuroinvasive capacity: Is it time for melatonin?","volume":"42","author":"Romero","year":"2020","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cell.2020.02.052","article-title":"SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor","volume":"181","author":"Hoffmann","year":"2020","journal-title":"Cell"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1126\/science.abd2985","article-title":"Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity","volume":"370","author":"Ojha","year":"2020","journal-title":"Science"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/jmv.25728","article-title":"The neuroinvasive potential of SARS-CoV-2 may play a role in the respiratory failure of COVID-19 patients","volume":"92","author":"Li","year":"2020","journal-title":"J. Med. Virol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/emph\/eoaa046","article-title":"Conflicts over calcium and the treatment of COVID-19","volume":"9","author":"Crespi","year":"2020","journal-title":"Evol. Med. Public Health"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1007\/s12035-020-02134-7","article-title":"Neurological complications associated with the blood-brain barrier damage induced by the inflammatory response during SARS-CoV-2 infection","volume":"58","author":"Aguilera","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1111\/all.14364","article-title":"Immune response to SARS-CoV-2 and mechanisms of immunopathological changes in COVID-19","volume":"75","author":"Azkur","year":"2020","journal-title":"Allergy"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1007\/s10072-020-04694-x","article-title":"Headache and pleocytosis in CSF associated with COVID-19: Case report","volume":"41","author":"Palmeira","year":"2020","journal-title":"Neurol. Sci."},{"key":"ref_177","first-page":"1543","article-title":"COVID-19 and Oxidative Stress","volume":"85","author":"Chernyak","year":"2020","journal-title":"Biochemistry"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41580-020-0230-3","article-title":"Reactive oxygen species (ROS) as pleiotropic physiological signalling agents","volume":"21","author":"Sies","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/s41577-020-0331-4","article-title":"Pathological inflammation in patients with COVID-19: A key role for monocytes and macrophages","volume":"20","author":"Merad","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0140-6736(20)30628-0","article-title":"COVID-19: Consider cytokine storm syndromes and immunosuppression","volume":"395","author":"Mehta","year":"2020","journal-title":"Lancet"},{"key":"ref_181","first-page":"e6","article-title":"Neutrophil-to-lymphocyte ratio as an independent risk factor for mortality in hospitalized patients with COVID-19","volume":"81","author":"Liu","year":"2020","journal-title":"J. Infect."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s12035-020-02093-z","article-title":"Effects of antimalarial drugs on neuroinflammation-potential use for treatment of COVID-19-related neurologic complications","volume":"58","author":"Ong","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"ref_183","unstructured":"Ferreira-Gomes, M., Kruglov, A., Durek, P., Heinrich, F., Tizian, C., Heinz, G.A., Pascual-Reguant, A., Du, W., Mothes, R., and Fan, C. (2020). In severe COVID-19. SARS-CoV-2 induces a chronic, TGF-\u03b2-dominated adaptive immune response. medRxiv."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"e1240","DOI":"10.1002\/cti2.1240","article-title":"RGD-binding integrins and TGF-\u03b2 in SARS-CoV-2 infections\u2013novel targets to treat COVID-19 patients?","volume":"10","author":"Carvacho","year":"2021","journal-title":"Clin. Transl. Immunol."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.freeradbiomed.2011.06.033","article-title":"Cross talk between mitochondria and NADPH oxidases","volume":"51","author":"Dikalov","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/cr.2008.15","article-title":"SARS coronavirus entry into host cells through a novel clathrin- and caveolae-independent endocytic pathway","volume":"18","author":"Wang","year":"2008","journal-title":"Cell Res."},{"key":"ref_187","doi-asserted-by":"crossref","unstructured":"Beltr\u00e1n-Garc\u00eda, J., Osca-Verdegal, R., Pallard\u00f3, F.V., Ferreres, J., Rodr\u00edguez, M., Mulet, S., Carbonell, F., and Garc\u00eda-Gim\u00e9nez, J.L. (2020). Oxidative Stress and Inflammation in COVID-19-Associated Sepsis: The Potential Role of Anti-Oxidant Therapy in Avoiding Disease Progression. Antioxidants, 9.","DOI":"10.3390\/antiox9100936"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.tcb.2015.12.002","article-title":"TNF and ROS Crosstalk in Inflammation","volume":"26","author":"Blaser","year":"2016","journal-title":"Trends Cell Biol."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3389\/fphys.2018.00065","article-title":"TNF-\u03b1 Increases Production of Reactive Oxygen Species through Cdk5 Activation in Nociceptive Neurons","volume":"9","author":"Sandoval","year":"2018","journal-title":"Front. Physiol."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mito.2020.06.008","article-title":"Mitochondria and microbiota dysfunction in COVID-19 pathogenesis","volume":"54","author":"Saleh","year":"2020","journal-title":"Mitochondrion"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/cmi.2015.95","article-title":"Molecular mechanisms regulating NLRP3 inflammasome activation","volume":"13","author":"Jo","year":"2015","journal-title":"Cell. Mol. Immunol."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1007\/s11427-020-1643-8","article-title":"Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury","volume":"63","author":"Liu","year":"2020","journal-title":"Sci. China Life Sci."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1002\/jnr.24220","article-title":"The neuroprotective role of melatonin in neurological disorders","volume":"96","author":"Alghamdi","year":"2018","journal-title":"J. Neurosci. Res."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1600-079X.2006.00407.x","article-title":"One molecule, many derivatives: A never-ending interaction of melatonin with reactive oxygen and nitrogen species?","volume":"42","author":"Tan","year":"2007","journal-title":"J. Pineal Res."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"311","DOI":"10.32794\/mr11250064","article-title":"High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection","volume":"3","author":"Cardinali","year":"2020","journal-title":"Melatonin Res."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/S0140-6736(20)30566-3","article-title":"Clinical course and risk factors for mortality of adult in patients with COVID-19 in Wuhan, China: A retrospective cohort study","volume":"395","author":"Zhou","year":"2020","journal-title":"Lancet"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/jpi.12071","article-title":"Melatonin ameliorates A ngiotensin II-induced vascular endothelial damage via its antioxidative properties","volume":"55","author":"Nakao","year":"2013","journal-title":"J. Pineal Res."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/nyas.14436","article-title":"Therapeutic potential of neurogenesis and melatonin regulation in Alzheimer\u2019s disease","volume":"1478","author":"Mihardja","year":"2020","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/BF01923944","article-title":"Calmodulin mediates melatonin cytoskeletal effects","volume":"49","year":"1993","journal-title":"Experientia"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.neuroscience.2019.09.009","article-title":"Melatonin promotes nerve regeneration following end-to-side neurorrhaphy by accelerating cytoskeletal remodeling via the melatonin receptor-dependent pathway","volume":"429","author":"Liu","year":"2020","journal-title":"Neuroscience"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"31108","DOI":"10.1007\/s11356-021-12951-5","article-title":"Melatonin exerts a neuroprotective effect against \u03b3-radiation-induced brain injury in the rat through the modulation of neurotransmitters, inflammatory cytokines, oxidative stress, and apoptosis","volume":"28","author":"Shabana","year":"2021","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"102535","DOI":"10.1016\/j.msard.2020.102535","article-title":"How does the COVID-19 cause seizure and epilepsy in patients? The potential mechanisms","volume":"46","author":"Nikbakht","year":"2020","journal-title":"Mult. Scler. Relat. Disord."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1007\/s11064-015-1613-2","article-title":"Melatonin protects methamphetamine-induced neuroinflammation through NF-\u03baB and Nrf2 pathways in glioma cell line","volume":"40","author":"Jumnongprakhon","year":"2015","journal-title":"Neurochem. Res."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/27\/20\/6934\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:55:03Z","timestamp":1760144103000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/27\/20\/6934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,16]]},"references-count":203,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["molecules27206934"],"URL":"https:\/\/doi.org\/10.3390\/molecules27206934","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,16]]}}}