{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:42:45Z","timestamp":1792806165214,"version":"4.5.0"},"reference-count":52,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"French Agence Nationale de la Recherche and the R\u00e9gion Pays de la Loire","award":["2020 07132"],"award-info":[{"award-number":["2020 07132"]}],"id":[{"id":"https:\/\/ror.org\/00rbzpz17","id-type":"ROR","asserted-by":"crossref"}]},{"name":"French Agence Nationale de la Recherche and the R\u00e9gion Pays de la Loire","award":["TURSP-2020\/310"],"award-info":[{"award-number":["TURSP-2020\/310"]}],"id":[{"id":"https:\/\/ror.org\/00rbzpz17","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Taif University Researchers Supporting","award":["2020 07132"],"award-info":[{"award-number":["2020 07132"]}],"id":[{"id":"https:\/\/ror.org\/014g1a453","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Taif University Researchers Supporting","award":["TURSP-2020\/310"],"award-info":[{"award-number":["TURSP-2020\/310"]}],"id":[{"id":"https:\/\/ror.org\/014g1a453","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Litsea glutinosa (L. glutinosa) is considered an evidence-based medicinal plant for the treatment of cancer, the leading cause of death worldwide. In our study, the in vitro antioxidant and in vivo anticancer properties of an essential ethno-medicinal plant, L. glutinosa, were examined using non-toxic doses and a phytochemical analysis was executed using gas-chromatography\u2013mass-spectrometry. The in vitro antioxidant study of the L. glutinosa methanolic extract (LGBME) revealed a concentration-dependent antioxidant property. The bark extract showed promising antioxidant effects in the 2,2-diphenyl-1-picryl-hydrazyl (DPPH) assay. The strongest antioxidant activity was demonstrated at the maximum concentration (50 \u00b5g\/mL). The IC50 values of the LGBME and BHT were 5.51 and 5.01 \u00b5g\/mL, respectively. At the same concentration, the total antioxidant capacity of the LGBME was 0.161 \u00b5g\/mL and the ferric reducing antioxidant power assay result of the LGBME was 1.783 \u00b5g\/mL. In the cytotoxicity study, the LD50 of the LGBME and gallic acid were 24.93 \u00b5g\/mL and 7.23 \u00b5g\/mL, respectively. In the in vivo anticancer-activity studies, the LGBME, particularly at a dose of 150 mg\/kg\/bw, showed significant cell-growth inhibition, decreased tumor weight, increased mean survival rate, and upregulated the reduced hematological parameters in EAC (Ehrlich\u2019s ascites carcinoma)-induced Swiss albino mice. The highest cell-growth inhibition, 85.76%, was observed with the dose of 150 mg\/kg\/bw. Furthermore, the upregulation of pro-apoptotic genes (p53, Bax) and the downregulation of anti-apoptotic Bcl-2 were observed. In conclusion, LGBME extract has several bioactive phytoconstituents, which confirms the antioxidant and anticancer properties of L. glutinosa.<\/jats:p>","DOI":"10.3390\/molecules27206964","type":"journal-article","created":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T00:31:01Z","timestamp":1666053061000},"page":"6964","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Phytochemical Analysis and Understanding the Antioxidant and Anticancer Properties of Methanol Extract from Litsea glutinosa: In Vitro and In Vivo Studies"],"prefix":"10.3390","volume":"27","author":[{"given":"Shafia","family":"Shafiq","sequence":"first","affiliation":[{"name":"Department of Pharmacy, University of Rajshahi, Rajshahi 6205, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronok","family":"Zahan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Rajshahi, Rajshahi 6205, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samina","family":"Yesmin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Rajshahi, Rajshahi 6205, Bangladesh"},{"name":"Biomedical and Toxicological Research Institute (BTRI), BCSIR, Dhaka 1205, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alam","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Rajshahi, Rajshahi 6205, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Sabbir","family":"Mahmud","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Rajshahi, Rajshahi 6205, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Abu","family":"Reza","sequence":"additional","affiliation":[{"name":"Department of Genetic Engineering and Biotechnology, University of Rajshahi, Rajshahi 6205, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0774-5550","authenticated-orcid":false,"given":"Sarah M.","family":"Albogami","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4326-6066","authenticated-orcid":false,"given":"Mohammed","family":"Alorabi","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2782-9615","authenticated-orcid":false,"given":"Michel","family":"De Waard","sequence":"additional","affiliation":[{"name":"Smartox Biotechnology, 6 rue des Platanes, 38120 Saint-Egr\u00e8ve, France"},{"name":"L\u2019institut du Thorax, INSERM, CNRS, Universit\u00e9 de Nantes, 44007 Nantes, France"},{"name":"LabEx \u00abIon Channels, Science & Therapeutics\u00bb, Universit\u00e9 de Nice Sophia-Antipolis, 06560 Valbonne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9555-7300","authenticated-orcid":false,"given":"Hebatallah M.","family":"Saad","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Veterinary Medicine, Matrouh University, Mersa Matruh 51744, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9040-5647","authenticated-orcid":false,"given":"Jean-Marc","family":"Sabatier","sequence":"additional","affiliation":[{"name":"Institut de Neurophysiopathologie (INP), CNRS UMR 7051, Facult\u00e9 des Scienes M\u00e9dicales et Param\u00e9dicales, Aix-Marseille Universit\u00e9, 27 Bd Jean Moulin, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarannum","family":"Naz","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Rajshahi, Rajshahi 6205, Bangladesh"},{"name":"Department of Pharmacy, Varendra University, Rajshahi 6204, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7817-425X","authenticated-orcid":false,"given":"Gaber El-Saber","family":"Batiha","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,17]]},"reference":[{"key":"ref_1","first-page":"e7219","article-title":"Phytochemicals in cancer prevention: A review of the evidence","volume":"10","author":"Meybodi","year":"2017","journal-title":"Iran. 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