{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T10:54:57Z","timestamp":1771066497701,"version":"3.50.1"},"reference-count":33,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T00:00:00Z","timestamp":1666051200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Cheng Ching Hospital, Taichung, Taiwan","award":["CH10700223B"],"award-info":[{"award-number":["CH10700223B"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Imperatorin is a furanocoumarin derivative and an effective ingredient in several Chinese medicinal herbs. It has favorable expectorant, analgesic, and anti-inflammatory effects. In this study, we investigated whether imperatorin has protective effects against Dermatophagoides pteronyssinus (Der p)-induced asthma in mice. Lung and bronchial tissues were histopathologically examined through hematoxylin\u2013eosin staining. The concentrations of immunoglobin E (IgE), IgG1, IgG2a in serum and those of T helper 1 (Th1) and two cytokines and eosinophil-activated chemokines in bronchoalveolar lavage fluid (BALF) were detected using an enzyme immunoassay. Histological examination revealed that imperatorin reduced inflammatory cell infiltration, mucus hypersecretion, and endothelial cell hyperplasia. The examination also indicated that imperatorin could reduce the inflammatory cell count in BALF as well as IgE and IgG1 expression in serum, but IgG2a expression was significantly increased. Imperatorin reduced the production of interleukin (IL)-4, IL-5, and IL-13 by Th2, promoted the production of interferon-\u03b3 and IL-12 by Th1, and increased the production of IL-10 in bronchoalveolar lavage fluid. These findings suggest that imperatorin has a considerable anti-inflammatory effect on Der p-induced allergic asthma in mice.<\/jats:p>","DOI":"10.3390\/molecules27207028","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T00:58:51Z","timestamp":1666141131000},"page":"7028","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Ameliorative Effect of Imperatorin on Dermatophagoides pteronyssinus-Induced Allergic Asthma by Suppressing the Th2 Response in Mice"],"prefix":"10.3390","volume":"27","author":[{"given":"Chia-Chen","family":"Hsieh","sequence":"first","affiliation":[{"name":"Department of Medicine Division of Chest Medicine, Cheng Ching Hospital, Taichung 40764, Taiwan"},{"name":"Department of Medicinal Botanicals and Foods on Health Applications, Da-Yeh University, ChangHua 51591, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-Yan","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Chung-Kang Branch, Cheng Ching Hospital, Taichung 40764, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1852-2857","authenticated-orcid":false,"given":"Wei-Sung","family":"Li","sequence":"additional","affiliation":[{"name":"Plant Pathology Division, Taiwan Agricultural Research Institute, Council of Agriculture, Executive Yuan, Wufeng 41362, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung-Yuh","family":"Tzeng","sequence":"additional","affiliation":[{"name":"Department of Medicinal Botanicals and Foods on Health Applications, Da-Yeh University, ChangHua 51591, Taiwan"},{"name":"Department of Orthopedics, Taichung Veterans General Hospital, Taichung 40705, Taiwan"},{"name":"Institute of Biomedical Sciences, National Chung Hsing University, Taichung 40227, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsai-Yi","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Bioresources, Da-Yeh University, Changhua 51591, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan-Hsiang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Medicinal Botanicals and Foods on Health Applications, Da-Yeh University, ChangHua 51591, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9550-9579","authenticated-orcid":false,"given":"Jen-Chieh","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Medicinal Botanicals and Foods on Health Applications, Da-Yeh University, ChangHua 51591, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/all.12770","article-title":"Dendritic cells revisited in human allergic rhinitis and asthma","volume":"71","author":"Froidure","year":"2016","journal-title":"Allergy"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.jaci.2014.06.036","article-title":"Allergens and the airway epithelium response: Gateway to allergic sensitization","volume":"134","author":"Lambrecht","year":"2014","journal-title":"J. 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