{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:16:56Z","timestamp":1791227816352,"version":"4.1.0"},"reference-count":210,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T00:00:00Z","timestamp":1666310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Vascular diseases, such as peripheral artery disease (PAD), are associated with diabetes mellitus and a higher risk of cardiovascular disease and even death. Surgical revascularization and pharmacological treatments (mainly antiplatelet, lipid-lowering drugs, and antidiabetic agents) have some effectiveness, but the response and efficacy of therapy are overly dependent on the patient\u2019s conditions. Thus, the demand for new cures exists. In this regard, new studies on natural polyphenols that act on key points involved in the pathogenesis of vascular diseases and, thus, on PAD are of great urgency. The purpose of this review is to take into account the mechanisms that lead to endothelium dysfunction, such as the glycoxidation process and the production of advanced glycation end-products (AGEs) that result in protein misfolding, and to suggest plant-derived polyphenols that could be useful in PAD. Thus, five polyphenols are considered, baicalein, curcumin, mangiferin, quercetin and resveratrol, reviewing the literature in PubMed. The key molecular mechanisms and preclinical and clinical studies of each selected compound are examined. Furthermore, the safety profiles of the polyphenols are outlined, together with the unwanted effects reported in humans, also by searching the WHO database (VigiBase).<\/jats:p>","DOI":"10.3390\/molecules27207110","type":"journal-article","created":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T08:19:06Z","timestamp":1666599546000},"page":"7110","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Selected Plant-Derived Polyphenols as Potential Therapeutic Agents for Peripheral Artery Disease: Molecular Mechanisms, Efficacy and Safety"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5936-1789","authenticated-orcid":false,"given":"Guglielmina","family":"Froldi","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0390-6823","authenticated-orcid":false,"given":"Eugenio","family":"Ragazzi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,21]]},"reference":[{"key":"ref_1","unstructured":"Riley, L., and Cowan, M. (2022). Non-Communicable Diseases Progress Monitor 2022, Licence: CC BY-NC-SA 3.0 IGO. Electronic Version."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1161\/CIRCRESAHA.116.303849","article-title":"Epidemiology of Peripheral Artery Disease","volume":"116","author":"Criqui","year":"2015","journal-title":"Circ. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.atherosclerosis.2018.05.033","article-title":"Update on peripheral artery disease: Epidemiology and evidence-based facts","volume":"275","author":"Shu","year":"2018","journal-title":"Atherosclerosis"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.atherosclerosis.2005.07.016","article-title":"Association between nutrient intake and peripheral artery disease: Results from the InCHIANTI study","volume":"186","author":"Pedone","year":"2006","journal-title":"Atherosclerosis"},{"key":"ref_5","unstructured":"(2022, September 28). Johns Hopkins University Lifetime Risk and Prevalence of Lower Extremity Peripheral Artery Disease (PAD). Available online: http:\/\/ckdpcrisk.org\/padrisk\/."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1093\/eurheartj\/ehx095","article-title":"2017 ESC Guidelines on the Diagnosis and Treatment of Peripheral Arterial Diseases, in collaboration with the European Society for Vascular Surgery (ESVS): Document covering atherosclerotic disease of extracranial carotid and vertebral, mesenteric, renal, upper and lower extremity arteries","volume":"39","author":"Aboyans","year":"2018","journal-title":"Eur. Heart J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.ejvs.2019.05.006","article-title":"Global Vascular Guidelines on the Management of Chronic Limb-Threatening Ischemia","volume":"58","author":"Conte","year":"2019","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.ejvs.2018.03.004","article-title":"The 2017 ESC Guidelines on the Diagnosis and Treatment of Peripheral Arterial Diseases, in Collaboration with the European Society for Vascular Surgery (ESVS)","volume":"55","author":"Halliday","year":"2018","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/1358863X12467491","article-title":"A systematic review and meta-analysis of propionyl-l-carnitine effects on exercise performance in patients with claudication","volume":"18","author":"Brass","year":"2013","journal-title":"Vasc. Med."},{"key":"ref_10","first-page":"e17592","article-title":"Effectiveness of Propionyl-L-Carnitine Supplementation on Exercise Performance in Intermittent Claudication: A Systematic Review","volume":"13","author":"Tama","year":"2021","journal-title":"Cureus"},{"key":"ref_11","first-page":"CD010117","article-title":"Propionyl-L-carnitine for intermittent claudication","volume":"12","author":"Kamoen","year":"2021","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_12","first-page":"CD012058","article-title":"Gene therapy for peripheral arterial disease","volume":"10","author":"Forster","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1161\/CIRCULATIONAHA.107.719369","article-title":"Symptomatic peripheral arterial disease in women: Nontraditional biomarkers of elevated risk","volume":"117","author":"Pradhan","year":"2008","journal-title":"Circulation"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1024\/0301-1526\/a000556","article-title":"The risk of peripheral artery disease in older adults-seven-year results of the getABI study","volume":"45","author":"Krause","year":"2016","journal-title":"Vasa"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.pcad.2014.11.005","article-title":"Assessment and prognosis of peripheral artery measures of vascular function","volume":"57","author":"Anderson","year":"2015","journal-title":"Prog. Cardiovasc. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.jvs.2006.12.037","article-title":"Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II)","volume":"45","author":"Norgren","year":"2007","journal-title":"J. Vasc. Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2042018819890532","DOI":"10.1177\/2042018819890532","article-title":"The association between dietary intake, lifestyle and incident symptomatic peripheral arterial disease among individuals with diabetes mellitus: Insights from the Malm\u00f6 Diet and Cancer study","volume":"10","author":"Lilja","year":"2019","journal-title":"Ther. Adv. Endocrinol. Metab."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"16","DOI":"10.20463\/pan.2021.0003","article-title":"Relationship between plasma asymmetric dimethylarginine and nitric oxide levels affects aerobic exercise training-induced reduction of arterial stiffness in middle-aged and older adults","volume":"25","author":"Shimomura","year":"2021","journal-title":"Phys. Act. Nutr."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"111888","DOI":"10.1016\/j.exger.2022.111888","article-title":"Time-dependent relationships between exercise training-induced changes in nitric oxide production and hormone regulation","volume":"166","author":"Fujie","year":"2022","journal-title":"Exp. Gerontol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Toma, L., Stancu, C.S., and Sima, A.V. (2021). Endothelial dysfunction in diabetes is aggravated by glycated lipoproteins; novel molecular therapies. Biomedicines, 9.","DOI":"10.3390\/biomedicines9010018"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Mustapha, S., Mohammed, M., Azemi, A.K., Jatau, A.I., Shehu, A., Mustapha, L., Aliyu, I.M., Danraka, R.N., Amin, A., and Bala, A.A. (2021). Current status of endoplasmic reticulum stress in type II diabetes. Molecules, 26.","DOI":"10.20944\/preprints202106.0227.v1"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.bcp.2009.04.029","article-title":"Inflammatory cytokines in vascular dysfunction and vascular disease","volume":"78","author":"Sprague","year":"2009","journal-title":"Biochem. Pharmacol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Pizzimenti, M., Riou, M., Charles, A.L., Talha, S., Meyer, A., Andres, E., Chakf\u00e9, N., Lejay, A., and Geny, B. (2019). The rise of mitochondria in peripheral arterial disease physiopathology: Experimental and clinical data. J. Clin. Med., 8.","DOI":"10.3390\/jcm8122125"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"880","DOI":"10.14336\/AD.2017.1121","article-title":"Glycation damage: A possible hub for major pathophysiological disorders and aging","volume":"9","author":"Fournet","year":"2018","journal-title":"Aging Dis."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.pharmthera.2009.06.013","article-title":"RAGE, vascular tone and vascular disease","volume":"124","author":"Farmer","year":"2009","journal-title":"Pharmacol. Ther."},{"key":"ref_26","first-page":"2169","article-title":"Advanced glycation endproducts induce apoptosis of endothelial progenitor cells by activating receptor RAGE and NADPH oxidase\/JNK signaling axis","volume":"8","author":"Chen","year":"2016","journal-title":"Am. J. Transl. Res."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Islam, R.A., Khalsa, S.S.S., Vyas, A.K., and Rahimian, R. (2021). Sex-specific impacts of exercise on cardiovascular remodeling. Journal of Clinical Medicine, 10.","DOI":"10.3390\/jcm10173833"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Twarda-clapa, A., Olczak, A., Bia\u0142kowska, A.M., and Kozio\u0142kiewicz, M. (2022). Advanced glycation end-products (AGEs): Formation, chemistry, classification, receptors, and diseases related to AGEs. Cells, 11.","DOI":"10.3390\/cells11081312"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.molmet.2013.11.006","article-title":"Vascular effects of advanced glycation endproducts: Clinical effects and molecular mechanisms","volume":"3","author":"Stirban","year":"2014","journal-title":"Mol. Metab."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"352","DOI":"10.2174\/1570161115666170327162639","article-title":"A Glycation Angle to Look into the Diabetic Vasculopathy: Cause and Cure","volume":"15","author":"Ahmad","year":"2017","journal-title":"Curr. Vasc. Pharmacol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.redox.2018.09.025","article-title":"New insights into oxidative stress and inflammation during diabetes mellitus-accelerated atherosclerosis","volume":"20","author":"Yuan","year":"2019","journal-title":"Redox Biol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Brown, O.I., Bridge, K.I., and Kearney, M.T. (2021). Nicotinamide adenosine dinucleotide phosphate oxidases in glucose homeostasis and diabetes-related endothelial cell dysfunction. Cells, 10.","DOI":"10.3390\/cells10092315"},{"key":"ref_33","first-page":"180","article-title":"Ageing, neurodegeneration and brain rejuvenation","volume":"10","year":"2016","journal-title":"Nature"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.fct.2018.01.022","article-title":"Dietary polyphenols: Structures, bioavailability and protective effects against atherosclerosis","volume":"113","author":"Santhakumar","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Yang, L., Wen, K.S., Ruan, X., Zhao, Y.X., Wei, F., and Wang, Q. (2018). Response of plant secondary metabolites to environmental factors. Molecules, 23.","DOI":"10.3390\/molecules23040762"},{"key":"ref_36","unstructured":"Hasanuzzaman, M., and Nahar, K. (2022). Phenolic Compounds in the Plant Development and Defense: An Overview. Plant Stress Physiology, IntechOpen."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.foodchem.2019.04.010","article-title":"Effect of sodium nitroprusside treatment on shikimate and phenylpropanoid pathways of apple fruit","volume":"290","author":"Ge","year":"2019","journal-title":"Food Chem."},{"key":"ref_38","first-page":"393","article-title":"Phenolics in Human Health","volume":"5","author":"Ozcan","year":"2014","journal-title":"Int. J. Chem. Eng. Appl."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Sch\u00f6n, C., Allegrini, P., Engelhart-jentzsch, K., Riva, A., and Petrangolini, G. (2021). Grape Seed Extract PositivelyModulates Blood Pressure and Perceived Stress: ARandomized, Double-Blind, Placebo-Controlled Study in Healthy Volunteers. Nutrients, 13.","DOI":"10.3390\/nu13020654"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s12937-017-0291-0","article-title":"The effect of an apple polyphenol extract rich in epicatechin and flavan-3-ol oligomers on brachial artery flow-mediated vasodilatory function in volunteers with elevated blood pressure","volume":"16","author":"Saarenhovi","year":"2017","journal-title":"Nutr. J."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12970-017-0186-7","article-title":"Acute cocoa Flavanols intake has minimal effects on exercise-induced oxidative stress and nitric oxide production in healthy cyclists: A randomized controlled trial","volume":"14","author":"Decroix","year":"2017","journal-title":"J. Int. Soc. Sport. Nutr."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1080\/19390211.2017.1331944","article-title":"A Randomized Single Dose Parallel Study on Enhancement of Nitric Oxide in Serum and Saliva with the Use of Natural Sports Supplement in Healthy Adults","volume":"15","author":"Jacob","year":"2018","journal-title":"J. Diet. Suppl."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/1475-2891-10-67","article-title":"Acute reduction of serum 8-iso-PGF2-alpha and advanced oxidation protein products in vivo by a polyphenol-rich beverage; A pilot clinical study with phytochemical and in vitro antioxidant characterization","volume":"10","author":"Nemzer","year":"2011","journal-title":"Nutr. J."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3233\/CH-2011-1424","article-title":"Cardioprotection by resveratrol: A human clinical trial in patients with stable coronary artery disease","volume":"50","author":"Magyar","year":"2012","journal-title":"Clin. Hemorheol. Microcirc."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Ashor, A.W., Lara, J., Siervo, M., Celis-Morales, C., and Mathers, J.C. (2014). Effects of exercise modalities on arterial stiffness and wave reflection: A systematic review and meta-analysis of randomized controlled trials. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0110034"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1017\/S0007114516001884","article-title":"Reversibility of endothelial dysfunction in diabetes: Role of polyphenols","volume":"116","author":"Suganya","year":"2016","journal-title":"Br. J. Nutr."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.atherosclerosis.2022.04.025","article-title":"Exercise and the hallmarks of peripheral arterial disease","volume":"350","author":"Valenzuela","year":"2022","journal-title":"Atherosclerosis"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/00003677-200301000-00006","article-title":"Exercise-induced vascular remodeling","volume":"31","author":"Prior","year":"2003","journal-title":"Exerc. Sport Sci. Rev."},{"key":"ref_49","unstructured":"Kawamura, K., Ejiri, K., and Toda, H. (2022). Association between home-based exercise using a pedometer and clinical prognosis after endovascular treatment in patients with peripheral artery disease. J. Cardiol., S0914-5087(22)00228-3."},{"key":"ref_50","unstructured":"Ehrman, J.K., Gardner, A.W., Salisbury, D., Lui, K., and Treat-Jacobson, D. Supervised Exercise Therapy for Symptomatic Peripheral Artery Disease: A review of current experience and practice-based recommendations, J. Cardiopulm. Rehabil. Prev., epub ahead of print."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/j.jacc.2016.11.008","article-title":"2016 AHA\/ACC Guideline on the Management of Patients with Lower Extremity Peripheral Artery Disease: Executive Summary: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"69","author":"Gornik","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Craig, J.C., Hart, C.R., Layec, G., Kwon, O.S., Richardson, R.S., and Trinity, J.D. (Am. J. Physiol. -Regul. Integr. Comp. Physiol., 2022). Impaired hemodynamic response to exercise in patients with peripheral artery disease: Evidence of a link to inflammation and oxidative stress, Am. J. Physiol. -Regul. Integr. Comp. Physiol., epub ahead of print.","DOI":"10.1152\/ajpregu.00159.2022"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1177\/2040622311430006","article-title":"Evidence for a protective effect of polyphenols-containing foods on cardiovascular health: An update for clinicians","volume":"3","author":"Habauzit","year":"2012","journal-title":"Ther. Adv. Chronic Dis."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"201","DOI":"10.2174\/1573399810666140613124326","article-title":"Vascular endothelial dysfunction and nutritional compounds in early type 1 diabetes","volume":"10","author":"Hoffman","year":"2014","journal-title":"Curr. Diabetes Rev."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2097096","DOI":"10.1155\/2020\/2097096","article-title":"Protective Effects of Polyphenols Present in Mediterranean Diet on Endothelial Dysfunction","volume":"2020","author":"Stromsnes","year":"2020","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.freeradbiomed.2018.03.018","article-title":"Potential mechanisms underlying cardiovascular protection by polyphenols: Role of the endothelium","volume":"122","author":"Oak","year":"2018","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"E679","DOI":"10.1152\/ajpendo.00377.2013","article-title":"Mechanisms for food polyphenols to ameliorate insulin resistance and endothelial dysfunction: Therapeutic implications for diabetes and its cardiovascular complications","volume":"305","author":"Munir","year":"2013","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"203","DOI":"10.2174\/1381612823666171109103939","article-title":"Polyphenols and Microvascular Function in Humans: A Systematic Review","volume":"24","author":"Woodward","year":"2018","journal-title":"Curr. Pharm. Des."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.clnu.2021.11.002","article-title":"Olive oil consumption is associated with a lower risk of cardiovascular disease and stroke","volume":"41","author":"Amiano","year":"2022","journal-title":"Clin. Nutr."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1089\/ars.2012.4581","article-title":"Dietary (poly)phenolics in human health: Structures, bioavailability, and evidence of protective effects against chronic diseases","volume":"18","author":"Spencer","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1161\/CIRCULATIONAHA.107.713867","article-title":"Dark chocolate improves coronary vasomotion and reduces platelet reactivity","volume":"116","author":"Flammer","year":"2007","journal-title":"Circulation"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"104399","DOI":"10.1016\/j.jff.2021.104399","article-title":"Evaluation of blood pressure lowering effects of cocoa flavanols in diabetes mellitus: A systematic review and meta-analysis","volume":"79","author":"Tanghe","year":"2021","journal-title":"J. Funct. Foods"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"602086","DOI":"10.3389\/fcvm.2021.602086","article-title":"Acute Effects of Cocoa Flavanols on Blood Pressure and Peripheral Vascular Reactivity in Type 2 Diabetes Mellitus and Essential Hypertension: A Protocol for an Acute, Randomized, Double-Blinded, Placebo-Controlled Cross-Over Trial","volume":"8","author":"Tanghe","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) (2012). Scientific Opinion on the substantiation of a health claim related to cocoa flavanols and maintenance of normal endothelium-dependent vasodilation pursuant to Article 13(5) of Regulation (EC) No 1924\/2006. EFSA J., 10, 2809.","DOI":"10.2903\/j.efsa.2012.2809"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ejmech.2017.03.004","article-title":"Therapeutic potentials of baicalin and its aglycone, baicalein against inflammatory disorders","volume":"131","author":"Dinda","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.jep.2014.12.027","article-title":"Oroxylum indicum (L.) Kurz, an important Asian traditional medicine: From traditional uses to scientific data for its commercial exploitation","volume":"161","author":"Dinda","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"ref_67","first-page":"571","article-title":"Detection of Baicalin Metabolites Baicalein and Oroxylin-A in Mouse Pancreas and Pancreatic Xenografts","volume":"23","author":"Lu","year":"2007","journal-title":"Tissue Eng."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"147626","DOI":"10.1016\/j.brainres.2021.147626","article-title":"Baicalein ameliorates ischemic brain damage through suppressing proinflammatory microglia polarization via inhibiting the TLR4\/NF-\u03baB and STAT1 pathway","volume":"1770","author":"Ran","year":"2021","journal-title":"Brain Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s13020-020-00384-0","article-title":"Applications, phytochemistry, pharmacological effects, pharmacokinetics, toxicity of Scutellaria baicalensis Georgi. And its probably potential therapeutic effects on COVID-19: A review","volume":"15","author":"Song","year":"2020","journal-title":"Chin. Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1007\/s00894-010-0942-y","article-title":"Mechanistic study of the structure-activity relationship for the free radical scavenging activity of baicalein","volume":"17","year":"2011","journal-title":"J. Mol. Model."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Salleh, N.N.H.N., Othman, F.A., Kamarudin, N.A., and Tan, S.C. (2020). The Biological Activities and Therapeutic Potentials of Baicalein Extracted from Oroxylum indicum: A Systematic Review. Molecules, 25.","DOI":"10.3390\/molecules25235677"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"114733","DOI":"10.1016\/j.ejmech.2022.114733","article-title":"Review of bioactivity and structure-activity relationship on baicalein (5,6,7-trihydroxyflavone) and wogonin (5,7-dihydroxy-8-methoxyflavone) derivatives: Structural modifications inspired from flavonoids in Scutellaria baicalensis","volume":"243","author":"Zhao","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1111\/jphp.13129","article-title":"Scutellaria baicalensis Georgi. (Lamiaceae): A review of its traditional uses, botany, phytochemistry, pharmacology and toxicology","volume":"71","author":"Zhao","year":"2019","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"13201","DOI":"10.1038\/s41598-022-17586-1","article-title":"Exploring native Scutellaria species provides insight into differential accumulation of flavones with medicinal properties","volume":"12","author":"Costine","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"519","DOI":"10.5483\/BMBRep.2015.48.9.017","article-title":"Baicalin, baicalein and wogonin inhibits high glucose-induced vascular inflammation in vitro and in vivo","volume":"48","author":"Ku","year":"2015","journal-title":"BMB Rep."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"3558","DOI":"10.1002\/ptr.7046","article-title":"Promising influences of Scutellaria baicalensis and its two active constituents, baicalin, and baicalein, against metabolic syndrome: A review","volume":"35","author":"Askari","year":"2021","journal-title":"Phytother. Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"8319","DOI":"10.1021\/acs.jafc.7b02531","article-title":"Dietary Flavonoids and Acarbose Synergistically Inhibit \u03b1-Glucosidase and Lower Postprandial Blood Glucose","volume":"65","author":"Zhang","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Froldi, G., Djeujo, F.M., Bulf, N., Caparelli, E., and Ragazzi, E. (2022). Comparative Evaluation of the Antiglycation and Anti-\u03b1-Glucosidase Activities of Baicalein, Baicalin (Baicalein 7-O-Glucuronide) and the Antidiabetic Drug Metformin. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14102141"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.taap.2014.09.003","article-title":"Vascular barrier protective effects of baicalin, baicalein and wogonin in vitro and in vivo","volume":"281","author":"Kwak","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"953305","DOI":"10.3389\/fendo.2022.953305","article-title":"Protective effect of the curcumin-baicalein combination against macrovascular changes in diabetic angiopathy","volume":"13","author":"Wang","year":"2022","journal-title":"Frontiers in Endocrinology"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1016\/j.phymed.2014.08.012","article-title":"Baicalein protects against hypertension associated with diabetes: Effect on vascular reactivity and stiffness","volume":"21","author":"Hassan","year":"2014","journal-title":"Phytomedicine"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.jff.2018.04.070","article-title":"Anti-diabetic effect of baicalein is associated with the modulation of gut microbiota in streptozotocin and high-fat-diet induced diabetic rats","volume":"46","author":"Zhang","year":"2018","journal-title":"J. Funct. Foods"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Bitew, M., Desalegn, T., Demissie, T.B., Belayneh, A., Endale, M., and Eswaramoorthy, R. (2021). Pharmacokinetics and drug-likeness of antidiabetic flavonoids: Molecular docking and DFT study. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0260853"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"4442","DOI":"10.1002\/ptr.7149","article-title":"Targeting inflammation-associated AMPK\/\/Mfn-2\/MAPKs signaling pathways by baicalein exerts anti-atherosclerotic action","volume":"35","author":"Zhang","year":"2021","journal-title":"Phytother. Res."},{"key":"ref_85","first-page":"3085","article-title":"Baicalein protects against endothelial cell injury by inhibiting the TLR4\/NF-\u03baB signaling pathway","volume":"17","author":"Wan","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"883","DOI":"10.18632\/oncotarget.13669","article-title":"Baicalein reduces angiogenesis in the inflammatory microenvironment via inhibiting the expression of AP-1","volume":"8","author":"Huang","year":"2017","journal-title":"Oncotarget"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"72458","DOI":"10.18632\/oncotarget.12788","article-title":"Baicalein protects against oxLDL-caused oxidative stress and inflammation by modulation of AMPK-alpha","volume":"7","author":"Tsai","year":"2016","journal-title":"Oncotarget"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.ejphar.2007.03.009","article-title":"Baicalein impairs vascular tone in normal rat aortas: Role of superoxide anions","volume":"565","author":"Machha","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0014-2999(99)00291-5","article-title":"Endothelium-dependent contraction and direct relaxation induced by baicalein in rat mesenteric artery","volume":"374","author":"Chen","year":"1999","journal-title":"Eur. J. Pharmacol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1097\/01.fjc.0000162769.83324.c1","article-title":"Chronic treatment with flavonoids prevents endothelial dysfunction in spontaneously hypertensive rat aorta","volume":"46","author":"Machha","year":"2005","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s00210-008-0328-1","article-title":"Baicalein attenuates intimal hyperplasia after rat carotid balloon injury through arresting cell-cycle progression and inhibiting ERK, Akt, and NF-\u03baB activity in vascular smooth-muscle cells","volume":"378","author":"Peng","year":"2008","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Sulistyowati, E., Hsu, J.H., Lee, S.J., Huang, S.E., Sihotang, W.Y., Wu, B.N., Dai, Z.K., Lin, M.C., and Yeh, J.L. (2022). Potential Actions of Baicalein for Preventing Vascular Calcification of Smooth Muscle Cells In Vitro and In Vivo. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23105673"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1111\/cts.13063","article-title":"Safety, tolerability, and pharmacokinetics of oral baicalein tablets in healthy Chinese subjects: A single-center, randomized, double-blind, placebo-controlled multiple-ascending-dose study","volume":"14","author":"Li","year":"2021","journal-title":"Clin. Transl. Sci."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"114052","DOI":"10.1016\/j.jep.2021.114052","article-title":"Safety, tolerability, pharmacokinetics, and food effect of baicalein tablets in healthy Chinese subjects: A single-center, randomized, double-blind, placebo-controlled, single-dose phase I study","volume":"274","author":"Dong","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"ref_95","unstructured":"(2022, September 28). WHO Global Database VigiBase. Available online: https:\/\/www.vigiaccess.org\/."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1007\/s40261-016-0418-7","article-title":"Multiple-Ascending-Dose Pharmacokinetics and Safety Evaluation of Baicalein Chewable Tablets in Healthy Chinese Volunteers","volume":"36","author":"Pang","year":"2016","journal-title":"Clin. Drug Investig."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1124\/dmd.121.000714","article-title":"Inhibition of Human UDP-Glucuronosyltransferases1A1\u2013Mediated Bilirubin Glucuronidation by the Popular Flavonoids Baicalein, Baicalin, and Hyperoside Is Responsible for Herb (Shuang-Huang-Lian)-Induced JaundiceS","volume":"50","author":"Yang","year":"2022","journal-title":"Drug Metab. Dispos."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"20091","DOI":"10.3390\/molecules191220091","article-title":"The chemistry of curcumin: From extraction to therapeutic agent","volume":"19","author":"Priyadarsini","year":"2014","journal-title":"Molecules"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Hewlings, S.J., and Kalman, D.S. (2017). Curcumin: A review of its effects on human health. Foods, 6.","DOI":"10.3390\/foods6100092"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1155\/2014\/161346","article-title":"Molecular mechanisms of curcumin on diabetes-induced endothelial dysfunctions: Txnip, ICAM-1, and NOX2 expressions","volume":"2014","author":"Wongeakin","year":"2014","journal-title":"BioMed. Res. Int."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Rungseesantivanon, S., Thenchaisri, N., Ruangvejvorachai, P., and Patumraj, S. (2010). Curcumin supplementation could improve diabetes-induced endothelial dysfunction associated with decreased vascular superoxide production and PKC inhibition. BMC Complement. Altern. Med., 10.","DOI":"10.1186\/1472-6882-10-57"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.2174\/1381612823666170222122822","article-title":"Curcumin and Endothelial Function: Evidence and Mechanisms of Protective Effects","volume":"23","author":"Karimian","year":"2017","journal-title":"Curr. Pharm. Des."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1089\/jmf.2013.2965","article-title":"Effects of Curcumin (Curcuma longa) on Learning and Spatial Memory as Well as Cell Proliferation and Neuroblast Differentiation in Adult and Aged Mice by Upregulating Brain-Derived Neurotrophic Factor and CREB Signaling","volume":"17","author":"Nam","year":"2014","journal-title":"J. Med. Food"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"De Lorenzi, E., Contardi, C., Serra, M., Bisceglia, F., Franceschini, D., Pagetta, A., Zusso, M., Di Martino, R.M.C., Seghetti, F., and Belluti, F. (2022). Modulation of Amyloid \u03b2-induced Microglia Activation and Neuronal Cell Death by Curcumin and Analogues. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23084381"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"e30194","DOI":"10.1097\/MD.0000000000030194","article-title":"A network pharmacology approach to identify the mechanisms and molecular targets of curcumin against Alzheimer disease","volume":"101","author":"Wu","year":"2022","journal-title":"Medicine"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"4817","DOI":"10.1074\/jbc.M114.618785","article-title":"Unraveling curcumin degradation: Autoxidation proceeds through spiroepoxide and vinylether intermediates en route to the main bicyclopentadione","volume":"290","author":"Gordon","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"21243","DOI":"10.1074\/jbc.RA117.000123","article-title":"The anti-inflammatory activity of curcumin is mediated by its oxidative metabolites","volume":"292","author":"Edwards","year":"2017","journal-title":"J. Biol. Chem."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"4509","DOI":"10.1021\/acs.jafc.7b01792","article-title":"Structure-Activity Relationship of Curcumin: Role of the Methoxy Group in Anti-inflammatory and Anticolitis Effects of Curcumin","volume":"65","author":"Yang","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"e39","DOI":"10.1016\/j.jss.2011.08.021","article-title":"Curcumin protects against ischemia\/reperfusion injury in rat skeletal muscle","volume":"172","author":"Avci","year":"2012","journal-title":"J. Surg. Res."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.12659\/MSM.896217","article-title":"Curcumin ameliorates ischemia-induced limb injury through immunomodulation","volume":"22","author":"Liu","year":"2016","journal-title":"Med. Sci. Monit."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/s13287-017-0636-9","article-title":"Curcumin induces therapeutic angiogenesis in a diabetic mouse hindlimb ischemia model via modulating the function of endothelial progenitor cells","volume":"8","author":"You","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"ref_112","first-page":"798","article-title":"Curcumin improves perfusion recovery in experimental peripheral arterial disease by upregulating microRNA-93 expression","volume":"17","author":"Zhang","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"ref_113","first-page":"1816","article-title":"Curcumin inhibits HIF-1\u03b1 induced functional changes of macrophages","volume":"23","author":"Ouyang","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1080\/10408398.2017.1396200","article-title":"Curcumin against advanced glycation end products (AGEs) and AGEs-induced detrimental agents","volume":"59","author":"Alizadeh","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/labinvest.2014.42","article-title":"Laboratory Investigation","volume":"94","author":"Tang","year":"2014","journal-title":"Lab. Investig."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Mahmoudi, A., Atkin, S.L., Nikiforov, N.G., and Sahebkar, A. (2022). Therapeutic Role of Curcumin in Diabetes: An Analysis Based on Bioinformatic Findings. Nutrients, 14.","DOI":"10.3390\/nu14153244"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1159\/000506180","article-title":"Curcumin Preparations Can Improve Flow-Mediated Dilation and Endothelial Function: A Meta-Analysis","volume":"27","author":"Changal","year":"2020","journal-title":"Complement. Med. Res."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/978-3-030-56153-6_6","article-title":"Protective Effects of Curcumin on Endothelium: An Updated Review","volume":"1291","author":"Alidadi","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1021\/mp700113r","article-title":"Bioavailability of curcumin: Problems and promises","volume":"4","author":"Anand","year":"2007","journal-title":"Mol. Pharm."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Stohs, S.J., Chen, O., Ray, S.D., Ji, J., Bucci, L.R., and Preuss, H.G. (2020). Promising Avenues for Curcumin-Based Research and Application: A Review. Molecules, 25.","DOI":"10.3390\/molecules25061397"},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Witika, B.A., Makoni, P.A., Matafwali, S.K., Mweetwa, L.L., Shandele, G.C., and Walker, R.B. (2021). Enhancement of biological and pharmacological properties of an encapsulated polyphenol: Curcumin. Molecules, 26.","DOI":"10.3390\/molecules26144244"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.biomaterials.2014.11.016","article-title":"ROS-responsive microspheres for on demand antioxidant therapy in a model of diabetic peripheral arterial disease","volume":"41","author":"Poole","year":"2015","journal-title":"Biomaterials"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.biomaterials.2018.07.003","article-title":"Ultrasound imaging and on-demand therapy of peripheral arterial diseases using H2O2-Activated bubble generating anti-inflammatory polymer particles","volume":"179","author":"Jung","year":"2018","journal-title":"Biomaterials"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"111705","DOI":"10.1016\/j.foodres.2022.111705","article-title":"Formulation and characterization of nano-curcumin fortified milk cream powder through microfluidization and spray drying","volume":"160","author":"Verma","year":"2022","journal-title":"Food Res. Int."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"820806","DOI":"10.3389\/fphar.2022.820806","article-title":"A Comprehensive Review on the Therapeutic Potential of Curcuma longa Linn. in Relation to its Major Active Constituent Curcumin","volume":"13","author":"Fuloria","year":"2022","journal-title":"Front. Pharmacol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1002\/mnfr.200700354","article-title":"Multi-targeted therapy by curcumin: How spicy is it?","volume":"52","author":"Goel","year":"2008","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1002\/ptr.6054","article-title":"Turmeric (Curcuma longa) and its major constituent (curcumin) as nontoxic and safe substances: Review","volume":"32","author":"Soleimani","year":"2018","journal-title":"Phytother. Res."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"865497","DOI":"10.3389\/fnut.2022.865497","article-title":"Curcumin-The Nutraceutical with Pleiotropic Effects? Which Cardiometabolic Subjects Might Benefit the Most?","volume":"9","author":"Surma","year":"2022","journal-title":"Front. Nutr."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/bcp.14460","article-title":"Acute liver injury following turmeric use in Tuscany: An analysis of the Italian Phytovigilance database and systematic review of case reports","volume":"87","author":"Lombardi","year":"2021","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Haynes, L.J., and Taylor, D.R. (1966). C-glycosyl compounds. Part V. Mangiferin; the nuclear magnetic resonance spectra of xanthones. J. Chem. Soc. C Org., 1685\u20131687.","DOI":"10.1039\/j39660001685"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/biof.1292","article-title":"Mangiferin: A xanthonoid with multipotent anti-inflammatory potential","volume":"42","author":"Saha","year":"2016","journal-title":"BioFactors"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"5599","DOI":"10.1021\/jf800738r","article-title":"Characterization and quantitation of polyphenolic compounds in bark, kernel, leaves, and peel of mango (Mangifera indica L.)","volume":"56","author":"Barreto","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s12944-017-0449-y","article-title":"Mangiferin: A natural miracle bioactive compound against lifestyle related disorders","volume":"16","author":"Imran","year":"2017","journal-title":"Lipids Health Dis."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"582","DOI":"10.2174\/1389557515666150401111410","article-title":"Medicinal Properties of Mangiferin, Structural Features, Derivative Synthesis, Pharmacokinetics and Biological Activities","volume":"15","author":"Benard","year":"2015","journal-title":"Mini-Rev. Med. Chem."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.taap.2012.01.015","article-title":"Mangiferin exerts hepatoprotective activity against D-galactosamine induced acute toxicity and oxidative\/nitrosative stress via Nrf2-NF\u03baB pathways","volume":"260","author":"Das","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Pal, P.B., Sinha, K., and Sil, P.C. (2013). Mangiferin, a Natural Xanthone, Protects Murine Liver in Pb(II) Induced Hepatic Damage and Cell Death via MAP Kinase, NF-\u03baB and Mitochondria Dependent Pathways. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0056894"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ejphar.2005.03.007","article-title":"Iron complexing activity of mangiferin, a naturally occurring glucosylxanthone, inhibits mitochondrial lipid peroxidation induced by Fe 2+-citrate","volume":"513","author":"Andreu","year":"2005","journal-title":"Eur. J. Pharmacol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.metabol.2014.11.008","article-title":"Mangiferin inhibits endoplasmic reticulum stress-associated thioredoxin-interacting protein\/NLRP3 inflammasome activation with regulation of AMPK in endothelial cells","volume":"64","author":"Song","year":"2015","journal-title":"Metab. Clin. Exp."},{"key":"ref_139","first-page":"369","article-title":"[Relationship between endothelial damage and p120-catenin in paraquat intoxication and the protective effect of mangiferin]","volume":"26","author":"He","year":"2014","journal-title":"Zhonghua Wei Zhong Bing Ji Jiu Yi Xue"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.3923\/jbs.2007.1227.1232","article-title":"In vitro protective effect of mangiferin against glycated protein-iron chelate induced toxicity in human umbelical vein endothelial cells","volume":"7","author":"Venugopal","year":"2007","journal-title":"J. Biol. Sci."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"473","DOI":"10.3892\/mmr.2021.12112","article-title":"Mangiferin inhibits cell migration and angiogenesis via PI3K\/AKT\/mTOR signaling in high glucose- and hypoxia-induced RRCECs","volume":"23","author":"Shi","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"5181","DOI":"10.1021\/jf100249s","article-title":"Mango extracts and the mango component mangiferin promote endothelial cell migration","volume":"58","author":"Daud","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1139\/cjpp-2015-0073","article-title":"Mangiferin suppressed advanced glycation end products (AGEs) through NF-\u03baB deactivation and displayed anti-inflammatory effect in streptozotocin and high fat diet-diabetic cardiomyopathy rats","volume":"94","author":"Hou","year":"2016","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jphs.2018.07.004","article-title":"jun Mangiferin inhibits high-fat diet induced vascular injury via regulation of PTEN\/AKT\/eNOS pathway","volume":"137","author":"Jiang","year":"2018","journal-title":"J. Pharmacol. Sci."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.nutres.2020.12.017","article-title":"Oral administration of mangiferin ameliorates diabetes in animal models: A meta-analysis and systematic review","volume":"87","author":"Wu","year":"2021","journal-title":"Nutr. Res."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/cbin.10950","article-title":"Mangifera indica L. extract (Vimang\u00ae) reduces plasma and liver cholesterol and leucocyte oxidative stress in hypercholesterolemic LDL receptor deficient mice","volume":"42","author":"Dorighello","year":"2018","journal-title":"Cell Biol. Int."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.jtcme.2021.05.004","article-title":"Peripheral arterial disease: Effects of ethanolic extracts of seed kernels of mango (Mangifera indica L.) on acute hind limb ischemia-reperfusion injury in diabetic rats","volume":"11","author":"RamPravinKumar","year":"2021","journal-title":"J. Tradit. Complement. Med."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"10344","DOI":"10.1038\/srep10344","article-title":"Mangiferin supplementation improves serum lipid profiles in overweight patients with hyperlipidemia: A double-blind randomized controlled trial","volume":"5","author":"Na","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.foodchem.2011.10.079","article-title":"Pharmacokinetic study of mangiferin in human plasma after oral administration","volume":"132","author":"Hou","year":"2012","journal-title":"Food Chem."},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Xu, D., Hu, M.J., Wang, Y.Q., and Cui, Y.L. (2019). Antioxidant activities of quercetin and its complexes for medicinal application. Molecules, 24.","DOI":"10.3390\/molecules24061123"},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Li, Y., Yao, J., Han, C., Yang, J., Chaudhry, M.T., Wang, S., Liu, H., and Yin, Y. (2016). Quercetin, inflammation and immunity. Nutrients, 8.","DOI":"10.3390\/nu8030167"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"11","DOI":"10.4014\/jmb.1907.07003","article-title":"A Review on Structure, Modifications and Structure-Activity Relation of Quercetin and Its Derivatives","volume":"30","author":"Magar","year":"2020","journal-title":"J. Microbiol. Biotechnol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1002\/ptr.7352","article-title":"O-Glycoside quercetin derivatives: Biological activities, mechanisms of action, and structure\u2013activity relationship for drug design, a review","volume":"36","author":"Alizadeh","year":"2022","journal-title":"Phytother. Res."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s10517-018-4167-x","article-title":"The Effect of Dihydroquercetin on Catalytic Activity of Iron (II) Ions in the Fenton Reaction","volume":"165","author":"Babenkova","year":"2018","journal-title":"Bull. Exp. Biol. Med."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"84","DOI":"10.4103\/0973-7847.194044","article-title":"Overviews of biological importance of quercetin: A bioactive flavonoid","volume":"10","author":"Arulmoli","year":"2016","journal-title":"Pharmacogn. Rev."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"5352","DOI":"10.1002\/ptr.7144","article-title":"Quercetin and metabolic syndrome: A review","volume":"35","author":"Hosseini","year":"2021","journal-title":"Phytotherapy Research"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-2999(93)90968-N","article-title":"Vasodilator effects of quercetin in isolated rat vascular smooth muscle","volume":"239","author":"Duarte","year":"1993","journal-title":"Eur. J. Pharmacol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1271\/bbb.70.933","article-title":"Antihypertensive effect of quercetin in rats fed with a high-fat high-sucrose diet","volume":"70","author":"Yamamoto","year":"2006","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/0306-3623(95)02001-2","article-title":"Vasorelaxing activity of resveratrol and quercetin in isolated rat aorta","volume":"27","author":"Chen","year":"1996","journal-title":"Gen. Pharmacol. Vasc. Syst."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/sj.bjp.0704064","article-title":"Antihypertensive effects of the flavonoid quercetin in spontaneously hypertensive rats","volume":"133","author":"Duarte","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s00417-007-0728-9","article-title":"guang Quercetin inhibits choroidal and retinal angiogenesis in vitro","volume":"246","author":"Chen","year":"2008","journal-title":"Graefe\u2019s Arch. Clin. Exp. Ophthalmol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0304-3835(01)00443-8","article-title":"Resveratrol and quercetin inhibit angiogenesis in vitro","volume":"171","author":"Igura","year":"2001","journal-title":"Cancer Lett."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0014-2999(02)02848-0","article-title":"Quercetin, a dietary-derived flavonoid, possesses antiangiogenic potential","volume":"459","author":"Tan","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/cpr.12102","article-title":"Quercetin ameliorates tunicamycin-induced endoplasmic reticulum stress in endothelial cells","volume":"47","author":"Suganya","year":"2014","journal-title":"Cell Prolif."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"2986796","DOI":"10.1155\/2016\/2986796","article-title":"Mechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More","volume":"2016","author":"Costa","year":"2016","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Bao, D., Wang, J., Pang, X., and Liu, H. (2017). Protective Effect of Quercetin against Oxidative Stress-Induced Cytotoxicity in Rat Pheochromocytoma (PC-12) Cells. Molecules, 22.","DOI":"10.3390\/molecules22071122"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1093\/jn\/137.5.1208","article-title":"Quercetin inhibits TNF-induced NF-\u03baB transcription factor recruitment to proinflammatory gene promoters in murine intestinal epithelial cells","volume":"137","author":"Ruiz","year":"2007","journal-title":"J. Nutr."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.lfs.2007.12.021","article-title":"Kaempferol and quercetin isolated from Euonymus alatus improve glucose uptake of 3T3-L1 cells without adipogenesis activity","volume":"82","author":"Fang","year":"2008","journal-title":"Life Sci."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1093\/jn\/128.3.593","article-title":"Supplementation with quercetin markedly increases plasma quercetin concentration without effect on selected risk factors for heart disease in healthy subjects","volume":"128","author":"Conquer","year":"1998","journal-title":"J. Nutr."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1093\/jn\/137.11.2405","article-title":"Quercetin reduces blood pressure in hypertensive subjects","volume":"137","author":"Edwards","year":"2007","journal-title":"J. Nutr."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1017\/S0007114509359127","article-title":"Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: A double-blinded, placebo-controlled cross-over study","volume":"102","author":"Egert","year":"2009","journal-title":"Br. J. Nutr."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"101350","DOI":"10.1016\/j.cpcardiol.2022.101350","article-title":"The effects of quercetin supplementation on blood pressure\u2013meta-analysis","volume":"47","author":"Fornal","year":"2022","journal-title":"Curr. Probl. Cardiol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"e002713","DOI":"10.1161\/JAHA.115.002713","article-title":"Effects of Quercetin on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","volume":"5","author":"Serban","year":"2016","journal-title":"J. Am. Heart Assoc."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1093\/nutrit\/nuz071","article-title":"Effect of quercetin supplementation on plasma lipid profiles, blood pressure, and glucose levels: A systematic review and meta-analysis","volume":"78","author":"Huang","year":"2020","journal-title":"Nutr. Rev."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1527-3466.2004.tb00139.x","article-title":"Cardiovascular protective effects of resveratrol","volume":"22","author":"Bradamante","year":"2004","journal-title":"Cardiovasc. Drug Rev."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0031-6989(88)80846-4","article-title":"Resveratrol activity on guinea pig isolated trachea from normal and albumin-sensitized animals","volume":"20","author":"Ragazzi","year":"1988","journal-title":"Pharmacol. Res. Commun."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1096\/fj.03-0168rev","article-title":"Resveratrol: From grapevines to mammalian biology","volume":"17","author":"Pervaiz","year":"2003","journal-title":"FASEB J."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1089\/jmf.2010.0272","article-title":"Structure-Activity relationship of resveratrol and its analogue, 4,4\u2032-dihydroxy-trans-stilbene, toward the endothelin axis in human endothelial cells","volume":"14","author":"Coppa","year":"2011","journal-title":"J. Med. Food"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"22586","DOI":"10.1074\/jbc.M101846200","article-title":"Specific Structural Determinants Are Responsible for the Antioxidant Activity and the Cell Cycle Effects of Resveratrol","volume":"276","author":"Stivala","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.freeradbiomed.2016.08.006","article-title":"Hormetic shifting of redox environment by pro-oxidative resveratrol protects cells against stress","volume":"99","author":"Plauth","year":"2016","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_181","doi-asserted-by":"crossref","unstructured":"Shaito, A., Posadino, A.M., Younes, N., Hasan, H., Halabi, S., Alhababi, D., Al-Mohannadi, A., Abdel-Rahman, W.M., Eid, A.H., and Nasrallah, G.K. (2020). Potential adverse effects of resveratrol: A literature review. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21062084"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.vph.2005.12.003","article-title":"Resveratrol decreases calcium sensitivity of vascular smooth muscle and enhances cytosolic calcium increase in endothelium","volume":"44","author":"Buluc","year":"2006","journal-title":"Vasc. Pharmacol."},{"key":"ref_183","first-page":"207","article-title":"Relaxant effect of trans-resveratrol on isolated porcine coronary arteries","volume":"49","year":"1999","journal-title":"Arzneimittelforschung"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1006\/bbrc.2002.6598","article-title":"Resveratrol activates membrane-bound guanylyl cyclase in coronary arterial smooth muscle: A novel signaling mechanism in support of coronary protection","volume":"291","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1042\/cs0980537","article-title":"Resveratrol induces vasorelaxation of mesenteric and uterine arteries from female guinea-pigs","volume":"98","author":"Naderali","year":"2000","journal-title":"Clin. Sci. (Lond. Engl. 1979)"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1096\/fj.07-103366","article-title":"Resveratrol stimulates nitric oxide production by increasing estrogen receptor \u03b1a-Src-caveolin-1 interaction and phosphorylation in human umbilical vein endothelial cells","volume":"22","author":"Klinge","year":"2008","journal-title":"FASEB J."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s12263-012-0319-1","article-title":"Resveratrol ameliorates high-glucose-induced hyperpermeability mediated by caveolae via VEGF\/KDR pathway","volume":"8","author":"Tian","year":"2013","journal-title":"Genes Nutr."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/1753-0407.12296","article-title":"Resveratrol inhibits inflammation and ameliorates insulin resistant endothelial dysfunction via regulation of AMP-activated protein kinase and sirtuin 1 activities","volume":"8","author":"Liu","year":"2016","journal-title":"J. Diabetes"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1152\/ajpheart.00340.2006","article-title":"Resveratrol attenuates TNF-\u03b1-induced activation of coronary arterial endothelial cells: Role of NF-\u03baB inhibition","volume":"291","author":"Csiszar","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.bbrc.2011.10.115","article-title":"Flavonoids inhibit high glucose-induced up-regulation of ICAM-1 via the p38 MAPK pathway in human vein endothelial cells","volume":"415","author":"Kim","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ejphar.2013.10.034","article-title":"Protective effects of chronic resveratrol treatment on vascular inflammatory injury in streptozotocin-induced type 2 diabetic rats: Role of NF-kappa B signaling","volume":"720","author":"Zheng","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"H18-24","DOI":"10.1152\/ajpheart.00260.2010","article-title":"Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2","volume":"299","author":"Ungvari","year":"2010","journal-title":"Am. J. Physiology. Heart Circ. Physiol."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.bbadis.2014.10.013","article-title":"Resveratrol and diabetes: From animal to human studies","volume":"1852","author":"Szkudelski","year":"2015","journal-title":"Biochim. Et Biophys. Acta Mol. Basis Dis."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/nature06261","article-title":"Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes","volume":"450","author":"Milne","year":"2007","journal-title":"Nature"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1080\/02713683.2019.1625406","article-title":"Cross-Talk between Sirtuin 1 and the Proinflammatory Mediator High-Mobility Group Box-1 in the Regulation of Blood-Retinal Barrier Breakdown in Diabetic Retinopathy","volume":"44","author":"Mohammad","year":"2019","journal-title":"Curr. Eye Res."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"145532","DOI":"10.1016\/j.gene.2021.145532","article-title":"An updated pharmacological insight of resveratrol in the treatment of diabetic nephropathy","volume":"780","author":"Li","year":"2021","journal-title":"Gene"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.ejphar.2007.04.062","article-title":"Resveratrol enhances insulin secretion by blocking KATP and KV channels of beta cells","volume":"568","author":"Chen","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1530\/eje.0.1380619","article-title":"Resveratrol, a phytoestrogen found in red wine. A possible explanation for the conundrum of the \u2018French paradox\u2019?","volume":"138","author":"Kopp","year":"1998","journal-title":"Eur. J. Endocrinol."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1536\/ihj.16-373","article-title":"Resveratrol ameliorates arterial stiffness assessed by cardio-ankle vascular index in patients with type 2 diabetes mellitus","volume":"58","author":"Imamura","year":"2017","journal-title":"Int. Heart J."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1161\/HYPERTENSIONAHA.111.01009","article-title":"Resveratrol improves vascular function in patients with hypertension and dyslipidemia by modulating NO metabolism","volume":"62","author":"Carrizzo","year":"2013","journal-title":"Hypertension"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.3945\/ajcn.2009.28641","article-title":"Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: A double-blind, placebo-controlled, crossover investigation","volume":"91","author":"Kennedy","year":"2010","journal-title":"American J. Clin. Nutr."},{"key":"ref_202","doi-asserted-by":"crossref","unstructured":"Wong, R.H.X., Raederstorff, D., and Howe, P.R.C. (2016). Acute resveratrol consumption improves neurovascular coupling capacity in adults with type 2 diabetes mellitus. Nutrients, 8.","DOI":"10.3390\/nu8070425"},{"key":"ref_203","first-page":"CD011919","article-title":"Resveratrol for adults with type 2 diabetes mellitus","volume":"2020","author":"Jeyaraman","year":"2020","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1001\/jamacardio.2017.0538","article-title":"Effect of Resveratrol on Walking Performance in Older People with Peripheral Artery Disease: The RESTORE Randomized Clinical Trial","volume":"2","author":"McDermott","year":"2017","journal-title":"JAMA Cardiol."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.toxlet.2018.10.028","article-title":"Trans-resveratrol, but not other natural stilbenes occurring in food, carries the risk of drug-food interaction via inhibition of cytochrome P450 enzymes or interaction with xenosensor receptors","volume":"300","author":"Hyrsova","year":"2019","journal-title":"Toxicol. Lett."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.fct.2017.06.044","article-title":"Resveratrol has anti-thyroid effects both in vitro and in vivo","volume":"107","author":"Giuliani","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.1016\/j.fct.2011.08.023","article-title":"Subchronic oral toxicity and cardiovascular safety pharmacology studies of resveratrol, a naturally occurring polyphenol with cancer preventive activity","volume":"49","author":"Johnson","year":"2011","journal-title":"Food Chem. Toxicol."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"9003","DOI":"10.1158\/0008-5472.CAN-10-2364","article-title":"Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: Safety, pharmacokinetics, and effect on the insulin-like growth factor axis","volume":"70","author":"Brown","year":"2010","journal-title":"Cancer Res."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1158\/1055-9965.EPI-07-0022","article-title":"Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent","volume":"16","author":"Boocock","year":"2007","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_210","doi-asserted-by":"crossref","unstructured":"EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies) (2016). Safety of synthetic trans-resveratrol as a novel food pursuant to Regulation (EC) No 258\/97. EFSA J., 14, 4368.","DOI":"10.2903\/j.efsa.2016.4368"}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/27\/20\/7110\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:58:47Z","timestamp":1760144327000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/27\/20\/7110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,21]]},"references-count":210,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["molecules27207110"],"URL":"https:\/\/doi.org\/10.3390\/molecules27207110","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,21]]}}}