{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:58:01Z","timestamp":1787029081716,"version":"build-2736575974"},"reference-count":37,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T00:00:00Z","timestamp":1666310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Deanship of Scientific Research at Umm Al-Qura University","award":["22UQU4320141DSR58"],"award-info":[{"award-number":["22UQU4320141DSR58"]}]},{"name":"Deanship of Scientific Research at Umm Al-Qura University","award":["GRP\/242\/43"],"award-info":[{"award-number":["GRP\/242\/43"]}]},{"DOI":"10.13039\/501100007446","name":"Deanship of Scientific Research at King Khalid University","doi-asserted-by":"publisher","award":["22UQU4320141DSR58"],"award-info":[{"award-number":["22UQU4320141DSR58"]}],"id":[{"id":"10.13039\/501100007446","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007446","name":"Deanship of Scientific Research at King Khalid University","doi-asserted-by":"publisher","award":["GRP\/242\/43"],"award-info":[{"award-number":["GRP\/242\/43"]}],"id":[{"id":"10.13039\/501100007446","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A unique series of sulphonamide derivatives was attempted to be synthesized in this study using a new and effective method. All of the synthesized compounds were verified using several spectroscopic methods, including FTIR, 1H-NMR, 13C-NMR, and HREI-MS, and their binding interactions were studied using molecular docking. The enzymes urease and \u03b1-glucosidase were evaluated against each derivative (1\u201315). When compared to their respective standard drug such as acarbose and thiourea, almost all compounds were shown to have excellent activity. Among the screened series, analogs 5 (IC50 = 3.20 \u00b1 0.40 and 2.10 \u00b1 0.10 \u00b5M) and 6 (IC50 = 2.50 \u00b1 0.40 and 5.30 \u00b1 0.20 \u00b5M), emerged as potent molecules when compared to the standard drugs acarbose (IC50 = 8.24 \u00b1 0.08 \u00b5M) and urease (IC50 = 7.80 \u00b1 0.30). Moreover, an anti-microbial study also demonstrated that analogs 5 and 6 were found with minimum inhibitory concentrations (MICs) in the presence of standard drugs streptomycin and terinafine.<\/jats:p>","DOI":"10.3390\/molecules27207129","type":"journal-article","created":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T08:19:06Z","timestamp":1666599546000},"page":"7129","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Synthesis, In Vitro Anti-Microbial Analysis and Molecular Docking Study of Aliphatic Hydrazide-Based Benzene Sulphonamide Derivatives as Potent Inhibitors of \u03b1-Glucosidase and Urease"],"prefix":"10.3390","volume":"27","author":[{"given":"Shoaib","family":"Khan","sequence":"first","affiliation":[{"name":"Department of Chemistry, Hazara University, Mansehra 21120, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4607-6217","authenticated-orcid":false,"given":"Shahid","family":"Iqbal","sequence":"additional","affiliation":[{"name":"Department of Chemistry, School of Natural Sciences (SNS), National University of Science and Technology (NUST), H-12, Islamabad 46000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazloom","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Abbottabad University of Science and Technology (AUST), Abbottabad 22010, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wajid","family":"Rehman","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Hazara University, Mansehra 21120, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafaqat","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Hazara University, Mansehra 21120, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liaqat","family":"Rasheed","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Hazara University, Mansehra 21120, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0820-3884","authenticated-orcid":false,"given":"Hamad","family":"Alrbyawi","sequence":"additional","affiliation":[{"name":"Pharmaceutics and Pharmaceutical Technology Department, College of Pharmacy, Taibah University, Medina 42353, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6248-8983","authenticated-orcid":false,"given":"Ayed A.","family":"Dera","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha 61413, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Issa","family":"Alahmdi","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, University of Tabuk, Tabuk 71491, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rami Adel","family":"Pashameah","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Applied Science, Umm Al-Qura University, Makkah 24230, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman","family":"Alzahrani","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abd-ElAziem","family":"Farouk","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.diabres.2011.10.029","article-title":"IDF diabetes atlas: Global estimates of the prevalence of diabetes for 2011 and 2030","volume":"94","author":"Whiting","year":"2011","journal-title":"Diabetes Res. Clin. 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