{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T03:26:23Z","timestamp":1768965983799,"version":"3.49.0"},"reference-count":28,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T00:00:00Z","timestamp":1666656000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31872394"],"award-info":[{"award-number":["31872394"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Feed Quality and Safety"],"award-info":[{"award-number":["Feed Quality and Safety"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Z211100007021001"],"award-info":[{"award-number":["Z211100007021001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Innovation Program of the Chinese Academy of Agricultural Science","award":["31872394"],"award-info":[{"award-number":["31872394"]}]},{"name":"Innovation Program of the Chinese Academy of Agricultural Science","award":["Feed Quality and Safety"],"award-info":[{"award-number":["Feed Quality and Safety"]}]},{"name":"Innovation Program of the Chinese Academy of Agricultural Science","award":["Z211100007021001"],"award-info":[{"award-number":["Z211100007021001"]}]},{"name":"Beijing Municipal Science and Technology Project","award":["31872394"],"award-info":[{"award-number":["31872394"]}]},{"name":"Beijing Municipal Science and Technology Project","award":["Feed Quality and Safety"],"award-info":[{"award-number":["Feed Quality and Safety"]}]},{"name":"Beijing Municipal Science and Technology Project","award":["Z211100007021001"],"award-info":[{"award-number":["Z211100007021001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Hydroxylated polychlorinated biphenyls (OH-PCBs) are a group of metabolites biotransformed from polychlorinated biphenyls by animals with higher toxicities than their parent compounds. The present work developed and validated an analytical method for determinating penta-, hexa-, and hepta-chlorine substituted OH-PCBs in animal-derived food based on ultra-performance liquid chromatography\u2013tandem mass spectrometry (UPLC\u2013MS\/MS) with isotope-dilution. The target analytes were extracted with a 50% n-hexane\/dichloromethane (v\/v), purified by sulfuric acid-silica gel, and separated by 5% hydrated silica gel, achieving a final concentration of 100 times before injection to LC\u2013MS\/MS. The limits of detection (LOD) and quantification (LOQ) for target OH-PCBs were within the ranges of 0.003\u20130.010 \u03bcg\/kg and 0.009\u20130.030 \u03bcg\/kg, respectively. Average recoveries ranged between 76.7% and 116.5%, with relative standard deviations of less than 18.4%. The proposed method is simple, time-saving, sensitive, and accurate, making it a powerful tool for risk monitoring of OH-PCBs in animal-derived food.<\/jats:p>","DOI":"10.3390\/molecules27217247","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T02:47:26Z","timestamp":1666752446000},"page":"7247","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Development of an Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry Method for Hydroxylated Polychlorinated Biphenyls in Animal-Derived Food"],"prefix":"10.3390","volume":"27","author":[{"given":"Wenyu","family":"Zhao","sequence":"first","affiliation":[{"name":"Institute of Quality Standards and Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing 100081, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Cui","sequence":"additional","affiliation":[{"name":"Institute of Quality Standards and Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing 100081, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Quality Standards and Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing 100081, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zihao","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Quality Standards and Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing 100081, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peilong","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Quality Standards and Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing 100081, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haijun","family":"Liang","sequence":"additional","affiliation":[{"name":"CHINA FEED Magazine Agency, Beijing 100710, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruiguo","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Quality Standards and Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing 100081, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoou","family":"Su","sequence":"additional","affiliation":[{"name":"Institute of Quality Standards and Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing 100081, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,25]]},"reference":[{"key":"ref_1","unstructured":"(2022, October 01). 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