{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T17:50:57Z","timestamp":1788630657670,"version":"build-2803163510"},"reference-count":38,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"MCIN\/AEI\/10.13039\/501100011033","award":["PID2020-113081RB-I00"],"award-info":[{"award-number":["PID2020-113081RB-I00"]}]},{"name":"MCIN\/AEI\/10.13039\/501100011033","award":["PRE2018-086441"],"award-info":[{"award-number":["PRE2018-086441"]}]},{"name":"MCIN\/AEI\/10.13039\/501100011033","award":["20977\/PI\/18"],"award-info":[{"award-number":["20977\/PI\/18"]}]},{"name":"Seneca Foundation of Science and Technology of Murcia, Spain","award":["PID2020-113081RB-I00"],"award-info":[{"award-number":["PID2020-113081RB-I00"]}]},{"name":"Seneca Foundation of Science and Technology of Murcia, Spain","award":["PRE2018-086441"],"award-info":[{"award-number":["PRE2018-086441"]}]},{"name":"Seneca Foundation of Science and Technology of Murcia, Spain","award":["20977\/PI\/18"],"award-info":[{"award-number":["20977\/PI\/18"]}]},{"name":"Spanish Ministry of Universities","award":["PID2020-113081RB-I00"],"award-info":[{"award-number":["PID2020-113081RB-I00"]}]},{"name":"Spanish Ministry of Universities","award":["PRE2018-086441"],"award-info":[{"award-number":["PRE2018-086441"]}]},{"name":"Spanish Ministry of Universities","award":["20977\/PI\/18"],"award-info":[{"award-number":["20977\/PI\/18"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>When the [Ru(p-cymene)(\u03bc-Cl)Cl]2 complex is made to react, in dichloromethane, with the following ligands: 2-aminobenzonitrile (2abn), 4-aminobenzonitrile (4abn), 2-aminopyridine (2ampy) and 4-aminopyridine (4ampy), after addition of hexane, the following compounds are obtained: [Ru(p-cymene)Cl2(2abn)] (I), [Ru(p-cymene)Cl2(4abn)] (II), [Ru(p-cymene)Cl2(2ampy] (III) and [Ru(p-cymene)Cl2(\u03bc-(4ampy)] (IV). All the compounds are characterized by elemental analysis of carbon, hydrogen and nitrogen, proton nuclear magnetic resonance, COSY 1H-1H, high-resolution mass spectrometry (ESI), thermogravimetry and single-crystal X-ray diffraction (the crystal structure of III is reported and compared with the closely related literature of II). The cytotoxicity effects of complexes were described for cervical cancer HeLa cells via 3-(4.5-dimethylthiazol-2-yl)-2.5-diphenyltetrazolium bromide (MTT) assay. The results demonstrate a low in vitro anticancer potential of the complexes.<\/jats:p>","DOI":"10.3390\/molecules27217264","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T07:17:48Z","timestamp":1666768668000},"page":"7264","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Synthesis and Characterization of New Ruthenium (II) Complexes of Stoichiometry [Ru(p-Cymene)Cl2L] and Their Cytotoxicity against HeLa-Type Cancer Cells"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5201-117X","authenticated-orcid":false,"given":"Marta G.","family":"Fuster","sequence":"first","affiliation":[{"name":"Departamento de Ingenier\u00eda Qu\u00edmica, Facultad de Qu\u00edmica, Campus Regional de Excelencia \u201cCampus Mare Nostrum\u201d, Universidad de Murcia, 30071 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3395-4786","authenticated-orcid":false,"given":"Imane","family":"Moulefera","sequence":"additional","affiliation":[{"name":"Departamento de Ingenier\u00eda Qu\u00edmica, Facultad de Qu\u00edmica, Campus Regional de Excelencia \u201cCampus Mare Nostrum\u201d, Universidad de Murcia, 30071 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1085-3042","authenticated-orcid":false,"given":"Mercedes G.","family":"Montalb\u00e1n","sequence":"additional","affiliation":[{"name":"Departamento de Ingenier\u00eda Qu\u00edmica, Facultad de Qu\u00edmica, Campus Regional de Excelencia \u201cCampus Mare Nostrum\u201d, Universidad de Murcia, 30071 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Departamento de Ingenier\u00eda Qu\u00edmica y Medioambiental, ETSII, Universidad Polit\u00e9cnica de Cartagena, 30203 Cartagena, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7325-9131","authenticated-orcid":false,"given":"Gloria","family":"V\u00edllora","sequence":"additional","affiliation":[{"name":"Departamento de Ingenier\u00eda Qu\u00edmica, Facultad de Qu\u00edmica, Campus Regional de Excelencia \u201cCampus Mare Nostrum\u201d, Universidad de Murcia, 30071 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Inorg\u00e1nica, Facultad de Qu\u00edmica, Campus Regional de Excelencia \u201cCampus Mare Nostrum\u201d, Universidad de Murcia, 30071 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/222385a0","article-title":"Platinum Compounds: A New Class of Potent Antitumour Agents","volume":"222","author":"Rosenberg","year":"1969","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1595\/003214073X171213","article-title":"Anti-Tumour Platinum Compounds. 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