{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T15:15:34Z","timestamp":1770909334290,"version":"3.50.1"},"reference-count":164,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T00:00:00Z","timestamp":1667174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573663"],"award-info":[{"award-number":["81573663"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2020JDTD0022"],"award-info":[{"award-number":["2020JDTD0022"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["QJJJ2022002"],"award-info":[{"award-number":["QJJJ2022002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Experimental Formulary Sichuan Youth Science and technology Innovation research team","award":["81573663"],"award-info":[{"award-number":["81573663"]}]},{"name":"Experimental Formulary Sichuan Youth Science and technology Innovation research team","award":["2020JDTD0022"],"award-info":[{"award-number":["2020JDTD0022"]}]},{"name":"Experimental Formulary Sichuan Youth Science and technology Innovation research team","award":["QJJJ2022002"],"award-info":[{"award-number":["QJJJ2022002"]}]},{"name":"Xing Lin Scholars Program of Chengdu University of TCM","award":["81573663"],"award-info":[{"award-number":["81573663"]}]},{"name":"Xing Lin Scholars Program of Chengdu University of TCM","award":["2020JDTD0022"],"award-info":[{"award-number":["2020JDTD0022"]}]},{"name":"Xing Lin Scholars Program of Chengdu University of TCM","award":["QJJJ2022002"],"award-info":[{"award-number":["QJJJ2022002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Breast cancer (BC) is a serious global challenge, and depression is one of the risk factors and comorbidities of BC. Recently, the research on the comorbidity of BC and depression has focused on the dysfunction of the hypothalamic\u2013pituitary\u2013adrenal axis and the persistent stimulation of the inflammatory response. However, the further mechanisms for comorbidity remain unclear. Epoxide metabolism has been shown to have a regulatory function in the comorbid mechanism with scattered reports. Hence, this article reviews the role of epoxide metabolism in depression and BC. The comprehensive review discloses the imbalance in epoxide metabolism and its downstream effect shared by BC and depression, including overexpression of inflammation, upregulation of toxic diols, and disturbed lipid metabolism. These downstream effects are mainly involved in the construction of the breast malignancy microenvironment through liver regulation. This finding provides new clues on the mechanism of BC and depression comorbidity, suggesting in particular a potential relationship between the liver and BC, and provides potential evidence of comorbidity for subsequent studies on the pathological mechanism.<\/jats:p>","DOI":"10.3390\/molecules27217269","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T06:42:17Z","timestamp":1667371337000},"page":"7269","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Crosstalk between Depression and Breast Cancer via Hepatic Epoxide Metabolism: A Central Comorbidity Mechanism"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0687-8901","authenticated-orcid":false,"given":"Zhen","family":"Ye","sequence":"first","affiliation":[{"name":"School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3198-6066","authenticated-orcid":false,"given":"Kumar","family":"Ganesan","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingquan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Sichuan Orthopedic Hospital, Chengdu 610093, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingqi","family":"She","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianqian","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Social Science, The Hang Seng University, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiaobo","family":"Ye","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6494-5271","authenticated-orcid":false,"given":"Jianping","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China"},{"name":"School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong"},{"name":"Department of Breast Surgery, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou 510405, China"},{"name":"Shenzhen Institute of Research and Innovation, The University of Hong Kong, Shenzhen 518057, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.1002\/cncr.33587","article-title":"The ever-increasing importance of cancer as a leading cause of premature death worldwide","volume":"127","author":"Bray","year":"2021","journal-title":"Cancer"},{"key":"ref_2","unstructured":"American Cancer Society (2021). 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