{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T08:48:04Z","timestamp":1762073284815,"version":"build-2065373602"},"reference-count":22,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T00:00:00Z","timestamp":1666915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Schinus molle is a plant traditionally used in Mexico to treat gastric disorders. However, no scientific evidence has been reported on its gastroprotective effect. The aim of the current contribution was to conduct a bioassay-guided study on S. molle to evaluate its gastroprotective activity in a model of Wistar rats given ethanol orally to induce gastric lesions. The hexane and dichloromethane extracts from the tested plant showed over 99% gastroprotection at a dose of 100 mg\/kg. From the hexane extract, two of the three fractions (F1 and F2) afforded over 99% gastroprotection. The F1 fraction was subjected to column chromatography, which revealed a white solid. Based on the ESI-MS analysis, the two main compounds in this solid were identified. The predominant compound was probably a triterpene. This mixture of compounds furnished about 67% gastroprotection at a dose of 100 mg\/kg. Pretreatment with L-NAME, indomethacin, and NEM was carried out to explore the possible involvement of nitric oxide, prostaglandins, and\/or sulfhydryl groups, respectively, in the gastroprotective activity of the white solid. We found evidence for the participation of all three factors. No antisecretory activity was detected (tested by pylorus ligation). In conclusion, evidence is herein provided for the first time of the gastroprotective effect of S. molle.<\/jats:p>","DOI":"10.3390\/molecules27217321","type":"journal-article","created":{"date-parts":[[2022,10,30]],"date-time":"2022-10-30T09:01:42Z","timestamp":1667120502000},"page":"7321","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["First Evidence of Gastroprotection by Schinus molle: Roles of Nitric Oxide, Prostaglandins, and Sulfhydryls Groups in Its Mechanism of Action"],"prefix":"10.3390","volume":"27","author":[{"given":"Mar\u00eda Elena","family":"S\u00e1nchez-Mendoza","sequence":"first","affiliation":[{"name":"Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Plan de San Luis y D\u00edaz Mir\u00f3n, Colonia Casco de Santo Tom\u00e1s, Miguel Hidalgo, Mexico City 11340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaraset","family":"L\u00f3pez-Lorenzo","sequence":"additional","affiliation":[{"name":"Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Plan de San Luis y D\u00edaz Mir\u00f3n, Colonia Casco de Santo Tom\u00e1s, Miguel Hidalgo, Mexico City 11340, Mexico"},{"name":"Ingenier\u00eda en Tecnolog\u00eda Ambiental, Universidad Polit\u00e9cnica de Chiapas, Campus Suchiapa, Carretera Tuxtla Guti\u00e9rrez\u2014Portillo Zaragoza km 21+500, Colonia Las Brisas, Suchiapa 29150, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leticia","family":"Cruz-Antonio","sequence":"additional","affiliation":[{"name":"Facultad de Estudios Superiores Zaragoza, UNAM, Av. Guelatao No. 66, Colonia Ej\u00e9rcito de Oriente, Iztapalapa, Mexico City 09230, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Arrieta-Baez","sequence":"additional","affiliation":[{"name":"Centro de Nanociencias y Micro y Nanotecnolog\u00edas, Instituto Polit\u00e9cnico Nacional, Unidad Profesional Adolfo L\u00f3pez Mateos, Av. Luis Enrique Erro s\/n, Mexico City 07738, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miranda Carolina","family":"P\u00e9rez-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Plan de San Luis y D\u00edaz Mir\u00f3n, Colonia Casco de Santo Tom\u00e1s, Miguel Hidalgo, Mexico City 11340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2928-744X","authenticated-orcid":false,"given":"Jes\u00fas","family":"Arrieta","sequence":"additional","affiliation":[{"name":"Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Plan de San Luis y D\u00edaz Mir\u00f3n, Colonia Casco de Santo Tom\u00e1s, Miguel Hidalgo, Mexico City 11340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1080\/13880209.2022.2087690","article-title":"Gastroprotective activity of (E)-ethyl-12-cyclohexyl-4,5-dihydroxydodec-2-enoate, a compound isolated from Heliotropium indicum: Role of nitric oxide, prostaglandins, and sulfhydryls in its mechanism of action","volume":"60","author":"Arrieta","year":"2022","journal-title":"Pharm. 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