{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T05:12:21Z","timestamp":1768626741732,"version":"3.49.0"},"reference-count":32,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T00:00:00Z","timestamp":1667433600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["32161143019"],"award-info":[{"award-number":["32161143019"]}]},{"name":"National Natural Science Foundation of China","award":["21JR7RA075"],"award-info":[{"award-number":["21JR7RA075"]}]},{"name":"National Natural Science Foundation of China","award":["E20458YZ"],"award-info":[{"award-number":["E20458YZ"]}]},{"name":"National Natural Science Foundation of China","award":["E2054ASL"],"award-info":[{"award-number":["E2054ASL"]}]},{"name":"Natural Science Foundation of Gansu Province","award":["32161143019"],"award-info":[{"award-number":["32161143019"]}]},{"name":"Natural Science Foundation of Gansu Province","award":["21JR7RA075"],"award-info":[{"award-number":["21JR7RA075"]}]},{"name":"Natural Science Foundation of Gansu Province","award":["E20458YZ"],"award-info":[{"award-number":["E20458YZ"]}]},{"name":"Natural Science Foundation of Gansu Province","award":["E2054ASL"],"award-info":[{"award-number":["E2054ASL"]}]},{"name":"the foundation of Chinese Academy of Sciences via Special Research Assistant Program","award":["32161143019"],"award-info":[{"award-number":["32161143019"]}]},{"name":"the foundation of Chinese Academy of Sciences via Special Research Assistant Program","award":["21JR7RA075"],"award-info":[{"award-number":["21JR7RA075"]}]},{"name":"the foundation of Chinese Academy of Sciences via Special Research Assistant Program","award":["E20458YZ"],"award-info":[{"award-number":["E20458YZ"]}]},{"name":"the foundation of Chinese Academy of Sciences via Special Research Assistant Program","award":["E2054ASL"],"award-info":[{"award-number":["E2054ASL"]}]},{"name":"CAS \u201cLight of West China\u201d Program","award":["32161143019"],"award-info":[{"award-number":["32161143019"]}]},{"name":"CAS \u201cLight of West China\u201d Program","award":["21JR7RA075"],"award-info":[{"award-number":["21JR7RA075"]}]},{"name":"CAS \u201cLight of West China\u201d Program","award":["E20458YZ"],"award-info":[{"award-number":["E20458YZ"]}]},{"name":"CAS \u201cLight of West China\u201d Program","award":["E2054ASL"],"award-info":[{"award-number":["E2054ASL"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Natural products (NPs) were a rich source of diverse bioactive molecules. Most anti-tumor agents were built on natural scaffolds. Nardostachys jatamansi DC. was an important plant used to process the traditional Chinese herbal medicines \u201cgansong\u201d. Pancreatic cancer was the fourth most common cause of cancer-related death in the world. Hence, there was an urgent need to develop novel agents for the treatment of pancreatic cancer. In this paper, nardoguaianone L (G-6) is isolated from N. jatamansi, which inhibited SW1990 cells colony formation and cell migration, and induced cell apoptosis. Furthermore, we analyzed the differential expression proteins after treatment with G-6 in SW1990 cells by using iTRAQ\/TMT-based quantitative proteomics technology, and the results showed that G-6 regulated 143 proteins\u2019 differential expression by GO annotation, including biological process, cellular component, and molecular function. Meanwhile, KEGG enrichment found that with Human T-cell leukemia virus, one infection was the most highly enhanced pathway. Furthermore, the MET\/PTEN\/TGF-\u03b2 pathway was identified as a significant pathway that had important biological functions, including cell migration and motility by PPI network analysis in SW1990 cells. Taken together, our study found that G-6 is a potential anti-pancreatic cancer agent with regulation of MET\/PTEN\/TGF-\u03b2 pathway.<\/jats:p>","DOI":"10.3390\/molecules27217490","type":"journal-article","created":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T03:53:07Z","timestamp":1667447587000},"page":"7490","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Potential Anti-Tumor Activity of Nardoguaianone L Isolated from Nardostachys jatamansi DC. in SW1990 Cells"],"prefix":"10.3390","volume":"27","author":[{"given":"Chun-Yan","family":"Sang","sequence":"first","affiliation":[{"name":"CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Dan","family":"Zheng","sequence":"additional","affiliation":[{"name":"College of Life Science, Northwest Normal University, Lanzhou 730070, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Mei","family":"Ma","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, China"},{"name":"Beijing Research Institute, University of Chinese Academy of Sciences, Beijing 100049, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, China"},{"name":"Beijing Research Institute, University of Chinese Academy of Sciences, Beijing 100049, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-Bo","family":"Wang","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian","family":"Chai","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Komila A.","family":"Eshbakova","sequence":"additional","affiliation":[{"name":"S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences, Tashkent 100170, Uzbekistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7199-0214","authenticated-orcid":false,"given":"Jun-Li","family":"Yang","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"752863","DOI":"10.3389\/fpls.2021.752863","article-title":"Superiority verification of deep learning in the identification of medicinal plants: Taking Paris polyphylla var. yunnanensis as an example","volume":"12","author":"Yue","year":"2021","journal-title":"Front. 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