{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T07:25:11Z","timestamp":1788247511091,"version":"build-2803163510"},"reference-count":64,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T00:00:00Z","timestamp":1667952000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and Higher Education in Poland","award":["WZ\/WB-INL\/3\/2021"],"award-info":[{"award-number":["WZ\/WB-INL\/3\/2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The chemical composition of propolis of four species of stingless bees (SLBs) from Argentina was determined, and its antibacterial and anticancer activity was evaluated on selected types of microbes and cancer cell lines. Volatile secretions of all propolis samples are formed by 174 C2\u2013C15 organic compounds, mainly mono- and sesquiterpenes and their derivatives. The chromatograms of ether extracts showed 287 peaks, of which 210 were identified. The most representative groups in the extracts of various propolis samples were diterpenoids (mainly resin acids), triterpenoids and phenolic compounds: long-chain alkenyl phenols, resorcinols and salicylates. The composition of both volatile and extractive compounds turned out to be species-specific; however, in both cases, the pairwise similarity of the propolis of Scaptotrigona postica and Tetragonisca fiebrigi versus that of Tetragona clavipes and Melipona quadrifasciata quadrifasciata was observed, which indicated the similarity of the preferences of the respective species when choosing plant sources of resin. The composition of the studied extracts completely lacked flavonoids and phenolcarboxylic acids, which are usually associated with the biological activity and medicinal properties of propolis. However, tests on selected microbial species and cancer cell lines showed such activity. All propolis samples tested against Paenibacillus larvae, two species of Bacillus and E. coli showed biofilm inhibition unrelated to the inhibition of bacterial growth, leading to a decrease in their pathogenicity. Testing the anticancer activity of ether extracts using five types of cell cultures showed that all four types of propolis studied inhibit the growth of cancer cells in a dose- and time-dependent manner. Propolis harvested by T. clavipes demonstrated the highest cytotoxicity on all tested cell lines.<\/jats:p>","DOI":"10.3390\/molecules27227686","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T02:44:32Z","timestamp":1667961872000},"page":"7686","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Chemical Composition and Biological Activity of Argentinian Propolis of Four Species of Stingless Bees"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8185-3301","authenticated-orcid":false,"given":"Valery A.","family":"Isidorov","sequence":"first","affiliation":[{"name":"Institute of Forest Sciences, Bialystok Technical University, 15-351 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolanta","family":"Maslowiecka","sequence":"additional","affiliation":[{"name":"Institute of Forest Sciences, Bialystok Technical University, 15-351 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukasz","family":"Szoka","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Medical University of Bialystok, 15-222 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naldo","family":"Pellizzer","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Forestales, Universidad Nacional de Misiones, Bertoni 124, Eldorado 3380, Misiones, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dora","family":"Miranda","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Forestales, Universidad Nacional de Misiones, Bertoni 124, Eldorado 3380, Misiones, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Olchowik-Grabarek","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Biological Faculty, University of Bialystok, 15-328 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Zambrzycka","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Biological Faculty, University of Bialystok, 15-328 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2750-9451","authenticated-orcid":false,"given":"Izabela","family":"Swiecicka","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Biological Faculty, University of Bialystok, 15-328 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1051\/apido\/2010016","article-title":"Propolis and bee health: The natural history and significance of resin use by honey bees","volume":"41","author":"Spivak","year":"2010","journal-title":"Apidologie"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Simone-Finstrom, M., Borba, R.S., Wilson, M., and Spivak, M. 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