{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:29:28Z","timestamp":1790958568810,"version":"4.1.0"},"reference-count":40,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T00:00:00Z","timestamp":1668211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Natural Science Foundation of Jilin province","award":["YDZJ202201ZYTS552"],"award-info":[{"award-number":["YDZJ202201ZYTS552"]}]},{"name":"Natural Science Foundation of Jilin province","award":["202113706009"],"award-info":[{"award-number":["202113706009"]}]},{"name":"National Students\u2019 Program for Innovation and Entrepreneurship Training","award":["YDZJ202201ZYTS552"],"award-info":[{"award-number":["YDZJ202201ZYTS552"]}]},{"name":"National Students\u2019 Program for Innovation and Entrepreneurship Training","award":["202113706009"],"award-info":[{"award-number":["202113706009"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Known as electrophiles, maleimides are often used as acceptors in Michael additions to produce succinimides. However, reactions with maleimides as nucleophiles for enantioselective functionalization are only rarely performed. In this paper, a series of bifunctional Takemoto\u2019s catalysts were used to organocatalyze the enantioselective Michael reaction of aminomaleimides with nitroolefins. The resulting products were obtained in good yields (76\u201386%) with up to 94% enantiomer excess (ee). The catalyst type and the substrate scope were broadened using this methodology.<\/jats:p>","DOI":"10.3390\/molecules27227787","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T04:24:10Z","timestamp":1668399850000},"page":"7787","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Organocatalytic Enantioselective Michael Reaction of Aminomaleimides with Nitroolefins Catalyzed by Takemoto\u2019s Catalyst"],"prefix":"10.3390","volume":"27","author":[{"given":"Hongwen","family":"Mu","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Jilin Medical University, Jilin 132013, China"},{"name":"College of Science, Yanbian University, Yanji 133000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Jin","sequence":"additional","affiliation":[{"name":"College of Science, Yanbian University, Yanji 133000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongrong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Jilin Medical University, Jilin 132013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Jilin Medical University, Jilin 132013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1518-1601","authenticated-orcid":false,"given":"Ying","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Jilin Medical University, Jilin 132013, China"},{"name":"College of Science, Yanbian University, Yanji 133000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1016\/j.bmcl.2014.02.074","article-title":"Synthesis, biological evaluation, and docking analysis of a novel family of 1-methyl-1H-pyrrole-2,5-diones as highly potent and selective cyclooxygenase-2 (COX-2) inhibitors","volume":"24","author":"Kim","year":"2014","journal-title":"Bioorg. 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