{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T09:17:43Z","timestamp":1762075063018,"version":"build-2065373602"},"reference-count":28,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2022,11,13]],"date-time":"2022-11-13T00:00:00Z","timestamp":1668297600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>An amine-terminated polyamidoamine (PAMAM) dendron and two long alkyl groups were designed as a novel drug carrier that possesses an interior for the encapsulation of drugs and a biocompatible surface. We synthesized three dendron-bearing lipids, DL-G1, DL-G2, and DL-G3, which included first, second, and third generation polyamidoamine dendrons, respectively. The synthesized dendrimer encapsulating anticancer drug, 5-fluorouracil (5-FU), was prepared by extraction with chloroform from mixtures of the dendrimers and varying amounts of the drug. In vitro cytotoxicity of PAMAM conjugated di-n-dodecylamine micelles (G1, G2, G3) were analyzed on human gastric adenocarcinoma cells (AGS) by water-soluble tetrazolium-1 (WST-1) cell proliferation assay. Upon exposure to 5-FU loaded micelles, the viability of the cells decreased gradually in all generations. Cytotoxicity increased with increasing generation and reached its highest rate of 69.8 \u00b1 3.2% upon 15 \u00b5M 5FU-loaded 25 \u00b5M PAMAM DL-3 micelle treatment. These results demonstrate that 5FU-loaded PAMAM conjugated di-n-dodecylamine treatment inhibits the proliferation of AGS cells in a generation-dependent manner.<\/jats:p>","DOI":"10.3390\/molecules27227817","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T04:24:10Z","timestamp":1668399850000},"page":"7817","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Polyamidoamine Dendron-Bearing Lipids as Drug-Delivery Excipients"],"prefix":"10.3390","volume":"27","author":[{"given":"Ender","family":"Sarigul","sequence":"first","affiliation":[{"name":"BSI Group, Kozyatagi, Istanbul 34742, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merve","family":"Zaim","sequence":"additional","affiliation":[{"name":"SANKARA Brain and Biotechnology Research Center, Avcilar, Istanbul 34320, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7366-4746","authenticated-orcid":false,"given":"Mehmet","family":"Senel","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy, Biruni University, Istanbul 34010, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3717-8828","authenticated-orcid":false,"given":"Tugba","family":"Sagir","sequence":"additional","affiliation":[{"name":"Pim Grup Cosmetics Consultancy, Gokturk, Istanbul 34077, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sevim","family":"Isik","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Faculty of Science and Engineering, Uskudar University, Uskudar, Istanbul 34662, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,13]]},"reference":[{"key":"ref_1","first-page":"162","article-title":"An Investigation on Enchacement of Solubility of 5 Flourouracil by Applying Complexation Technique-Characterization, Dissolution and Molecular-Modeling Studies","volume":"3","author":"Kavitha","year":"2013","journal-title":"J. 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