{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T23:15:54Z","timestamp":1790982954955,"version":"4.1.0"},"reference-count":100,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T00:00:00Z","timestamp":1668384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173440"],"award-info":[{"award-number":["82173440"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The skin is the largest organ of the body and plays multiple essential roles, ranging from regulating temperature, preventing infections, to ultimately affecting human health. A hair follicle is a complex cutaneous appendage. Skin diseases and hair loss have a significant effect on the quality of life and psychosocial adjustment of individuals. However, the available traditional drugs for treating skin and hair diseases may have some insufficiencies; therefore, a growing number of researchers are interested in natural materials that could achieve satisfactory results and minimize adverse effects. Natural polyphenols, named for the multiple phenolic hydroxyl groups in their structures, are promising candidates and continue to be of scientific interest due to their multifunctional biological properties and safety. Polyphenols have a wide range of pharmacological effects. In addition to the most common effect, antioxidation, polyphenols have anti-inflammatory, bacteriostatic, antitumor, and other biological effects associated with reduced risk of a number of chronic diseases. Various polyphenols have also shown efficacy against different types of skin and hair diseases, both in vitro and in vivo, via different mechanisms. Thus, this paper reviews the research progress in natural polyphenols for the protection of skin and hair health, especially focusing on their potential therapeutic mechanisms against skin and hair disorders. A deep understanding of natural polyphenols provides a new perspective for the safe treatment of skin diseases and hair loss.<\/jats:p>","DOI":"10.3390\/molecules27227832","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T04:24:10Z","timestamp":1668399850000},"page":"7832","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Effects of Natural Polyphenols on Skin and Hair Health: A Review"],"prefix":"10.3390","volume":"27","author":[{"given":"Mang","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Dermatology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xining","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuqing","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Daping Hospital, The Army Medical University, Chongqing 400042, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqi","family":"Liu","sequence":"additional","affiliation":[{"name":"Bioengineering College, Chongqing University, Chongqing 400030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2225-7651","authenticated-orcid":false,"given":"Hengguang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1002\/pon.4039","article-title":"Cancer-related hair loss: A selective review of the alopecia research literature","volume":"26","author":"Dua","year":"2017","journal-title":"Psycho-Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.3390\/nu2111106","article-title":"Polyphenols and human health: Prevention of disease and mechanisms of action","volume":"2","author":"Vauzour","year":"2010","journal-title":"Nutrients"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Brimson, J.M., Prasanth, M.I., Malar, D.S., Sharika, R., Sivamaruthi, B.S., Kesika, P., Chaiyasut, C., Tencomnao, T., and Prasansuklab, A. 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