{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T09:36:46Z","timestamp":1762076206692,"version":"build-2065373602"},"reference-count":40,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T00:00:00Z","timestamp":1668556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["PN-756"],"award-info":[{"award-number":["PN-756"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Flavonoids are naturally occurring compounds widely distributed in the Citrus genus. These natural compounds have many health benefits, mainly for metabolic and cardiovascular diseases. In fact, some these compounds are components of drug products with approved indications for peripheral vascular insufficiency and hemorrhoids. However, information on pharmacological effects of these compounds remains disperse and there is scarce comprehensive analysis of whole data and evidence. These kinds of evidence analyses could be necessary in drug design and the development of novel and innovate drug products in diabetes and hypertension. We aimed to systematically search for evidence on the efficacy of citroflavonoids in diabetes and hypertension in in vivo models. We searched four literature databases based on a PICO strategy. After database curation, twenty-nine articles were retrieved to analyze experimental data. There was high heterogeneity in both outcomes and methodology. Naringenin and hesperetin derivates were the most studied citroflavonoids in both experimental models. More investigation is still needed to determine its potential for drug design and development.<\/jats:p>","DOI":"10.3390\/molecules27227933","type":"journal-article","created":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T06:19:01Z","timestamp":1668665941000},"page":"7933","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Citroflavonoids as Promising Agents for Drug Discovery in Diabetes and Hypertension: A Systematic Review of Experimental Studies"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8822-7389","authenticated-orcid":false,"given":"Rolffy","family":"Ortiz-Andrade","sequence":"first","affiliation":[{"name":"Laboratorio de Farmacolog\u00eda, Facultad de Qu\u00edmica, Universidad Aut\u00f3noma de Yucat\u00e1n, Merida 97069, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6697-5017","authenticated-orcid":false,"given":"Jes\u00fas Alfredo","family":"Araujo Le\u00f3n","sequence":"additional","affiliation":[{"name":"Unidad de Bioqu\u00edmica y Biolog\u00eda Molecular de Plantas, Centro de Investigaci\u00f3n Cient\u00edfica de Yucat\u00e1n, A.C., Calle 43 No. 130 x 32 y 34, Col. Chuburn\u00e1 de Hidalgo, M\u00e9rida 97205, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2796-2440","authenticated-orcid":false,"given":"Juan Carlos","family":"S\u00e1nchez-Salgado","sequence":"additional","affiliation":[{"name":"Hypermedic MX, Ciudad de Mexico 04930, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1429-8085","authenticated-orcid":false,"given":"Amanda","family":"S\u00e1nchez-Recillas","sequence":"additional","affiliation":[{"name":"Laboratorio de Farmacolog\u00eda, Facultad de Qu\u00edmica, Universidad Aut\u00f3noma de Yucat\u00e1n, Merida 97069, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3495-7244","authenticated-orcid":false,"given":"Priscila","family":"Vazquez-Garcia","sequence":"additional","affiliation":[{"name":"Laboratorio de Farmacolog\u00eda, Facultad de Qu\u00edmica, Universidad Aut\u00f3noma de Yucat\u00e1n, Merida 97069, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7467-7538","authenticated-orcid":false,"given":"Emanuel","family":"Hern\u00e1ndez-N\u00fa\u00f1ez","sequence":"additional","affiliation":[{"name":"Departamento de Recursos del Mar, Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional-Unidad M\u00e9rida, Merida 97205, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5092","DOI":"10.2174\/092986732627191001091228","article-title":"Flavonoids as Promising Therapeutics of the Future: A Hub for Cells Survival or Death","volume":"26","author":"Barreca","year":"2019","journal-title":"Curr. 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