{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T23:24:56Z","timestamp":1763767496088,"version":"build-2065373602"},"reference-count":53,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T00:00:00Z","timestamp":1668556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The straightforward, continuous-flow synthesis of cyclopropyl carbaldehydes and ketones has been developed starting from 2-hydroxycyclobutanones and aryl thiols. This acid-catalyzed mediated procedure allows access to the multigram and easily scalable synthesis of cyclopropyl adducts under mild conditions, using reusable Amberlyst-35 as a catalyst. The resins, suitably ground and used for filling steel columns, have been characterized via TGA, ATR, SEM and BET analyses to describe the physical\u2013chemical properties of the packed bed and the continuous-flow system in detail. To highlight the synthetic versatility of the arylthiocyclopropyl carbonyl compounds, a series of selective oxidation reactions have been performed to access sulfoxide and sulfone carbaldehyde cyclopropanes, oxiranes and carboxylic acid derivatives.<\/jats:p>","DOI":"10.3390\/molecules27227943","type":"journal-article","created":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T06:19:01Z","timestamp":1668665941000},"page":"7943","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Continuous-Flow Synthesis of Arylthio-Cyclopropyl Carbonyl Compounds"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2470-9351","authenticated-orcid":false,"given":"Davide","family":"Moi","sequence":"first","affiliation":[{"name":"Department of Chemical and Geological Science, University of Cagliari, S.P. No. 8 Km 0.700, 09042 Monserrato, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Chiara","family":"Cabua","sequence":"additional","affiliation":[{"name":"Department of Chemical and Geological Science, University of Cagliari, S.P. No. 8 Km 0.700, 09042 Monserrato, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktoria","family":"Velichko","sequence":"additional","affiliation":[{"name":"Department of Chemical and Geological Science, University of Cagliari, S.P. No. 8 Km 0.700, 09042 Monserrato, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1320-3814","authenticated-orcid":false,"given":"Andrea","family":"Cocco","sequence":"additional","affiliation":[{"name":"Department of Chemical and Geological Science, University of Cagliari, S.P. No. 8 Km 0.700, 09042 Monserrato, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annalisa","family":"Chiappone","sequence":"additional","affiliation":[{"name":"Department of Chemical and Geological Science, University of Cagliari, S.P. No. 8 Km 0.700, 09042 Monserrato, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8249-9735","authenticated-orcid":false,"given":"Rita","family":"Mocci","sequence":"additional","affiliation":[{"name":"Department of Chemical and Geological Science, University of Cagliari, S.P. No. 8 Km 0.700, 09042 Monserrato, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2258-0697","authenticated-orcid":false,"given":"Stefania","family":"Porcu","sequence":"additional","affiliation":[{"name":"Department of Physics, University of Cagliari, S.P. No. 8 Km 0.700, 09042 Monserrato, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Piras","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences and Public Health, University of Cagliari, 09042 Monserrato, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Bianco","sequence":"additional","affiliation":[{"name":"Department of Applied Science and Technology, Politecnico di Torino, C.so Duca degli Abruzzi 24, 10129 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6792-6292","authenticated-orcid":false,"given":"Fabio","family":"Pesciaioli","sequence":"additional","affiliation":[{"name":"Department of Physical and Chemical Sciences, University of L\u2019Aquila, Via Vetoio, 67100 L\u2019Aquila, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0443-2890","authenticated-orcid":false,"given":"Francesco","family":"Secci","sequence":"additional","affiliation":[{"name":"Department of Chemical and Geological Science, University of Cagliari, S.P. 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