{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T07:07:04Z","timestamp":1783148824095,"version":"3.54.6"},"reference-count":91,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T00:00:00Z","timestamp":1669075200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Tunisian Ministry of Higher Education and Scientific Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Two silver(I) complexes, bis{diethyl[(5-phenyl-1,3,4-oxadiazol-2-yl-\u03baN3:\u03baN4-amino) (4-trifluoromethylphenyl)methyl]phosphonate-(tetrafluoroborato-\u03baF)}-di-silver(I) and tetrakis-{diethyl[(5-phenyl-1,3,4-oxadiazol-2-yl-\u03baN3-amino)(4-trifluoromethylphenyl)methyl]phosphonate} silver(I) tetrafluoroborate, were prepared starting from the diethyl[(5-phenyl-1,3,4-oxadiazol-2-yl-amino)(4-trifluoromethylphenyl)methyl]phosphonate (1) ligand and AgBF4 salt in Ag\/ligand ratios of 1\/1 and 1\/4, respectively. The structure, stoichiometry, and geometry of the silver complexes were fully characterized by elemental analyses, infrared, single-crystal X-ray diffraction studies, multinuclear NMR, and mass spectroscopies. The binuclear complex ([Ag2(1)2(BF4)2]; 2) crystallizes in the monoclinic asymmetric space group P21\/c and contains two silver atoms adopting a {AgN2F} planar trigonal geometry, which are simultaneously bridged by two oxadiazole rings of two ligands, while the mononuclear complex ([Ag(1)4]BF4; 3) crystallizes in the non-usual cubic space group Fd-3c in which the silver atom binds to four distinct electronically enriched nitrogen atoms of the oxadiazole ring, in a slightly distorted {AgN4} tetrahedral geometry. The \u03b1-aminophosphonate and the monomeric silver complex were evaluated in vitro against MCF-7 and PANC-1 cell lines. The silver complex is promising as a drug candidate for breast cancer and the pancreatic duct with half-maximal inhibitory concentration (IC50) values of 8.3 \u00b1 1.0 and 14.4 \u00b1 0.6 \u03bcM, respectively. Additionally, the interactions of the ligand and the mononuclear complex with Vascular Endothelial Growth Factor Receptor-2 and DNA were evaluated by molecular docking methods.<\/jats:p>","DOI":"10.3390\/molecules27238131","type":"journal-article","created":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T03:15:24Z","timestamp":1669173324000},"page":"8131","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Silver(I) Complexes Based on Oxadiazole-Functionalized \u03b1-Aminophosphonate: Synthesis, Structural Study, and Biological Activities"],"prefix":"10.3390","volume":"27","author":[{"given":"Shaima","family":"Hkiri","sequence":"first","affiliation":[{"name":"Synth\u00e8se Organom\u00e9tallique et Catalyse, UMR-CNRS 7177, University of Strasbourg, 4 rue Blaise Pascal, 67008 Strasbourg, France"},{"name":"Laboratory of Hetero-Organic Compounds and Nanostructured Materials (LR18ES11), Faculty of Sciences of Bizerte, University of Carthage, Bizerte 7021, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0047-8368","authenticated-orcid":false,"given":"K\u00fcbra A\u00e7\u0131kal\u0131n","family":"Co\u015fkun","sequence":"additional","affiliation":[{"name":"Department of Medical Biology and Genetics, Faculty of Medicine, University of \u0130stanbul Ayd\u0131n, Istanbul 34295, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvan","family":"\u00dcst\u00fcn","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Art and Science, University of Ordu, Ordu 52200, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8334-7565","authenticated-orcid":false,"given":"Ali","family":"Samarat","sequence":"additional","affiliation":[{"name":"Laboratory of Hetero-Organic Compounds and Nanostructured Materials (LR18ES11), Faculty of Sciences of Bizerte, University of Carthage, Bizerte 7021, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf","family":"Tutar","sequence":"additional","affiliation":[{"name":"Department of Basic Pharmaceutical Sciences, Faculty of Pharmacy, University of Health Sciences-Turkey, Istanbul 34668, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neslihan","family":"\u015eahin","sequence":"additional","affiliation":[{"name":"Department of Science Education, Faculty of Education, University of Cumhuriyet, Sivas 58140, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2582-4191","authenticated-orcid":false,"given":"David","family":"S\u00e9meril","sequence":"additional","affiliation":[{"name":"Synth\u00e8se Organom\u00e9tallique et Catalyse, UMR-CNRS 7177, University of Strasbourg, 4 rue Blaise Pascal, 67008 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3407","DOI":"10.3390\/ma3053407","article-title":"Of chains and rings: Synthetic strategies and theoretical investigations for tuning the structure of silver coordination compounds and their applications","volume":"3","author":"Slenters","year":"2010","journal-title":"Materials"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3393","DOI":"10.1039\/C5CE00238A","article-title":"Luminescent silver(I) coordination architectures containing 2-aminopyrimidyl ligands","volume":"17","author":"Wang","year":"2015","journal-title":"CrystEngComm"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1080\/00958972.2015.1070147","article-title":"Multimetallic silver(I)-pyridinyl complexes: Coordination of silver(I) and luminescence","volume":"68","author":"Njogu","year":"2015","journal-title":"J. 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