{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:45:43Z","timestamp":1791233143688,"version":"4.1.0"},"reference-count":40,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T00:00:00Z","timestamp":1669334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81703684"],"award-info":[{"award-number":["81703684"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973604"],"award-info":[{"award-number":["81973604"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2022yjscx059"],"award-info":[{"award-number":["2022yjscx059"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Heilongjiang Touyan Innovation Team Program","award":["81703684"],"award-info":[{"award-number":["81703684"]}]},{"name":"Heilongjiang Touyan Innovation Team Program","award":["81973604"],"award-info":[{"award-number":["81973604"]}]},{"name":"Heilongjiang Touyan Innovation Team Program","award":["2022yjscx059"],"award-info":[{"award-number":["2022yjscx059"]}]},{"name":"National Famous Old Traditional Chinese Medicine Experts Inheritance Studio Construction Program of the National Administration of TCM","award":["81703684"],"award-info":[{"award-number":["81703684"]}]},{"name":"National Famous Old Traditional Chinese Medicine Experts Inheritance Studio Construction Program of the National Administration of TCM","award":["81973604"],"award-info":[{"award-number":["81973604"]}]},{"name":"National Famous Old Traditional Chinese Medicine Experts Inheritance Studio Construction Program of the National Administration of TCM","award":["2022yjscx059"],"award-info":[{"award-number":["2022yjscx059"]}]},{"name":"Seventh Batch of National Old Traditional Chinese Medicine Experts Academic Experience Inheritance Program","award":["81703684"],"award-info":[{"award-number":["81703684"]}]},{"name":"Seventh Batch of National Old Traditional Chinese Medicine Experts Academic Experience Inheritance Program","award":["81973604"],"award-info":[{"award-number":["81973604"]}]},{"name":"Seventh Batch of National Old Traditional Chinese Medicine Experts Academic Experience Inheritance Program","award":["2022yjscx059"],"award-info":[{"award-number":["2022yjscx059"]}]},{"name":"Traditional Chinese Medicine Processing Technology Inheritance Base Project","award":["81703684"],"award-info":[{"award-number":["81703684"]}]},{"name":"Traditional Chinese Medicine Processing Technology Inheritance Base Project","award":["81973604"],"award-info":[{"award-number":["81973604"]}]},{"name":"Traditional Chinese Medicine Processing Technology Inheritance Base Project","award":["2022yjscx059"],"award-info":[{"award-number":["2022yjscx059"]}]},{"name":"Central Finance","award":["81703684"],"award-info":[{"award-number":["81703684"]}]},{"name":"Central Finance","award":["81973604"],"award-info":[{"award-number":["81973604"]}]},{"name":"Central Finance","award":["2022yjscx059"],"award-info":[{"award-number":["2022yjscx059"]}]},{"name":"Graduate Innovative Research Project Foundation of Heilongjiang University of Chinese Medicine","award":["81703684"],"award-info":[{"award-number":["81703684"]}]},{"name":"Graduate Innovative Research Project Foundation of Heilongjiang University of Chinese Medicine","award":["81973604"],"award-info":[{"award-number":["81973604"]}]},{"name":"Graduate Innovative Research Project Foundation of Heilongjiang University of Chinese Medicine","award":["2022yjscx059"],"award-info":[{"award-number":["2022yjscx059"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Traditional Chinese medicine considers Lonicerae japonicae flos to have antibacterial detoxification, liver protection, and gallbladder protection. At present, studies have proven that Lonicerae japonicae flos has a good therapeutic effect on liver injury. Therefore, to confirm the clinical applicability of Lonicerae japonicae flos in the treatment of liver injury, we were the first to compare the pharmacokinetics of an oral ethanol extract of Lonicerae japonicae flos in normal rats and carbon tetrachloride-induced liver injury model rats. A method was developed for the simultaneous determination of 3-caffeoylquinic acid, 4-caffeoylquinic acid, 5-caffeoylquinic acid, 3,5-dicaffeoylquinic acid, 4,5-dicaffeoylquinic acid, protocatechuic acid, Sweroside, and Secoxyloganin in rat plasma by ultra-performance liquid chromatography tandem mass spectrometry. The results show that the method is reliable and reproducible and can be used for quantitative determination of biological samples. The pharmacokinetic parameters showed that the area under the concentration\u2013time curve of eight compounds in the model group was significantly increased. The results showed that the total absorption of the active components of Lonicerae japonicae flos in the blood increased, the clearance rate slowed down, and the bioavailability of Lonicerae japonicae flos increased in liver injury diseases.<\/jats:p>","DOI":"10.3390\/molecules27238211","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T03:34:24Z","timestamp":1669347264000},"page":"8211","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Pharmacokinetic Comparison of Eight Major Compounds of Lonicerae japonicae flos after Oral Administration in Normal Rats and Rats with Liver Injury"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6818-1640","authenticated-orcid":false,"given":"Xuejiao","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4554-9753","authenticated-orcid":false,"given":"Songtao","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, China"},{"name":"School of Pharmacy, Jiangxi University of Chinese Medicine, Ministry of Education, Nanchang 330004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaojiao","family":"Dong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahao","family":"Lv","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9607-1107","authenticated-orcid":false,"given":"Liu","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2722-3330","authenticated-orcid":false,"given":"Hai","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,25]]},"reference":[{"key":"ref_1","first-page":"15","article-title":"Brief discussion on textual research ideas of ancient books and textual collection of predecessors:A case study of Lonicera japonica","volume":"52","author":"Liu","year":"2021","journal-title":"Chin. 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