{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:58:26Z","timestamp":1787029106938,"version":"build-2736575974"},"reference-count":72,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,11,26]],"date-time":"2022-11-26T00:00:00Z","timestamp":1669420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003566","name":"Ministry of Oceans and Fisheries","doi-asserted-by":"publisher","award":["20210656"],"award-info":[{"award-number":["20210656"]}],"id":[{"id":"10.13039\/501100003566","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Sargassum horneri (SH) is a seaweed that has several features that benefit health. In this study, we investigated the immune-enhancing effect of SH, focusing on the role of spleen-mediated immune functions. Chromatographic analysis of SH identified six types of monosaccharide contents, including mannose, rhamnose glucose, galactose xylose and fucose. SH increased cell proliferation of primary cultured na\u00efve splenocytes treated with or without cyclophosphamide (CPA), an immunosuppression agent. SH also reversed the CPA-induced decrease in Th1 cytokines. In vivo investigation revealed that SH administration can increase the tissue weight of major immune organs, such as the spleen and thymus. A similar effect was observed in CPA-injected immunosuppressed BALB\/c mice. SH treatment increased the weight of the spleen and thymus, blood immune cell count and Th1 cytokine expression. Additionally, the YAC-1-targeting activities of natural killer cells, which are important in innate immunity, were upregulated upon SH treatment. Overall, our study demonstrates the immune-enhancing effect of SH, suggesting its potential as a medicinal or therapeutic agent for pathologic conditions involving immunosuppression.<\/jats:p>","DOI":"10.3390\/molecules27238253","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T07:38:49Z","timestamp":1669621129000},"page":"8253","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Immune-Enhancing Effect of Sargassum horneri on Cyclophosphamide-Induced Immunosuppression in BALB\/c Mice and Primary Cultured Splenocytes"],"prefix":"10.3390","volume":"27","author":[{"given":"Hyo In","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6843-0360","authenticated-orcid":false,"given":"Dong-Sub","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Natural Product Research, Korea Prime Pharmacy Co., Ltd., Suwon 16229, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunu","family":"Jung","sequence":"additional","affiliation":[{"name":"Division of Natural Product Research, Korea Prime Pharmacy Co., Ltd., Suwon 16229, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nak-Yun","family":"Sung","sequence":"additional","affiliation":[{"name":"Division of Natural Product Research, Korea Prime Pharmacy Co., Ltd., Suwon 16229, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjee","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Natural Product Research, Korea Prime Pharmacy Co., Ltd., Suwon 16229, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8706-8363","authenticated-orcid":false,"given":"In-Jun","family":"Han","sequence":"additional","affiliation":[{"name":"Division of Natural Product Research, Korea Prime Pharmacy Co., Ltd., Suwon 16229, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Yeong","family":"Nho","sequence":"additional","affiliation":[{"name":"Division of Natural Product Research, Korea Prime Pharmacy Co., Ltd., Suwon 16229, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3131-0047","authenticated-orcid":false,"given":"Joon Ho","family":"Hong","sequence":"additional","affiliation":[{"name":"Nano Bio Research Center, Jeonnam Bioindustry Foundation, Jangsung 57248, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Kyu","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Food Regulatory Science, Korea University, Sejong 30019, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Boo","sequence":"additional","affiliation":[{"name":"Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye-Lin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangyul","family":"Baik","sequence":"additional","affiliation":[{"name":"School of Mechanical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Oh","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Anatomy, College of Medicine, Chung-Ang University, Seoul 06974, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0395-207X","authenticated-orcid":false,"given":"Sanghyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Plant Science and Technology, Chung-Ang University, Anseong 17546, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun Sung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Oral Biochemistry, College of Dentistry, Chosun University, Gwangju 61452, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5984-5855","authenticated-orcid":false,"given":"Jinbong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea"},{"name":"Department of Pharmacology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1111\/jpn.13509","article-title":"Current knowledge and future perspectives of the use of seaweeds for livestock production and meat quality: A systematic review","volume":"105","author":"Costa","year":"2021","journal-title":"J. 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