{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T01:54:32Z","timestamp":1785376472368,"version":"3.55.0"},"reference-count":31,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,11,27]],"date-time":"2022-11-27T00:00:00Z","timestamp":1669507200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Research Administration of Kuwait University","award":["SC04\/19"],"award-info":[{"award-number":["SC04\/19"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>5-(Alkylamino)-6-aryl\/alkylpyrazine-2,3-dicarbonitriles were successfully synthesized in good to moderate yields by reacting alkyl isocyanides with aryl\/alkyl carbonyl chlorides, followed by the addition of diaminomaleonitrile. The synthesized pyrazines were fully characterized in this investigation, and X-ray crystal structure analysis was performed on some derivatives. The antibacterial and antifungal activities of the newly synthesized pyrazine-2,3-dicarbonitriles were assessed in addition to their UV and fluorescence results. All the compounds showed similar UV\u2013Vis spectral features with absorption peaks (\u03bbmax) around 267, 303, and 373 nm.<\/jats:p>","DOI":"10.3390\/molecules27238278","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T07:38:49Z","timestamp":1669621129000},"page":"8278","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Construction of 5-(Alkylamino)-6-aryl\/alkylpyrazine-2,3-dicarbonitriles via the One-Pot Reaction of Alkyl Isocyanides with Aryl\/Alkyl Carbonyl Chlorides and Diaminomaleonitrile: Fluorescence and Antimicrobial Activity Evaluation"],"prefix":"10.3390","volume":"27","author":[{"given":"Amal","family":"Al-Azmi","sequence":"first","affiliation":[{"name":"Chemistry Department, Kuwait University, P.O. Box 5969, Safat 13060, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"John","sequence":"additional","affiliation":[{"name":"Chemistry Department, Kuwait University, P.O. Box 5969, Safat 13060, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1016\/S0040-4020(03)00153-4","article-title":"The chemistry of diaminomaleonitrile and its utility in heterocyclic synthesis","volume":"59","author":"Elassar","year":"2003","journal-title":"Tetrahedron"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"110","DOI":"10.2174\/1570179412666141226190750","article-title":"Recent developments in the chemistry of diaminomaleonitrile","volume":"12","year":"2015","journal-title":"Curr. Org. 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