{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T01:59:51Z","timestamp":1768615191877,"version":"3.49.0"},"reference-count":81,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T00:00:00Z","timestamp":1669766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fondecyt","award":["210751 (EGP)"],"award-info":[{"award-number":["210751 (EGP)"]}]},{"name":"Fondecyt","award":["AFB180001 (PH-I)"],"award-info":[{"award-number":["AFB180001 (PH-I)"]}]},{"name":"Basal project","award":["210751 (EGP)"],"award-info":[{"award-number":["210751 (EGP)"]}]},{"name":"Basal project","award":["AFB180001 (PH-I)"],"award-info":[{"award-number":["AFB180001 (PH-I)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>3-formyl-2-quinolones have attracted the scientific community\u2019s attention because they are used as versatile building blocks in the synthesis of more complex compounds showing different and attractive biological activities. Using copper-catalyzed Chan\u2013Lam coupling, we synthesized 32 new N-aryl-3-formyl-2-quinolone derivatives at 80 \u00b0C, in air and using inexpensive phenylboronic acids as arylating agents. 3-formyl-2-quinolones and substituted 3-formyl-2-quinolones can act as substrates, and among the products, the p-methyl derivative 9a was used as a substrate to obtain different derivatives such as alcohol, amine, nitrile, and chalcone.<\/jats:p>","DOI":"10.3390\/molecules27238345","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T07:38:50Z","timestamp":1669793930000},"page":"8345","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["N-Arylation of 3-Formylquinolin-2(1H)-ones Using Copper(II)-Catalyzed Chan\u2013Lam Coupling"],"prefix":"10.3390","volume":"27","author":[{"given":"Jhesua","family":"Valencia","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica y Biolog\u00eda, Divisi\u00f3n de Ciencias B\u00e1sicas, Universidad del Norte, Km 5 V\u00eda Puerto Colombia, Barranquilla 081007, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oriel A.","family":"S\u00e1nchez-Velasco","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Faculty of Chemistry and Pharmacy, Pontificia Universidad Cat\u00f3lica de Chile, Santiago 7820436, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2536-3065","authenticated-orcid":false,"given":"Jorge","family":"Saavedra-Olavarr\u00eda","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Faculty of Chemistry and Pharmacy, Pontificia Universidad Cat\u00f3lica de Chile, Santiago 7820436, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2272-9690","authenticated-orcid":false,"given":"Patricio","family":"Hermosilla-Ib\u00e1\u00f1ez","sequence":"additional","affiliation":[{"name":"Center for the Development of Nanoscience and Nanotechnology (CEDENNA), Materials Chemistry Department, Faculty of Chemistry and Biology, University of Santiago, Chile, Santiago 9170022, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3777-6297","authenticated-orcid":false,"given":"Edwin G.","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Faculty of Chemistry and Pharmacy, Pontificia Universidad Cat\u00f3lica de Chile, Santiago 7820436, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9662-9505","authenticated-orcid":false,"given":"Daniel","family":"Insuasty","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica y Biolog\u00eda, Divisi\u00f3n de Ciencias B\u00e1sicas, Universidad del Norte, Km 5 V\u00eda Puerto Colombia, Barranquilla 081007, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ejmech.2016.02.069","article-title":"Synthesis and Biological Evaluation of Quinoline Analogues of Flavones as Potential Anticancer Agents and Tubulin Polymerization Inhibitors","volume":"114","author":"Shobeiri","year":"2016","journal-title":"Eur. 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