{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T06:05:59Z","timestamp":1775196359151,"version":"3.50.1"},"reference-count":71,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012190","name":"Ministry of Science and Higher Education of the Russian Federation","doi-asserted-by":"publisher","award":["075-15-2020-777"],"award-info":[{"award-number":["075-15-2020-777"]}],"id":[{"id":"10.13039\/501100012190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Linked to Alzheimer\u2019s disease (AD), amyloids and tau-protein are known to contain a large number of cysteine (Cys) residues. In addition, certain levels of some common biogenic thiols (cysteine (Cys), homocysteine (Hcy), glutathione (GSH), etc.) in biological fluids are closely related to AD as well as other diseases. Therefore, probes with a selective interaction with the above-mentioned thiols can be used for the monitoring and visualizing changes of (bio)thiols in the biological fluids as well as in the brain of animal models of Alzheimer\u2019s disease. In this study, new Eu(III), Tb(III), Gd(III) and Sm(III) complexes of 2,2\u2032-bipyridine ligands containing TEMPO fragments as receptor units for (bio)thiols are reported. The presence of free radical fragments of the ligand in the complexes was proved by using the electronic paramagnetic resonance (EPR) method. Among all the complexes, the Eu(III) complex turned out to be the most promising one as luminescence- and spin-probe for the detection of biogenic thiols. The EPR and fluorescent titration methods showed the interaction of the resulting complex with free Cys and GSH in solution. To study the practical applicability of the probes for the monitoring of AD in-vivo, by using the above-mentioned Eu(III)-based probe, the staining of the brain of mice with amyloidosis and Vero cell cultures supplemented with the cysteine-enriched medium was studied as well as the fluorescence titration of Bovine Serum Albumin, BSA (as the model for the thiol moieties containing protein), was carried out. Based on the results of fluorescence titration, the formation of a non-covalent inclusion complex between the above-mentioned Eu(III) complex and BSA was suggested.<\/jats:p>","DOI":"10.3390\/molecules27238414","type":"journal-article","created":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T03:00:36Z","timestamp":1669950036000},"page":"8414","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["New TEMPO\u2013Appended 2,2\u2032-Bipyridine-Based Eu(III), Tb(III), Gd(III) and Sm(III) Complexes: Synthesis, Photophysical Studies and Testing Photoluminescence-Based Bioimaging Abilities"],"prefix":"10.3390","volume":"27","author":[{"given":"Nataliya V.","family":"Slovesnova","sequence":"first","affiliation":[{"name":"Ural Federal University, 19 Mira Street, 620002 Yekaterinburg, Russia"},{"name":"Urals State Medical University, 3 Repina Street, 620028 Yekaterinburg, Russia"},{"name":"I. Ya. Postovskiy Institute of Organic Synthesis, UB of the RAS 22, S. Kovalevskoy Street, 620219 Yekaterinburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3305-3195","authenticated-orcid":false,"given":"Artem S.","family":"Minin","sequence":"additional","affiliation":[{"name":"Ural Federal University, 19 Mira Street, 620002 Yekaterinburg, Russia"},{"name":"I. Ya. Postovskiy Institute of Organic Synthesis, UB of the RAS 22, S. Kovalevskoy Street, 620219 Yekaterinburg, Russia"},{"name":"M.N. Miheev Institute of Metal Physics, Ural Branch of the RAS, Russian Federation 18, S. Kovalevskoy Street, 620108 Yekaterinburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna V.","family":"Belousova","sequence":"additional","affiliation":[{"name":"Institute of Immunology and Physiology, Ural Branch of the RAS 106, Pervomaiskaya Street, 620049 Yekaterinburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1977-4797","authenticated-orcid":false,"given":"Aleksey A.","family":"Ustyugov","sequence":"additional","affiliation":[{"name":"Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry of the RAS 1, Severniy Proezd, 142432 Chernogolovka, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0258-1879","authenticated-orcid":false,"given":"Kirill D.","family":"Chaprov","sequence":"additional","affiliation":[{"name":"Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry of the RAS 1, Severniy Proezd, 142432 Chernogolovka, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexey P.","family":"Krinochkin","sequence":"additional","affiliation":[{"name":"Ural Federal University, 19 Mira Street, 620002 Yekaterinburg, Russia"},{"name":"I. Ya. Postovskiy Institute of Organic Synthesis, UB of the RAS 22, S. Kovalevskoy Street, 620219 Yekaterinburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria I.","family":"Valieva","sequence":"additional","affiliation":[{"name":"Ural Federal University, 19 Mira Street, 620002 Yekaterinburg, Russia"},{"name":"I. Ya. Postovskiy Institute of Organic Synthesis, UB of the RAS 22, S. Kovalevskoy Street, 620219 Yekaterinburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaroslav K.","family":"Shtaitz","sequence":"additional","affiliation":[{"name":"Ural Federal University, 19 Mira Street, 620002 Yekaterinburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ekaterina S.","family":"Starnovskaya","sequence":"additional","affiliation":[{"name":"Ural Federal University, 19 Mira Street, 620002 Yekaterinburg, Russia"},{"name":"I. Ya. Postovskiy Institute of Organic Synthesis, UB of the RAS 22, S. Kovalevskoy Street, 620219 Yekaterinburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2493-0056","authenticated-orcid":false,"given":"Igor L.","family":"Nikonov","sequence":"additional","affiliation":[{"name":"Ural Federal University, 19 Mira Street, 620002 Yekaterinburg, Russia"},{"name":"I. Ya. Postovskiy Institute of Organic Synthesis, UB of the RAS 22, S. Kovalevskoy Street, 620219 Yekaterinburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton N.","family":"Tsmokalyuk","sequence":"additional","affiliation":[{"name":"Ural Federal University, 19 Mira Street, 620002 Yekaterinburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grigory A.","family":"Kim","sequence":"additional","affiliation":[{"name":"Ural Federal University, 19 Mira Street, 620002 Yekaterinburg, Russia"},{"name":"I. Ya. Postovskiy Institute of Organic Synthesis, UB of the RAS 22, S. Kovalevskoy Street, 620219 Yekaterinburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sougata","family":"Santra","sequence":"additional","affiliation":[{"name":"Ural Federal University, 19 Mira Street, 620002 Yekaterinburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitry S.","family":"Kopchuk","sequence":"additional","affiliation":[{"name":"Ural Federal University, 19 Mira Street, 620002 Yekaterinburg, Russia"},{"name":"I. Ya. Postovskiy Institute of Organic Synthesis, UB of the RAS 22, S. Kovalevskoy Street, 620219 Yekaterinburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0177-1582","authenticated-orcid":false,"given":"Emiliya V.","family":"Nosova","sequence":"additional","affiliation":[{"name":"Ural Federal University, 19 Mira Street, 620002 Yekaterinburg, Russia"},{"name":"I. Ya. Postovskiy Institute of Organic Synthesis, UB of the RAS 22, S. Kovalevskoy Street, 620219 Yekaterinburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grigory V.","family":"Zyryanov","sequence":"additional","affiliation":[{"name":"Ural Federal University, 19 Mira Street, 620002 Yekaterinburg, Russia"},{"name":"I. Ya. Postovskiy Institute of Organic Synthesis, UB of the RAS 22, S. Kovalevskoy Street, 620219 Yekaterinburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"100731","DOI":"10.1016\/j.ssmph.2021.100731","article-title":"The origins of the 4 \u00d7 4 framework for noncommunicable disease at the World Health Organization","volume":"13","author":"Schwartz","year":"2021","journal-title":"SSM-Popul. 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