{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T19:25:29Z","timestamp":1775589929240,"version":"3.50.1"},"reference-count":45,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T00:00:00Z","timestamp":1669939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 109-2221-E-035-041-MY3"],"award-info":[{"award-number":["MOST 109-2221-E-035-041-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["TCVGH-FCU1118202"],"award-info":[{"award-number":["TCVGH-FCU1118202"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["TCVGH-1115401C"],"award-info":[{"award-number":["TCVGH-1115401C"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Taichung Veterans General Hospital, Taiwan","award":["MOST 109-2221-E-035-041-MY3"],"award-info":[{"award-number":["MOST 109-2221-E-035-041-MY3"]}]},{"name":"Taichung Veterans General Hospital, Taiwan","award":["TCVGH-FCU1118202"],"award-info":[{"award-number":["TCVGH-FCU1118202"]}]},{"name":"Taichung Veterans General Hospital, Taiwan","award":["TCVGH-1115401C"],"award-info":[{"award-number":["TCVGH-1115401C"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Vertical-aligned CuO nanowires have been directly fabricated on Cu foil through a facile thermal oxidation process by a hotplate at 550 \u00b0C for 6 h under ambient conditions. The intermediate layer of resorcinol\u2013formaldehyde (RF) and silver (Ag) nanoparticles can be sequentially deposited on Cu nanowires to form CuO@RF@Ag core-shell nanowires by a two-step wet chemical approach. The appropriate resorcinol weight and silver nitrate concentration can be favorable to grow the CuO@RF@Ag nanowires with higher surface-enhanced Raman scattering (SERS) enhancement for detecting rhodamine 6G (R6G) molecules. Compared with CuO@Ag nanowires grown by ion sputtering, CuO@RF@Ag nanowires exhibited a higher SERS enhancement factor of 5.33 \u00d7 108 and a lower detection limit (10\u221212 M) for detecting R6G molecules. This result is ascribed to the CuO@RF@Ag nanowires with higher-density hot spots and surface-active sites for enhanced high SERS enhancement, good reproducibility, and uniformity. Furthermore, the CuO@RF@Ag nanowires can also reveal a high-sensitivity SERS-active substrate for detecting amoxicillin (10\u221210 M) and 5-fluorouracil (10\u22127 M). CuO@RF@Ag nanowires exhibit a simple fabrication process, high SERS sensitivity, high reproducibility, high uniformity, and low detection limit, which are helpful for the practical application of SERS in different fields.<\/jats:p>","DOI":"10.3390\/molecules27238460","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T06:29:09Z","timestamp":1670221749000},"page":"8460","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Ag Nanoparticles Decorated CuO@RF Core-Shell Nanowires for High-Performance Surface-Enhanced Raman Spectroscopy Application"],"prefix":"10.3390","volume":"27","author":[{"given":"Tung-Hao","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Changhua Christian Hospital, Changhua 50006, Taiwan"},{"name":"Department of Radiological Technology, Yuanpei University, Hsinchu 30015, Taiwan"},{"name":"Department of Medical Imaging and Radiological Sciences, Central Taiwan University of Science and Technology, Taichung 40601, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin-Wei","family":"Di","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering, Feng Chia University, Taichung 407102, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5474-680X","authenticated-orcid":false,"given":"Yu-Cheng","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering, Feng Chia University, Taichung 407102, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4616-437X","authenticated-orcid":false,"given":"Chia-Man","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Surgery, Taichung Veterans General Hospital, Taichung 40705, Taiwan"},{"name":"College of Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan"},{"name":"Department of Post-Baccalaureate Medicine, National Chung Hsing University, Taichung 40227, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4204","DOI":"10.1016\/j.chroma.2010.03.014","article-title":"Rapid determination of melamine and cyanuric acid in milk powder using direct analysis in real time-time-of-flight mass spectrometry","volume":"1217","author":"Vaclavik","year":"2010","journal-title":"J. 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