{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T16:13:33Z","timestamp":1774887213626,"version":"3.50.1"},"reference-count":84,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T00:00:00Z","timestamp":1670198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"publisher","award":["2019\/26821-7"],"award-info":[{"award-number":["2019\/26821-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"publisher","award":["2019\/09831-9"],"award-info":[{"award-number":["2019\/09831-9"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"publisher","award":["2018\/25377-3"],"award-info":[{"award-number":["2018\/25377-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Commonly found colonizing the human microbiota, Candida albicans is a microorganism known for its ability to cause infections, mainly in the vulvovaginal region known as vulvovaginal candidiasis (VVC). This pathology is, in fact, one of the main C. albicans clinical manifestations, changing from a colonizer to a pathogen. The increase in VVC cases and limited antifungal therapy make C. albicans an increasingly frequent risk in women\u2019s lives, especially in immunocompromised patients, pregnant women and the elderly. Therefore, it is necessary to develop new therapeutic options, especially those involving natural products associated with nanotechnology, such as lycopene and mesoporous silica nanoparticles. From this perspective, this study sought to assess whether lycopene, mesoporous silica nanoparticles and their combination would be an attractive product for the treatment of this serious disease through microbiological in vitro tests and acute toxicity tests in an alternative in vivo model of Galleria mellonella. Although they did not show desirable antifungal activity for VVC therapy, the present study strongly encourages the use of mesoporous silica nanoparticles impregnated with lycopene for the treatment of other human pathologies, since the products evaluated here did not show toxicity in the in vivo test performed, being therefore, a topic to be further explored.<\/jats:p>","DOI":"10.3390\/molecules27238558","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T07:07:31Z","timestamp":1670224051000},"page":"8558","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Lycopene, Mesoporous Silica Nanoparticles and Their Association: A Possible Alternative against Vulvovaginal Candidiasis?"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4071-5364","authenticated-orcid":false,"given":"Gabriela Corr\u00eaa","family":"Carvalho","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences, S\u00e3o Paulo State University (UNESP), Araraquara 14800-903, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4573-5743","authenticated-orcid":false,"given":"Gabriel Davi","family":"Marena","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, S\u00e3o Paulo State University (UNESP), Araraquara 14800-903, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela Ricci","family":"Leonardi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Ribeir\u00e3o Preto (UNAERP), Ribeir\u00e3o Preto 14096-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3852-2184","authenticated-orcid":false,"given":"Rafael Miguel","family":"S\u00e1bio","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, S\u00e3o Paulo State University (UNESP), Araraquara 14800-903, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8953-9058","authenticated-orcid":false,"given":"Ione","family":"Corr\u00eaa","sequence":"additional","affiliation":[{"name":"Medical School, S\u00e3o Paulo State University (UNESP), Botucatu 18618-687, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6698-0545","authenticated-orcid":false,"given":"Marlus","family":"Chorilli","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, S\u00e3o Paulo State University (UNESP), Araraquara 14800-903, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tais Maria","family":"Bauab","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, S\u00e3o Paulo State University (UNESP), Araraquara 14800-903, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,5]]},"reference":[{"key":"ref_1","first-page":"1","article-title":"Vulvovaginal Candidiasis in Primary Health Care: Diagnosis and Treatment","volume":"94","author":"Cruz","year":"2020","journal-title":"Rev. Enferm. Atual Derme"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Czechowicz, P., Nowicka, J., and Go\u015bciniak, G. (2022). Virulence Factors of Candida Spp. and Host Immune Response Important in the Pathogenesis of Vulvovaginal Candidiasis. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23115895"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Balakrishnan, S.N., Yamang, H., Lorenz, M.C., Chew, S.Y., and Than, L.T.L. (2022). Role of Vaginal Mucosa, Host Immunity and Microbiota in Vulvovaginal Candidiasis. Pathogens, 11.","DOI":"10.3390\/pathogens11060618"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"913","DOI":"10.14295\/idonline.v14i53.2785","article-title":"dos A. Benef\u00edcio Dos Alimentos Usados Como Terapia Complementar Para Candid\u00edase Vulvovaginal Recorrente\/The Benefit of Food and Its Usage as Complementary Therapy for Recurrent Vulvovaginal Candidiasis","volume":"14","author":"Firmiano","year":"2020","journal-title":"ID Line Rev. Psicol."},{"key":"ref_5","first-page":"28","article-title":"Candid\u00edase Vulvovaginal: Uma Revis\u00e3o de Literatura Com Abordagem Para Candida Albicans","volume":"25","author":"Soares","year":"2018","journal-title":"Braz. J. Surg Clin Res-BJSCR"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3390\/futurepharmacol2010002","article-title":"Antioxidant and Antifungal Activity of the Cynophalla flexuosa (L.) J. Presl (Capparaceae) against Opportunistic Fungal Pathogens","volume":"2","author":"Salazar","year":"2022","journal-title":"Futur. Pharmacol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e339","DOI":"10.1016\/S1473-3099(18)30103-8","article-title":"Global Burden of Recurrent Vulvovaginal Candidiasis: A Systematic Review","volume":"18","author":"Denning","year":"2018","journal-title":"Lancet Infect. Dis."},{"key":"ref_8","unstructured":"(2022, October 05). CDC Vaginal Candidiasis, Available online: https:\/\/www.cdc.gov\/fungal\/diseases\/candidiasis\/genital\/index.html."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1007\/s11908-002-0038-7","article-title":"Pathogenesis of Recurrent Vulvovaginal Candidiasis","volume":"4","author":"Sobel","year":"2002","journal-title":"Curr. Infect. Dis. Rep."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.3855\/jidc.15536","article-title":"Prevalence of Vulvovaginal Candidiasis among Pregnant Women in Africa: A Systematic Review and Meta-Analysis","volume":"16","year":"2022","journal-title":"J. Infect. Dev. Ctries."},{"key":"ref_11","first-page":"319","article-title":"Candid\u00edase Vulvovaginal: Fatores Predisponentes Do Hospedeiro e Virul\u00eancia Das Leveduras","volume":"43","author":"Svidzinski","year":"2007","journal-title":"J. Bras. Patol. Med. Lab."},{"key":"ref_12","first-page":"17","article-title":"Bacterial Vaginosis and Candida Vulvovaginitis","volume":"24","author":"Davis","year":"2020","journal-title":"Prof. Nurs. Today"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.1128\/IAI.00449-12","article-title":"Candida Albicans and Bacterial Microbiota Interactions in the Cecum during Recolonization Following Broad-Spectrum Antibiotic Therapy","volume":"80","author":"Mason","year":"2012","journal-title":"Infect. Immun."},{"key":"ref_14","first-page":"9","article-title":"Intestinal Candidiasis. A Clinical Report and Comments about This Opportunistic Pathology","volume":"156","author":"Tay","year":"2003","journal-title":"Mycopathologia"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/myc.13248","article-title":"Guideline: Vulvovaginal Candidosis (AWMF 015\/072, Level S2k)","volume":"64","author":"Farr","year":"2021","journal-title":"Mycoses"},{"key":"ref_16","first-page":"22","article-title":"Candid\u00edase","volume":"22","author":"Barbedo","year":"2010","journal-title":"DST J. Bras. Doen\u00e7as Sex. Transm."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"905","DOI":"10.3109\/1040841X.2015.1091805","article-title":"Vulvovaginal Candidiasis: Epidemiology, Microbiology and Risk Factors","volume":"42","author":"Ferreira","year":"2016","journal-title":"Crit. Rev. Microbiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.9734\/mrji\/2019\/v28i630151","article-title":"Prevalence and Antifungal Susceptibility Patterns of Candida Isolated on CHROMagarTMCandida at a Tertiary Referral Hospital, Eastern Uganda","volume":"28","author":"Jane","year":"2019","journal-title":"Microbiol. Res. J. Int."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1097\/AOG.0b013e31827307b2","article-title":"Fluconazole-Resistant Candida Albicans Vulvovaginitis","volume":"120","author":"Marchaim","year":"2012","journal-title":"Obstet. Gynecol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.tifs.2021.10.015","article-title":"Lycopene: From Tomato to Its Nutraceutical Use and Its Association with Nanotechnology","volume":"118","author":"Carvalho","year":"2021","journal-title":"Trends Food Sci. Technol."},{"key":"ref_21","first-page":"1189","article-title":"Plants with Anti-Candida Activity and Their Mechanism of Action: A Review","volume":"9","author":"Vikrant","year":"2015","journal-title":"J. Environ. Res. Dev."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmed.2016.00011","article-title":"Emerging Threats in Antifungal-Resistant Fungal Pathogens","volume":"3","author":"Sanglard","year":"2016","journal-title":"Front. Med."},{"key":"ref_23","first-page":"674","article-title":"An Overview of Properties and Analytical Methods for Lycopene in Organic Nanocarriers","volume":"51","author":"Carvalho","year":"2021","journal-title":"Crit. Rev. Anal. Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.tifs.2021.12.016","article-title":"Lycopene Nanodelivery Systems; Recent Advances","volume":"119","author":"Falsafi","year":"2021","journal-title":"Trends Food Sci. Technol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s11095-020-02917-6","article-title":"Highlights in Mesoporous Silica Nanoparticles as a Multifunctional Controlled Drug Delivery Nanoplatform for Infectious Diseases Treatment","volume":"37","author":"Carvalho","year":"2020","journal-title":"Pharm. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/S1359-6446(03)02903-9","article-title":"Nanotech Approaches to Drug Delivery and Imaging","volume":"8","author":"Sahoo","year":"2003","journal-title":"Drug Discov. Today"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"13850","DOI":"10.1002\/chem.201500578","article-title":"Mesoporous-Silica-Functionalized Nanoparticles for Drug Delivery","volume":"21","author":"Giret","year":"2015","journal-title":"Chem. Eur. J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"214309","DOI":"10.1016\/j.ccr.2021.214309","article-title":"Chemically Engineered Mesoporous Silica Nanoparticles-Based Intelligent Delivery Systems for Theranostic Applications in Multiple Cancerous\/Non-Cancerous Diseases","volume":"452","author":"Zhou","year":"2022","journal-title":"Coord. Chem. Rev."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1021\/cm0011559","article-title":"A New Property of MCM-41: Drug Delivery System","volume":"13","year":"2001","journal-title":"Chem. Mater."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.actbio.2021.10.011","article-title":"Our Contributions to Applications of Mesoporous Silica Nanoparticles","volume":"137","year":"2022","journal-title":"Acta Biomater."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.ejpb.2021.02.010","article-title":"Recent Update of Toxicity Aspects of Nanoparticulate Systems for Drug Delivery","volume":"161","author":"Patnaik","year":"2021","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Wright, C.L., and Kavanagh, O. (2022). Galleria Mellonella as a Novel In Vivo Model to Screen Natural Product-Derived Modulators of Innate Immunity. Appl. Sci., 12.","DOI":"10.3390\/app12136587"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Piatek, M., Sheehan, G., and Kavanagh, K. (2021). Galleria Mellonella: The Versatile Host for Drug Discovery, In Vivo Toxicity Testing and Characterising Host-Pathogen Interactions. Antibiotics, 10.","DOI":"10.3390\/antibiotics10121545"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.cej.2018.01.011","article-title":"Interactions between Bovine Serum Albumin and Mesoporous Silica Nanoparticles Functionalized with Biopolymers","volume":"340","author":"Nairi","year":"2018","journal-title":"Chem. Eng. J."},{"key":"ref_35","unstructured":"Rocha, L.A. (2010). Materiais Meso-Estruturados Luminescentes. [Doctoral Thesis, Universidade Estadual Paulista, Instituto de Qu\u00edmica]. Available online: http:\/\/hdl.handle.net\/11449\/105768."},{"key":"ref_36","unstructured":"S\u00e1bio, R.M. (2012). Ancoragem de Complexos de Rut\u00eanio Com Ligantes Siliados Em S\u00edlica Mesoporosa Obtida via Pir\u00f3lise de Spray. [Master\u2019s Thesis, Instituto de Qu\u00edmica (IQ)]."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1016\/j.jnoncrysol.2011.01.037","article-title":"High Yield Synthesis and Characterization of Well-Ordered Mesoporous Silica Nanoparticles Using Sodium Carboxy Methyl Cellulose","volume":"357","author":"Vahid","year":"2011","journal-title":"J. Non. Cryst. Solids"},{"key":"ref_38","first-page":"9","article-title":"Isolation and Quantification of Lycopene from Tomato Cultivated in Dezfoul, Iran","volume":"6","author":"Aghel","year":"2011","journal-title":"Jundishapur J. Nat. Pharm. Prod."},{"key":"ref_39","first-page":"1094","article-title":"Chromatographic And Spectroscopic Characterisation Of Lycopen Extracted From Fresh And Thermally Processed Tomato Fruit","volume":"9","author":"Cancar","year":"2018","journal-title":"Res. J. Pharm. Biol. Chem. Sci."},{"key":"ref_40","unstructured":"(2002). Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts (Standard No. M27-A2)."},{"key":"ref_41","unstructured":"EUCAST The European Committee on Antimicrobial Susceptibility Testing (2022, September 09). Breakpoint Tables for Interpretation of MICs for Antifungal Agents, Version 10.0. Available online: http:\/\/Www.Eucast.Org\/Astoffungi\/Clinicalbreakpointsforantifungals\/."},{"key":"ref_42","first-page":"5081","article-title":"Nanostructured Lipid System as a Strategy to Improve the Anti-Candida Albicans Activity of Astronium Sp.","volume":"10","author":"Negri","year":"2015","journal-title":"Int. J. Nanomed."},{"key":"ref_43","unstructured":"(2020). Performance Standards for Antifungal Susceptibility Testing of Yeasts (Standard No. CLSI M 60)."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.biochi.2015.05.009","article-title":"Lycopene Induces Apoptosis in Candida Albicans through Reactive Oxygen Species Production and Mitochondrial Dysfunction","volume":"115","author":"Choi","year":"2015","journal-title":"Biochimie"},{"key":"ref_45","first-page":"1797","article-title":"Damage to the Cytoplasmic Membrane and Cell Death Caused by Lycopene in Candida Albicans","volume":"17","author":"Sung","year":"2007","journal-title":"J. Microbiol. Biotechnol."},{"key":"ref_46","unstructured":"(2021, September 18). ATCC Candida Albicans (Robin) Berkhout 18804TM. Available online: https:\/\/www.atcc.org\/products\/18804."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1093\/gbe\/evy166","article-title":"Utilization of Hybrid Assembly Approach to Determine the Genome of an Opportunistic Pathogenic Fungus, Candida Albicans TIMM 1768","volume":"10","author":"Panthee","year":"2018","journal-title":"Genome Biol. Evol."},{"key":"ref_48","first-page":"257","article-title":"Studies on Isolation and Quantification of Lycopene from Tomato and Papaya and Its Antioxidant and Antifungal Properties","volume":"6","author":"Desai","year":"2018","journal-title":"Int. J. Agric. Innov. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/s41578-020-0230-0","article-title":"Synthetic Amorphous Silica Nanoparticles: Toxicity, Biomedical and Environmental Implications","volume":"5","author":"Croissant","year":"2020","journal-title":"Nat. Rev. Mater."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"110593","DOI":"10.1016\/j.micromeso.2020.110593","article-title":"Biocompatibility and Internalization Assessment of Bare and Functionalised Mesoporous Silica Nanoparticles","volume":"310","author":"Herrera","year":"2021","journal-title":"Microporous Mesoporous Mater."},{"key":"ref_51","first-page":"73","article-title":"Anti-Fungal Activity of chitosan nanoparticle incorporated lycopene against Candida Albicans using minimal inhibitory concentration assay","volume":"21","author":"Natarajan","year":"2020","journal-title":"Plant Cell Biotechnol. Mol. Biol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/s12247-018-9335-z","article-title":"Hydrogel Containing PEG-Coated Fluconazole Nanoparticles with Enhanced Solubility and Antifungal Activity","volume":"14","author":"Abdellatif","year":"2019","journal-title":"J. Pharm. Innov."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1001\/jama.1976.03270170023019","article-title":"Resistance to Nalidixic Acid","volume":"236","author":"Stamey","year":"1976","journal-title":"JAMA"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ibiod.2017.05.011","article-title":"Zinc Oxide Nanoparticles Hinder Fungal Biofilm Development in an Ancient Egyptian Tomb","volume":"122","author":"Gambino","year":"2017","journal-title":"Int. Biodeterior. Biodegrad."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Salouti, M., and Ahangari, A. (2014). Nanoparticle Based Drug Delivery Systems for Treatment of Infectious Diseases. Application of Nanotechnology in Drug Delivery, InTech. Janeza Trdine.","DOI":"10.5772\/58423"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/s41565-017-0013-y","article-title":"Bacterial Resistance to Silver Nanoparticles and How to Overcome It","volume":"13","author":"Prucek","year":"2018","journal-title":"Nat. Nanotechnol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.ijmm.2017.03.005","article-title":"ROS Formation Is a Differential Contributory Factor to the Fungicidal Action of Amphotericin B and Micafungin in Candida Albicans","volume":"307","author":"Alburquerque","year":"2017","journal-title":"Int. J. Med. Microbiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"237","DOI":"10.2147\/IDR.S118892","article-title":"Fluconazole Resistance in Candida Species: A Current Perspective","volume":"10","author":"Berkow","year":"2017","journal-title":"Infect. Drug Resist."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1002\/jcph.1622","article-title":"Proposal of a Safe and Effective Study Design for CYP3A-Mediated Drug-Drug Interactions","volume":"60","author":"Rohr","year":"2020","journal-title":"J. Clin. Pharmacol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1099\/mic.0.000589","article-title":"A Novel Mechanism of Fluconazole: Fungicidal Activity through Dose-Dependent Apoptotic Responses in Candida Albicans","volume":"164","author":"Lee","year":"2018","journal-title":"Microbiology"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1128\/AAC.48.1.161-167.2004","article-title":"Fungicidal Activity of Fluconazole against Candida Albicans in a Synthetic Vagina-Simulative Medium","volume":"48","author":"Moosa","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_62","first-page":"19","article-title":"Formulation and in vitro evaluation of fluconazole loaded nanoemulgel against candida albicans","volume":"21","author":"Narang","year":"2020","journal-title":"J. Nat. Remedies"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1039\/C4EN00031E","article-title":"Zeolite and Mesoporous Silica Nanomaterials: Greener Syntheses, Environmental Applications and Biological Toxicity","volume":"1","author":"Lehman","year":"2014","journal-title":"Environ. Sci. Nano"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1517\/14656566.9.6.927","article-title":"Fungicidal versus Fungistatic: What\u2019s in a Word?","volume":"9","author":"Lewis","year":"2008","journal-title":"Expert Opin. Pharmacother."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"L\u00f3pez-Prieto, A., Vecino, X., Rodr\u00edguez-L\u00f3pez, L., Moldes, A., and Cruz, J. (2020). Fungistatic and Fungicidal Capacity of a Biosurfactant Extract Obtained from Corn Steep Water. Foods, 9.","DOI":"10.3390\/foods9050662"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1080\/21505594.2016.1203486","article-title":"Galleria Mellonella as a Model Host for Microbiological and Toxin Research","volume":"7","author":"Champion","year":"2016","journal-title":"Virulence"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"129235","DOI":"10.1016\/j.chemosphere.2020.129235","article-title":"Utility of Galleria Mellonella Larvae for Evaluating Nanoparticle Toxicology","volume":"266","author":"Vukomanovic","year":"2021","journal-title":"Chemosphere"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"597","DOI":"10.4161\/viru.25906","article-title":"An Analysis of the Structural and Functional Similarities of Insect Hemocytes and Mammalian Phagocytes","volume":"4","author":"Browne","year":"2013","journal-title":"Virulence"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.ces.2013.06.049","article-title":"Synthesis of Spherical Macroporous WO3 Particles and Their High Photocatalytic Performance","volume":"101","author":"Nandiyanto","year":"2013","journal-title":"Chem. Eng. Sci."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Maturi, F.E., S\u00e1bio, R.M., Silva, R.R., Lahoud, M.G., Meneguin, A.B., Valente, G.T., Caface, R.A., Leite, I.S., Inada, N.M., and Ribeiro, S.J.L. (2019). Luminescent Mesoporous Silica Nanohybrid Based on Drug Derivative Terbium Complex. Materials, 12.","DOI":"10.3390\/ma12060933"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.ijpharm.2016.09.042","article-title":"Phytochemical-Loaded Mesoporous Silica Nanoparticles for Nose-to-Brain Olfactory Drug Delivery","volume":"513","author":"Lungare","year":"2016","journal-title":"Int. J. Pharm."},{"key":"ref_72","unstructured":"BRASIL (2019). Farmacop\u00e9ia Brasileira, Ag\u00eancia Nacional de Vigil\u00e2ncia Sanit\u00e1ria (ANVISA). [6th ed.]."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"118257","DOI":"10.1016\/j.memsci.2020.118257","article-title":"Enhanced Permeance for PDMS Organic Solvent Nanofiltration Membranes Using Modified Mesoporous Silica Nanoparticles","volume":"612","author":"Li","year":"2020","journal-title":"J. Memb. Sci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.micromeso.2015.08.026","article-title":"Protocol Optimization for the Mild Detemplation of Mesoporous Silica Nanoparticles Resulting in Enhanced Texture and Colloidal Stability","volume":"220","author":"Zhang","year":"2016","journal-title":"Microporous Mesoporous Mater."},{"key":"ref_75","unstructured":"(2017). Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts (Standard No. M27)."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1055\/a-1323-3622","article-title":"Hydroalcoholic Extract of Myrcia Bella Loaded into a Microemulsion System: A Study of Antifungal and Mutagenic Potential","volume":"88","author":"Marena","year":"2022","journal-title":"Planta Med."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Pereira, T., de Barros, P., Fugisaki, L., Rossoni, R., Ribeiro, F., de Menezes, R., Junqueira, J., and Scorzoni, L. (2018). Recent Advances in the Use of Galleria Mellonella Model to Study Immune Responses against Human Pathogens. J. Fungi, 4.","DOI":"10.3390\/jof4040128"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"151023","DOI":"10.1016\/j.scitotenv.2021.151023","article-title":"Galleria Mellonella for Systemic Assessment of Anti-Candida Auris Using Amphotericin B Loaded in Nanoemulsion","volume":"807","author":"Marena","year":"2021","journal-title":"Sci. Total Environ."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.micinf.2010.03.001","article-title":"Role of Filamentation in Galleria Mellonella Killing by Candida Albicans","volume":"12","author":"Fuchs","year":"2010","journal-title":"Microbes Infect."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/1744-7917.12325","article-title":"Immunity of the Greater Wax Moth Galleria Mellonella","volume":"24","author":"Wojda","year":"2017","journal-title":"Insect Sci."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"350","DOI":"10.4161\/viru.25240","article-title":"Developing Galleria Mellonella as a Model Host for Human Pathogens","volume":"4","author":"Cook","year":"2013","journal-title":"Virulence"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1080\/21505594.2015.1135289","article-title":"Galleria Mellonella Infection Models for the Study of Bacterial Diseases and for Antimicrobial Drug Testing","volume":"7","author":"Tsai","year":"2016","journal-title":"Virulence"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"66","DOI":"10.4161\/21505594.2014.986412","article-title":"Cryptococcus Neoformans Induces Antimicrobial Responses and Behaves as a Facultative Intracellular Pathogen in the Non Mammalian Model Galleria Mellonella","volume":"6","author":"Scorzoni","year":"2015","journal-title":"Virulence"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.chemosphere.2018.01.175","article-title":"Galleria Mellonella Larvae Allow the Discrimination of Toxic and Non-Toxic Chemicals","volume":"198","author":"Allegra","year":"2018","journal-title":"Chemosphere"}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/27\/23\/8558\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:34:10Z","timestamp":1760146450000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/27\/23\/8558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,5]]},"references-count":84,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["molecules27238558"],"URL":"https:\/\/doi.org\/10.3390\/molecules27238558","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,5]]}}}