{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T13:19:56Z","timestamp":1785590396031,"version":"3.56.0"},"reference-count":55,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T00:00:00Z","timestamp":1670198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Biological Resources Programme, Chinese Academy of Science","award":["KFJ-BRP-007-014"],"award-info":[{"award-number":["KFJ-BRP-007-014"]}]},{"name":"the Biological Resources Programme, Chinese Academy of Science","award":["YZJJZX202013"],"award-info":[{"award-number":["YZJJZX202013"]}]},{"name":"the President Foundation of Hefei Institute of Physical Science of the Chinese Academy of Sciences","award":["KFJ-BRP-007-014"],"award-info":[{"award-number":["KFJ-BRP-007-014"]}]},{"name":"the President Foundation of Hefei Institute of Physical Science of the Chinese Academy of Sciences","award":["YZJJZX202013"],"award-info":[{"award-number":["YZJJZX202013"]}]},{"name":"the Foundation for Talented Scholars from the city of Sanmenxia","award":["KFJ-BRP-007-014"],"award-info":[{"award-number":["KFJ-BRP-007-014"]}]},{"name":"the Foundation for Talented Scholars from the city of Sanmenxia","award":["YZJJZX202013"],"award-info":[{"award-number":["YZJJZX202013"]}]},{"name":"Elite Program from the city of Xuchang","award":["KFJ-BRP-007-014"],"award-info":[{"award-number":["KFJ-BRP-007-014"]}]},{"name":"Elite Program from the city of Xuchang","award":["YZJJZX202013"],"award-info":[{"award-number":["YZJJZX202013"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Eucommia ulmoides Oliver staminate flower (ESF) tea enjoys a good reputation in folk medicine and displays multiple bioactivities, such as antioxidant and antifatigue properties. However, the underlying biological mechanisms remain largely unknown. In this study, we aimed to investigate whether ESF tea can mitigate cellular oxidative stress. Crude ethyl alcohol extract and its three subfractions prepared by sequential extraction with chloroform, n-butyl alcohol and residual water were prepared from ESF tea. The results of antioxidant activity tests in vitro manifested n-butyl alcohol fraction (n-BUF) showed the strongest antioxidant capacity (DPPH: IC50 = 24.45 \u00b1 0.74 \u03bcg\/mL, ABTS: IC50 = 17.25 \u00b1 0.04 \u03bcg\/mL). Moreover, all subfractions of ESF tea, especially the n-BUF, exhibited an obvious capacity to scavenge the reactive oxygen species (ROS) and stimulate the NRF2 antioxidative response in human keratinocytes HaCaT treated by H2O2. Using ultra-high-performance liquid chromatography, we identified geniposidic acid (GPA) as the most abundant component in ESF tea extract. Furthermore, it was found that GPA relieved oxidative stress in H2O2-induced HaCaT cells by activating the Akt\/Nrf2\/OGG1 pathway. Our findings indicated that ESF tea may be a source of natural antioxidants to protect against skin cell oxidative damage and deserves further development and utilization.<\/jats:p>","DOI":"10.3390\/molecules27238568","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T08:10:57Z","timestamp":1670227857000},"page":"8568","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Geniposidic Acid from Eucommia\u00a0ulmoides Oliver Staminate Flower Tea Mitigates Cellular Oxidative Stress via Activating AKT\/NRF2 Signaling"],"prefix":"10.3390","volume":"27","author":[{"given":"Shuo","family":"Cheng","sequence":"first","affiliation":[{"name":"The Center for Ion Beam Bioengineering & Green Agriculture, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China"},{"name":"The Science Island Branch of the Graduate School, University of Science and Technology of China, Hefei 230031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5559-5422","authenticated-orcid":false,"given":"Huiling","family":"Jia","sequence":"additional","affiliation":[{"name":"The Center for Ion Beam Bioengineering & Green Agriculture, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China"},{"name":"The Science Island Branch of the Graduate School, University of Science and Technology of China, Hefei 230031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yisen","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Center for Ion Beam Bioengineering & Green Agriculture, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanjuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"The Center for Ion Beam Bioengineering & Green Agriculture, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Chen","sequence":"additional","affiliation":[{"name":"The Center for Ion Beam Bioengineering & Green Agriculture, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China"},{"name":"Zhongke Taihe Experimental Station, Fuyang 236626, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifang","family":"Wu","sequence":"additional","affiliation":[{"name":"The Center for Ion Beam Bioengineering & Green Agriculture, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China"},{"name":"The Science Island Branch of the Graduate School, University of Science and Technology of China, Hefei 230031, China"},{"name":"Zhongke Taihe Experimental Station, Fuyang 236626, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"The Center for Ion Beam Bioengineering & Green Agriculture, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China"},{"name":"Zhongke Taihe Experimental Station, Fuyang 236626, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jep.2013.11.023","article-title":"Eucommia ulmoides Oliv.: Ethnopharmacology, phytochemistry and pharmacology of an important traditional Chinese medicine","volume":"151","author":"He","year":"2014","journal-title":"J. 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