{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:22:52Z","timestamp":1790382172425,"version":"4.1.0"},"reference-count":88,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2022,12,10]],"date-time":"2022-12-10T00:00:00Z","timestamp":1670630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Xanthones are significant bioactive compounds and secondary metabolites in mangosteen pericarps. A xanthone is a phenolic compound and versatile scaffold that consists of a tricyclic xanthene-9-one structure. A xanthone may exist in glycosides, aglycones, monomers or polymers. It is well known that xanthones possess a multitude of beneficial properties, including antioxidant activity, anti-inflammatory activity, and antimicrobial properties. Additionally, xanthones can be used as raw material and\/or an ingredient in many food, pharmaceutical, and cosmetic applications. Although xanthones can be used in various therapeutic and functional applications, their properties and stability are determined by their extraction procedures. Extracting high-quality xanthones from mangosteen with effective therapeutic effects could be challenging if the extraction method is insufficient. Although several extraction processes are in use today, their efficiency has not yet been rigorously evaluated. Therefore, selecting an appropriate extraction procedure is imperative to recover substantial yields of xanthones with enhanced functionality from mangosteens. Hence, the present review will assist in establishing a precise scenario for finding the most appropriate extraction method for xanthones from mangosteen pericarp by critically analyzing various conventional and unconventional extraction methods and their ability to preserve the stability and biological effects of xanthones.<\/jats:p>","DOI":"10.3390\/molecules27248775","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T04:34:20Z","timestamp":1670819660000},"page":"8775","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["A Review of the Influence of Various Extraction Techniques and the Biological Effects of the Xanthones from Mangosteen (Garcinia mangostana L.) Pericarps"],"prefix":"10.3390","volume":"27","author":[{"given":"Vasin","family":"Yuvanatemiya","sequence":"first","affiliation":[{"name":"Faculty of Marine Technology, Burapha University, Chanthaburi Campus, Thamai, Chanthaburi 22170, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2330-9660","authenticated-orcid":false,"given":"Pao","family":"Srean","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture and Food Processing, National University of Battambang, Battambang 020101, Cambodia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5247-166X","authenticated-orcid":false,"given":"Wiyada Kwanhian","family":"Klangbud","sequence":"additional","affiliation":[{"name":"Center of Excellence Research for Melioidosis and Microorganisms, School of Allied Health Sciences, Walailak University, Thasala, Nakhon Si Thammarat 80160, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1028-0590","authenticated-orcid":false,"given":"Karthikeyan","family":"Venkatachalam","sequence":"additional","affiliation":[{"name":"Faculty of Innovative Agriculture and Fishery Establishment Project, Prince of Songkla University, Surat Thani Campus, Makham Tia, Mueang, Surat Thani 84000, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8338-8893","authenticated-orcid":false,"given":"Jittimon","family":"Wongsa","sequence":"additional","affiliation":[{"name":"Department of Agricultural Engineering for Industry, Faculty of Industrial Technology and Management, King Mongkut\u2019s University of Technology North Bangkok, Prachinburi Campus, Prachinburi 25230, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5907-2218","authenticated-orcid":false,"given":"Thanya","family":"Parametthanuwat","sequence":"additional","affiliation":[{"name":"Department of Agricultural Engineering for Industry, Faculty of Industrial Technology and Management, King Mongkut\u2019s University of Technology North Bangkok, Prachinburi Campus, Prachinburi 25230, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7691-7665","authenticated-orcid":false,"given":"Narin","family":"Charoenphun","sequence":"additional","affiliation":[{"name":"Faculty of Science and Arts, Burapha University, Chanthaburi Campus, Thamai, Chanthaburi 22170, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Pittayapruek, P., Meephansan, J., Prapapan, O., Komine, M., and Ohtsuki, M. 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