{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:38:00Z","timestamp":1790959080844,"version":"4.1.0"},"reference-count":52,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T00:00:00Z","timestamp":1670803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81900736"],"award-info":[{"award-number":["81900736"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["WST2018004"],"award-info":[{"award-number":["WST2018004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2019-11"],"award-info":[{"award-number":["2019-11"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shandong Province \u201cDouble-Hundred Talent Plan\u201d on 100 Foreign Experts and 100 Foreign Expert Teams Introduction","award":["81900736"],"award-info":[{"award-number":["81900736"]}]},{"name":"Shandong Province \u201cDouble-Hundred Talent Plan\u201d on 100 Foreign Experts and 100 Foreign Expert Teams Introduction","award":["WST2018004"],"award-info":[{"award-number":["WST2018004"]}]},{"name":"Shandong Province \u201cDouble-Hundred Talent Plan\u201d on 100 Foreign Experts and 100 Foreign Expert Teams Introduction","award":["2019-11"],"award-info":[{"award-number":["2019-11"]}]},{"name":"Innovation Project of Shandong Academy of Medical Sciences","award":["81900736"],"award-info":[{"award-number":["81900736"]}]},{"name":"Innovation Project of Shandong Academy of Medical Sciences","award":["WST2018004"],"award-info":[{"award-number":["WST2018004"]}]},{"name":"Innovation Project of Shandong Academy of Medical Sciences","award":["2019-11"],"award-info":[{"award-number":["2019-11"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Advanced glycation end products (AGEs) cause damage to pancreatic \u03b2-cells and trigger oxidative stress and inflammation, which promotes the development and progression of diabetes and its complications. Therefore, it is important to inhibit the formation of AGEs as part of the treatment of diabetes. Allicin is a natural antimicrobial agent with abundant pharmacological activities, and recent studies have reported its therapeutic effects in diabetes; however, the mechanism of these therapeutic effects is still unclear. Thus, the purpose of this study was to further investigate the association between allicin treatment of diabetes and AGEs. First, we established a streptozocin (STZ)-induced diabetic rat model and treated the rats with allicin for six weeks. We measured glycolipid metabolism, AGE levels, receptor of advanced glycation end products (RAGE) levels, oxidative stress, and other related indicators. The results showed that allicin improved blood glucose and body weight, reduced lipid accumulation, and inhibited AGE formation in rats. Treatment with allicin also inhibited RAGEs and thereby prevented AGE activity, which, in turn, alleviated oxidative stress and promoted insulin secretion. To further verify the effect of allicin on AGEs, we also performed in vitro nonenzymatic glycation simulation experiments. These results showed that allicin inhibited the production of AGEs by suppressing the production of AGEs intermediates. Thus, our research suggests that allicin may alleviate diabetes by inhibiting the formation of AGEs and reducing RAGE levels to relieve oxidative stress and promote insulin secretion.<\/jats:p>","DOI":"10.3390\/molecules27248793","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T05:10:19Z","timestamp":1670821819000},"page":"8793","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Allicin Alleviates Diabetes Mellitus by Inhibiting the Formation of Advanced Glycation End Products"],"prefix":"10.3390","volume":"27","author":[{"given":"Linzehao","family":"Li","sequence":"first","affiliation":[{"name":"Endocrine and Metabolic Diseases Hospital of Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghe","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Linyi People\u2019s Hospital, Linyi 276000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiandang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250118, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Surgery, Qilu Hospital of Shandong University, Jinan 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6950-4309","authenticated-orcid":false,"given":"Xiaolei","family":"Wang","sequence":"additional","affiliation":[{"name":"Endocrine and Metabolic Diseases Hospital of Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.jada.2010.03.018","article-title":"Advanced glycation end products in foods and a practical guide to their reduction in the diet","volume":"110","author":"Uribarri","year":"2010","journal-title":"J. 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