{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:07:31Z","timestamp":1792004851794,"version":"4.4.0"},"reference-count":33,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T00:00:00Z","timestamp":1670889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Scientific Research Projects of Gansu Provincial Administration of Traditional Chinese Medicine","award":["GZK-2017-40"],"award-info":[{"award-number":["GZK-2017-40"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Curcumin is one of the most studied chemo-preventive agents, which may cause suppression, retardation, or inversion of carcinogenesis. But its application is currently limited because of its poor water-solubility and bioaccessibility. A curcumin O\/W emulsion was prepared by high-pressure homogenization, using triglyceride monolaurate as an emulsifier and medium chain triglycerides (MCT) as the oil phase. The effects of emulsifiers, emulsifier concentration, oil type, oil-to-water ratio, and homogenization pressure and processing cycles on the physical stability and droplet size distribution of curcumin-encapsulated O\/W emulsions were evaluated in this study. The results showed that the mean droplet size of the O\/W emulsions remained remarkably stable during 60 days of storage under both light and dark conditions. Curcumin retentions in O\/W emulsions after 60 days of storage under light and dark conditions were 97.9% and 81.6%, respectively. In addition, during the simulated gastrointestinal digestion process, the mean droplet size of the O\/W emulsions increased from 260 nm to 2743 nm after incubation with simulated gastric fluid (SGF) for 24 h, while the mean droplet size remained unchanged after incubation with simulated intestinal fluid (SIF). The results displayed negligible changes in curcumin content during incubation with simulated gastrointestinal fluids, indicating that effective protection of curcumin was achieved by encapsulation in the O\/W emulsion. It is expected that curcumin will acquire high bioaccessibility and bioavailability when the O\/W emulsion is to be used in clinical applications.<\/jats:p>","DOI":"10.3390\/molecules27248861","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T03:21:52Z","timestamp":1670988112000},"page":"8861","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Preparation and Optimization of O\/W Emulsions Stabilized by Triglycerol Monolaurate for Curcumin Encapsulation"],"prefix":"10.3390","volume":"27","author":[{"given":"Guiqiong","family":"Zhang","sequence":"first","affiliation":[{"name":"Gansu Provincial Cancer Hospital, Lanzhou 730050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Gansu Provincial Cancer Hospital, Lanzhou 730050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Wang","sequence":"additional","affiliation":[{"name":"Gansu Provincial Academic Institute for Medical Research, Lanzhou 730050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Ji","sequence":"additional","affiliation":[{"name":"Gansu Provincial Academic Institute for Medical Research, Lanzhou 730050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengbing","family":"Han","sequence":"additional","affiliation":[{"name":"Gansu Provincial Cancer Hospital, Lanzhou 730050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengju","family":"Zhao","sequence":"additional","affiliation":[{"name":"Gansu Provincial Cancer Hospital, Lanzhou 730050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Su","sequence":"additional","affiliation":[{"name":"Gansu Provincial Cancer Hospital, Lanzhou 730050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1016\/0006-2952(76)90421-4","article-title":"Antioxidant activity of curcumin and related compounds","volume":"25","author":"Sharma","year":"1976","journal-title":"Biochem. Pharmacol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1016\/S0006-2952(98)00114-2","article-title":"In vivo inhibition of nitric oxide synthase gene expression by curcumin, a cancer preventive natural product with Anti-Inflammatory properties","volume":"55","author":"Chan","year":"1998","journal-title":"Biochem. Pharmacol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Zoi, V., Galani, V., Lianos, G.D., Voulgaris, S., Kyritsis, A.P., and Alexiou, G.A. (2021). The role of curcumin in cancer treatment. Biomedicines, 9.","DOI":"10.3390\/biomedicines9091086"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1002\/ijc.30224","article-title":"Curcumin: A new candidate for melanoma therapy?","volume":"139","author":"Mirzaei","year":"2016","journal-title":"Int. J. Cancer"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1080\/01635581.2017.1285405","article-title":"Curcumin nanotechnologies and its anticancer activity","volume":"69","author":"Subramani","year":"2017","journal-title":"Nutr. Cancer"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Tro\u0161elj, K.G., Samar\u017eija, I., Tomljanovi\u0107, M., Kujund\u017ei\u0107, R.N., \u0110akovi\u0107, N., and Mojze\u0161, A. (2020). Implementing curcumin in translational oncology research. Molecules, 25.","DOI":"10.3390\/molecules25225240"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.canlet.2004.09.041","article-title":"Chemopreventive and therapeutic effects of curcumin","volume":"223","author":"Duvoix","year":"2005","journal-title":"Cancer Lett."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"694","DOI":"10.3109\/1061186X.2016.1157883","article-title":"Oral bioavailability of curcumin: Problems and advancements","volume":"24","author":"Liu","year":"2016","journal-title":"J. Drug Target."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"9141","DOI":"10.1021\/jf9013923","article-title":"Evaluation of an oral carrier system in rats: Bioavailability and antioxidant properties of Liposome-Encapsulated curcumin","volume":"57","author":"Takahashi","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1021\/jf204867v","article-title":"Effects of curcumin concentration and temperature on the spectroscopic properties of liposomal curcumin","volume":"60","author":"Niu","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.tifs.2017.11.009","article-title":"Recent advances in emulsion-based delivery approaches for curcumin: From encapsulation to bioaccessibility","volume":"71","author":"Akhtar","year":"2018","journal-title":"Trends Food Sci. Tech."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1477-3155-5-3","article-title":"Polymeric nanoparticle-encapsulated curcumin (\u201cnanocurcumin\u201d): A novel strategy for human cancer therapy","volume":"5","author":"Bisht","year":"2007","journal-title":"J. Nanobiotechnol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1007\/s00396-022-04998-8","article-title":"Encapsulation of curcumin in gliadin-pectin in a core\u2013shell nanostructure for efficient delivery of curcumin to cancer cells in vitro","volume":"300","author":"Banaee","year":"2022","journal-title":"Colloid Polym. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"6377","DOI":"10.1016\/j.biomaterials.2013.05.005","article-title":"A biodegradable hydrogel system containing curcumin encapsulated in micelles for cutaneous wound healing","volume":"34","author":"Gong","year":"2013","journal-title":"Biomaterials"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.foodhyd.2016.02.036","article-title":"Encapsulation of curcumin in polysaccharide-based hydrogel beads: Impact of bead type on lipid digestion and curcumin bioaccessibility","volume":"58","author":"Zhang","year":"2016","journal-title":"Food Hydrocolloid."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Obeid, M.A., Alsaadi, M., and Aljabali, A.A. (2022). Recent updates in curcumin delivery. J. Liposome Res., 1\u201312.","DOI":"10.1080\/08982104.2022.2086567"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1146\/annurev-food-032818-121738","article-title":"Curcumin: Recent advances in the development of strategies to improve oral bioavailability","volume":"10","author":"Sanidad","year":"2019","journal-title":"Annu. Rev. Food Sci. Technol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1021\/acs.jafc.6b04815","article-title":"Physical and chemical stability of curcumin in aqueous solutions and emulsions: Impact of pH, temperature, and molecular environment","volume":"65","author":"Kharat","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.foodchem.2011.11.039","article-title":"Nanoemulsion- and emulsion-based delivery systems for curcumin: Encapsulation and release properties","volume":"132","author":"Ahmed","year":"2012","journal-title":"Food Chem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.foodchem.2007.10.086","article-title":"Enhancing anti-inflammation activity of curcumin through O\/W nanoemulsions","volume":"108","author":"Wang","year":"2008","journal-title":"Food Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1080\/01932691.2011.616365","article-title":"Direct and accelerated characterization of formulation stability","volume":"32","author":"Lerche","year":"2011","journal-title":"J. Disper. Sci. Technol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.1007\/s13197-018-3273-0","article-title":"Development of stable curcumin nanoemulsions: Effects of emulsifier type and surfactant-to-oil ratios","volume":"55","author":"Ma","year":"2018","journal-title":"J. Food Sci. Technol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1080\/01932691.2015.1048459","article-title":"Effect of emulsifier type on the characterization of O\/W emulsions using a spectroscopy technique","volume":"37","author":"Celis","year":"2016","journal-title":"J. Disper. Sci. Technol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"7548","DOI":"10.1021\/jf301129k","article-title":"Physical and antimicrobial properties of peppermint oil nanoemulsions","volume":"60","author":"Liang","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.ijpharm.2007.04.031","article-title":"Poly(d,l-lactide-co-glycolide) (PLGA) nanoparticles prepared by high pressure homogenization for paclitaxel chemotherapy","volume":"342","author":"Dong","year":"2007","journal-title":"Int. J. Pharmaceut."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1080\/01932691.2020.1844731","article-title":"Development of polyglycerol fatty acid ester-based low-energy nanoemulsion for the improvement of curcumin stability","volume":"43","author":"Chen","year":"2020","journal-title":"J. Disper. Sci. Technol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.ijpharm.2018.08.060","article-title":"Curcumin-loaded low-energy nanoemulsions as a prototype of multifunctional vehicles for different administration routes: Physicochemical and in vitro peculiarities important for dermal application","volume":"550","author":"Nikolic","year":"2018","journal-title":"Int. J. Pharmaceut."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jfoodeng.2015.08.012","article-title":"Curcumin-loaded nanoemulsions produced by the emulsion inversion point (EIP) method: An evaluation of process parameters and physico-chemical stability","volume":"169","author":"Borrin","year":"2016","journal-title":"J. Food Eng."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.foodres.2012.12.027","article-title":"Fate of curcumin encapsulated in silica nanoparticle stabilized Pickering emulsion during storage and simulated digestion","volume":"51","author":"Tikekar","year":"2013","journal-title":"Food Res. Int."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.foodhyd.2015.07.015","article-title":"Preparation and optimization of Pickering emulsion stabilized by chitosan-tripolyphosphate nanoparticles for curcumin encapsulation","volume":"52","author":"Shah","year":"2016","journal-title":"Food Hydrocolloid."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ijpharm.2008.09.009","article-title":"An in vitro study of liposomal curcumin: Stability, toxicity and biological activity in human lymphocytes and Epstein-Barr virus-transformed human B-cells","volume":"366","author":"Chen","year":"2009","journal-title":"Int. J. Pharmaceut."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.ijbiomac.2018.06.147","article-title":"Influence of a nonionic surfactant on curcumin delivery of nanocellulose reinforced chitosan hydrogel","volume":"118","author":"Ching","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.foodres.2018.05.021","article-title":"Stability of curcumin in oil-in-water emulsions: Impact of emulsifier type and concentration on chemical degradation","volume":"111","author":"Kharat","year":"2018","journal-title":"Food Res. 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