{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T03:08:22Z","timestamp":1783480102264,"version":"3.55.0"},"reference-count":29,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T00:00:00Z","timestamp":1670976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2022ME048, ZR2019MB035"],"award-info":[{"award-number":["ZR2022ME048, ZR2019MB035"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["JYGC2022KJ007"],"award-info":[{"award-number":["JYGC2022KJ007"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["JY2017KJ049"],"award-info":[{"award-number":["JY2017KJ049"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["cx2020003, S202010443010"],"award-info":[{"award-number":["cx2020003, S202010443010"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Natural Science Foundation Cultivation Project in Jining medical university","award":["ZR2022ME048, ZR2019MB035"],"award-info":[{"award-number":["ZR2022ME048, ZR2019MB035"]}]},{"name":"National Natural Science Foundation Cultivation Project in Jining medical university","award":["JYGC2022KJ007"],"award-info":[{"award-number":["JYGC2022KJ007"]}]},{"name":"National Natural Science Foundation Cultivation Project in Jining medical university","award":["JY2017KJ049"],"award-info":[{"award-number":["JY2017KJ049"]}]},{"name":"National Natural Science Foundation Cultivation Project in Jining medical university","award":["cx2020003, S202010443010"],"award-info":[{"award-number":["cx2020003, S202010443010"]}]},{"name":"Teacher Research Support Foundation in Jining medical university","award":["ZR2022ME048, ZR2019MB035"],"award-info":[{"award-number":["ZR2022ME048, ZR2019MB035"]}]},{"name":"Teacher Research Support Foundation in Jining medical university","award":["JYGC2022KJ007"],"award-info":[{"award-number":["JYGC2022KJ007"]}]},{"name":"Teacher Research Support Foundation in Jining medical university","award":["JY2017KJ049"],"award-info":[{"award-number":["JY2017KJ049"]}]},{"name":"Teacher Research Support Foundation in Jining medical university","award":["cx2020003, S202010443010"],"award-info":[{"award-number":["cx2020003, S202010443010"]}]},{"name":"Student Innovation Training Program in Jining Medical University","award":["ZR2022ME048, ZR2019MB035"],"award-info":[{"award-number":["ZR2022ME048, ZR2019MB035"]}]},{"name":"Student Innovation Training Program in Jining Medical University","award":["JYGC2022KJ007"],"award-info":[{"award-number":["JYGC2022KJ007"]}]},{"name":"Student Innovation Training Program in Jining Medical University","award":["JY2017KJ049"],"award-info":[{"award-number":["JY2017KJ049"]}]},{"name":"Student Innovation Training Program in Jining Medical University","award":["cx2020003, S202010443010"],"award-info":[{"award-number":["cx2020003, S202010443010"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Reduced imine cage (RCC3) was covalently bonded to the surface of silica spheres, and then the secondary amine group of the molecular cage was embedded in non-polar C10 for modification to prepare a novel RCC3-C10@silica HPLC stationary phase with multiple separation functions. Through infrared spectroscopy, thermogravimetric analysis and nitrogen adsorption\u2013desorption characterization, it was confirmed that RCC3-C10 was successfully bonded to the surface of silica spheres. The resolution of RCC3-C10@silica in reversed-phase separation mode is as high as 2.95, 3.73, 3.27 and 4.09 for p-phenethyl alcohol, 1-phenyl-2-propanol, p-methylphenethyl alcohol and 1-phenyl-1-propanol, indicating that the stationary phase has excellent chiral resolution performance. In reversed-phase and hydrophilic separation modes, RCC3-C10@silica realized the separation and analysis of a total of 70 compounds in 8 classes of Tanaka mixtures, alkylbenzene rings, polyphenyl rings, phenols, anilines, sulfonamides, nucleosides and flavonoids, and the analysis of a variety of chiral and achiral complex mixtures have been completed at the same time. Compared with the traditional C18 commercial column, RCC3-C10@silica exhibits better chromatographic separation selectivity, aromatic selectivity and polar selectivity. The multifunctional separation mechanism exhibited by the stationary phase originates from various synergistic effects such as hydrophobic interaction, \u03c0-\u03c0 interaction, hydrogen bonding and steric interaction provided by RCC3 and C10 groups. This work provides flexible selectivity and application prospects for novel multi-separation functional chromatographic columns.<\/jats:p>","DOI":"10.3390\/molecules27248895","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T03:01:51Z","timestamp":1671073311000},"page":"8895","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Porous Organic Cage-Embedded C10-Modified Silica as HPLC Stationary Phase and Its Multiple Separation Functions"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3734-6676","authenticated-orcid":false,"given":"Litao","family":"Wang","sequence":"first","affiliation":[{"name":"School of Pharmacy, Jining Medical University, Jining 272000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Han","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jining Medical University, Jining 272000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyang","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jining Medical University, Jining 272000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jining Medical University, Jining 272000, China"},{"name":"School of Pharmacy, Weifang Medical University, Weifang 261000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Pei","sequence":"additional","affiliation":[{"name":"Qingdao Center of Resource Chemistry & New Materials, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Qingdao 266000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Lv","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jining Medical University, Jining 272000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiasheng","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jining Medical University, Jining 272000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyu","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jining Medical University, Jining 272000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruifang","family":"Ding","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jining Medical University, Jining 272000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qibao","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jining Medical University, Jining 272000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Lv","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jining Medical University, Jining 272000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.talanta.2014.12.008","article-title":"Determination of five antiarrhythmic drugs in human plasma by dispersive liquid-liquid microextraction and high-performance liquid chromatography","volume":"134","author":"Jouyban","year":"2015","journal-title":"Talanta"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.chroma.2019.01.022","article-title":"Determination of some red dyes in food samples using a hydrophobic deep eutectic solvent-based vortex assisted dispersive liquid-liquid microextraction coupled with high performance liquid chromatography","volume":"1591","author":"Faraji","year":"2019","journal-title":"J. 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