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In this feature paper, we summarize recent advances in the construction of small-molecule scaffolds, such as benzene, cyclopentene, furan, and pyran, based on gold-catalyzed cyclization of arylalkyne derivatives within the last decade. We hope that this review will serve as a useful reference for chemists to apply gold-catalyzed strategies to the syntheses of related natural products and active molecules, hopefully providing useful guidance for the exploration of additional novel gold-catalyzed approaches.<\/jats:p>","DOI":"10.3390\/molecules27248956","type":"journal-article","created":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T03:55:39Z","timestamp":1671162939000},"page":"8956","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Recent Advances in Gold(I)-Catalyzed Approaches to Three-Type Small-Molecule Scaffolds via Arylalkyne Activation"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9727-4849","authenticated-orcid":false,"given":"Lu","family":"Yang","sequence":"first","affiliation":[{"name":"Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China"},{"name":"Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China"},{"name":"Institute of Drug Research in Medicine Capital of China, Shenyang Pharmaceutical University, Benxi 117000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongwei","family":"Su","sequence":"additional","affiliation":[{"name":"Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China"},{"name":"Institute of Drug Research in Medicine Capital of China, Shenyang Pharmaceutical University, Benxi 117000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Sun","sequence":"additional","affiliation":[{"name":"Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China"},{"name":"Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China"},{"name":"Institute of Drug Research in Medicine Capital of China, Shenyang Pharmaceutical University, Benxi 117000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China"},{"name":"Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China"},{"name":"Institute of Drug Research in Medicine Capital of China, Shenyang Pharmaceutical University, Benxi 117000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maosheng","family":"Cheng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China"},{"name":"Institute of Drug Research in Medicine Capital of China, Shenyang Pharmaceutical University, Benxi 117000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongxiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China"},{"name":"Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China"},{"name":"Institute of Drug Research in Medicine Capital of China, Shenyang Pharmaceutical University, Benxi 117000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1039\/c3973000444b","article-title":"Hydrogenation over supported gold catalysts","volume":"13","author":"Bond","year":"1973","journal-title":"J. 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