{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T18:02:38Z","timestamp":1786384958941,"version":"build-2736575974"},"reference-count":107,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2022,12,17]],"date-time":"2022-12-17T00:00:00Z","timestamp":1671235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the National Natural Science Foundation of China","award":["81670088"],"award-info":[{"award-number":["81670088"]}]},{"name":"the National Natural Science Foundation of China","award":["2020GGJS038"],"award-info":[{"award-number":["2020GGJS038"]}]},{"name":"the National Natural Science Foundation of China","award":["222102310490"],"award-info":[{"award-number":["222102310490"]}]},{"name":"the National Natural Science Foundation of China","award":["222102310495"],"award-info":[{"award-number":["222102310495"]}]},{"name":"the Training Program for Young Backbone Teachers of Institutions of Higher Learning in Henan Province, China","award":["81670088"],"award-info":[{"award-number":["81670088"]}]},{"name":"the Training Program for Young Backbone Teachers of Institutions of Higher Learning in Henan Province, China","award":["2020GGJS038"],"award-info":[{"award-number":["2020GGJS038"]}]},{"name":"the Training Program for Young Backbone Teachers of Institutions of Higher Learning in Henan Province, China","award":["222102310490"],"award-info":[{"award-number":["222102310490"]}]},{"name":"the Training Program for Young Backbone Teachers of Institutions of Higher Learning in Henan Province, China","award":["222102310495"],"award-info":[{"award-number":["222102310495"]}]},{"name":"the Foundation of Science &amp; Technology Department of Henan Province, China","award":["81670088"],"award-info":[{"award-number":["81670088"]}]},{"name":"the Foundation of Science &amp; Technology Department of Henan Province, China","award":["2020GGJS038"],"award-info":[{"award-number":["2020GGJS038"]}]},{"name":"the Foundation of Science &amp; Technology Department of Henan Province, China","award":["222102310490"],"award-info":[{"award-number":["222102310490"]}]},{"name":"the Foundation of Science &amp; Technology Department of Henan Province, China","award":["222102310495"],"award-info":[{"award-number":["222102310495"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Lung cancer is one of the 10 most common cancers in the world, which seriously affects the normal life and health of patients. According to the investigation report, the 3-year survival rate of patients with lung cancer is less than 20%. Heredity, the environment, and long-term smoking or secondhand smoke greatly promote the development and progress of the disease. The mechanisms of action of the occurrence and development of lung cancer have not been fully clarified. As a new type of gas signal molecule, hydrogen sulfide (H2S) has received great attention for its physiological and pathological roles in mammalian cells. It has been found that H2S is widely involved in the regulation of the respiratory system and digestive system, and plays an important role in the occurrence and development of lung cancer. H2S has the characteristics of dissolving in water and passing through the cell membrane, and is widely expressed in body tissues, which determines the possibility of its participation in the occurrence of lung cancer. Both endogenous and exogenous H2S may be involved in the inhibition of lung cancer cells by regulating mitochondrial energy metabolism, mitochondrial DNA integrity, and phosphoinositide 3-kinase\/protein kinase B co-pathway hypoxia-inducible factor-1\u03b1 (HIF-1\u03b1). This article reviews and discusses the molecular mechanism of H2S in the development of lung cancer, and provides novel insights for the prevention and targeted therapy of lung cancer.<\/jats:p>","DOI":"10.3390\/molecules27249005","type":"journal-article","created":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T09:05:09Z","timestamp":1671440709000},"page":"9005","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The Role of Hydrogen Sulfide in the Development and Progression of Lung Cancer"],"prefix":"10.3390","volume":"27","author":[{"given":"Yi-Lun","family":"Yang","sequence":"first","affiliation":[{"name":"Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China"},{"name":"School of Stomatology, Henan University, Kaifeng 475004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ka","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, Henan University, Kaifeng 475004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze-Tao","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, Henan University, Kaifeng 475004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Liang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China"},{"name":"School of Clinical Medicine, Henan University, Kaifeng 475004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Stomatology, Henan University, Kaifeng 475004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Xia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3487-1640","authenticated-orcid":false,"given":"Zhi-Hui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of General Practice, Henan Provincial People\u2019s Hospital, People\u2019s Hospital of Zhengzhou University, Zhengzhou 450003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Ying","family":"Ji","sequence":"additional","affiliation":[{"name":"Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China"},{"name":"Faculty of Basic Medical Subjects, Shu-Qing Medical College of Zhengzhou, Zhengzhou 450064, China"},{"name":"Kaifeng Key Laboratory for Infectious Diseases and Biosafety, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6739-8437","authenticated-orcid":false,"given":"Dong-Dong","family":"Wu","sequence":"additional","affiliation":[{"name":"Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China"},{"name":"School of Stomatology, Henan University, Kaifeng 475004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. 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