{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:56:28Z","timestamp":1789750588356,"version":"4.0.1"},"reference-count":80,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2022,12,17]],"date-time":"2022-12-17T00:00:00Z","timestamp":1671235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Tyrosinase is a multifunctional, copper-containing and rate-limiting oxidase that catalyses crucial steps in the melanogenesis pathway and is responsible for skin-pigmentation abnormalities in mammals. Numerous tyrosinase inhibitors derived from natural and synthetic sources have been identified as an objective for the development of anti-melanogenesis agents. However, due to side effects and lack of expected efficiency, only a small percentage of them are used for medical and cosmetic purposes. This critical review focuses on searching for novel active substances and recently discovered plant-derived anti-tyrosinase inhibitors from the Morus genus (Moraceae family). A detailed analysis of their structure\u2013activity relationships is discussed. The information contained in this article is crucial for the cosmetics and medical industries, in order to show new directions for the effective search for natural anti-melanogenesis products (with satisfactory efficiency and safety) to treat and cure hyperpigmentation.<\/jats:p>","DOI":"10.3390\/molecules27249011","type":"journal-article","created":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T09:05:09Z","timestamp":1671440709000},"page":"9011","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Screening and Structure\u2013Activity Relationship for Selective and Potent Anti-Melanogenesis Agents Derived from Species of Mulberry (Genus Morus)"],"prefix":"10.3390","volume":"27","author":[{"given":"Anna","family":"Gryn-Rynko","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Medicine, University of Warmia and Mazury, Warszawska 30 Street, 10-082 Olsztyn, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8956-6120","authenticated-orcid":false,"given":"Beata","family":"Sperkowska","sequence":"additional","affiliation":[{"name":"Department of Toxicology and Bromatology, Faculty of Pharmacy, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toru\u0144, A. Jurasza 2 Street, 85-089 Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6304-0673","authenticated-orcid":false,"given":"Micha\u0142 S.","family":"Majewski","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Medicine, University of Warmia and Mazury, Warszawska 30 Street, 10-082 Olsztyn, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4066","DOI":"10.3390\/ijms10094066","article-title":"Mechanisms regulating skin pigmentation: The rise and fall of complexion coloration","volume":"10","author":"Ebanks","year":"2009","journal-title":"Int. J. Mol. Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"30","DOI":"10.5114\/pdia.2013.33376","article-title":"Skin melanocytes: Biology and development","volume":"30","author":"Cichorek","year":"2013","journal-title":"Postepy Dermatol. Alergol."},{"key":"ref_3","first-page":"1000223","article-title":"Understanding the challenges of melanogenesis: Key role of bioactive compounds in the treatment of hyperpigmentory disorders","volume":"2","author":"Ali","year":"2015","journal-title":"J. Pigment. Disord."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1080\/14756366.2018.1545767","article-title":"A comprehensive review on tyrosinase inhibitors","volume":"34","author":"Zolghadri","year":"2019","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.fct.2014.03.001","article-title":"Betulinic acid isolated from Vitis amurensis root inhibits 3-isobutyl-1-methylxanthine induced melanogenesis via the regulation of MEK\/ERK and PI3K\/Akt pathways in B16F10 cells","volume":"68","author":"Jin","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"262364","DOI":"10.1155\/2015\/262364","article-title":"Estimation of inhibitory effect against tyrosinase activity through homology modeling and molecular docking","volume":"2015","author":"Nokinsee","year":"2015","journal-title":"Enzyme Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1080\/07391102.2014.893203","article-title":"A new insight into mushroom tyrosinase inhibitors: Docking, pharmacophore-based virtual screening, and molecular modeling studies","volume":"33","author":"Bagherzadeh","year":"2015","journal-title":"J. Biomol. Struct. Dyn."},{"key":"ref_8","first-page":"244","article-title":"Tyrosinase inhibitors of fungi and lichens as regulators of melanogenesis","volume":"4","author":"Bylka","year":"2015","journal-title":"Post. Fitoter."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"854687","DOI":"10.1155\/2014\/854687","article-title":"Microbial Tyrosinases: Promising enzymes for pharmaceutical, food bioprocessing, and environmental industry","volume":"2014","author":"Zaidi","year":"2014","journal-title":"Biochem. Res. Int."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.3390\/ma5091661","article-title":"Natural melanogenesis inhibitors acting through the down-regulation of tyrosinase activity","volume":"5","author":"Chang","year":"2012","journal-title":"Materials"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Michalak, M., Pierzak, M., Kr\u0119cisz, B., and Suliga, E. (2021). Bioactive Compounds for Skin Health: A Review. Nutrients, 13.","DOI":"10.3390\/nu13010203"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Nagatsu, T., Nakashima, A., Watanabe, H., Ito, S., and Wakamatsu, K. (2022). Neuromelanin in Parkinson\u2019s disease: Tyrosine hydroxylase and tyrosinase. Int. J. Mol. Sci., 10.","DOI":"10.20944\/preprints202203.0274.v1"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1002\/ijc.25912","article-title":"The association between Parkinson\u2019s disease and melanoma","volume":"128","author":"Pan","year":"2011","journal-title":"Int. J. Cancer"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"7995","DOI":"10.1038\/srep07995","article-title":"Discovery of highly potent tyrosinase inhibitor, T1, with significant anti-melanogenesis a ility by zebrafish in vivo assay and computational molecular modeling","volume":"5","author":"Chen","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Phasha, V., Senabe, J., Ndzotoyi, P., Okole, B., Fouche, G., and Chuturgoon, A. (2022). Review on the use of kojic acid\u2014A skin-lightening ingredient. Cosmetics, 9.","DOI":"10.3390\/cosmetics9030064"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Juliano, C.C.A. (2022). Spreading of dangerous skin-lightening products as a result of colourism: A review. Appl. Sci., 12.","DOI":"10.3390\/app12063177"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1080\/14756366.2016.1256882","article-title":"Skin whitening agents: Medicinal chemistry perspective of tyrosinase inhibitors","volume":"32","author":"Pillaiyar","year":"2017","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"244S","DOI":"10.1177\/1091581810385956","article-title":"Final report of the safety assessment of Kojic acid as used in cosmetics","volume":"29","author":"Burnett","year":"2010","journal-title":"Int. J. Toxicol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/jidsymp.2008.8","article-title":"The use of botanical extracts as topical skin-lightening agents for the improvement of skin pigmentation disorders","volume":"13","author":"Zhu","year":"2008","journal-title":"J. Investig. Dermatol. Symp. Proc."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1021\/ci500370x","article-title":"Serendipitous discovery of short peptides from natural products as tyrosinase inhibitors","volume":"54","author":"Hsiao","year":"2014","journal-title":"J. Chem. Inf. Model."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0006-2952(98)00340-2","article-title":"Inhibitors of mammalian melanocyte tyrosinase: In vitro comparisons of alkyl esters of gentisic acid with other putative inhibitors","volume":"57","author":"Curto","year":"1999","journal-title":"Biochem. Pharmacol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e1305","DOI":"10.7717\/peerj.1305","article-title":"Antityrosinase activity of Euphorbia characias extracts","volume":"3","author":"Pintus","year":"2015","journal-title":"PeerJ."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Fawole, O.A., Makunga, N.P., and Opara, U.L. (2012). Antibacterial, antioxidant and tyrosinase-inhibition activities of pomegranate fruit peel methanolic extract. BMC Complement. Altern. Med., 12.","DOI":"10.1186\/1472-6882-12-200"},{"key":"ref_24","first-page":"91","article-title":"Synergistic effect of anti-oxidant, anti-tyrosinase and anti-bacterial activities of Tridax procumbens, Lantana camara, Euphorbia hirta and Thevetia peruviana plant extracts for cosmetic and personal care applications","volume":"6","author":"Sindhuja","year":"2014","journal-title":"Int. J. Pharm. Pharm. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.biopha.2016.09.081","article-title":"New potential phytotherapeutics obtained from white mulberry (Morus alba L.) leaves","volume":"84","author":"Bazylak","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.foodchem.2011.09.040","article-title":"Bioassay-guided screening and isolation of \u03b1-glucosidase and tyrosinase inhibitors from leaves of Morus alba","volume":"131","author":"Yang","year":"2012","journal-title":"Food Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.fitote.2012.06.001","article-title":"Tyrosinase inhibition constituents from the roots of Morus australis","volume":"83","author":"Zheng","year":"2012","journal-title":"Fitoterapia"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"5368","DOI":"10.1021\/jf1003607","article-title":"Tyrosinase inhibitory constituents from the roots of Morus nigra: A structure-activity relationship study","volume":"58","author":"Zheng","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"ref_29","first-page":"198","article-title":"Tyrosinase inhibitory constituents of Morus bombycis cortex","volume":"17","author":"Kang","year":"2011","journal-title":"Nat. Prod. Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.3390\/ijms13022472","article-title":"Antioxidant activity of mulberry fruit extracts","volume":"13","author":"Arfan","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1016\/j.sjbs.2021.03.056","article-title":"Nutritional constituents of mulberry and their potential applications in food and pharmaceuticals: A review","volume":"28","author":"Jan","year":"2021","journal-title":"Saudi J. Biol. Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"202100740","DOI":"10.1002\/cbdv.202100740","article-title":"Highly potent inhibition of tyrosinase by mulberrosides and the inhibitory mechanism in vitro","volume":"19","author":"Liu","year":"2022","journal-title":"Chem. Biodivers."},{"key":"ref_33","first-page":"271","article-title":"Mulberry: Life enhancer","volume":"2","author":"Kumar","year":"2008","journal-title":"J. Med. Plants Res."},{"key":"ref_34","first-page":"311","article-title":"Skin-whitening effects of Mediterranean herbal extracts by in vitro and in vivo models","volume":"63","author":"Rizza","year":"2012","journal-title":"J. Cosmet. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/j.phytochem.2004.04.016","article-title":"Chalcones as potent tyrosinase inhibitors: The effect of hydroxyl positions and numbers","volume":"65","author":"Nerya","year":"2004","journal-title":"Phytochemistry"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.3390\/ijms10062440","article-title":"An updated review of tyrosinase inhibitors","volume":"10","author":"Chang","year":"2009","journal-title":"Int. J. Mol. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"22578","DOI":"10.3390\/molecules201219864","article-title":"Chemoprevention of breast cancer by dietary polyphenols","volume":"20","author":"Mocanu","year":"2015","journal-title":"Molecules"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"289392","DOI":"10.1155\/2013\/289392","article-title":"Cocoa polyphenols: Can we consider cocoa and chocolate as potential functional food?","volume":"2013","author":"Ackar","year":"2013","journal-title":"J. Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"322","DOI":"10.3390\/molecules18010322","article-title":"Molecular mechanism underlying anti-inflammatory and anti-allergic activities ofphytochemicals: An update","volume":"18","author":"Bellik","year":"2012","journal-title":"Molecules"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1021\/jf8033286","article-title":"Tyrosinase inhibitory polyphenols from roots of Morus lhou","volume":"57","author":"Jeong","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1080\/14756360701810207","article-title":"Inhibitory effects on mushroom tyrosinase by flavones from the stem barks of Morus lhou (S.) Koidz","volume":"23","author":"Ryu","year":"2008","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Dej-Adisai, S., Parndaeng, K., Wattanapiromsakul, C., and Hwang, J.S. (2021). Three New Isoprenylated Flavones from Artocarpus chama Stem and Their Bioactivities. Molecules, 27.","DOI":"10.3390\/molecules27010003"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Zhang, L., Tao, G., Chen, J., and Zheng, Z.-P. (2016). Characterization of a New Flavone and Tyrosinase Inhibition Constituents from the Twigs of Morus alba L.. Molecules, 21.","DOI":"10.3390\/molecules21091130"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1021\/jf0521855","article-title":"Flavonoids as mushroom tyrosinase inhibitors: A fluorescence quenching study","volume":"54","author":"Kim","year":"2006","journal-title":"J. Agric. Food Chem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.lwt.2019.02.076","article-title":"Relationships of dietary flavonoid structure with its tyrosinase inhibitory activity and affinity","volume":"107","author":"Fan","year":"2019","journal-title":"LWT"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1080\/14756366.2022.2061966","article-title":"Paving the way towards effective plant-based inhibitors of hyaluronidase and tyrosinase: A critical review on a structure\u2013activity relationship","volume":"37","author":"Graczyk","year":"2022","journal-title":"J. Enzyme. Inhib. Med. Chem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"8730","DOI":"10.3390\/molecules20058730","article-title":"Characterization of melanogenesis inhibitory constituents of Morus alba leaves and optimization of extraction conditions using response surface methodology","volume":"20","author":"Jeong","year":"2015","journal-title":"Molecules"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"487","DOI":"10.4172\/2161-0444.1000183","article-title":"Chalcone scaffold based antimycobacterial agents","volume":"4","author":"Macaev","year":"2014","journal-title":"Med. Chem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1248\/bpb.32.86","article-title":"Inhibitory effect of 2,4,2\u2032,4\u2032-tetrahydroxy-3-(3-methyl-2-butenyl)-chalcone on tyrosinase activity and melanin biosynthesis","volume":"32","author":"Zhang","year":"2009","journal-title":"Biol. Pharm. Bull."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"585","DOI":"10.5650\/jos.61.585","article-title":"A novel bioactive chalcone of Morus australis inhibits tyrosinase activity and melanin biosynthesis in B16 melanoma cells","volume":"61","author":"Takahashi","year":"2012","journal-title":"J. Oleo Sci."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Panzella, L., and Napolitano, A. (2019). Natural and bioinspired phenolic compounds as tyrosinase inhibitors for the treatment of skin hyperpigmentation: Recent advances. Cosmetics, 6.","DOI":"10.3390\/cosmetics6040057"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Wang, S., Liu, X.M., Zhang, J., and Zhang, Y.Q. (2014). An efficient preparation of mulberroside a from the branch bark of mulberry and its effect on the inhibition of tyrosinase activity. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0109396"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s10295-010-0722-9","article-title":"Biotransformation of mulberroside A from Morus alba results in enhancement of tyrosinase inhibition","volume":"37","author":"Kim","year":"2010","journal-title":"J. Ind. Microbiol. Biotechnol."},{"key":"ref_54","first-page":"1253","article-title":"Enhanced mulberroside a production from cell suspension and root cultures of Morus alba using elicitation","volume":"10","author":"Komaikul","year":"2015","journal-title":"Nat. Prod. Commun."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.1016\/j.fct.2011.09.008","article-title":"Inhibitory effect of mulberroside A and its derivatives on melanogenesis induced by ultraviolet B irradiation","volume":"49","author":"Park","year":"2011","journal-title":"Food Chem. Toxicol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/pca.2576","article-title":"Development of a Rapid Immunochromatographic Strip Test for the Detection of Mulberroside A","volume":"26","author":"Inyai","year":"2015","journal-title":"Phytochem. Anal."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1055\/s-0029-1186160","article-title":"Three major metabolites of mulberroside A in rat intestinal contents and feces","volume":"76","author":"Zhaxi","year":"2010","journal-title":"Planta Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"380692","DOI":"10.1155\/2013\/380692","article-title":"Variations in the leaves of mulberroside A, oxyresveratrol, and resveratrol in mulberries in different seasons and during growth","volume":"2013","author":"Zhou","year":"2013","journal-title":"Sci. World J."},{"key":"ref_59","first-page":"69","article-title":"Rapid analysis of oxyresveratrol-4-3\u2019-\u03b2-O-D-diglycosie in branch bark of mulberry by HPCE-DAD","volume":"1","author":"Zhao","year":"2013","journal-title":"Adv. Biomed. Eng. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"4","DOI":"10.4103\/0974-2077.110089","article-title":"Cosmeceuticals for hyperpigmentation: What is available?","volume":"6","author":"Sarkar","year":"2013","journal-title":"J. Cutan. Aesthet. Surg."},{"key":"ref_61","first-page":"103","article-title":"Pharmacological properties of traditional medicines (XXI) analysis of plasma, urine and bile of rats after oral administration of water extract of Mori Cortex","volume":"50","author":"Qiu","year":"1996","journal-title":"Nat. Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1021\/jf204495t","article-title":"In vitro pharmacokinetic characterization of mulberroside A, the main polyhydroxylated stilbene in mulberry (Morus alba L.), and its bacterial metabolite oxyresveratrol in traditional oral use","volume":"60","author":"Mei","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"495","DOI":"10.3109\/14756366.2011.598866","article-title":"Evaluation of the inhibition of mushroom tyrosinase and cellular tyrosinase activities of oxyresveratrol: Comparison with mulberroside A","volume":"27","author":"Kim","year":"2012","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1556\/JPC.24.2011.2.8","article-title":"Quantitative analysis of oxyresveratrol in different plant parts of Morus species and related genera by HPTLC and HPLC","volume":"24","author":"Ayinampudi","year":"2011","journal-title":"J. Planar. Chromatogr. Mod. TLC"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1002\/bmc.1309","article-title":"Identification of seven metabolites of oxyresveratrol in rat urine and bile using liquid chromatography\/tandem mass spectrometry","volume":"24","author":"Huang","year":"2010","journal-title":"Biomed. Chromatogr."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s00403-014-1440-3","article-title":"Effects of resveratrol, oxyresveratrol, and their acetylated derivatives on cellular melanogenesis","volume":"306","author":"Park","year":"2014","journal-title":"Arch. Dermatol. Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.5012\/bkcs.2014.35.12.3453","article-title":"Facile synthesis of natural moracin compounds using Pd(OAc)2\/P(tBu)3-HBF4 as a sonogashira coupling reagent","volume":"35","author":"Lee","year":"2014","journal-title":"Bull. Korean Chem. Soc."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1248\/bpb.25.1045","article-title":"Mulberroside F Isolated from the leaves of Morus alba inhibits melanin biosynthesis","volume":"25","author":"Lee","year":"2002","journal-title":"Biol. Pharm. Bull."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.ejmech.2014.11.047","article-title":"Bioactive benzofuran derivatives: Moracins A-Z in medicinal chemistry","volume":"90","author":"Naik","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"497","DOI":"10.4314\/tjpr.v15i3.10","article-title":"Determination of phytochemical compounds, and tyrosinase inhibitory and antimicrobial activities of bioactive compounds from Streblus ilicifolius (S Vidal) Corner","volume":"15","author":"Parndaeng","year":"2016","journal-title":"Trop. J. Pharm. Res."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Li, H.X., Park, J.U., Su, X.D., Kim, K.T., Kang, J.S., Kim, Y.R., Kim, Y.H., and Yang, S.Y. (2018). Identification of anti-melanogenesis constituents from Morus alba L.. leaves. Molecules, 23.","DOI":"10.3390\/molecules23102559"},{"key":"ref_72","first-page":"517","article-title":"Peel-off mask formulation from black mulberries (Morus nigra L.) leaves extract as a tyrosinase inhibitor","volume":"9","author":"Budiman","year":"2019","journal-title":"Int. J. Drug Deliv. Technol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"216","DOI":"10.4103\/jpbs.JPBS_57_18","article-title":"Formulation of antioxidant gel from black mulberry fruit extract (Morus nigra L.)","volume":"11","author":"Budiman","year":"2019","journal-title":"J. Pharm. Bioallied. Sci."},{"key":"ref_74","first-page":"97","article-title":"Whitening and antierythemic effect of a cream containing Morus alba extract","volume":"4","author":"Akhtar","year":"2012","journal-title":"Hygeia. J. D Med."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Memete, A.R., Timar, A.V., Vuscan, A., Miere Groza, F., Venter, A.C., and Vicas, S.I. (2022). Phytochemical composition of different botanical parts of Morus species, health benefits and application in food industry. Plants, 11.","DOI":"10.3390\/plants11020152"},{"key":"ref_76","first-page":"e115266","article-title":"Formulation and physicochemical evaluation of a 3% cream using crude 70% ethanolic extract of Morus alba L. leaves for skin hyperpigmentation","volume":"17","author":"Zakeri","year":"2022","journal-title":"Jundishapur J. Nat. Pharm. Prod."},{"key":"ref_77","first-page":"85","article-title":"Formulation and evaluation of Morus alba anti-aging cream","volume":"1","author":"Abhijith","year":"2021","journal-title":"Nat. J. Pharm."},{"key":"ref_78","first-page":"1025","article-title":"A comparative study of the safety and efficacy of 75% mulberry (Morus alba) extract oil versus placebo as a topical treatment for melasma: A randomized, single-blind, placebo-controlled trial","volume":"10","author":"Alvin","year":"2011","journal-title":"J. Drugs Dermatol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"134180","DOI":"10.1016\/j.molstruc.2022.134180","article-title":"The structural differences between mushroom and human tyrosinase cleared by investigating the inhibitory activities of stilbenes","volume":"1272","author":"Oyama","year":"2023","journal-title":"J. Mol. Struct."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1039\/C9MD00005D","article-title":"Thiosemicarbazones with tyrosinase inhibitory activity","volume":"10","author":"Latajka","year":"2019","journal-title":"Medchemcomm"}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/27\/24\/9011\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:43:16Z","timestamp":1760146996000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/27\/24\/9011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,17]]},"references-count":80,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["molecules27249011"],"URL":"https:\/\/doi.org\/10.3390\/molecules27249011","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,17]]}}}