{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:13:17Z","timestamp":1777662797210,"version":"3.51.4"},"reference-count":10,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T00:00:00Z","timestamp":1671580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["305250\/2019-1"],"award-info":[{"award-number":["305250\/2019-1"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>For dental caries and periodontal diseases initiated by dental plaque (as bacterial communities) and to inhibit the growth of oral pathogenic bacteria, oral care products containing antiseptic active ingredients are highly recommended, nonetheless, side effects of such actives are a concern (teeth discoloration\/staining and taste perception, for example). In this context, we challenged xylityl sesquicaprylate, an antiseptic compound from natural resources, as an active ingredient to be used in an alcohol-free mouthwash formulation. The xylityl sesquicaprylate sample was compared to a respective blank mouthwash formulation and one containing triclosan. The in vitro efficacy was screened by the time-kill assay against eight microorganisms. The xylityl sesquicaprylate-containing mouthwash (0.45% w\/w) presented a particularly interesting profile of efficacy against Actinomyces\u00a0viscosus, Fusobacterium nucleatum, Porphyromonas\u00a0gingivalis, and Tannerella forsythia, with results of greater magnitude to reduce the log10 of those microorganisms in comparison with the triclosan sample.<\/jats:p>","DOI":"10.3390\/molecules28010028","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T03:59:26Z","timestamp":1671595166000},"page":"28","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Xylityl Sesquicaprylate Efficacy as an Antiseptic Ingredient for Oral Care Products (Mouthwash): An In Vitro Screening Investigation against Eight Microorganisms"],"prefix":"10.3390","volume":"28","author":[{"given":"Cec\u00edlia","family":"Nogueira","sequence":"first","affiliation":[{"name":"Research and Development Department, Chemyunion Ltd., Sorocaba 18087-101, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliam","family":"Mussi","sequence":"additional","affiliation":[{"name":"Research and Development Department, Chemyunion Ltd., Sorocaba 18087-101, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9197-3024","authenticated-orcid":false,"given":"Andr\u00e9 Rolim","family":"Baby","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roseli","family":"Zupeli","sequence":"additional","affiliation":[{"name":"Research and Development Department, Phisalia Produtos de Beleza Ltd., Osasco 06276-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4530-2785","authenticated-orcid":false,"given":"Wagner Vidal","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Research and Development Department, Chemyunion Ltd., Sorocaba 18087-101, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"100273","DOI":"10.1016\/j.hermed.2019.100273","article-title":"Antiplaque and Antimicrobial Efficacy of Polyherbal Mouth Rinse among Adult Human Volunteers\u2014A Short Term Randomized Controlled Trial","volume":"17\u201318","author":"Chandrashekar","year":"2019","journal-title":"J. Herb. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1007\/s10068-020-00803-w","article-title":"Synergistic Antimicrobial Properties of Nanoencapsulated Clove Oil and Thymol against Oral Bacteria","volume":"29","author":"Lee","year":"2020","journal-title":"Food Sci. Biotechnol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.jsps.2018.03.017","article-title":"Use of Herbal Extract from Artemisia Herba-Alba (Shih) in Pharmaceutical Preparations for Dental Hygiene","volume":"26","author":"Mohammed","year":"2018","journal-title":"Saudi Pharm. J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"5657","DOI":"10.3390\/ijerph120505657","article-title":"Triclosan: Current Status, Occurrence, Environmental Risks and Bioaccumulation Potential","volume":"12","author":"Dhillon","year":"2015","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Morocho-J\u00e1come, A.L., Santos, B.B.D., Carvalho, J.C.M.D., Almeida, T.S.D., Rijo, P., Velasco, M.V.R., Rosado, C., and Baby, A.R. (2022). Microalgae as a Sustainable, Natural-Oriented and Vegan Dermocosmetic Bioactive Ingredient: The Case of Neochloris Oleoabundans. Cosmetics, 9.","DOI":"10.3390\/cosmetics9010009"},{"key":"ref_6","unstructured":"Pereda, M.D.C.V., Polezel, M.A., Dieamant, G.C., Nogueira, C., Mussi, L., Rossan, M.R., Correia, C.R.D., and Camilo, N.S. (2014). Xylitol Esters and Ethers Applied as Alternative Emulsifiers, Solvents, Co-Emulsifiers and Preservative Systems for Pharmaceutical and Cosmetic Products. (8716506B2), U.S. Patent."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Chaiwut, P., Jirarat, A., Tiensri, N., Sangthong, S., and Pintathong, P. (2022). Green Synthesis Optimization of Glucose Palm Oleate and Its Potential Use as Natural Surfactant in Cosmetic Emulsion. 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Sci."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/28\/1\/28\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:45:05Z","timestamp":1760147105000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/28\/1\/28"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,21]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["molecules28010028"],"URL":"https:\/\/doi.org\/10.3390\/molecules28010028","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,21]]}}}