{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T17:43:25Z","timestamp":1787247805406,"version":"build-2736575974"},"reference-count":63,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T00:00:00Z","timestamp":1671580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Education, Universities and Research","award":["PON-MIUR 03PE000_78_1"],"award-info":[{"award-number":["PON-MIUR 03PE000_78_1"]}]},{"name":"Ministry of Education, Universities and Research","award":["PON-MIUR 03PE000_78_2"],"award-info":[{"award-number":["PON-MIUR 03PE000_78_2"]}]},{"name":"Progetto AgrInfra Calabria","award":["PON-MIUR 03PE000_78_1"],"award-info":[{"award-number":["PON-MIUR 03PE000_78_1"]}]},{"name":"Progetto AgrInfra Calabria","award":["PON-MIUR 03PE000_78_2"],"award-info":[{"award-number":["PON-MIUR 03PE000_78_2"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Ornamental plants often gain relevance not only for their decorative use, but also as a source of phytochemicals with interesting healing properties. Herein, spontaneous Centranthus ruber (L.) DC. and Tropaeolum majus L., mainly used as ornamental species but also traditionally consumed and used in popular medicine, were investigated. The aerial parts were extracted with methanol trough maceration, and resultant crude extracts were partitioned using solvents with increasing polarity. As previous studies mostly dealt with the phenolic content of these species, the phytochemical investigation mainly focused on nonpolar constituents, detected with GC-MS. The total phenolic and flavonoid content was also verified, and HPTLC analyses were performed. In order to explore the potential antiarthritic and anti-obesity properties, extracts and their fractions were evaluated for their anti-denaturation effects, with the use of the BSA assay, and for their ability to inhibit pancreatic lipase. The antioxidant properties and the inhibitory activity on the NO production were verified, as well. Almost all the extracts and fractions demonstrated good inhibitory effects on NO production. The n-hexane and dichloromethane fractions from T. majus, as well as the n-hexane fraction from C. ruber, were effective in protecting the protein from heat-induced denaturation (IC50 = 154.0 \u00b1 1.9, 270.8 \u00b1 2.3 and 450.1 \u00b1 15.5 \u03bcg\/mL, respectively). The dichloromethane fractions from both raw extracts were also effective in inhibiting pancreatic lipase, with IC50 values equal to 2.23 \u00b1 0.02 mg\/mL (for C. ruber sample), and 2.05 \u00b1 0.02 mg\/mL (T. majus). Obtained results support the traditional use of these species for their beneficial health properties and suggest that investigated plant species could be potential sources of novel antiarthritic and anti-obesity agents.<\/jats:p>","DOI":"10.3390\/molecules28010032","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T04:28:55Z","timestamp":1671596935000},"page":"32","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Centranthus ruber (L.) DC. and Tropaeolum majus L.: Phytochemical Profile, In Vitro Anti-Denaturation Effects and Lipase Inhibitory Activity of Two Ornamental Plants Traditionally Used as Herbal Remedies"],"prefix":"10.3390","volume":"28","author":[{"given":"Vincenzo","family":"Musolino","sequence":"first","affiliation":[{"name":"Laboratory of Pharmaceutical Biology, Department of Health Sciences, Institute of Research for Food Safety and Health (IRC-FSH), University Magna Gr\u00e6cia of Catanzaro, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3741-4261","authenticated-orcid":false,"given":"Mariangela","family":"Marrelli","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, 87036 Cosenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rosaria","family":"Perri","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, 87036 Cosenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Palermo","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, 87036 Cosenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micaela","family":"Gliozzi","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Institute of Research for Food Safety and Health (IRC-FSH), University Magna Gr\u00e6cia of Catanzaro, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Mollace","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Institute of Research for Food Safety and Health (IRC-FSH), University Magna Gr\u00e6cia of Catanzaro, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6699-005X","authenticated-orcid":false,"given":"Filomena","family":"Conforti","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, 87036 Cosenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Mileva, M., Ilieva, Y., Jovtchev, G., Gateva, S., Zaharieva, M.M., Georgieva, A., Dimitrova, L., Dobreva, A., Angelova, T., and Vilhelmova-Ilieva, N. (2021). Rose flowers\u2014A delicate perfume or a natural healer?. Biomolecules, 11.","DOI":"10.3390\/biom11010127"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.5530\/jyp.2020.12.2","article-title":"Medicinal value of domiciliary ornamental plants of the Asteraceae family","volume":"12","author":"Saini","year":"2020","journal-title":"J. Young Pharm."},{"key":"ref_3","unstructured":"Holban, A.M. (2019). Nutrients in Beverages. The Science of Beverages, Academic Press."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.tifs.2011.04.006","article-title":"Fresh edible flowers of ornamental plants\u2013A new source of nutraceutical foods","volume":"22","author":"Mlcek","year":"2011","journal-title":"Trends Food Sci. Technol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Fuentes, J.L., Pedraza Barrera, C.A., Villamizar Mantilla, D.A., Fl\u00f3rez Gonz\u00e1lez, S.J., Sierra, L.J., Ocazionez, R.E., and Stashenko, E.E. (2022). Flower extracts from ornamental plants as sources of sunscreen ingredients: Determination by in vitro methods of photoprotective efficacy, antigenotoxicity and safety. Molecules, 27.","DOI":"10.3390\/molecules27175525"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e20180468","DOI":"10.1590\/0001-3765201920180468","article-title":"Antibacterial and cytotoxicity activities and phytochemical analysis of three ornamental plants grown in Mexico","volume":"91","year":"2019","journal-title":"An. Acad. Bras. Cienc."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s10340-007-0173-x","article-title":"Screening of medicinal and ornamental plants for insecticidal and growth regulating activity","volume":"80","author":"Alexenizer","year":"2007","journal-title":"J. Pest Sci."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Marrelli, M., Statti, G., and Conforti, F. (2020). A review of biologically active natural products from Mediterranean wild edible plants: Benefits in the treatment of obesity and its related disorders. Molecules, 25.","DOI":"10.3390\/molecules25030649"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1002\/jsfa.6544","article-title":"In vitro investigation of the potential health benefits of wild Mediterranean dietary plants as anti-obesity agents with \u03b1-amylase and pancreatic lipase inhibitory activities","volume":"94","author":"Marrelli","year":"2014","journal-title":"J. Sci. Food Agric."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1007\/s11130-013-0390-9","article-title":"Inhibition of key enzymes linked to obesity by preparations from Mediterranean dietary plants: Effects on \u03b1-amylase and pancreatic lipase activities","volume":"68","author":"Marrelli","year":"2013","journal-title":"Plant Foods Hum. Nutr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1002\/ptr.3603","article-title":"Wild Mediterranean dietary plants as inhibitors of pancreatic lipase","volume":"26","author":"Conforti","year":"2012","journal-title":"Phytother. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/j.foodchem.2011.05.085","article-title":"Bioactive phytonutrients (omega fatty acids, tocopherols, polyphenols), in vitro inhibition of nitric oxide production and free radical scavenging activity of non-cultivated Mediterranean vegetables","volume":"129","author":"Conforti","year":"2011","journal-title":"Food Chem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jep.2007.11.015","article-title":"In vivo anti-inflammatory and in vitro antioxidant activities of Mediterranean dietary plants","volume":"116","author":"Conforti","year":"2008","journal-title":"J. Ethnopharmacol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.foodchem.2008.06.013","article-title":"The protective ability of Mediterranean dietary plants against the oxidative damage: The role of radical oxygen species in inflammation and the polyphenol, flavonoid and sterol contents","volume":"112","author":"Conforti","year":"2009","journal-title":"Food Chem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.fct.2015.09.011","article-title":"Inhibitory effects of wild dietary plants on lipid peroxidation and on the proliferation of human cancer cells","volume":"86","author":"Marrelli","year":"2015","journal-title":"Food Chem. Toxicol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.sajb.2019.11.029","article-title":"Potential use in the treatment of inflammatory disorders and obesity of selected wild edible plants from Calabria region (Southern Italy)","volume":"128","author":"Marrelli","year":"2020","journal-title":"S. Afr. J. Bot."},{"key":"ref_17","unstructured":"WFO (2022, November 09). Centranthus ruber (L.) DC. Available online: http:\/\/www.worldfloraonline.org\/taxon\/wfo-0000594324."},{"key":"ref_18","first-page":"151","article-title":"Checklist dei generi e delle famiglie della flora vascolare italiana","volume":"42","author":"Peruzzi","year":"2010","journal-title":"Inform. Bot. Ital."},{"key":"ref_19","first-page":"243","article-title":"Taxonomic significance of palynomorphological characteristics of selected Centranthus (Caprifoliaceae) species","volume":"20","author":"Tsymbalyuk","year":"2021","journal-title":"Hacquetia"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Das, G., Shin, H.S., Tundis, R., Gon\u00e7alves, S., Tantengco, O.A.G., Campos, M.G., Acquaviva, R., Malfa, G.A., Romano, A., and Robles, J.A.H. (2021). Plant Species of Sub-Family Valerianaceae\u2014A Review on Its Effect on the Central Nervous System. Plants, 10.","DOI":"10.3390\/plants10050846"},{"key":"ref_21","first-page":"a2345","article-title":"Invasive potential and management of naturalised ornamentals across an urban environmental gradient with a focus on Centranthus ruber","volume":"48","author":"Holmes","year":"2018","journal-title":"Afr. Biodivers. Conserv."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"C46","DOI":"10.1111\/j.1750-3841.2010.01949.x","article-title":"Wild Mediterranean plants as traditional food: A valuable source of antioxidants","volume":"76","author":"Vanzani","year":"2011","journal-title":"J. Food Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.chroma.2018.10.044","article-title":"Purification of two valepotriates from Centranthus ruber by centrifugal partition chromatography: From analytical to preparative scale","volume":"1580","author":"Chami","year":"2018","journal-title":"J. Chromatogr. A"},{"key":"ref_24","first-page":"119","article-title":"Garden nasturtium (Tropaeolum majus L.)-a source of mineral elements and bioactive compounds","volume":"69","author":"Jakubczyk","year":"2018","journal-title":"Rocz. Panstw. Zakl. Hig."},{"key":"ref_25","first-page":"391","article-title":"The effect of Tropaeolum majus L. on bacterial infections and in vitro efficacy on apoptosis and DNA lesions in hyperosmotic stress","volume":"69","author":"Jurca","year":"2018","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.foodchem.2008.09.013","article-title":"Major anthocyanins and antioxidant activity of Nasturtium flowers (Tropaeolum majus)","volume":"114","author":"Wrolstad","year":"2009","journal-title":"Food Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.jep.2012.05.023","article-title":"Evaluation of subchronic toxicity of the hydroethanolic extract of Tropaeolum majus in Wistar rats","volume":"142","author":"Gomes","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1021\/jf503366c","article-title":"Identification of phenolic compounds in petals of nasturtium flowers (Tropaeolum majus) by high-performance liquid chromatography coupled to mass spectrometry and determination of oxygen radical absorbance capacity (ORAC)","volume":"63","author":"Manns","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"S605","DOI":"10.1111\/j.1365-2621.2005.tb08336.x","article-title":"Flowers and leaves of Tropaeolum majus L. as rich sources of lutein","volume":"70","author":"Niizu","year":"2005","journal-title":"J. Food Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.indcrop.2013.07.003","article-title":"Comparison of antioxidant, anti-inflammatory, antimicrobial activity and chemical composition of aqueous and hydroethanolic extracts of the herb of Tropaeolum majus L.","volume":"50","author":"Bazylko","year":"2013","journal-title":"Ind. Crops Prod."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.jep.2010.12.026","article-title":"Antihypertensive effects of isoquercitrin and extracts from Tropaeolum majus L.: Evidence for the inhibition of angiotensin converting enzyme","volume":"134","author":"Gasparotto","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.jep.2012.03.018","article-title":"Mechanisms underlying the diuretic effects of Tropaeolum majus L. extracts and its main component isoquercitrin","volume":"141","author":"Prando","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"251","DOI":"10.5530\/jyp.2017.9.49","article-title":"Protective cardiorenal effects of Tropaeolum majus L. in rats with renovascular hypertension","volume":"9","author":"Prando","year":"2017","journal-title":"J. Young Pharm."},{"key":"ref_34","first-page":"5900","article-title":"Antimicrobial and anti-inflammatory activities of the volatile oil compounds from Tropaeolum majus L. (Nasturtium)","volume":"10","author":"Butnariu","year":"2011","journal-title":"Afr. J. Biotechnol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.bone.2016.01.019","article-title":"Inflammatory mediators in osteoarthritis: A critical review of the state-of-the-art, current prospects, and future challenges","volume":"85","author":"Rahmati","year":"2016","journal-title":"Bone"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.phymed.2016.02.025","article-title":"Nasturtium (Indian cress, Tropaeolum majus nanum) dually blocks the COX and LOX pathway in primary human immune cells","volume":"23","author":"Tran","year":"2016","journal-title":"Phytomedicine"},{"key":"ref_37","unstructured":"(2012). The modern analytical determination of botanicals and similar novel natural products by the HPTLC fingerprint approach. Studies in Natural Products Chemistry, Elsevier."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Kowalska, T., and Sajewicz, M. (2022). Thin-Layer Chromatography (TLC) in the Screening of Botanicals\u2013Its Versatile Potential and Selected Applications. Molecules, 27.","DOI":"10.20944\/preprints202207.0355.v1"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.freeradbiomed.2007.04.026","article-title":"Methods to detect nitric oxide and its metabolites in biological samples","volume":"43","author":"Bryan","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"ref_40","first-page":"8","article-title":"New arthritis foundation guidelines on CBD use could be first of many more to come","volume":"26","author":"Khaleghi","year":"2020","journal-title":"Altern. Ther. Health Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1093\/ecam\/neh117","article-title":"Biological basis for the use of botanicals in osteoarthritis and rheumatoid arthritis: A review","volume":"2","author":"Ahmed","year":"2005","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_42","first-page":"3","article-title":"Medicinal plants in the treatment of arthritis","volume":"2","author":"Subramoniam","year":"2013","journal-title":"Ann. Phytomed."},{"key":"ref_43","first-page":"131","article-title":"A review on plants having anti-arthritic potential","volume":"7","author":"Arya","year":"2011","journal-title":"Int. J. Pharm. Sci. Rev. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.hermed.2018.08.003","article-title":"Ethnopharmacological profile of anti-arthritic plants of Asia-a systematic review","volume":"13","author":"Sadia","year":"2018","journal-title":"J. Herb. Med."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Marrelli, M., Amodeo, V., Perri, M.R., Conforti, F., and Statti, G. (2020). Essential oils and bioactive components against arthritis: A novel perspective on their therapeutic potential. Plants, 9.","DOI":"10.3390\/plants9101252"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Marrelli, M., Conforti, F., Araniti, F., and Statti, G.A. (2016). Effects of saponins on lipid metabolism: A review of potential health benefits in the treatment of obesity. Molecules, 21.","DOI":"10.3390\/molecules21101404"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"133955","DOI":"10.1080\/16546628.2017.1339555","article-title":"Anti-adipogenic effects of Tropaeolum majus (Nasturtium) ethanol extract on 3T3-L1 cells","volume":"61","author":"Kim","year":"2017","journal-title":"Food Nutr. Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"4369","DOI":"10.1007\/s13197-014-1488-2","article-title":"Anti-obesity and cardioprotective effects of cinnamic acid in high fat diet-induced obese rats","volume":"52","author":"Mnafgui","year":"2015","journal-title":"J. Food Sci. Technol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Lee, H.G., Kim, H.S., Je, J.G., Hwang, J., Sanjeewa, K.A., Lee, D.S., Song, K.M., Choi, Y.S., Kang, M.C., and Jeon, Y.J. (2021). Lipid inhibitory effect of (\u2212)-loliolide isolated from Sargassum horneri in 3T3-L1 adipocytes: Inhibitory mechanism of adipose-specific proteins. Mar. Drugs, 19.","DOI":"10.3390\/md19020096"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Marrelli, M., Morrone, F., Argentieri, M.P., Gambacorta, L., Conforti, F., and Avato, P. (2018). Phytochemical and biological profile of Moricandia arvensis (L.) DC.: An inhibitor of pancreatic lipase. Molecules, 23.","DOI":"10.3390\/molecules23112829"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"144","DOI":"10.5344\/ajev.1965.16.3.144","article-title":"Colorimetry of total phenolics with phosphomolybdic-Phosphotungstic acid reagents","volume":"16","author":"Singleton","year":"1965","journal-title":"Am. J. Enol. Vitic."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"5183","DOI":"10.1021\/jf049645z","article-title":"Total phenolics and antioxidant activities of fenugreek, green tea, black tea, grape seed, ginger, rosemary, gotu kola, and ginkgo extracts, vitamin E, and tert-butylhydroquinone","volume":"52","author":"Rababah","year":"2004","journal-title":"J. Agric. Food Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"633","DOI":"10.3109\/10715762.2014.996146","article-title":"Advantages and limitations of common testing methods for antioxidants","volume":"49","author":"Amorati","year":"2015","journal-title":"Free Radic. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.foodchem.2005.04.028","article-title":"Antioxidant activity of some Algerian medicinal plants extracts containing phenolic compounds","volume":"97","author":"Djeridane","year":"2006","journal-title":"Food Chem."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Amodeo, V., Marrelli, M., Pontieri, V., Cassano, R., Trombino, S., Conforti, F., and Statti, G. (2019). Chenopodium album L. and Sisymbrium officinale (L.) Scop.: Phytochemical content and in vitro antioxidant and anti-inflammatory potential. Plants, 8.","DOI":"10.3390\/plants8110505"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1080\/14786419.2010.545356","article-title":"Comparative chemical composition and antioxidant activity of Calamintha nepeta (L.) Savi subsp. glandulosa (Req.) Nyman and Calamintha grandiflora (L.) Moench (Labiatae)","volume":"26","author":"Conforti","year":"2012","journal-title":"Nat.-Prod. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.indcrop.2017.01.016","article-title":"Variation of Malva sylvestris essential oil yield, chemical composition and biological activity in response to different environments across Southern Italy","volume":"98","author":"Delfine","year":"2017","journal-title":"Ind. Crops Prod."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"100235","DOI":"10.1016\/j.phyplu.2022.100235","article-title":"Phytochemical and biological characterization of dry outer scales extract from Tropea red onion (Allium cepa L. var. Tropea)\u2013A promising inhibitor of pancreatic lipase","volume":"2","author":"Marrelli","year":"2022","journal-title":"Phytomedicine Plus"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"147","DOI":"10.5455\/jice.20150313021918","article-title":"Medicinal plants with potential anti-arthritic activity","volume":"4","author":"Choudhary","year":"2015","journal-title":"J. Intercult. Ethnopharmacol."},{"key":"ref_60","first-page":"44","article-title":"Herbal plants used in treatment of rheumatoid arthritis: A review","volume":"4","author":"Kaur","year":"2012","journal-title":"Int. J. Pharm. Pharm. Sci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1080\/10408398.2020.1769548","article-title":"Effects and mechanisms of edible and medicinal plants on obesity: An updated review","volume":"61","author":"Shang","year":"2021","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"110314","DOI":"10.1016\/j.biopha.2020.110314","article-title":"Lipase inhibitors for obesity: A review","volume":"128","author":"Liu","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"339","DOI":"10.3415\/VCOT-08-08-0069","article-title":"A review of osteoarthritis and obesity: Current understanding of the relationship and benefit of obesity treatment and prevention in the dog","volume":"22","author":"Marshall","year":"2009","journal-title":"Veter Comp. Orthop. Traumatol."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/28\/1\/32\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:45:08Z","timestamp":1760147108000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/28\/1\/32"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,21]]},"references-count":63,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["molecules28010032"],"URL":"https:\/\/doi.org\/10.3390\/molecules28010032","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,21]]}}}