{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:42:18Z","timestamp":1762080138938,"version":"build-2065373602"},"reference-count":34,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T00:00:00Z","timestamp":1671580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Zhejiang Provincial Natural Science Foundation of China","doi-asserted-by":"publisher","award":["LTGN23C140002","LY19C140002","LY19B020009","KYY-HX-20210140","KYY-HX-20190720","2022CG02","2022JCY04","58-6060-1-001"],"award-info":[{"award-number":["LTGN23C140002","LY19C140002","LY19B020009","KYY-HX-20210140","KYY-HX-20190720","2022CG02","2022JCY04","58-6060-1-001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chemical Company for Research","award":["LTGN23C140002","LY19C140002","LY19B020009","KYY-HX-20210140","KYY-HX-20190720","2022CG02","2022JCY04","58-6060-1-001"],"award-info":[{"award-number":["LTGN23C140002","LY19C140002","LY19B020009","KYY-HX-20210140","KYY-HX-20190720","2022CG02","2022JCY04","58-6060-1-001"]}]},{"name":"Open Fund of Key Laboratory of Study, Discovery of Small Targeted Molecules of Hunan Province","award":["LTGN23C140002","LY19C140002","LY19B020009","KYY-HX-20210140","KYY-HX-20190720","2022CG02","2022JCY04","58-6060-1-001"],"award-info":[{"award-number":["LTGN23C140002","LY19C140002","LY19B020009","KYY-HX-20210140","KYY-HX-20190720","2022CG02","2022JCY04","58-6060-1-001"]}]},{"name":"Institute for Frontiers and Interdisciplinary Sciences, Zhejiang University of Technology","award":["LTGN23C140002","LY19C140002","LY19B020009","KYY-HX-20210140","KYY-HX-20190720","2022CG02","2022JCY04","58-6060-1-001"],"award-info":[{"award-number":["LTGN23C140002","LY19C140002","LY19B020009","KYY-HX-20210140","KYY-HX-20190720","2022CG02","2022JCY04","58-6060-1-001"]}]},{"DOI":"10.13039\/100000199","name":"USDA","doi-asserted-by":"publisher","award":["LTGN23C140002","LY19C140002","LY19B020009","KYY-HX-20210140","KYY-HX-20190720","2022CG02","2022JCY04","58-6060-1-001"],"award-info":[{"award-number":["LTGN23C140002","LY19C140002","LY19B020009","KYY-HX-20210140","KYY-HX-20190720","2022CG02","2022JCY04","58-6060-1-001"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Natural products are a source for pesticide or drug discovery. In order to discover lead compounds with high fungicidal or herbicidal activity, new niacinamide derivatives derived from the natural product niacinamide, containing chiral flexible chains, were designed and synthesized. Their structures were confirmed by 1H NMR, 13C NMR and HRMS analysis. The fungicidal and herbicidal activities of these compounds were tested. The fungicidal activity results demonstrated that the compound (S)-2-(2-chloronicotinamido)propyl-2-methylbenzoate (3i) exhibited good fungicidal activity (92.3% inhibition) against the plant pathogen Botryosphaeria berengriana at 50 \u03bcg\/mL and with an EC50 of 6.68 \u00b1 0.72 \u03bcg\/mL, which is the same as the positive control (fluxapyroxad). Compound 3i was not phytotoxic and could therefore be used as a fungicide on crops. Structure-activity relationships (SAR) were studied by molecular docking simulations with the succinate dehydrogenase of the fungal mitochondrial respiratory chain.<\/jats:p>","DOI":"10.3390\/molecules28010047","type":"journal-article","created":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T02:31:11Z","timestamp":1671676271000},"page":"47","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Synthesis and Pesticidal Activity of New Niacinamide Derivatives Containing a Flexible, Chiral Chain"],"prefix":"10.3390","volume":"28","author":[{"given":"Zhe-Cheng","family":"Wei","sequence":"first","affiliation":[{"name":"College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiao","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2209-4226","authenticated-orcid":false,"given":"Li-Jing","family":"Min","sequence":"additional","affiliation":[{"name":"Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, College of Life Science, Huzhou University, Huzhou 313000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Bajsa-Hirschel","sequence":"additional","affiliation":[{"name":"Natural Products Utilization Research Unit, Agricultural Research Service, U.S. Department of Agriculture, Oxford, MS 38677, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5163-9045","authenticated-orcid":false,"given":"Charles L.","family":"Cantrell","sequence":"additional","affiliation":[{"name":"Natural Products Utilization Research Unit, Agricultural Research Service, U.S. Department of Agriculture, Oxford, MS 38677, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Han","sequence":"additional","affiliation":[{"name":"College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1000-8578","authenticated-orcid":false,"given":"Cheng-Xia","family":"Tan","sequence":"additional","affiliation":[{"name":"College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5513-6421","authenticated-orcid":false,"given":"Jian-Quan","family":"Weng","sequence":"additional","affiliation":[{"name":"College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Xin","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Elemento-Organic Chemistry, Department of Chemistry, Nankai University, Tianjin 300071, China"},{"name":"Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, Hunan Normal University, Changsha 430081, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na-Bo","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Biology and Environmental Engineering, Zhejiang Shuren University, Hangzhou 310015, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7210-5168","authenticated-orcid":false,"given":"Stephen O.","family":"Duke","sequence":"additional","affiliation":[{"name":"National Center for Natural Product Research, School of Pharmacy, University of Mississippi, Oxford, MS 38677, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1464-1426","authenticated-orcid":false,"given":"Xing-Hai","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4557","DOI":"10.1002\/ps.7075","article-title":"Guaiacol as a natural melanin biosynthesis inhibitor to control northern corn leaf blight","volume":"78","author":"Wang","year":"2022","journal-title":"Pest Manag. 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