{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T04:47:53Z","timestamp":1783572473969,"version":"3.55.0"},"reference-count":46,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T00:00:00Z","timestamp":1671580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research, Development and Innovation Office-NKFIA (Hungary)","award":["TKP-2021-EGA-32"],"award-info":[{"award-number":["TKP-2021-EGA-32"]}]},{"name":"National Research, Development and Innovation Office-NKFIA (Hungary)","award":["K124544"],"award-info":[{"award-number":["K124544"]}]},{"name":"National Research, Development and Innovation Office-NKFIA (Hungary)","award":["LP2019-6\/2019"],"award-info":[{"award-number":["LP2019-6\/2019"]}]},{"name":"National Research, Development and Innovation Office-NKFIA (Hungary)","award":["BO\/00158\/22\/5"],"award-info":[{"award-number":["BO\/00158\/22\/5"]}]},{"name":"\u2018Lend\u00fclet\u2019 Programme","award":["TKP-2021-EGA-32"],"award-info":[{"award-number":["TKP-2021-EGA-32"]}]},{"name":"\u2018Lend\u00fclet\u2019 Programme","award":["K124544"],"award-info":[{"award-number":["K124544"]}]},{"name":"\u2018Lend\u00fclet\u2019 Programme","award":["LP2019-6\/2019"],"award-info":[{"award-number":["LP2019-6\/2019"]}]},{"name":"\u2018Lend\u00fclet\u2019 Programme","award":["BO\/00158\/22\/5"],"award-info":[{"award-number":["BO\/00158\/22\/5"]}]},{"name":"J\u00e1nos Bolyai Research Scholarship","award":["TKP-2021-EGA-32"],"award-info":[{"award-number":["TKP-2021-EGA-32"]}]},{"name":"J\u00e1nos Bolyai Research Scholarship","award":["K124544"],"award-info":[{"award-number":["K124544"]}]},{"name":"J\u00e1nos Bolyai Research Scholarship","award":["LP2019-6\/2019"],"award-info":[{"award-number":["LP2019-6\/2019"]}]},{"name":"J\u00e1nos Bolyai Research Scholarship","award":["BO\/00158\/22\/5"],"award-info":[{"award-number":["BO\/00158\/22\/5"]}]},{"name":"\u00daNKP-22-5-SZTE-588 New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund","award":["TKP-2021-EGA-32"],"award-info":[{"award-number":["TKP-2021-EGA-32"]}]},{"name":"\u00daNKP-22-5-SZTE-588 New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund","award":["K124544"],"award-info":[{"award-number":["K124544"]}]},{"name":"\u00daNKP-22-5-SZTE-588 New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund","award":["LP2019-6\/2019"],"award-info":[{"award-number":["LP2019-6\/2019"]}]},{"name":"\u00daNKP-22-5-SZTE-588 New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund","award":["BO\/00158\/22\/5"],"award-info":[{"award-number":["BO\/00158\/22\/5"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A series of novel estradiol-based salicylaldehyde (thio)semicarbazones ((T)SCs) bearing (O,N,S) and (O,N,O) donor sets and their Cu(II) complexes were developed and characterized in detail by 1H and \u00b9\u00b3C nuclear magnetic resonance spectroscopy, UV\u2013visible and electron paramagnetic resonance spectroscopy, electrospray ionization mass spectrometry and elemental analysis. The structure of the Cu(II)-estradiol-semicarbazone complex was revealed by X-ray crystallography. Proton dissociation constants of the ligands and stability constants of the metal complexes were determined in 30% (v\/v) DMSO\/H2O. Estradiol-(T)SCs form mono-ligand complexes with Cu(II) ions and exhibit high stability with the exception of estradiol-SC. The Cu(II) complexes of estradiol-TSC and its N,N-dimethyl derivative displayed the highest cytotoxicity among the tested compounds in MCF-7, MCF-7 KCR, DU-145, and A549 cancer cells. The complexes do not damage DNA according to both in vitro cell-free and cellular assays. All the Cu(II)-TSC complexes revealed significant activity against the Gram-positive Staphylococcus aureus bacteria strain. Estradiol-TSCs showed efficient antioxidant activity, which was decreased by complexation with Cu(II) ions. The exchange of estrone moiety to estradiol did not result in significant changes to physico-chemical and biological properties.<\/jats:p>","DOI":"10.3390\/molecules28010054","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T06:42:57Z","timestamp":1671604977000},"page":"54","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Estradiol-Based Salicylaldehyde (Thio)Semicarbazones and Their Copper Complexes with Anticancer, Antibacterial and Antioxidant Activities"],"prefix":"10.3390","volume":"28","author":[{"given":"Tatsiana V.","family":"Petrasheuskaya","sequence":"first","affiliation":[{"name":"Department of Inorganic and Analytical Chemistry, Interdisciplinary Excellence Centre, University of Szeged, D\u00f3m t\u00e9r 7, H-6720 Szeged, Hungary"},{"name":"MTA-SZTE Lend\u00fclet Functional Metal Complexes Research Group, University of Szeged, D\u00f3m t\u00e9r 7, H-6720 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Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4770-4681","authenticated-orcid":false,"given":"N\u00f3ra V.","family":"May","sequence":"additional","affiliation":[{"name":"Centre for Structural Science, Research Centre for Natural Sciences, Magyar tud\u00f3sok k\u00f6r\u00fatja 2, H-1117 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8085-0950","authenticated-orcid":false,"given":"Gabriella","family":"Spengler","sequence":"additional","affiliation":[{"name":"MTA-SZTE Lend\u00fclet Functional Metal Complexes Research Group, University of Szeged, D\u00f3m t\u00e9r 7, H-6720 Szeged, Hungary"},{"name":"Department of Medical Microbiology, Albert Szent-Gy\u00f6rgyi Health Center and Albert Szent-Gy\u00f6rgyi Medical School, University of Szeged, Semmelweis u. 6, H-6725 Szeged, 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