{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T19:27:58Z","timestamp":1780601278493,"version":"3.54.1"},"reference-count":58,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:00:00Z","timestamp":1671753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science, Technology and Innovation","award":["C-FP44842-212-2018"],"award-info":[{"award-number":["C-FP44842-212-2018"]}]},{"name":"Ministry of Education","award":["C-FP44842-212-2018"],"award-info":[{"award-number":["C-FP44842-212-2018"]}]},{"name":"Ministry of Industry, Commerce and Tourism","award":["C-FP44842-212-2018"],"award-info":[{"award-number":["C-FP44842-212-2018"]}]},{"name":"ICETEX","award":["C-FP44842-212-2018"],"award-info":[{"award-number":["C-FP44842-212-2018"]}]},{"name":"Programme Ecosistema Cient\u00edfico-Colombia Cient\u00edfica, from the Francisco Jos\u00e9 de Caldas Fund","award":["C-FP44842-212-2018"],"award-info":[{"award-number":["C-FP44842-212-2018"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Candida albicans infections are related to biofilm formation. The increase in antifungal resistance and their adverse effects have led to the search for therapeutic options as plant derivatives. This scoping review aims to identify the current status of in vitro research on the cytotoxicity and inhibitory effects of plant derivatives on C. albicans biofilms. In this study, PRISMA items were followed. After recognition of the inclusion criteria, full texts were read and disagreements were resolved with a third party. A risk of bias assessment was performed, and information was summarized using Microsoft Office Excel. Thirty-nine papers fulfilling the selection criteria were included. The risk of bias analysis identified most of the studies as low risk. Studies evaluated plant derivatives such as extracts, essential oils, terpenes, alkaloids, flavonoids and polyphenols. Some studies evaluated the inhibition of C. albicans biofilm formation, inhibition on preformed biofilms or both. The derivatives at concentrations greater than or equal to those that have an inhibitory effect on C. albicans biofilms, without showing cytotoxicity, include magnoflorin, ellagic acid, myricetin and eucarobustol from Eucalyptus robusta and, as the works in which these derivatives were studied are of good quality, it is desirable to carry out study in other experimental phases, with methodologies that generate comparable information.<\/jats:p>","DOI":"10.3390\/molecules28010130","type":"journal-article","created":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T02:53:11Z","timestamp":1672109591000},"page":"130","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Cytotoxic and Inhibitory Effects of Plant Derivatives on Candida albicans Biofilms: A Scoping Review"],"prefix":"10.3390","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6839-1982","authenticated-orcid":false,"given":"Manuela","family":"Loaiza-Oliva","sequence":"first","affiliation":[{"name":"Laboratory of Oral Microbiology, Faculty of Dentistry, Universidad de Antioquia, Medell\u00edn 050010, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Arias-Durango","sequence":"additional","affiliation":[{"name":"Laboratory of Oral Microbiology, Faculty of Dentistry, Universidad de Antioquia, Medell\u00edn 050010, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8115-3089","authenticated-orcid":false,"given":"Mar\u00eda Cecilia","family":"Mart\u00ednez-Pab\u00f3n","sequence":"additional","affiliation":[{"name":"Laboratory of Oral Microbiology, Faculty of Dentistry, Universidad de Antioquia, Medell\u00edn 050010, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmed.2018.00028","article-title":"Candida biofilms: Threats, challenges, and promising strategies","volume":"5","author":"Cavalheiro","year":"2018","journal-title":"Front. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/myc.12470","article-title":"Epidemiology, risk factor, species distribution, antifungal resistance and outcome of candidemia at a single French hospital: A 7-year study","volume":"59","author":"Tadec","year":"2016","journal-title":"Mycoses"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12879-017-2636-x","article-title":"Evaluation of candidemia in epidemiology and risk factors among cancer patients in a cancer center of China: An 8-year case-control study","volume":"17","author":"Li","year":"2017","journal-title":"BMC Infect. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"328","DOI":"10.3109\/1040841X.2011.585606","article-title":"Oral candidosis clinical challenges of a biofilm disease","volume":"37","author":"Rautemaa","year":"2011","journal-title":"Crit. Rev. Microbiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/femsyr\/fov077","article-title":"Polymicrobial Candida biofilms: Friends and foe in the oral cavity","volume":"15","author":"Donnell","year":"2015","journal-title":"FEMS Yeast Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.idc.2006.07.004","article-title":"Invasive candidiasis","volume":"20","author":"Pappas","year":"2006","journal-title":"Infect. Dis. Clin. N. Am."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/jop.12152","article-title":"The role of oral flora in the development of chemotherapy-induced oral mucositis","volume":"44","author":"Stringer","year":"2015","journal-title":"J. Oral Pathol. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/odi.12224","article-title":"Microbiota and their role in the pathogenesis of oral mucositis","volume":"21","author":"Vanhoecke","year":"2014","journal-title":"Oral Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/s40496-015-0069-4","article-title":"Oral mucositis induced by anticancer therapies","volume":"2","author":"Zecha","year":"2015","journal-title":"Curr. Oral Heal. Rep."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.cden.2013.12.005","article-title":"Chemotherapy or radiation- induced oral mucositis oral mucositis stomatitis cancer chemotherapy radiation therapy","volume":"58","author":"Lalla","year":"2014","journal-title":"Dent. Clin. N. Am."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S0966-842X(02)00002-1","article-title":"Candida biofilms and their role in infection","volume":"11","author":"Douglas","year":"2003","journal-title":"Trends Microbiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/femspd\/ftw018","article-title":"Pathogenesis of Candida albicans biofilm","volume":"74","author":"Tsui","year":"2016","journal-title":"Pathog. Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s12275-016-5514-0","article-title":"Interaction of Candida albicans with host cells: Virulence factors, host defense, escape strategies, and the microbiota","volume":"54","author":"Mogavero","year":"2016","journal-title":"J. Microbiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.mib.2011.06.001","article-title":"Mucosal biofilms of Candida albicans","volume":"14","author":"Ganguly","year":"2012","journal-title":"Curr. Opin. Microbiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"845352","DOI":"10.1155\/2012\/845352","article-title":"Candida biofilms and the host: Models and new concepts for eradication","volume":"2012","author":"Tournu","year":"2012","journal-title":"Int. J. Microbiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12906-019-2730-2","article-title":"Determination of the effects of cinnamon bark fractions on Candida albicans and oral epithelial cells","volume":"19","author":"Veilleux","year":"2019","journal-title":"BMC Complement Altern. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1021\/acsinfecdis.9b00033","article-title":"Inhibition of biofilm formation by Candida albicans and polymicrobial microorganisms by nepodin via hyphal-growth suppression","volume":"5","author":"Lee","year":"2019","journal-title":"ACS Infect. Dis."},{"key":"ref_18","first-page":"1851740","article-title":"Lycorine hydrochloride inhibits the virulence traits of Candida albicans","volume":"2019","author":"Yang","year":"2019","journal-title":"BioMed Res. Int."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Ribeiro, S.M., Fratucelli, \u00c9.D.O., Bueno, P.C.P., de Castro, M.K.V., Francisco, A.A., Cavalheiro, A.J., and Klein, M.I. (2019). Antimicrobial and antibiofilm activities of Casearia Sylvestris extracts from distinct brazilian biomes against Streptococcus mutans and Candida albicans. BMC Complement Altern. Med., 19.","DOI":"10.1186\/s12906-019-2717-z"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11274-018-2549-x","article-title":"Antifungal activity of magnoflorine against Candida Strains","volume":"34","author":"Kim","year":"2018","journal-title":"World J. Microbiol. Biotechnol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.ijbiomac.2017.12.039","article-title":"PgTeL, the lectin found in Punica Granatum Juice, is an antifungal agent against Candida albicans and Candida krusei","volume":"108","author":"Gomes","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"4651726","DOI":"10.1155\/2018\/4651726","article-title":"Dioscin inhibits virulence factors of Candida albicans","volume":"2018","author":"Yang","year":"2018","journal-title":"BioMed Res. Int."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.mycmed.2017.12.011","article-title":"Dracorhodin perchlorate inhibits biofilm formation and virulence factors of Candida albicans","volume":"28","author":"Yang","year":"2018","journal-title":"J. Mycol. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2217\/fmb-2016-0094","article-title":"Plant extracts: Initial screening, identification of bioactive compounds and effect against Candida albicans biofilms","volume":"12","author":"Salvador","year":"2017","journal-title":"Future Microbiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"685","DOI":"10.4014\/jmb.1607.07072","article-title":"Activity of Allyl isothiocyanate and its synergy with fluconazole against Candida albicans biofilms","volume":"27","author":"Raut","year":"2017","journal-title":"J. Microbiol. Biotechnol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.micpath.2017.04.020","article-title":"Novel properties of Hippophae rhamnoides L. twig and leaf extracts\u2014Anti-virulence action and synergy with antifungals studied in vitro on Candida spp. model","volume":"107","author":"Sadowska","year":"2017","journal-title":"Microb. Pathog."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Sun, L., Liao, K., and Wang, D. (2015). Effects of magnolol and honokiol on adhesion, yeast-hyphal transition, and formation of biofilm by Candida albicans. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0117695"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Souza, L.B.F.C., Silva-Rocha, W.P., Ferreira, M.R.A., Soares, L.A.L., Svidzinski, T.I.E., Milan, E.P., Pires, R.H., Almeida, A.M.F., Mendes-Giannini, M.J.S., and Chaves, G.M. (2018). Influence of Eugenia uniflora extract on adhesion to human buccal epithelial cells, biofilm formation, and cell surface hydrophobicity of Candida spp. from the oral cavity of kidney transplant recipients. Molecules, 23.","DOI":"10.3390\/molecules23102418"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"17913","DOI":"10.3390\/molecules201017913","article-title":"Potent activities of roemerine against Candida albicans and the underlying mechanisms","volume":"20","author":"Ma","year":"2015","journal-title":"Molecules"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/jam.12701","article-title":"Antibiofilm potential of flavonoids extracted from Moringa oleifera Seed Coat against Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans","volume":"118","author":"Onsare","year":"2015","journal-title":"J. Appl. Microbiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.micpath.2017.02.044","article-title":"Unexplored endemic fruit species from Brazil: Antibiofilm properties, insights into mode of action, and systemic toxicity of four Eugenia spp.","volume":"105","author":"Sardi","year":"2017","journal-title":"Microb. Pathog."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fcimb.2016.00071","article-title":"In vitro effects of lemongrass extract on Candida albicans biofilms, human cells viability, and denture surface","volume":"6","author":"Madeira","year":"2016","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jep.2016.06.023","article-title":"Chemical composition and biological activities of Artemisia judaica essential oil from southern desert of jordan","volume":"191","author":"Cabral","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1099\/jmm.0.075291-0","article-title":"New Pharmacological properties of Medicago sativa and Saponaria officinalis saponin-rich fractions addressed to Candida albicans","volume":"63","author":"Sadowska","year":"2014","journal-title":"J. Med. Microbiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/AAC.02707-16","article-title":"In vitro antibiofilm activity of eucarobustol e against Candida albicans","volume":"61","author":"Liu","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1111\/j.1439-0507.2011.02028.x","article-title":"Effect of licorice Compounds licochalcone A, glabridin and glycyrrhizic acid on growth and virulence properties of Candida albicans","volume":"54","author":"Messier","year":"2011","journal-title":"Mycoses"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"863","DOI":"10.3109\/13693786.2012.683540","article-title":"Candida albicans adhesion to human epithelial cells and polystyrene and formation of biofilm is reduced by sub-inhibitory Melaleuca alternifolia (tea tree) essential oil","volume":"50","author":"Sudjana","year":"2012","journal-title":"Med. Mycol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1099\/jmm.0.063834-0","article-title":"A Novel nerolidol-rich essential oil from Piper claussenianum modulates Candida albicans biofilm","volume":"63","author":"Curvelo","year":"2014","journal-title":"J. Med. Microbiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/mmy\/myz009","article-title":"\u03b2-Citronellol alters cell surface properties of Candida albicans to influence pathogenicity related traits","volume":"58","author":"Sharma","year":"2020","journal-title":"Med. Mycol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/AAC.02259-16","article-title":"Activity of sanguinarine against Candida albicans biofilms","volume":"61","author":"Zhong","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.archoralbio.2014.05.013","article-title":"Control of microorganisms of oral health interest with Arctium lappa L. (Burdock) extract non-cytotoxic to cell culture of macrophages (RAW 264.7)","volume":"59","author":"Jorge","year":"2014","journal-title":"Arch. Oral Biol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1177\/1535370216688571","article-title":"Biological activities of Rosmarinus officinalis L. (Rosemary) extract as analyzed in microorganisms and cells","volume":"242","author":"Figueira","year":"2017","journal-title":"Exp. Biol. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"10094","DOI":"10.3390\/molecules170910094","article-title":"Activity of spray-dried microparticles containing Pomegranate peel extract against Candida albicans","volume":"17","author":"Endo","year":"2012","journal-title":"Molecules"},{"key":"ref_44","first-page":"1","article-title":"Inhibitory activity of hinokitiol against biofilm formation in fluconazole-resistant Candida species","volume":"12","author":"Kim","year":"2017","journal-title":"PLoS ONE"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"103608","DOI":"10.1016\/j.micpath.2019.103608","article-title":"Chemical composition, antioxidant, antimicrobial and antibiofilm activities of Vitex gardneriana schauer leaves\u2019s essential oil","volume":"135","author":"Vale","year":"2019","journal-title":"Microb. Pathog."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1007\/s12010-019-02985-4","article-title":"Major phytoconstituents of Prunus cerasoides responsible for antimicrobial and antibiofilm potential against some reference strains of pathogenic bacteria and clinical isolates of MRSA","volume":"188","author":"Arora","year":"2019","journal-title":"Appl. Biochem. Biotechnol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"6305","DOI":"10.3390\/molecules17066305","article-title":"Biological activities of \u03b1-pinene and \u03b2-pinene enantiomers","volume":"17","author":"Lopes","year":"2012","journal-title":"Molecules"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"153223","DOI":"10.1016\/j.phymed.2020.153223","article-title":"In vitro and in vivo effects of the combination of myricetin and miconazole nitrate incorporated to thermosensitive hydrogels, on C. albicans Biofilms","volume":"71","author":"Mo","year":"2020","journal-title":"Phytomedicine"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"112120","DOI":"10.1016\/j.jep.2019.112120","article-title":"Unveiling the bioactive potential of the essential oil of a portuguese endemism, Santolina impressa","volume":"244","author":"Zuzarte","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S1349-0079(10)80007-6","article-title":"Hinokitiol inhibits Candida albicans adherence to oral epithelial cells","volume":"52","author":"Nakamura","year":"2010","journal-title":"J. Oral. Biosci."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Ivanov, M., Kannan, A., Stojkovi\u0107, D.S., Glamo\u010dlija, J., Calhelha, R.C., Ferreira, I.C.F.R., Sanglard, D., and Sokovi\u0107, M. (2021). Camphor and eucalyptol\u2014Anticandidal spectrum, antivirulence effect, efflux pumps interference and cytotoxicity. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22020483"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Kim, D., and Kim, K.Y. (2021). Adenophora triphylla var. japonica inhibits Candida biofilm formation, increases susceptibility to antifungal agents and reduces infection. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222212523"},{"key":"ref_53","first-page":"1","article-title":"Antimicrobial efficacy and biocompatibility of extracts from Cryptocarya Species","volume":"16","author":"Cavalheiro","year":"2021","journal-title":"PLoS ONE"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.3109\/13880209.2016.1155629","article-title":"Antifungal potential of Sideroxylon obtusifolium and Syzygium Cumini and their mode of action against Candida albicans","volume":"54","author":"Pereira","year":"2016","journal-title":"Pharm. Biol."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Vaou, N., Stavropoulou, E., Voidarou, C., Tsigalou, C., and Bezirtzoglou, E. (2021). Towards advances in medicinal plant antimicrobial activity: A review study on challenges and future perspectives. Microorganism, 9.","DOI":"10.3390\/microorganisms9102041"},{"key":"ref_56","unstructured":"(2022, October 20). EUCAST: Breakpoints for Antifungals. Available online: https:\/\/www.eucast.org\/astoffungi\/clinicalbreakpointsforantifungals\/."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Munn, Z., Peters, M.D.J., Stern, C., Tufanaru, C., Mcarthur, A., and Aromataris, E. (2018). Systematic review or scoping review? guidance for authors when choosing between a systematic or scoping review approach. BMC Med. Res. Methodol., 18.","DOI":"10.1186\/s12874-018-0611-x"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"31","DOI":"10.2341\/13-070-LIT","article-title":"The role of resin cement on bond strength of glass-fiber posts luted into root canals: A systematic review and meta- analysis of in vitro studies","volume":"39","author":"Skupien","year":"2014","journal-title":"Oper. Dent."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/28\/1\/130\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:49:33Z","timestamp":1760147373000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/28\/1\/130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,23]]},"references-count":58,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["molecules28010130"],"URL":"https:\/\/doi.org\/10.3390\/molecules28010130","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,23]]}}}