{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:37:54Z","timestamp":1792453074670,"version":"4.5.0"},"reference-count":138,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:00:00Z","timestamp":1671753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Matricaria chamomilla L. (MC) and Chamaemelum\u00a0nobile (L.) All. (CN) are two varieties of Chamomile. These herbs have been used for thousands of years in Greece, Rome and ancient Egypt. Chamomile has been used for the treatment of stomach problems, cramps, dermatitis, and minor infections. The purpose of this study was to introduce the botanical characteristics and geographical distribution, traditional uses, chemical constituents, pharmacological activities, toxicity studies and quality control studies, and lay a theoretical foundation for the rational development and utilization of chamomile. This review powered that chemical constituents include flavonoids, coumarins, volatile oils, terpenes, organic acids, polysaccharides, and others. These compounds possess anticancer, anti-infective, anti-inflammatory, antithrombotic, antioxidant, hypolipidaemic, hypoglycaemic, antihypertensive, antidepressant, neuroprotective activities, among others. Chamomile is a widely used herb in traditional medicine. It brings great economic value due to its numerous pharmacological effects and traditional uses. However, more toxicity tests should be carried out to confirm its safety. There is need for further research to provide concrete scientific evidence and validate its medicinal properties.<\/jats:p>","DOI":"10.3390\/molecules28010133","type":"journal-article","created":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T02:53:11Z","timestamp":1672109591000},"page":"133","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":149,"title":["Chamomile: A Review of Its Traditional Uses, Chemical Constituents, Pharmacological Activities and Quality Control Studies"],"prefix":"10.3390","volume":"28","author":[{"given":"Yun-Lei","family":"Dai","sequence":"first","affiliation":[{"name":"College of Pharmacy, Shandong University of Traditional Chinese Medicine, Ji\u2019nan 250355, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Shandong University of Traditional Chinese Medicine, Ji\u2019nan 250355, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Shandong University of Traditional Chinese Medicine, Ji\u2019nan 250355, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Jv","family":"Niu","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Shandong University of Traditional Chinese Medicine, Ji\u2019nan 250355, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun-Wei","family":"Li","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Shandong University of Traditional Chinese Medicine, Ji\u2019nan 250355, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Shandong University of Traditional Chinese Medicine, Ji\u2019nan 250355, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Shandong University of Traditional Chinese Medicine, Ji\u2019nan 250355, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Zheng","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Shandong University of Traditional Chinese Medicine, Ji\u2019nan 250355, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Na","family":"Gao","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Shandong University of Traditional Chinese Medicine, Ji\u2019nan 250355, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,23]]},"reference":[{"key":"ref_1","first-page":"753","article-title":"Research on the development history of traditional Chinese medicine","volume":"4","author":"Tian","year":"2007","journal-title":"Chin. 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