{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:08:19Z","timestamp":1793830099852,"version":"4.6.1"},"reference-count":177,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Natural products have been the most productive source for the development of drugs. Terpenoids are a class of natural active products with a wide range of pharmacological activities and therapeutic effects, which can be used to treat a variety of diseases. Non-alcoholic fatty liver disease (NAFLD), a common metabolic disorder worldwide, results in a health burden and economic problems. A literature search was conducted to obtain information relevant to the treatment of NAFLD with terpenoids using electronic databases, namely PubMed, Web of Science, Science Direct, and Springer, for the period 2011\u20132021. In total, we found 43 terpenoids used in the treatment of NAFLD. Over a dozen terpenoid compounds of natural origin were classified into five categories according to their structure: monoterpenoids, sesquiterpenoids, diterpenoids, triterpenoids, and tetraterpenoids. We found that terpenoids play a therapeutic role in NAFLD, mainly by regulating lipid metabolism disorder, insulin resistance, oxidative stress, and inflammation. The AMPK, PPARs, Nrf-2, and SIRT 1 pathways are the main targets for terpenoid treatment. Terpenoids are promising drugs and will potentially create more opportunities for the treatment of NAFLD. However, current studies are restricted to animal and cell experiments, with a lack of clinical research and systematic structure\u2013activity relationship (SAR) studies. In the future, we should further enrich the research on the mechanism of terpenoids, and carry out SAR studies and clinical research, which will increase the likelihood of breakthrough insights in the field.<\/jats:p>","DOI":"10.3390\/molecules28010272","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T03:18:18Z","timestamp":1672370298000},"page":"272","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Terpenoids: Natural Compounds for Non-Alcoholic Fatty Liver Disease (NAFLD) Therapy"],"prefix":"10.3390","volume":"28","author":[{"given":"Pengyu","family":"Yao","sequence":"first","affiliation":[{"name":"Shandong Laboratory of Engineering Technology, Suzhou Institution of Biomedical Engineering and Technology, Chinese Academy of Sciences, Jinan 250101, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Febrile Diseases, Shandong University of Traditional Chinese Medicine, Jinan 250355, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/s41575-021-00523-4","article-title":"Advancing the global public health agenda for NAFLD: A consensus statement","volume":"19","author":"Lazarus","year":"2022","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1016\/S0140-6736(20)32511-3","article-title":"Non-alcoholic fatty liver disease","volume":"397","author":"Powell","year":"2021","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3350\/cmh.2021.0178","article-title":"KASL clinical practice guidelines: Management of nonalcoholic fatty liver disease","volume":"27","author":"Kang","year":"2021","journal-title":"Clin. Mol. Hepatol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Kim, H., Lee, D.S., An, T.H., Park, H.J., Kim, W.K., Bae, K.H., and Oh, K.J. (2021). Metabolic Spectrum of Liver Failure in Type 2 Diabetes and Obesity: From NAFLD to NASH to HCC. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22094495"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1007\/s12072-020-10094-2","article-title":"The Asian Pacific Association for the Study of the Liver clinical practice guidelines for the diagnosis and management of metabolic associated fatty liver disease","volume":"14","author":"Eslam","year":"2020","journal-title":"Hepatol. Int."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1002\/hep.30782","article-title":"Report on the AASLD\/EASL Joint Workshop on Clinical Trial Endpoints in NAFLD","volume":"70","author":"Rinella","year":"2019","journal-title":"Hepatology"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Marchisello, S., Di Pino, A., Scicali, R., Urbano, F., Piro, S., Purrello, F., and Rabuazzo, A.M. (2019). Pathophysiological, Molecular and Therapeutic Issues of Nonalcoholic Fatty Liver Disease: An Overview. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20081948"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"226","DOI":"10.3803\/EnM.2019.34.3.226","article-title":"Nonalcoholic Fatty Liver Disease and Diabetes: An Epidemiological Perspective","volume":"34","author":"Rhee","year":"2019","journal-title":"Endocrinol. Metab."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.jacc.2018.11.050","article-title":"Nonalcoholic Fatty Liver Disease and the Heart: JACC State-of-the-Art Review","volume":"73","author":"Stahl","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s00392-020-01709-7","article-title":"NAFLD and cardiovascular diseases: A clinical review","volume":"110","author":"Kasper","year":"2021","journal-title":"Clin. Res. Cardiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e000295","DOI":"10.1136\/bmjgast-2019-000295","article-title":"Non-alcoholic fatty liver disease with obesity as an independent predictor for incident gastric and colorectal cancer: A population-based longitudinal study","volume":"6","author":"Hamaguchi","year":"2019","journal-title":"BMJ Open Gastroenterol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Fernando, D.H., Forbes, J.M., Angus, P.W., and Herath, C.B. (2019). Development and Progression of Non-Alcoholic Fatty Liver Disease: The Role of Advanced Glycation End Products. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20205037"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Fougerat, A., Montagner, A., Loiseau, N., Guillou, H., and Wahli, W. (2020). Peroxisome Proliferator-Activated Receptors and Their Novel Ligands as Candidates for the Treatment of Non-Alcoholic Fatty Liver Disease. Cells, 9.","DOI":"10.3390\/cells9071638"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"595371","DOI":"10.3389\/fmed.2021.595371","article-title":"Oxidative Stress in Non-alcoholic Fatty Liver Disease. An Updated Mini Review","volume":"8","author":"Marciano","year":"2021","journal-title":"Front. Med."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Di Ciaula, A., Passarella, S., Shanmugam, H., Noviello, M., Bonfrate, L., Wang, D.Q., and Portincasa, P. (2021). Nonalcoholic Fatty Liver Disease (NAFLD). Mitochondria as Players and Targets of Therapies?. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22105375"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Fujii, H., Kawada, N., and Japan Study Group Of Nafld Jsg-Nafld (2020). The Role of Insulin Resistance and Diabetes in Nonalcoholic Fatty Liver Disease. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21113863"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"4660","DOI":"10.1002\/ptr.7099","article-title":"Natural products: A lead for drug discovery and development","volume":"35","author":"Chopra","year":"2021","journal-title":"Phytother. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.7150\/ijbs.33837","article-title":"Treatment implications of natural compounds targeting lipid metabolism in nonalcoholic fatty liver disease, obesity and cancer","volume":"15","author":"Cheng","year":"2019","journal-title":"Int. J. Biol. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1021\/acs.jnatprod.9b01285","article-title":"Natural Products as Sources of New Drugs over the Nearly Four Decades from 01\/1981 to 09\/2019","volume":"83","author":"Newman","year":"2020","journal-title":"J. Nat. Prod."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1517\/13543784.2012.727395","article-title":"Terpenoids: Natural products for cancer therapy","volume":"21","author":"Huang","year":"2012","journal-title":"Expert Opin. Investig. Drugs"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Lai Shi Min, S., Liew, S.Y., Chear, N.J.Y., Goh, B.H., Tan, W.N., and Khaw, K.Y. (2022). Plant Terpenoids as the Promising Source of Cholinesterase Inhibitors for Anti-AD Therapy. Biology, 11.","DOI":"10.3390\/biology11020307"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.bbrc.2018.03.093","article-title":"Beneficial effects of paeoniflorin on osteoporosis induced by high-carbohydrate, high-fat diet-associated hyperlipidemia in vivo","volume":"498","author":"Wang","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Liang, Y., Liu, H., Huang, Y., Li, H., and Chen, B. (2020). Paeoniflorin attenuates gestational diabetes via Akt\/mTOR pathway in a rat model. Food. Nutr. Res., 64.","DOI":"10.29219\/fnr.v64.4362"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1248\/bpb.b14-00892","article-title":"Paeoniflorin Protects against Nonalcoholic Fatty Liver Disease Induced by a High-Fat Diet in Mice","volume":"38","author":"Zhang","year":"2015","journal-title":"Biol. Pharm. Bull."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"44819","DOI":"10.1038\/srep44819","article-title":"Beneficial effects of paeoniflorin on non-alcoholic fatty liver disease induced by high-fat diet in rats","volume":"7","author":"Ma","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Li, Y.C., Qiao, J.Y., Wang, B.Y., Bai, M., Shen, J.D., and Cheng, Y.X. (2018). Paeoniflorin Ameliorates Fructose-Induced Insulin Resistance and Hepatic Steatosis by Activating LKB1\/AMPK and AKT Pathways. Nutrients, 10.","DOI":"10.3390\/nu10081024"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.intimp.2016.06.023","article-title":"Paeoniflorin alleviates non-alcoholic steatohepatitis in rats: Involvement with the ROCK\/NF-\u03baB pathway","volume":"38","author":"Ma","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1080\/13813455.2020.1727927","article-title":"Catalpol promotes mitochondrial biogenesis in chondrocytes","volume":"128","author":"Chen","year":"2022","journal-title":"Arch. Physiol. Biochem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"6708061","DOI":"10.1155\/2020\/6708061","article-title":"Catalpol Attenuates Hepatic Steatosis by Regulating Lipid Metabolism via AMP-Activated Protein Kinase Activation","volume":"2020","author":"Tian","year":"2020","journal-title":"Biomed. Res. Int."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nrm.2017.95","article-title":"AMPK: Guardian of metabolism and mitochondrial homeostasis","volume":"19","author":"Herzig","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"9461","DOI":"10.18632\/aging.102396","article-title":"Catalpol induces autophagy and attenuates liver steatosis in ob\/ob and high-fat diet-induced obese mice","volume":"11","author":"Ren","year":"2019","journal-title":"Aging"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.18632\/aging.102721","article-title":"Targeting of miR-96-5p by catalpol ameliorates oxidative stress and hepatic steatosis in LDLr-\/- mice via p66shc\/cytochrome C cascade","volume":"12","author":"Zhang","year":"2020","journal-title":"Aging"},{"key":"ref_33","first-page":"746","article-title":"Intervention of Catalpol on High-fat Diet Induced Nonalcoholic Fatty Liver Disease in Mice","volume":"41","author":"Tian","year":"2019","journal-title":"Zhongguo Yi Xue Ke Xue Yuan Xue Bao"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3799","DOI":"10.1002\/ptr.7086","article-title":"Geniposide suppresses liver injury in a mouse model of DDC-induced sclerosing cholangitis","volume":"35","author":"Wen","year":"2021","journal-title":"Phytother. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"5097","DOI":"10.1111\/jcmm.15139","article-title":"Geniposide alleviates non-alcohol fatty liver disease via regulating Nrf2\/AMPK\/mTOR signalling pathways","volume":"24","author":"Shen","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/j.2042-7158.2011.01256.x","article-title":"Hepatoprotective effects of geniposide in a rat model of nonalcoholic steatohepatitis","volume":"63","author":"Ma","year":"2011","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"104945","DOI":"10.1016\/j.phrs.2020.104945","article-title":"Therapeutic potential of genipin in various acute liver injury, fulminant hepatitis, NAFLD and other non-cancer liver diseases: More friend than foe","volume":"159","author":"Fan","year":"2020","journal-title":"Pharmacol. Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/febs.14349","article-title":"Genipin alleviates high-fat diet-induced hyperlipidemia and hepatic lipid accumulation in mice via miR-142a-5p\/SREBP-1c axis","volume":"285","author":"Zhong","year":"2018","journal-title":"FEBS J."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1159\/000493651","article-title":"Genipin Reverses HFD-Induced Liver Damage and Inhibits UCP2-Mediated Pyroptosis in Mice","volume":"49","author":"Zhong","year":"2018","journal-title":"Cell Physiol. Biochem."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Wang, R., Dong, Z., Lan, X., Liao, Z., and Chen, M. (2019). Sweroside Alleviated LPS-Induced Inflammation via SIRT1 Mediating NF-\u03baB and FOXO1 Signaling Pathways in RAW264.7 Cells. Molecules, 24.","DOI":"10.3390\/molecules24050872"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.ejmech.2019.01.067","article-title":"Role of PPAR receptor in different diseases and their ligands: Physiological importance and clinical implications","volume":"166","author":"Mirza","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"112556","DOI":"10.1016\/j.jep.2020.112556","article-title":"Sweroside ameliorates NAFLD in high-fat diet induced obese mice through the regulation of lipid metabolism and inflammatory response","volume":"255","author":"Yang","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Yang, G., Jang, J.H., Kim, S.W., Han, S.H., Ma, K.H., Jang, J.K., Kang, H.C., Cho, Y.Y., Lee, H.S., and Lee, J.Y. (2020). Sweroside Prevents Non-Alcoholic Steatohepatitis by Suppressing Activation of the NLRP3 Inflammasome. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21082790"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"110561","DOI":"10.1016\/j.biopha.2020.110561","article-title":"Swertiamarin and quercetin combination ameliorates hyperglycemia, hyperlipidemia and oxidative stress in streptozotocin-induced type 2 diabetes mellitus in wistar rats","volume":"130","author":"Jaishree","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1080\/21623945.2021.1906510","article-title":"Swertiamarin supplementation prevents obesity-related chronic inflammation and insulin resistance in mice fed a high-fat diet","volume":"10","author":"Xu","year":"2021","journal-title":"Adipocyte"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"104443","DOI":"10.1016\/j.fitote.2019.104443","article-title":"A review of the pharmacology and toxicology of aucubin","volume":"140","author":"Zeng","year":"2020","journal-title":"Fitoterapia"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"4063","DOI":"10.1111\/jcmm.14293","article-title":"Aucubin inhibited lipid accumulation and oxidative stress via Nrf2\/HO-1 and AMPK signalling pathways","volume":"23","author":"Shen","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"107213","DOI":"10.1016\/j.intimp.2020.107213","article-title":"Gentiopicroside ameliorates ethanol-induced gastritis via regulating MMP-10 and pERK1\/2 signaling","volume":"90","author":"Chang","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2940746","DOI":"10.1155\/2020\/2940746","article-title":"Gentiopicroside Ameliorates Oxidative Stress and Lipid Accumulation through Nuclear Factor Erythroid 2-Related Factor 2 Activation","volume":"2020","author":"Jin","year":"2020","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1111\/jgh.13272","article-title":"Treatment with geraniol ameliorates methionine-choline-deficient diet-induced non-alcoholic steatohepatitis in rats","volume":"31","author":"Chen","year":"2016","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1080\/01635581.2020.1749676","article-title":"Therapeutic Effects of Curcumol in Several Diseases; An Overview","volume":"73","author":"Hashem","year":"2021","journal-title":"Nutr. Cancer"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e13107","DOI":"10.1111\/cpr.13107","article-title":"Curcumol inhibits ferritinophagy to restrain hepatocyte senescence through YAP\/NCOA4 in non-alcoholic fatty liver disease","volume":"54","author":"Qi","year":"2021","journal-title":"Cell Prolif."},{"key":"ref_53","first-page":"611","article-title":"Effects of curcumol on liver function and fibrosis in rats of nonalcoholic fatty liver disease and its mechanism","volume":"37","author":"Qi","year":"2021","journal-title":"Zhongguo Ying Yong Sheng Li Xue Za Zhi"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"111104","DOI":"10.1016\/j.biopha.2020.111104","article-title":"\u03b2-patchoulene improves lipid metabolism to alleviate non-alcoholic fatty liver disease via activating AMPK signaling pathway","volume":"134","author":"Xu","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"107915","DOI":"10.1016\/j.intimp.2021.107915","article-title":"\u03b2-patchoulene protects against non-alcoholic steatohepatitis via interrupting the vicious circle among oxidative stress, histanoxia and lipid accumulation in rats","volume":"98","author":"Luo","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1002\/mnfr.201600197","article-title":"\u03b2-Caryophyllene attenuates palmitate-induced lipid accumulation through AMPK signaling by activating CB2 receptor in human HepG2 hepatocytes","volume":"60","author":"Kamikubo","year":"2016","journal-title":"Mol. Nutr. Food. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1146\/annurev-arplant-050213-035705","article-title":"To gibberellins and beyond! Surveying the evolution of (di)terpenoid metabolism","volume":"65","author":"Zi","year":"2014","journal-title":"Annu. Rev. Plant. Biol."},{"key":"ref_58","first-page":"3952","article-title":"Analysis of carnosic acid metabolites in rats by UHPLC-Q-Exactive M.S","volume":"45","author":"Lou","year":"2020","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.phytochem.2014.12.026","article-title":"Carnosic acid","volume":"115","author":"Dussort","year":"2015","journal-title":"Phytochemistry"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1872-034X.2010.00747.x","article-title":"Carnosic acid prevents obesity and hepatic steatosis in ob\/ob mice","volume":"41","author":"Wang","year":"2011","journal-title":"Hepatol. Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1002\/jsfa.6973","article-title":"Carnosic acid attenuates obesity-induced glucose intolerance and hepatic fat accumulation by modulating genes of lipid metabolism in C57BL\/6J-ob\/ob mice","volume":"95","author":"Park","year":"2015","journal-title":"J. Sci. Food. Agric."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1124\/dmd.112.044909","article-title":"In vitro hepatotoxicity and cytochrome P450 induction and inhibition characteristics of carnosic acid, a dietary supplement with antiadipogenic properties","volume":"40","author":"Dickmann","year":"2012","journal-title":"Drug. Metab. Dispos."},{"key":"ref_63","first-page":"193","article-title":"Carnosic acid protects mice from high-fat diet-induced NAFLD by regulating MARCKS","volume":"42","author":"Song","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"e1833","DOI":"10.1038\/cddis.2015.196","article-title":"Activation of the SIRT1\/p66shc antiapoptosis pathway via carnosic acid-induced inhibition of miR-34a protects rats against nonalcoholic fatty liver disease","volume":"6","author":"Shan","year":"2015","journal-title":"Cell Death. Dis."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/j.dld.2019.05.015","article-title":"Brain involvement in non-alcoholic fatty liver disease (NAFLD): A systematic review","volume":"51","author":"Lombardi","year":"2019","journal-title":"Dig. Liver Dis."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s11011-016-9941-8","article-title":"Carnosic acid protects non-alcoholic fatty liver-induced dopaminergic neuron injury in rats","volume":"32","author":"Xu","year":"2017","journal-title":"Metab. Brain Dis."},{"key":"ref_67","first-page":"3288","article-title":"Advance in biosynthesis and metabolic regulation of ginkgolides","volume":"46","author":"Du","year":"2021","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"110908","DOI":"10.1016\/j.biopha.2020.110908","article-title":"Therapeutic promises of ginkgolide A: A literature-based review","volume":"132","author":"Sarkar","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.biopha.2017.01.114","article-title":"Ginkgolide A ameliorates non-alcoholic fatty liver diseases on high fat diet mice","volume":"88","author":"Jeong","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"37858","DOI":"10.1039\/C7RA05621D","article-title":"Ginkgolide B lowers body weight and ameliorates hepatic steatosis in high-fat diet-induced obese mice correlated with pregnane X receptor activation","volume":"7","author":"Luo","year":"2017","journal-title":"RSC Advances"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"152599","DOI":"10.1016\/j.tox.2020.152599","article-title":"Study on the attenuated effect of Ginkgolide B on ferroptosis in high fat diet induced nonalcoholic fatty liver disease","volume":"445","author":"Yang","year":"2020","journal-title":"Toxicology"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/jphp.12877","article-title":"Acanthoic acid suppresses lipin1\/2 via TLR4 and IRAK4 signalling pathways in EtOH- and lipopolysaccharide-induced hepatic lipogenesis","volume":"70","author":"Song","year":"2018","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.phymed.2009.07.011","article-title":"Acanthoic acid, a diterpene in Acanthopanax koreanum, protects acetaminophen-induced hepatic toxicity in mice","volume":"17","author":"Wu","year":"2010","journal-title":"Phytomedicine"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1248\/bpb.31.738","article-title":"A diterpenoid acanthoic acid from Acanthopanax koreanum protects against D-galactosamine\/lipopolysaccharide-induced fulminant hepatic failure in mice","volume":"31","author":"Nan","year":"2008","journal-title":"Biol. Pharm. Bull."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"108794","DOI":"10.1016\/j.cbi.2019.108794","article-title":"Acanthoic acid modulates lipogenesis in nonalcoholic fatty liver disease via FXR\/LXRs-dependent manner","volume":"311","author":"Han","year":"2019","journal-title":"Chem. Biol. Interact."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Kim, E., Kang, Y.G., Kim, Y.J., Lee, T.R., Yoo, B.C., Jo, M., Kim, J.H., Kim, J.H., Kim, D., and Cho, J.Y. (2019). Dehydroabietic Acid Suppresses Inflammatory Response Via Suppression of Src-, Syk-, and TAK1-Mediated Pathways. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20071593"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1007\/s11418-021-01491-4","article-title":"Dehydroabietic acid improves nonalcoholic fatty liver disease through activating the Keap1\/Nrf2-ARE signaling pathway to reduce ferroptosis","volume":"75","author":"Gao","year":"2021","journal-title":"J. Nat. Med."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.chemphyslip.2017.05.011","article-title":"Interaction of triterpenoids with human serum albumin: A review","volume":"207","author":"Abboud","year":"2017","journal-title":"Chem. Phys. Lipids"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1016\/j.apsb.2020.12.017","article-title":"Ginsenosides in Panax genus and their biosynthesis","volume":"11","author":"Hou","year":"2021","journal-title":"Acta Pharm. Sin. B."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1080\/09168451.2020.1793293","article-title":"Effect and mechanism of ginsenoside Rg1-regulating hepatic steatosis in HepG2 cells induced by free fatty acid","volume":"84","author":"Gao","year":"2020","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"117776","DOI":"10.1016\/j.lfs.2020.117776","article-title":"Ginsenoside Rg1 protects against d-galactose induced fatty liver disease in a mouse model via FOXO1 transcriptional factor","volume":"254","author":"Qi","year":"2020","journal-title":"Life Sci."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1248\/bpb.b18-00132","article-title":"Ginsenoside Rg1 Protects against Non-alcoholic Fatty Liver Disease by Ameliorating Lipid Peroxidation, Endoplasmic Reticulum Stress, and Inflammasome Activation","volume":"41","author":"Xu","year":"2018","journal-title":"Biol. Pharm. Bull."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"118986","DOI":"10.1016\/j.lfs.2020.118986","article-title":"Transcriptome analysis reveals the efficacy of ginsenoside-Rg1 in the treatment of nonalcoholic fatty liver disease","volume":"267","author":"Gu","year":"2021","journal-title":"Life Sci."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Wang, F., Park, J.S., Ma, Y., Ma, H., Lee, Y.J., Lee, G.R., Yoo, H.S., Hong, J.T., and Roh, Y.S. (2021). Ginseng Saponin Enriched in Rh1 and Rg2 Ameliorates Nonalcoholic Fatty Liver Disease by Inhibiting Inflammasome Activation. Nutrients, 13.","DOI":"10.3390\/nu13030856"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"4215","DOI":"10.1021\/acs.jafc.0c00833","article-title":"Ginsenoside Rg2 Ameliorates High-Fat Diet-Induced Metabolic Disease through SIRT1","volume":"68","author":"Cheng","year":"2020","journal-title":"J. Agric. Food. Chem."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"41144","DOI":"10.1038\/srep41144","article-title":"Ameliorative effects of Compound K and ginsenoside Rh1 on non-alcoholic fatty liver disease in rats","volume":"7","author":"Chen","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"2315230","DOI":"10.1155\/2020\/2315230","article-title":"Ginsenoside Rb1 Alleviated High-Fat-Diet-Induced Hepatocytic Apoptosis via Peroxisome Proliferator-Activated Receptor \u03b3","volume":"2020","author":"Song","year":"2020","journal-title":"Biomed. Res. Int."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Huang, Q., Wang, T., Yang, L., and Wang, H.Y. (2017). Ginsenoside Rb2 Alleviates Hepatic Lipid Accumulation by Restoring Autophagy via Induction of Sirt1 and Activation of AMPK. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18051063"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"112927","DOI":"10.1016\/j.jep.2020.112927","article-title":"Ginsenoside Mc1 improves liver steatosis and insulin resistance by attenuating ER stress","volume":"259","author":"Roh","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"e1800222","DOI":"10.1002\/ardp.201800222","article-title":"Ursolic acid: Pharmacokinetics process in vitro and in vivo, a mini review","volume":"352","author":"Jinhua","year":"2019","journal-title":"Arch. Pharm."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Li, S., Liao, X., Meng, F., Wang, Y., Sun, Z., Guo, F., Li, X., Meng, M., Li, Y., and Sun, C. (2014). Therapeutic role of ursolic acid on ameliorating hepatic steatosis and improving metabolic disorders in high-fat diet-induced non-alcoholic fatty liver disease rats. PLoS ONE, 9, Erratum in PLoS ONE 2014, 9, e92364.","DOI":"10.1371\/journal.pone.0092364"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1039\/C5FO00083A","article-title":"Ursolic acid inhibits the development of nonalcoholic fatty liver disease by attenuating endoplasmic reticulum stress","volume":"6","author":"Li","year":"2015","journal-title":"Food Funct."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"11647","DOI":"10.1021\/acs.jafc.8b04116","article-title":"Ursolic Acid, a Novel Liver X Receptor \u03b1 (LXR\u03b1) Antagonist Inhibiting Ligand-Induced Nonalcoholic Fatty Liver and Drug-Induced Lipogenesis","volume":"66","author":"Lin","year":"2018","journal-title":"J. Agric. Food. Chem."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1017\/S2040174420000124","article-title":"Administration of ursolic acid to new-born pups prevents dietary fructose-induced non-alcoholic fatty liver disease in Sprague Dawley rats","volume":"12","author":"Mukonowenzou","year":"2021","journal-title":"J. Dev. Orig. Health Dis."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1111\/bph.14570","article-title":"Betulinic acid alleviates endoplasmic reticulum stress-mediated nonalcoholic fatty liver disease through activation of farnesoid X receptors in mice","volume":"176","author":"Gu","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1016\/j.bcp.2013.02.007","article-title":"Betulinic acid alleviates non-alcoholic fatty liver by inhibiting SREBP1 activity via the AMPK-mTOR-SREBP signaling pathway","volume":"85","author":"Quan","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"13033","DOI":"10.1096\/fj.202000546R","article-title":"Betulinic acid improves nonalcoholic fatty liver disease through YY1\/FAS signaling pathway","volume":"34","author":"Mu","year":"2020","journal-title":"FASEB J."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"3716","DOI":"10.1039\/C6FO00773B","article-title":"Protective effects of glycyrrhizic acid from edible botanical glycyrrhiza glabra against non-alcoholic steatohepatitis in mice","volume":"7","author":"Wang","year":"2016","journal-title":"Food Funct."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ejphar.2017.04.021","article-title":"Protective effects of glycyrrhizic acid against non-alcoholic fatty liver disease in mice","volume":"806","author":"Sun","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"100387","DOI":"10.1016\/j.jhepr.2021.100387","article-title":"Bile acids contribute to the development of non-alcoholic steatohepatitis in mice","volume":"4","author":"Gillard","year":"2021","journal-title":"JHEP Rep."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1124\/dmd.118.082008","article-title":"Glycyrrhizin Alleviates Nonalcoholic Steatohepatitis via Modulating Bile Acids and Meta-Inflammation","volume":"46","author":"Yan","year":"2018","journal-title":"Drug Metab. Dispos."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.2174\/1389450116666150325231015","article-title":"The link between Hepatic Vitamin A Metabolism and Nonalcoholic Fatty Liver Disease","volume":"16","author":"Chen","year":"2015","journal-title":"Curr. Drug Targets"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"173167","DOI":"10.1016\/j.ejphar.2020.173167","article-title":"Glycyrrhetinic acid attenuates disturbed vitamin a metabolism in non-alcoholic fatty liver disease through AKR1B10","volume":"883","author":"Shi","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"104840","DOI":"10.1016\/j.phrs.2020.104840","article-title":"18\u03b2-Glycyrrhetinic acid acts through hepatocyte nuclear factor 4 alpha to modulate lipid and carbohydrate metabolism","volume":"157","author":"Yang","year":"2020","journal-title":"Pharmacol. Res."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1002\/hep.22239","article-title":"Prevention of free fatty acid-induced hepatic lipotoxicity by 18beta-glycyrrhetinic acid through lysosomal and mitochondrial pathways","volume":"47","author":"Wu","year":"2008","journal-title":"Hepatology"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.phytochem.2011.12.022","article-title":"Oleanolic acid","volume":"77","author":"Pollier","year":"2012","journal-title":"Phytochemistry"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"7884","DOI":"10.1021\/acs.jafc.1c02257","article-title":"Oleanolic Acid Targets the Gut-Liver Axis to Alleviate Metabolic Disorders and Hepatic Steatosis","volume":"69","author":"Xue","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"10964","DOI":"10.1021\/acs.jafc.8b03372","article-title":"Oleanolic Acid Inhibits Liver X Receptor Alpha and Pregnane X Receptor to Attenuate Ligand-Induced Lipogenesis","volume":"66","author":"Lin","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.2147\/DMSO.S218626","article-title":"Plant-derived oleanolic acid ameliorates markers associated with non-alcoholic fatty liver disease in a diet-induced pre-diabetes rat model","volume":"12","author":"Gamede","year":"2019","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1038\/aps.2017.142","article-title":"3-Acetyl-oleanolic acid ameliorates non-alcoholic fatty liver disease in high fat diet-treated rats by activating AMPK-related pathways","volume":"39","author":"Xuan","year":"2018","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1530\/JME-20-0075","article-title":"Oleanolic acid derivative HA-20 inhibits adipogenesis in a manner involving PPAR\u03b3-FABP4\/aP2 pathway","volume":"66","author":"Wang","year":"2021","journal-title":"J. Mol. Endocrinol."},{"key":"ref_112","first-page":"4700","article-title":"Research advances on astragaloside-IV in treatment of diabetes mellitus and its complications pharmacological effects","volume":"42","author":"You","year":"2017","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/aps.2016.175","article-title":"Astragaloside I.V attenuates free fatty acid-induced ER stress and lipid accumulation in hepatocytes via AMPK activation","volume":"38","author":"Zhou","year":"2017","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"113556","DOI":"10.1016\/j.jep.2020.113556","article-title":"Astragaloside I.V inhibits protein tyrosine phosphatase 1B and improves insulin resistance in insulin-resistant HepG2 cells and triglyceride accumulation in oleic acid (OA)-treated HepG2 cells","volume":"268","author":"Zhou","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"845","DOI":"10.4155\/fmc-2017-0255","article-title":"Pharmacological activities of mogrosides","volume":"10","author":"Liu","year":"2018","journal-title":"Future Med. Chem."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Zhang, X., Song, Y., Ding, Y., Wang, W., Liao, L., Zhong, J., Sun, P., Lei, F., Zhang, Y., and Xie, W. (2018). Effects of Mogrosides on High-Fat-Diet-Induced Obesity and Nonalcoholic Fatty Liver Disease in Mice. Molecules, 23.","DOI":"10.3390\/molecules23081894"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"7826874","DOI":"10.1155\/2020\/7826874","article-title":"Mogroside V Protects against Hepatic Steatosis in Mice on a High-Fat Diet and LO2 Cells Treated with Free Fatty Acids via AMPK Activation","volume":"2020","author":"Li","year":"2020","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1177\/2472630317751840","article-title":"Pharmacological Review on Asiatic Acid and Its Derivatives: A Potential Compound","volume":"23","author":"Lv","year":"2018","journal-title":"SLAS Technol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.intimp.2018.10.013","article-title":"Asiatic acid from Potentilla chinensis alleviates non-alcoholic fatty liver by regulating endoplasmic reticulum stress and lipid metabolism","volume":"65","author":"Wang","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"84","DOI":"10.3892\/ol.2020.12345","article-title":"Biological effects of corosolic acid as an anti-inflammatory, anti-metabolic syndrome and anti-neoplasic natural compound","volume":"21","author":"Zhao","year":"2021","journal-title":"Oncol. Lett."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"5214","DOI":"10.1002\/ptr.7195","article-title":"Corosolic acid ameliorates non-alcoholic steatohepatitis induced by high-fat diet and carbon tetrachloride by regulating TGF-\u03b21\/Smad2, N.F-\u03baB, and AMPK signaling pathways","volume":"35","author":"Liu","year":"2021","journal-title":"Phytother. Res."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.biochi.2013.01.016","article-title":"Arjunolic acid: A new multifunctional therapeutic promise of alternative medicine","volume":"95","author":"Ghosh","year":"2013","journal-title":"Biochimie"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.biopha.2018.08.019","article-title":"Curative effect of arjunolic acid from Terminalia arjuna in non-alcoholic fatty liver disease models","volume":"107","author":"Toppo","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1007\/s10753-021-01468-1","article-title":"Ganoderic Acid A Alleviates OVA-Induced Asthma in Mice","volume":"44","author":"Lu","year":"2021","journal-title":"Inflammation"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1007\/s12272-020-01256-9","article-title":"Ganoderic acid A attenuates high-fat-diet-induced liver injury in rats by regulating the lipid oxidation and liver inflammation","volume":"43","author":"Liu","year":"2020","journal-title":"Arch. Pharm. Res."},{"key":"ref_126","first-page":"436","article-title":"Ilexgenin A enhances the effects of simvastatin on non-alcoholic fatty liver disease without changes in simvastatin pharmacokinetics","volume":"16","author":"Lu","year":"2018","journal-title":"Chin. J. Nat. Med."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"545","DOI":"10.3389\/fonc.2019.00545","article-title":"Rotundic Acid Induces DNA Damage and Cell Death in Hepatocellular Carcinoma Through AKT\/mTOR and MAPK Pathways","volume":"9","author":"Roy","year":"2019","journal-title":"Front. Oncol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"108065","DOI":"10.1016\/j.intimp.2021.108065","article-title":"Rotundic acid ameliorates non-alcoholic steatohepatitis via SREBP-1c\/ SCD1 signaling pathway and modulating gut microbiota","volume":"99","author":"Liu","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"ref_129","first-page":"488","article-title":"Saikosaponin D inhibits proliferation of human osteosarcoma cells via the p53 signaling pathway","volume":"17","author":"Zhao","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Chang, G.R., Lin, W.L., Lin, T.C., Liao, H.J., and Lu, Y.W. (2021). The Ameliorative Effects of Saikosaponin in Thioacetamide-Induced Liver Injury and Non-Alcoholic Fatty Liver Disease in Mice. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222111383"},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Avila, C. (2020). Terpenoids in Marine Heterobranch Molluscs. Mar. Drugs, 18.","DOI":"10.3390\/md18030162"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"3218605","DOI":"10.1155\/2016\/3218605","article-title":"Lycopene Deficiency in Ageing and Cardiovascular Disease","volume":"2016","author":"Petyaev","year":"2016","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"2713511","DOI":"10.1155\/2021\/2713511","article-title":"Lycopene: Food Sources, Biological Activities, and Human Health Benefits","volume":"2021","author":"Khan","year":"2021","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"431","DOI":"10.3945\/jn.113.186676","article-title":"\u03b2-Carotene-9\u2019,10\u2019-oxygenase status modulates the impact of dietary tomato and lycopene on hepatic nuclear receptor-, stress-, and metabolism-related gene expression in mice","volume":"144","author":"Tan","year":"2014","journal-title":"J. Nutr."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"268","DOI":"10.3945\/jn.114.200238","article-title":"Lycopene and apo-10\u2019-lycopenoic acid have differential mechanisms of protection against hepatic steatosis in \u03b2-carotene-9\u2019,10\u2019-oxygenase knockout male mice","volume":"145","author":"Ip","year":"2015","journal-title":"J. Nutr."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.freeradbiomed.2019.11.036","article-title":"Lycopene prevents the progression of lipotoxicity-induced nonalcoholic steatohepatitis by decreasing oxidative stress in mice","volume":"152","author":"Ni","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"10180","DOI":"10.3748\/wjg.v22.i46.10180","article-title":"Hepatoprotective and antioxidant effects of lycopene on non-alcoholic fatty liver disease in rat","volume":"22","author":"Jiang","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1002\/mnfr.201200182","article-title":"Lycopene inhibits hepatic steatosis via microRNA-21-induced downregulation of fatty acid-binding protein 7 in mice fed a high-fat diet","volume":"56","author":"Ahn","year":"2012","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"e1900602","DOI":"10.1002\/mnfr.201900602","article-title":"Lycopene Alleviates Obesity-Induced Inflammation and Insulin Resistance by Regulating M1\/M2 Status of Macrophages","volume":"63","author":"Chen","year":"2019","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"108596","DOI":"10.1016\/j.jnutbio.2021.108596","article-title":"Dietary lycopene attenuates cigarette smoke-promoted nonalcoholic steatohepatitis by preventing suppression of antioxidant enzymes in ferrets","volume":"91","author":"Liu","year":"2021","journal-title":"J. Nutr. Biochem."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1097\/HJH.0000000000002200","article-title":"Association between dietary carotenoid intakes and hypertension in adults: National Health and Nutrition Examination Survey 2007\u20132014","volume":"37","author":"Li","year":"2019","journal-title":"J. Hypertens."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"657","DOI":"10.2174\/1573399815666190906151319","article-title":"Dietary Phytonutrients in the Prevention of Diabetes-related Complications","volume":"16","author":"Jha","year":"2020","journal-title":"Curr. Diabetes Rev."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.neulet.2016.05.014","article-title":"Protective effect of lycopene on high-fat diet-induced cognitive impairment in rats","volume":"627","author":"Wang","year":"2016","journal-title":"Neurosci. Lett."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"117990","DOI":"10.1016\/j.lfs.2020.117990","article-title":"Combination of luteolin and lycopene effectively protect against the \u201ctwo-hit\u201d in NAFLD through Sirt1\/AMPK signal pathway","volume":"256","author":"Zhu","year":"2020","journal-title":"Life Sci."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1007\/s00449-022-02709-9","article-title":"Accumulation and conversion of \u03b2-carotene and astaxanthin induced by abiotic stresses in Schizochytrium sp","volume":"45","author":"Li","year":"2022","journal-title":"Bioprocess Biosyst. Eng."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.2147\/DDDT.S230749","article-title":"Astaxanthin in Liver Health and Disease: A Potential Therapeutic Agent","volume":"14","author":"Li","year":"2020","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Kobori, M., Takahashi, Y., Sakurai, M., Ni, Y., Chen, G., Nagashimada, M., Kaneko, S., and Ota, T. (2017). Hepatic Transcriptome Profiles of Mice with Diet-Induced Nonalcoholic Steatohepatitis Treated with Astaxanthin and Vitamin E. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18030593"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1017\/S0007114514002554","article-title":"Astaxanthin lowers plasma TAG concentrations and increases hepatic antioxidant gene expression in diet-induced obesity mice","volume":"112","author":"Yang","year":"2014","journal-title":"Br. J. Nutr."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.bbagen.2014.10.014","article-title":"Astaxanthin prevents TGF\u03b21-induced pro-fibrogenic gene expression by inhibiting Smad3 activation in hepatic stellate cells","volume":"1850","author":"Yang","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Yang, M., Kimchi, E.T., Staveley-O\u2019Carroll, K.F., and Li, G. (2021). Astaxanthin Prevents Diet-Induced NASH Progression by Shaping Intrahepatic Immunity. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222011037"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"17192","DOI":"10.1038\/srep17192","article-title":"Astaxanthin prevents and reverses diet-induced insulin resistance and steatohepatitis in mice: A comparison with vitamin E","volume":"5","author":"Ni","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"3760","DOI":"10.1111\/bph.15099","article-title":"Astaxanthin attenuates hepatic damage and mitochondrial dysfunction in non-alcoholic fatty liver disease by up-regulating the FGF21\/PGC-1\u03b2pathway","volume":"177","author":"Wu","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Nishino, A., Maoka, T., and Yasui, H. (2021). Preventive Effects of \u03b2-Cryptoxanthin, a Potent Antioxidant and Provitamin A Carotenoid, on Lifestyle-Related Diseases-A Central Focus on Its Effects on Non-Alcoholic Fatty Liver Disease (NAFLD). Antioxidants, 11.","DOI":"10.3390\/antiox11010043"},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Haidari, F., Hojhabrimanesh, A., Helli, B., Seyedian, S.S., Ahmadi-Angali, K., and Abiri, B. (2020). A hypocaloric high-protein diet supplemented with \u03b2-cryptoxanthin improves non-alcoholic fatty liver disease: A randomized controlled trial. BMC Gastroenterol., 20.","DOI":"10.1186\/s12876-020-01502-w"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.nutres.2019.08.009","article-title":"An energy-restricted high-protein diet supplemented with \u03b2-cryptoxanthin alleviated oxidative stress and inflammation in nonalcoholic fatty liver disease: A randomized controlled trial","volume":"73","author":"Haidari","year":"2020","journal-title":"Nutr. Res."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1093\/jn\/nxz106","article-title":"Dietary \u03b2-Cryptoxanthin Inhibits High-Refined Carbohydrate Diet-Induced Fatty Liver via Differential Protective Mechanisms Depending on Carotenoid Cleavage Enzymes in Male Mice","volume":"149","author":"Lim","year":"2019","journal-title":"J. Nutr."},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Kobori, M., Ni, Y., Takahashi, Y., Watanabe, N., Sugiura, M., Ogawa, K., Nagashimada, M., Kaneko, S., Naito, S., and Ota, T. (2014). \u03b2-Cryptoxanthin alleviates diet-induced nonalcoholic steatohepatitis by suppressing inflammatory gene expression in mice. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0098294"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1210\/en.2014-1776","article-title":"Prevention and reversal of lipotoxicity-induced hepatic insulin resistance and steatohepatitis in mice by an antioxidant carotenoid, \u03b2-cryptoxanthin","volume":"156","author":"Ni","year":"2015","journal-title":"Endocrinology"},{"key":"ref_159","first-page":"161","article-title":"Carotenoids and non-alcoholic fatty liver disease","volume":"4","author":"Yilmaz","year":"2015","journal-title":"Hepatobiliary Surg. Nutr."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1159\/000496458","article-title":"Low Levels of Serum \u03b2-Carotene and \u03b2-Carotene\/Retinol Ratio Are Associated with Histological Severity in Nonalcoholic Fatty Liver Disease Patients","volume":"74","author":"Wang","year":"2019","journal-title":"Ann. Nutr. Metab."},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Christensen, K., Lawler, T., and Mares, J. (2019). Dietary Carotenoids and Non-Alcoholic Fatty Liver Disease among U.S Adults, NHANES 2003\u20132014. Nutrients, 11.","DOI":"10.3390\/nu11051101"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"12951","DOI":"10.1038\/srep12951","article-title":"Greater serum carotenoid levels associated with lower prevalence of nonalcoholic fatty liver disease in Chinese adults","volume":"5","author":"Cao","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_163","first-page":"275","article-title":"Effects of rosuvastatin and\/or \u03b2-carotene on non-alcoholic fatty liver in rats","volume":"10","author":"Hammam","year":"2015","journal-title":"Res. Pharm. Sci."},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Li, J., and Abdel-Aal, E.M. (2021). Dietary Lutein and Cognitive Function in Adults: A Meta-Analysis of Randomized Controlled Trials. Molecules, 26.","DOI":"10.3390\/molecules26195794"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"8061","DOI":"10.3748\/wjg.v21.i26.8061","article-title":"Ameliorative effects of lutein on non-alcoholic fatty liver disease in rats","volume":"21","author":"Qiu","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1080\/14786419.2019.1662011","article-title":"Anti-aging derivatives of cycloastragenol produced by biotransformation","volume":"35","author":"Chen","year":"2021","journal-title":"Nat. Prod. Res."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.phrs.2017.04.021","article-title":"Cycloastragenol improves hepatic steatosis by activating farnesoid X receptor signalling","volume":"121","author":"Gu","year":"2017","journal-title":"Pharmacol. Res."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1080\/13543776.2016.1182988","article-title":"Oleanolic acid derivatives for pharmaceutical use: A patent review","volume":"26","author":"Lin","year":"2016","journal-title":"Expert Opin. Ther. Pat."},{"key":"ref_169","first-page":"597","article-title":"Clinical and experimental study on yi-gan-ning granule in treating chronic hepatitis B","volume":"13","author":"Zhang","year":"1993","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/cns.13095","article-title":"Treatment of dementia and mild cognitive impairment with or without cerebrovascular disease: Expert consensus on the use of Ginkgo biloba extract, EGb 761\u00ae","volume":"25","author":"Kandiah","year":"2019","journal-title":"CNS Neurosci. Ther."},{"key":"ref_171","first-page":"e16454","article-title":"How Much Is Too Much? Exploring Pseudohyperaldosteronism in Glycyrrhizic Acid Toxicity From Chronic Licorice Root Consumption","volume":"13","author":"Patel","year":"2021","journal-title":"Cureus"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1002\/hep.30429","article-title":"Modulation of Insulin Resistance in Nonalcoholic Fatty Liver Disease","volume":"70","author":"Khan","year":"2019","journal-title":"Hepatology"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.14336\/AD.2019.0116","article-title":"Pyroptosis in Liver Disease: New Insights into Disease Mechanisms","volume":"10","author":"Wu","year":"2019","journal-title":"Aging Dis."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.cmet.2022.07.006","article-title":"Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis","volume":"34","author":"Gao","year":"2022","journal-title":"Cell Metab."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ceb.2017.01.005","article-title":"AMPK signalling in health and disease","volume":"45","author":"Carling","year":"2017","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_176","doi-asserted-by":"crossref","unstructured":"He, F., Ru, X., and Wen, T. (2020). NRF2, a Transcription Factor for Stress Response and Beyond. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21134777"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"852","DOI":"10.7150\/ijbs.19370","article-title":"Emerging roles of SIRT1 in fatty liver diseases","volume":"13","author":"Ding","year":"2017","journal-title":"Int. J. Biol. Sci."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/28\/1\/272\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:55:18Z","timestamp":1760147718000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/28\/1\/272"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,29]]},"references-count":177,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["molecules28010272"],"URL":"https:\/\/doi.org\/10.3390\/molecules28010272","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,29]]}}}