{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:58:03Z","timestamp":1787029083827,"version":"build-2736575974"},"reference-count":25,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T00:00:00Z","timestamp":1672358400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Philadelphia University","award":["511\/34\/100 PU"],"award-info":[{"award-number":["511\/34\/100 PU"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>This work aimed to develop a new one-pot and readily scaled-up formulation capable of retaining 5-fluorouracil and prolonging its release to obtain a site-specific medication delivery for the potential treatment of colorectal cancer. Six polymer-based formulations were successfully produced using a thermal bulk polymerization method and loaded with 5-fluorouracil, which is a chemotherapeutic agent used in the treatment of colorectal carcinoma. The pellets produced were characterized by measuring the glass transition temperature, tensile strength, Young\u2019s modulus, and tensile elongation at break. Studies on in vitro swelling and release were carried out in phosphate-buffered saline to evaluate the behaviour of the developed system. The Young\u2019s modulus, glass transition temperature, and tensile strength all increased significantly as the crosslinker concentration increased, but the fracture strain value reduced significantly. The in vitro swelling profile of the produced formulations was significantly reduced by increasing crosslinking density. Less than 27% cumulative drug release was achieved for all formulations after 5 h of starting the release study. The highest cumulative drug release reached after 24 h was 69%. The developed drug delivery system demonstrated the ability to delay the release of 5-fluorouracil in upper gastrointestinal tract-mimicking conditions, while permitting its release in a controlled way afterward, which makes it promising for the potential delivery of 5-fluorouracil to the colon.<\/jats:p>","DOI":"10.3390\/molecules28010306","type":"journal-article","created":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T03:00:59Z","timestamp":1672628459000},"page":"306","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Smart Pellets for Controlled Delivery of 5-Fluorouracil"],"prefix":"10.3390","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1736-1799","authenticated-orcid":false,"given":"Mohammad F.","family":"Bayan","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy, Philadelphia University, P.O. Box 1, Amman 19392, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4775-6238","authenticated-orcid":false,"given":"Abdolelah","family":"Jaradat","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Isra University, P.O. Box 33, Amman 11622, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2731-1071","authenticated-orcid":false,"given":"Mohammad H.","family":"Alyami","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, College of Pharmacy, Najran University, Najran 66462, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8440-7446","authenticated-orcid":false,"given":"Abdallah Y.","family":"Naser","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Isra University, P.O. Box 33, Amman 11622, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s43094-020-00057-7","article-title":"Recent advances in mesalamine colonic delivery systems","volume":"6","author":"Bayan","year":"2020","journal-title":"Futur. J. Pharm. Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"100","DOI":"10.4103\/japtr.JAPTR_26_19","article-title":"Advances in orally targeted drug delivery to colon","volume":"10","author":"Muchtaridi","year":"2019","journal-title":"J. Adv. Pharm. Technol. 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