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In this review, the biological, allelochemical, and chemical properties of acetophenone, as a metabolite involved in multiple interactions with various (mi-cro)organisms, are discussed. Further, the details of its biogenesis and chemical synthesis are provided, and the possibility of its application in different areas of life sciences, i.e., the status quo of acetophenone and its simple substituted analogs, is examined. In particular, natural and synthetic simple acetophenone derivatives are analyzed as promising agrochemicals and useful scaffolds for drug research and development.<\/jats:p>","DOI":"10.3390\/molecules28010370","type":"journal-article","created":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T03:08:59Z","timestamp":1672628939000},"page":"370","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Traveling across Life Sciences with Acetophenone\u2014A Simple Ketone That Has Special Multipurpose Missions"],"prefix":"10.3390","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0289-0831","authenticated-orcid":false,"given":"Fedor I.","family":"Zubkov","sequence":"first","affiliation":[{"name":"Department of Organic Chemistry, \u0420eoples\u2019 Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, 117198 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1417-8355","authenticated-orcid":false,"given":"Vladimir V.","family":"Kouznetsov","sequence":"additional","affiliation":[{"name":"Laboratorio de Qu\u00edmica Org\u00e1nica y Biomolecular, Escuela de Qu\u00edmica, Universidad Industrial de Santander, Cl. 9 # Cra 27, A.A., Bucaramanga 680006, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nature03194","article-title":"Lessons from natural molecules","volume":"432","author":"Clardy","year":"2004","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3670","DOI":"10.1016\/j.bbagen.2013.02.008","article-title":"Natural products: A continuing source of novel drug leads","volume":"1830","author":"Cragg","year":"2013","journal-title":"Biochim. 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