{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T09:38:41Z","timestamp":1791970721750,"version":"4.3.4"},"reference-count":49,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T00:00:00Z","timestamp":1672704000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Russian Science Foundation and Government of Sverdlovsk region","award":["22-26-20124"],"award-info":[{"award-number":["22-26-20124"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The addition of active groups of known fungicides, or systemic acquired resistance inducers, into novel compound molecules to search for potential antifungal compounds is a popular and effective strategy. In this work, a new series of N-acyl-N-arylalanines was developed and synthesized, in which 1,2,3-thiadiazol-5-ylcarbonyl or 3,4-dichloroisothiazol-5-ylcarbonyl (fragments from synthetic plant resistance activators tiadinil and isotianil, respectively) and a fragment of N-arylalanine, the toxophoric group of acylalanine fungicides. Several new synthesized compounds have shown moderate antifungal activity against fungi in vitro, such as B. cinerea, R. solani and S. sclerotiorum. In vivo tests against A. brassicicola showed that compound 1d was 92% effective at a concentration of 200 \u00b5g\/mL, similar to level of tiadinil, a known inducer of systemic resistance. Thus, 1d could be considered a new candidate fungicide for further detailed study. The present results will advance research and influence the search for more promising fungicides for disease control in agriculture.<\/jats:p>","DOI":"10.3390\/molecules28010419","type":"journal-article","created":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T02:54:55Z","timestamp":1672800895000},"page":"419","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Synthesis, Fungicidal Activity and Plant Protective Properties of 1,2,3-Thiadiazole and Isothiazole-Based N-acyl-N-arylalaninates"],"prefix":"10.3390","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7549-686X","authenticated-orcid":false,"given":"Tatiana A.","family":"Kalinina","sequence":"first","affiliation":[{"name":"Institute of Chemical Engineering, Ural Federal University Named after the First President of Russia B.N. Yeltsin, 19 Mira Street, 620002 Ekaterinburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeriya I.","family":"Balandina","sequence":"additional","affiliation":[{"name":"Institute of Chemical Engineering, Ural Federal University Named after the First President of Russia B.N. Yeltsin, 19 Mira Street, 620002 Ekaterinburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5884-4105","authenticated-orcid":false,"given":"Konstantin L.","family":"Obydennov","sequence":"additional","affiliation":[{"name":"Institute of Chemical Engineering, Ural Federal University Named after the First President of Russia B.N. Yeltsin, 19 Mira Street, 620002 Ekaterinburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel A.","family":"Slepukhin","sequence":"additional","affiliation":[{"name":"Postovsky Institute of Organic Synthesis, Ural Branch of Russian Academy of Sciences, 22\/20 S. Kovalevskaya Street, 620108 Ekaterinburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5565-0949","authenticated-orcid":false,"given":"Zhijin","family":"Fan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, No. 94, Weijin Road, Tianjin 300071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasiliy A.","family":"Bakulev","sequence":"additional","affiliation":[{"name":"Institute of Chemical Engineering, Ural Federal University Named after the First President of Russia B.N. 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