{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T19:11:02Z","timestamp":1777057862969,"version":"3.51.4"},"reference-count":101,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T00:00:00Z","timestamp":1672963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"SIREI project","award":["26650202238"],"award-info":[{"award-number":["26650202238"]}]},{"name":"SIREI project","award":["171055"],"award-info":[{"award-number":["171055"]}]},{"name":"SIREI project","award":["32753"],"award-info":[{"award-number":["32753"]}]},{"name":"SIREI project","award":["32935"],"award-info":[{"award-number":["32935"]}]},{"name":"Sistema Nacional de Investigadores (SNI)","award":["26650202238"],"award-info":[{"award-number":["26650202238"]}]},{"name":"Sistema Nacional de Investigadores (SNI)","award":["171055"],"award-info":[{"award-number":["171055"]}]},{"name":"Sistema Nacional de Investigadores (SNI)","award":["32753"],"award-info":[{"award-number":["32753"]}]},{"name":"Sistema Nacional de Investigadores (SNI)","award":["32935"],"award-info":[{"award-number":["32935"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Women have a high susceptibility to the negative effects of stress. Hormonal changes experienced throughout their reproductive life partially contribute to a higher incidence of anxiety and depression symptoms, particularly, during natural or surgical menopause. In preclinical research, the flavonoid chrysin (5,7-dihydroxyflavone) exerts anxiolytic- and anti-despair-like effects; however, it is unknown whether chrysin exerts a protective effect against the behavioral changes produced by acute stress on locomotor activity and behavioral despair in rats at 12-weeks post-ovariectomy. Ovariectomized female Wistar rats were assigned to eight groups: vehicle group (10% DMSO), three groups with chrysin and three groups with the same dose of allopregnanolone (0.5, 1, and 2 mg\/kg), and one group with diazepam (2 mg\/kg). The treatments were administered for seven consecutive days and the effects were evaluated in the locomotor activity and swimming tests. Chrysin (2 mg\/kg) increased the latency to first immobility and decreased the total immobility time in the swimming test as the reference drugs allopregnanolone and diazepam (2 mg\/kg); while locomotor activity prevented the behavioral changes produced by swimming. In conclusion, chrysin exerts a protective effect against the behavioral changes induced by acute stress, similarly to the neurosteroid allopregnanolone and the benzodiazepine diazepam in rats subjected to a surgical menopause model.<\/jats:p>","DOI":"10.3390\/molecules28020587","type":"journal-article","created":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T05:57:14Z","timestamp":1673243834000},"page":"587","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Behavioral Despair Is Blocked by the Flavonoid Chrysin (5,7-Dihydroxyflavone) in a Rat Model of Surgical Menopause"],"prefix":"10.3390","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6118-1069","authenticated-orcid":false,"given":"Luis \u00c1ngel","family":"Flores-Aguilar","sequence":"first","affiliation":[{"name":"Programa de Doctorado en Neuroetolog\u00eda, Instituto de Neuroetolog\u00eda, Universidad Veracruzana, Xalapa 91190, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Cueto-Escobedo","sequence":"additional","affiliation":[{"name":"Departamento de Investigaci\u00f3n Cl\u00ednica y Traslacional, Instituto de Ciencias de la Salud, Universidad Veracruzana, Xalapa 91190, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5968-0210","authenticated-orcid":false,"given":"Abraham","family":"Puga-Olgu\u00edn","sequence":"additional","affiliation":[{"name":"Unidad de Salud Integrativa, Centro de EcoAlfabetizaci\u00f3n y Di\u00e1logo de Saberes, Universidad Veracruzana, Xalapa 91060, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0730-4907","authenticated-orcid":false,"given":"Oscar Jer\u00f3nimo","family":"Olmos-V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurofarmacolog\u00eda, Instituto de Neuroetolog\u00eda, Universidad Veracruzana, Xalapa 91190, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilberto Uriel","family":"Rosas-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurofarmacolog\u00eda, Instituto de Neuroetolog\u00eda, Universidad Veracruzana, Xalapa 91190, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5370-4157","authenticated-orcid":false,"given":"Blandina","family":"Bernal-Morales","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurofarmacolog\u00eda, Instituto de Neuroetolog\u00eda, Universidad Veracruzana, Xalapa 91190, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5837-103X","authenticated-orcid":false,"given":"Juan Francisco","family":"Rodr\u00edguez-Landa","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurofarmacolog\u00eda, Instituto de Neuroetolog\u00eda, Universidad Veracruzana, Xalapa 91190, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1523\/JNEUROSCI.0733-19.2019","article-title":"Revisiting the stress concept: Implications for affective disorders","volume":"40","author":"McEwen","year":"2020","journal-title":"J. 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