{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T01:56:07Z","timestamp":1768614967488,"version":"3.49.0"},"reference-count":158,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T00:00:00Z","timestamp":1673568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Deanship of Scientific Research at King Khalid University","award":["RGP.2\/121\/43\/1443H"],"award-info":[{"award-number":["RGP.2\/121\/43\/1443H"]}]},{"name":"Deanship of Scientific Research at King Khalid University","award":["RGP.2\/121\/43\/1443H"],"award-info":[{"award-number":["RGP.2\/121\/43\/1443H"]}]},{"name":"Deanship of Scientific Research at King Khalid University","award":["RGP.2\/121\/43\/1443H"],"award-info":[{"award-number":["RGP.2\/121\/43\/1443H"]}]},{"name":"Deanship of Scientific Research at King Khalid University","award":["RGP.2\/121\/43\/1443H"],"award-info":[{"award-number":["RGP.2\/121\/43\/1443H"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The novel pathogenic virus was discovered in Wuhan, China (December 2019), and quickly spread throughout the world. Further analysis revealed that the pathogenic strain of virus was corona but it was distinct from other coronavirus strains, and thus it was renamed 2019-nCoV or SARS-CoV-2. This coronavirus shares many characteristics with other coronaviruses, including SARS-CoV and MERS-CoV. The clinical manifestations raised in the form of a cytokine storm trigger a complicated spectrum of pathophysiological changes that include cardiovascular, kidney, and liver problems. The lack of an effective treatment strategy has imposed a health and socio-economic burden. Even though the mortality rate of patients with this disease is lower, since it is judged to be the most contagious, it is considered more lethal. Globally, the researchers are continuously engaged to develop and identify possible preventive and therapeutic regimens for the management of disease. Notably, to combat SARS-CoV-2, various vaccine types have been developed and are currently being tested in clinical trials; these have also been used as a health emergency during a pandemic. Despite this, many old antiviral and other drugs (such as chloroquine\/hydroxychloroquine, corticosteroids, and so on) are still used in various countries as emergency medicine. Plant-based products have been reported to be safe as alternative options for several infectious and non-infectious diseases, as many of them showed chemopreventive and chemotherapeutic effects in the case of tuberculosis, cancer, malaria, diabetes, cardiac problems, and others. Therefore, plant-derived products may play crucial roles in improving health for a variety of ailments by providing a variety of effective cures. Due to current therapeutic repurposing efforts against this newly discovered virus, we attempted to outline many plant-based compounds in this review to aid in the fight against SARS-CoV-2.<\/jats:p>","DOI":"10.3390\/molecules28020795","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T02:57:33Z","timestamp":1673578653000},"page":"795","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["An Attention towards the Prophylactic and Therapeutic Options of Phytochemicals for SARS-CoV-2: A Molecular Insight"],"prefix":"10.3390","volume":"28","author":[{"given":"Shoaib","family":"Shoaib","sequence":"first","affiliation":[{"name":"Department Biochemistry, Faculty of Medicine, J. N. Medical College, Aligarh Muslim University, Aligarh 202002, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6122-5479","authenticated-orcid":false,"given":"Mohammad Azam","family":"Ansari","sequence":"additional","affiliation":[{"name":"Department of Epidemic Disease Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1552-7978","authenticated-orcid":false,"given":"Geetha","family":"Kandasamy","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, College of Pharmacy, King Khalid University (KKU), Abha 62529, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajalakshimi","family":"Vasudevan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Pharmacy, King Khalid University (KKU), Abha 62529, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4643-0922","authenticated-orcid":false,"given":"Umme","family":"Hani","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, College of Pharmacy, King Khalid University (KKU), Abha 62529, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waseem","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh 202002, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam S.","family":"Alhumaidi","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science, University of Hafr Al Batin, Hafr Al Batin 31991, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8691-086X","authenticated-orcid":false,"given":"Khadijah A.","family":"Altammar","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science, University of Hafr Al Batin, Hafr Al Batin 31991, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarfuddin","family":"Azmi","sequence":"additional","affiliation":[{"name":"Molecular Microbiology Biology Division, Scientific Research Centre (SRC), Prince Sultan Military Medical City (PSMMC), Riyadh 11159, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2639-9200","authenticated-orcid":false,"given":"Wasim","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Mohammed Al-Mana College for Medical Sciences, Dammam 34222, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9941-2918","authenticated-orcid":false,"given":"Shadma","family":"Wahab","sequence":"additional","affiliation":[{"name":"Deparment of Pharmacognosy, College of Pharmacy, King Khalid University, Abha 61421, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Najmul","family":"Islam","sequence":"additional","affiliation":[{"name":"Department Biochemistry, Faculty of Medicine, J. 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