{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:38:28Z","timestamp":1787683108401,"version":"build-2784847793"},"reference-count":30,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,15]],"date-time":"2023-01-15T00:00:00Z","timestamp":1673740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFD1800402"],"award-info":[{"award-number":["2021YFD1800402"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019-620-000-001-027"],"award-info":[{"award-number":["2019-620-000-001-027"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020736","name":"Hubei Agricultural Science and Technology Innovation Center","doi-asserted-by":"publisher","award":["2021YFD1800402"],"award-info":[{"award-number":["2021YFD1800402"]}],"id":[{"id":"10.13039\/501100020736","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020736","name":"Hubei Agricultural Science and Technology Innovation Center","doi-asserted-by":"publisher","award":["2019-620-000-001-027"],"award-info":[{"award-number":["2019-620-000-001-027"]}],"id":[{"id":"10.13039\/501100020736","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Pseudorabies virus (PRV) is a pathogen that causes Aujeszky\u2019s disease (AD) in animals, leading to huge economic losses to swine farms. In order to discover anti-PRV compounds, we studied the extracts of the strain Streptomyces jiujiangensis NBERC-24992, which showed significant anti-PRV activity. Eight benzoheterocyclic secondary metabolites, including three new compounds (1\u20133, virantmycins D\u2013G) and five known compounds (4\u20138, virantmycin, A-503451 D, A-503451 D acetylate, A-503451 A, and A-503451 B), were isolated from the broth of NBERC-24992. The structures of the new compounds were identified by using extensive spectroscopic data, including mass spectrometry (MS), nuclear magnetic resonance (NMR), and electronic circular dichroism (ECD). Compound 1 was found to be a novel heterocyclic compound with a tricyclic skeleton from natural product. All compounds were tested for antiviral activity, and 4 (virantmycin) showed an excellent effect against PRV and was better than ribavirin and acyclovir. Our study revealed that chlorine atom and tetrahydroquinoline skeleton were important active moiety for antiviral activity. Virantmycin could be a suitable leading compound for an antiviral drug against PRV.<\/jats:p>","DOI":"10.3390\/molecules28020878","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T04:57:19Z","timestamp":1673845039000},"page":"878","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Antiviral Activity of Benzoheterocyclic Compounds from Soil-Derived Streptomyces\u00a0jiujiangensis NBERC-24992"],"prefix":"10.3390","volume":"28","author":[{"given":"Manli","family":"Liu","sequence":"first","affiliation":[{"name":"Hubei Biopesticide Engineering Research Centre, Hubei Academy of Agricultural Sciences, No. 8, Nanhu Ave., Hongshan District, Wuhan 430064, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyao","family":"Ren","sequence":"additional","affiliation":[{"name":"Institute of Infection, Immunology and Tumor Microenvironment, Institute of Pharmaceutical Process, Department of Pharmacy, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Medicine, Wuhan University of Science and Technology, No. 2, Huangjiahu East Road, Hongshan District, Wuhan 430081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yani","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hubei Biopesticide Engineering Research Centre, Hubei Academy of Agricultural Sciences, No. 8, Nanhu Ave., Hongshan District, Wuhan 430064, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyi","family":"Wan","sequence":"additional","affiliation":[{"name":"Hubei Biopesticide Engineering Research Centre, Hubei Academy of Agricultural Sciences, No. 8, Nanhu Ave., Hongshan District, Wuhan 430064, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueyin","family":"Wang","sequence":"additional","affiliation":[{"name":"Hubei Biopesticide Engineering Research Centre, Hubei Academy of Agricultural Sciences, No. 8, Nanhu Ave., Hongshan District, Wuhan 430064, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Hubei Biopesticide Engineering Research Centre, Hubei Academy of Agricultural Sciences, No. 8, Nanhu Ave., Hongshan District, Wuhan 430064, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3440-3014","authenticated-orcid":false,"given":"Kaimei","family":"Wang","sequence":"additional","affiliation":[{"name":"Hubei Biopesticide Engineering Research Centre, Hubei Academy of Agricultural Sciences, No. 8, Nanhu Ave., Hongshan District, Wuhan 430064, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Fang","sequence":"additional","affiliation":[{"name":"Hubei Biopesticide Engineering Research Centre, Hubei Academy of Agricultural Sciences, No. 8, Nanhu Ave., Hongshan District, Wuhan 430064, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4473-7122","authenticated-orcid":false,"given":"Xiliang","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Infection, Immunology and Tumor Microenvironment, Institute of Pharmaceutical Process, Department of Pharmacy, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Medicine, Wuhan University of Science and Technology, No. 2, Huangjiahu East Road, Hongshan District, Wuhan 430081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1128\/MMBR.69.3.462-500.2005","article-title":"Molecular biology of pseudorabies virus: Impact on neurovirology and veterinary medicine","volume":"69","author":"Pomeranz","year":"2005","journal-title":"Microbiol. 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