{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:47:46Z","timestamp":1760147266713,"version":"build-2065373602"},"reference-count":42,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T00:00:00Z","timestamp":1674000000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Regional Development Fund"},{"name":"Region Grand Est through the CUPROCARE project"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>This work studies two copper-based alloys as potential antimicrobial weapons for sectors where surface hygiene is essential. Effects of different alloying elements addition at the same Cu content (92.5% by weight) on the corrosion resistance and the antibacterial performance of two copper alloys were studied in an aerated disinfectant solution (0.25% v\/v Aniosurf Premium (D)) by electrochemical corrosion, X-ray photoelectron spectroscopy (XPS), time-of-flight secondary ion mass spectroscopy (ToF-SIMS) and antibacterial tests. Results showed that the nature of the alloying elements had a clear influence on the corrosion resistance and antibacterial performance. Electrochemical impedance results and surface analyses demonstrate the presence of organic compounds bound on the substrate and that a film covers part of the total active surface and may act as a protective barrier by preventing the interaction between metal and solution, decreasing the antimicrobial performance of copper-based materials. Low zinc and silicon contents in copper alloys allows for better aging behavior in D solution while maintaining good antibacterial performance. The XPS and ToF-SIMS results indicated that artificial aging in disinfectant enhanced Cu enrichment in the organic film formed, which could effectively stimulate the release of Cu ions from the surface.<\/jats:p>","DOI":"10.3390\/molecules28030981","type":"journal-article","created":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T06:22:10Z","timestamp":1674109330000},"page":"981","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of Ageing in Disinfectant Solution on the Corrosion Resistance and Antimicrobial Behavior of Copper Alloys"],"prefix":"10.3390","volume":"28","author":[{"given":"Florica Simescu","family":"Lazar","sequence":"first","affiliation":[{"name":"Laboratoire Mat\u00e9riaux et Ing\u00e9nierie M\u00e9canique (MATIM), UFR de Sciences Exactes et Naturelles, Universit\u00e9 de Reims Champagne-Ardenne, 51687 Reims, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9841-6711","authenticated-orcid":false,"given":"Marius","family":"Colin","sequence":"additional","affiliation":[{"name":"Biomat\u00e9riaux et Inflammation en site Osseux (EA 4691 BIOS), SFR CAP-Sant\u00e9, UFR de Pharmacie, Universit\u00e9 de Reims Champagne-Ardenne, 51095 Reims, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0465-1818","authenticated-orcid":false,"given":"Ga\u00eblle","family":"Carr\u00e9","sequence":"additional","affiliation":[{"name":"Biomat\u00e9riaux et Inflammation en site Osseux (EA 4691 BIOS), SFR CAP-Sant\u00e9, UFR de Pharmacie, Universit\u00e9 de Reims Champagne-Ardenne, 51095 Reims, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Bachelard","sequence":"additional","affiliation":[{"name":"Laboratoire Mat\u00e9riaux et Ing\u00e9nierie M\u00e9canique (MATIM), UFR de Sciences Exactes et Naturelles, Universit\u00e9 de Reims Champagne-Ardenne, 51687 Reims, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Paul","family":"Chopart","sequence":"additional","affiliation":[{"name":"Laboratoire Mat\u00e9riaux et Ing\u00e9nierie M\u00e9canique (MATIM), UFR de Sciences Exactes et Naturelles, Universit\u00e9 de Reims Champagne-Ardenne, 51687 Reims, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2651-9372","authenticated-orcid":false,"given":"Sophie C.","family":"Gangloff","sequence":"additional","affiliation":[{"name":"Biomat\u00e9riaux et Inflammation en site Osseux (EA 4691 BIOS), SFR CAP-Sant\u00e9, UFR de Pharmacie, Universit\u00e9 de Reims Champagne-Ardenne, 51095 Reims, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,18]]},"reference":[{"key":"ref_1","unstructured":"European Centre for Disease Prevention and Control (2013). Point Prevalence Survey of Healthcare-Associated Infections and Antimicrobial Use in European Acute Care Hospitals: 2011\u20132012., The Publications Office of the European Union."},{"key":"ref_2","unstructured":"Savey, A., Machut, A., and Barreto, C. (2017). Enqu\u00eate Nationale de Pr\u00e9valence Des Infections Associ\u00e9es Aux Soins et Des Traitements Antibiotiques En \u00c9tablissements d\u2019h\u00e9bergement Pour Personnes \u00c2g\u00e9es D\u00e9pendantes; R\u00e9sultats Nationaux 2016. (National Prevalence Survey of Healthcare-Associated Infections and Antibiotic Use in Nursing Homes; 2016 national outcomes). St. Publique Fr., 67. (In French)."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Colin, M., Klingelschmitt, F., Charpentier, E., Josse, J., Kanagaratnam, L., De Champs, C., and Gangloff, S. (2018). Copper Alloy Touch Surfaces in Healthcare Facilities: An Effective Solution to Prevent Bacterial Spreading. Materials, 11.","DOI":"10.3390\/ma11122479"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"130712","DOI":"10.1016\/j.matlet.2021.130712","article-title":"Copper alloys to prevent bacterial biofilm formation on touch surfaces","volume":"305","author":"Colin","year":"2021","journal-title":"Mater. Lett."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1128\/JCM.01032-12","article-title":"Sustained Reduction of Microbial Burden on Common Hospital Surfaces through Introduction of Copper","volume":"50","author":"Schmidt","year":"2012","journal-title":"J. Clin. Microbiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/lam.12680","article-title":"Copper as an antibacterial material in different facilities","volume":"64","author":"Inkinen","year":"2017","journal-title":"Lett. Appl. Microbiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1086\/663644","article-title":"The Antimicrobial Efficacy of Copper Alloy Furnishing in the Clinical Environment: A Crossover Study","volume":"33","author":"Karpanen","year":"2012","journal-title":"Infect. Control Hosp. Epidemiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0001-2092(06)61994-7","article-title":"Survival of Enterococci and Staphylococci on Hospital Fabrics and Plastic","volume":"73","author":"Neelly","year":"2001","journal-title":"AORN J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1097\/00004630-200021060-00009","article-title":"A Survey of Gram-Negative Bacteria Survival on Hospital Fabrics and Plastics","volume":"21","author":"Neely","year":"2000","journal-title":"J. Burn Care Rehabil."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3704","DOI":"10.1128\/aem.60.10.3704-3710.1994","article-title":"Survival of enteric viruses on environmental fomites","volume":"60","author":"Abad","year":"1994","journal-title":"Appl. Environ. Microbiol. Novemb."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ajic.2005.05.013","article-title":"Survival on uncommon fomites of feline calicivirus, a surrogate of noroviruses","volume":"34","author":"Clay","year":"2006","journal-title":"Am. J. Infect. Control"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1016\/j.ajic.2012.12.004","article-title":"Evidence that contaminated surfaces contribute to the transmission of hospital pathogens and an overview of strategies to address contaminated surfaces in hospital settings","volume":"41","author":"Otter","year":"2013","journal-title":"Am. J. Infect. Control"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1097\/QCO.0b013e3283630f04","article-title":"The role of the surface environment in healthcare-associated infections","volume":"26","author":"Weber","year":"2013","journal-title":"Curr. Opin. Infect. Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1053\/jhin.2001.1013","article-title":"Evidence that hospital hygiene is important in the control of methicillin-resistant Staphylococcus aureus","volume":"49","author":"Rampling","year":"2001","journal-title":"J. Hosp. Infect."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1016\/j.ajic.2012.12.005","article-title":"Self-disinfecting surfaces: Review of current methodologies and future prospects","volume":"41","author":"Weber","year":"2013","journal-title":"Am. J. Infect. Control"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.jmbbm.2016.07.013","article-title":"Effect of current density during electrodeposition on microstructure and hardness of textured Cu coating in the application of antimicrobial Al touch surface","volume":"63","author":"Augustin","year":"2016","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.msec.2016.11.022","article-title":"Effect of copper addition on mechanical properties, corrosion resistance and antibacterial property of 316L stainless steel","volume":"71","author":"Xi","year":"2017","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"21159","DOI":"10.1021\/acsami.9b17815","article-title":"Antimicrobial Copper-Based Materials and Coatings: Potential Multifaceted Biomedical Applications","volume":"12","author":"Mitra","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1111\/jam.13681","article-title":"Contact killing and antimicrobial properties of copper","volume":"124","author":"Vincent","year":"2018","journal-title":"J. Appl. Microbiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.ijheh.2016.06.003","article-title":"Antimicrobial applications of copper","volume":"219","author":"Vincent","year":"2016","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jhazmat.2012.07.052","article-title":"Highly efficient antiviral and antibacterial activities of solid-state cuprous compounds","volume":"235\u2013236","author":"Sunada","year":"2012","journal-title":"J. Hazard. Mater."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jhin.2007.10.009","article-title":"The antimicrobial activity of copper and copper alloys against nosocomial pathogens and Mycobacterium tuberculosis isolated from healthcare facilities in the Western Cape: An in-vitro study","volume":"68","author":"Mehtar","year":"2008","journal-title":"J. Hosp. Infect."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.cmi.2018.03.034","article-title":"New insights on antimicrobial efficacy of copper surfaces in the healthcare environment: A systematic review","volume":"24","author":"Chyderiotis","year":"2018","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1128\/AEM.01704-10","article-title":"Mechanisms of Contact-Mediated Killing of Yeast Cells on Dry Metallic Copper Surfaces","volume":"77","author":"Quaranta","year":"2011","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e01697-15","DOI":"10.1128\/mBio.01697-15","article-title":"Human Coronavirus 229E Remains Infectious on Common Touch Surface Materials","volume":"6","author":"Warnes","year":"2015","journal-title":"mBio"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.jhin.2019.11.021","article-title":"Specific antibacterial activity of copper alloy touch surfaces in five long-term care facilities for older adults","volume":"104","author":"Colin","year":"2020","journal-title":"J. Hosp. Infect."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1017\/ice.2017.52","article-title":"Reduction of Environmental Contamination with Multidrug-Resistant Bacteria by Copper-Alloy Coating of Surfaces in a Highly Endemic Setting","volume":"38","author":"Souli","year":"2017","journal-title":"Infect. Control Hosp. Epidemiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jhin.2009.08.018","article-title":"Role of copper in reducing hospital environment contamination","volume":"74","author":"Casey","year":"2010","journal-title":"J. Hosp. Infect."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1128\/AEM.02766-10","article-title":"Metallic Copper as an Antimicrobial Surface","volume":"77","author":"Grass","year":"2011","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1128\/AEM.01599-10","article-title":"Bacterial Killing by Dry Metallic Copper Surfaces","volume":"77","author":"Santo","year":"2011","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"R\u00f3za\u00b4nska, A., Chmielarczyk, A., Romaniszyn, D., Sroka-Oleksiak, A., Bulanda, M., Walkowicz, M., Osuch, P., and Knych, T. (2017). Antimicrobial Properties of Selected Copper Alloys on Staphylococcus aureus and Escherichia coli in Different Simulations of Environmental Conditions: With vs. without Organic Contamination. Int. J. Environ. Res. Public Health, 14.","DOI":"10.3390\/ijerph14070813"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"108837","DOI":"10.1016\/j.corsci.2020.108837","article-title":"The native oxide film on a model aluminium-copper alloy studied by XPS and ToF-SIMS","volume":"174","author":"Cornette","year":"2020","journal-title":"Corros. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.corsci.2018.06.037","article-title":"Interfacial corrosion of copper in concentrated chloride solution and the formation of copper hydroxychloride","volume":"141","author":"Li","year":"2018","journal-title":"Corros. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.electacta.2017.04.092","article-title":"Enhanced Electrochemical Cu Release from Commercial Cu-Sn Alloys: Fate of the Alloying Elements in Artificial Perspiration","volume":"241","author":"Hutchison","year":"2017","journal-title":"Electrochim. Acta"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s10800-013-0642-2","article-title":"Single frequency electrochemical impedance investigation of zero charge potential for different surface states of Cu\u2013Ni alloys","volume":"44","author":"Normand","year":"2014","journal-title":"J. Appl. Electrochem."},{"key":"ref_36","unstructured":"Moulder, J., Stickle, W., Sobol, P., and Bomben, K. (1992). Handbook of X-ray Photoelectron Spectroscopy, Pekin-Elmer Corporation."},{"key":"ref_37","unstructured":"(2022, November 29). Available online: http:\/\/www.lasurface.com\/database\/liaisonxps.php."},{"key":"ref_38","unstructured":"(2022, November 29). Aniosurf Premium. Available online: https:\/\/procomed.ch\/wp-content\/uploads\/2017\/08\/ANIOSURF-PREMIUM-FT-1916-FR.pdf."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"109269","DOI":"10.1016\/j.corsci.2021.109269","article-title":"Surface analysis by gas cluster ion beam XPS and ToF-SIMS tandem MS of 2-mercaptobenzoxazole corrosion inhibitor for brass","volume":"182","year":"2021","journal-title":"Corros. Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"111113","DOI":"10.1016\/j.molliq.2019.111113","article-title":"Electrochemical, ToF-SIMS and computational studies of 4-amino-5-methyl-4H-1,2,4-triazole-3-thiol as a novel corrosion inhibitor for copper in 3.5% NaCl","volume":"289","author":"Chauhan","year":"2019","journal-title":"J. Mol. Liq."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1016\/0013-4686(72)87002-6","article-title":"Influence de l\u2019adsorption chimique du soufre sur le comportement electrochimique du cuivre dans une solution d\u2019acide nitrique","volume":"17","author":"Barbouth","year":"1972","journal-title":"Electrochim. Acta"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"6857","DOI":"10.1021\/la300021g","article-title":"Electrochemical and Spectroscopic Study of the Self-Assembling Mechanism of Normal and Chelating Alkanethiols on Copper","volume":"28","author":"Dilimon","year":"2012","journal-title":"Langmuir"}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/28\/3\/981\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:09:36Z","timestamp":1760119776000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/28\/3\/981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,18]]},"references-count":42,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["molecules28030981"],"URL":"https:\/\/doi.org\/10.3390\/molecules28030981","relation":{},"ISSN":["1420-3049"],"issn-type":[{"type":"electronic","value":"1420-3049"}],"subject":[],"published":{"date-parts":[[2023,1,18]]}}}