{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T15:23:10Z","timestamp":1775316190232,"version":"3.50.1"},"reference-count":49,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T00:00:00Z","timestamp":1674172800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH","award":["R01AI132614-01A1"],"award-info":[{"award-number":["R01AI132614-01A1"]}]},{"name":"NIH","award":["R21 AA027374-01"],"award-info":[{"award-number":["R21 AA027374-01"]}]},{"name":"NIH","award":["1R01NS109423-01A"],"award-info":[{"award-number":["1R01NS109423-01A"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Dearomative borylation of coumarins and chromenes via conjugate addition represents a relatively unexplored and challenging task. To address this issue, herein, we report a new and general copper (I) catalyzed dearomative borylation process to synthesize boron-containing oxacycles. In this report, the borylation of coumarins, chromones, and chromenes comprising functional groups, such as esters, nitriles, carbonyls, and amides, has been achieved. In addition, the method generates different classes of potential boron-based retinoids, including the ones with oxadiazole and anthocyanin motifs. The borylated oxacycles can serve as suitable intermediates to generate a library of compounds.<\/jats:p>","DOI":"10.3390\/molecules28031052","type":"journal-article","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T06:52:41Z","timestamp":1674197561000},"page":"1052","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Development of a New Methodology for Dearomative Borylation of Coumarins and Chromenes and Its Applications to Synthesize Boron-Containing Retinoids"],"prefix":"10.3390","volume":"28","author":[{"given":"Bhaskar C.","family":"Das","sequence":"first","affiliation":[{"name":"Arnold and Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY 11201, USA"},{"name":"Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"},{"name":"Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4845-4189","authenticated-orcid":false,"given":"Pratik","family":"Yadav","sequence":"additional","affiliation":[{"name":"Arnold and Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY 11201, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sasmita","family":"Das","sequence":"additional","affiliation":[{"name":"Arnold and Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY 11201, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariko","family":"Saito","sequence":"additional","affiliation":[{"name":"Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7148-9849","authenticated-orcid":false,"given":"Todd","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Surgery, Weill Cornell Medical College of Cornell University, New York, NY 10065, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.bmc.2013.11.025","article-title":"Retinoic acid signaling pathways in development and diseases","volume":"22","author":"Das","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/sj.bjc.6690312","article-title":"Retinoids: Present role and future potential","volume":"80","author":"Evans","year":"1999","journal-title":"Br. J. 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