{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:23:57Z","timestamp":1792099437301,"version":"4.4.0"},"reference-count":81,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,1,22]],"date-time":"2023-01-22T00:00:00Z","timestamp":1674345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Research, Innovation and Digitization, CCCDI-UEFISCDI","award":["PN-III-P2-2.1-PED-2021-4380"],"award-info":[{"award-number":["PN-III-P2-2.1-PED-2021-4380"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>With incidence of antimicrobial resistance rising globally, there is a continuous need for development of new antimicrobial molecules. Phenolic compounds having a versatile scaffold that allows for a broad range of chemical additions; they also exhibit potent antimicrobial activities which can be enhanced significantly through functionalization. Synthetic routes such as esterification, phosphorylation, hydroxylation or enzymatic conjugation may increase the antimicrobial activity of compounds and reduce minimal concentrations needed. With potent action mechanisms interfering with bacterial cell wall synthesis, DNA replication or enzyme production, phenolics can target multiple sites in bacteria, leading to a much higher sensitivity of cells towards these natural compounds. The current review summarizes some of the most important knowledge on functionalization of natural phenolic compounds and the effects on their antimicrobial activity.<\/jats:p>","DOI":"10.3390\/molecules28031114","type":"journal-article","created":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T01:36:26Z","timestamp":1674437786000},"page":"1114","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":403,"title":["Future Antimicrobials: Natural and Functionalized Phenolics"],"prefix":"10.3390","volume":"28","author":[{"given":"Andrei","family":"Lobiuc","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Biological Sciences, \u201c\u015etefan cel Mare\u201d University, 720229 Suceava, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi-Eunicia","family":"Pav\u0103l","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Biological Sciences, \u201c\u015etefan cel Mare\u201d University, 720229 Suceava, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4632-5076","authenticated-orcid":false,"given":"Ionel I.","family":"Mangalagiu","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, \u201cAlexandru Ioan Cuza\u201d University, 700506 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana","family":"Gheorghi\u021b\u0103","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Biological Sciences, \u201c\u015etefan cel Mare\u201d University, 720229 Suceava, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel-Ciprian","family":"Teliban","sequence":"additional","affiliation":[{"name":"Department of Horticulture Technologies, \u201cIon Ionescu de la Brad\u201d University of Life Sciences, 700490 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorina","family":"Am\u0103riuc\u0103i-Mantu","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, \u201cAlexandru Ioan Cuza\u201d University, 700506 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0485-0312","authenticated-orcid":false,"given":"Vasile","family":"Stoleru","sequence":"additional","affiliation":[{"name":"Department of Horticulture Technologies, \u201cIon Ionescu de la Brad\u201d University of Life Sciences, 700490 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e14264","DOI":"10.1111\/jfbc.14264","article-title":"Health benefits of polyphenols: A concise review","volume":"46","author":"Rana","year":"2022","journal-title":"J. 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