{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T23:26:55Z","timestamp":1774049215414,"version":"3.50.1"},"reference-count":67,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T00:00:00Z","timestamp":1675123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"King Saud University, Riyadh, Saudi Arabia","award":["RSP2023R119"],"award-info":[{"award-number":["RSP2023R119"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The present study was conducted to evaluate the acute toxicity and anti-inflammatory effect in vivo, as well as the antioxidant activity, of the essential oil of Thymus leptobotrys Murb. The results indicate that the tested essential oil is non-toxic, with an estimated LD50 of 2500 mg kg\u22121 of mice body weight. The anti-inflammatory test revealed that, at a dose of 200 mg kg\u22121, the essential oil reduced rat paw edemas by 89.59% within 3 h of oral administration, this reduction in edema size was greater than that obtained with indomethacin (75.78%). The antioxidant activity (IC50) of Thymus leptobotrys Murb essential oil was 346.896 \u00b5g mL\u22121 and 861.136 mg Trolox equivalent\/g essential oil in the 2.2-diphenyl1-picryl-hydrazyl radical scavenging capacity (DPPH) and Trolox equivalent antioxidant capacity (TEAC) assays, respectively. The toxicity test reveals an LD50 greater than 2500 mg kg\u22121 of body weight of mice which classifies it within category 5 of non-toxic substances that can be administered orally. These results suggest that the essential oil of Thymus leptobotrys Murb is not toxic, and it represents a valuable source of anti-inflammatory and antioxidant metabolites.<\/jats:p>","DOI":"10.3390\/molecules28031355","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T01:36:59Z","timestamp":1675215419000},"page":"1355","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Phytochemical Compounds, Acute Toxicity, Anti-Inflammatory and Antioxidant Activities of Thymus leptobotrys Murb Essential Oil"],"prefix":"10.3390","volume":"28","author":[{"given":"Asmaa","family":"Oubihi","sequence":"first","affiliation":[{"name":"Laboratory of Natural Resources and Sustainable Development, Faculty of Science, University Ibn Tofail, Kenitra B.P 242, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatima Zahrae","family":"Ballaoui","sequence":"additional","affiliation":[{"name":"Pharmacodynamy Research Team ERP, Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat B.P: 8007.N.U, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8410-3212","authenticated-orcid":false,"given":"Hamada","family":"Imtara","sequence":"additional","affiliation":[{"name":"Faculty of Arts and Sciences, Arab American University Palestine, Jenin P.O. Box 240, Palestine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassna","family":"Jaber","sequence":"additional","affiliation":[{"name":"Laboratory of Natural Resources and Sustainable Development, Faculty of Science, University Ibn Tofail, Kenitra B.P 242, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdessamad","family":"Ettouil","sequence":"additional","affiliation":[{"name":"Laboratory of Natural Resources and Sustainable Development, Faculty of Science, University Ibn Tofail, Kenitra B.P 242, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Haida","sequence":"additional","affiliation":[{"name":"Laboratory of Separation Processes, Team of Environment and Applied Chemistry, Faculty of Sciences, Ibn Tofail University, Kenitra B.P 242, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Ouhssine","sequence":"additional","affiliation":[{"name":"Laboratory of Natural Resources and Sustainable Development, Faculty of Science, University Ibn Tofail, Kenitra B.P 242, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0902-6381","authenticated-orcid":false,"given":"Omar M.","family":"Noman","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. 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Box 2457, Riyadh 11451, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud","family":"Tarayrah","sequence":"additional","affiliation":[{"name":"Groupe Hospitalier Cochin-Port Royal, Faculty of Medicine, Institut Cochin, Paris University, CNRS, IN-SERM, 75000 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zineb","family":"Guessous","sequence":"additional","affiliation":[{"name":"Laboratory of Natural Resources and Sustainable Development, Faculty of Science, University Ibn Tofail, Kenitra B.P 242, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s13596-018-0320-3","article-title":"Acute Toxicity and in Vivo Anti-Inflammatory Effects and in Vitro Antioxidant and Anti-Arthritic Potential of Scabiosa Stellata","volume":"18","author":"Mouffouk","year":"2018","journal-title":"Orient. 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